PL114723B1 - Proces for preparing novel derivatives of morphine - Google Patents

Proces for preparing novel derivatives of morphine Download PDF

Info

Publication number
PL114723B1
PL114723B1 PL1978205498A PL20549878A PL114723B1 PL 114723 B1 PL114723 B1 PL 114723B1 PL 1978205498 A PL1978205498 A PL 1978205498A PL 20549878 A PL20549878 A PL 20549878A PL 114723 B1 PL114723 B1 PL 114723B1
Authority
PL
Poland
Prior art keywords
formula
carbon atoms
group
morphine
hydrogen atom
Prior art date
Application number
PL1978205498A
Other languages
English (en)
Polish (pl)
Other versions
PL205498A1 (pl
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of PL205498A1 publication Critical patent/PL205498A1/xx
Publication of PL114723B1 publication Critical patent/PL114723B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL1978205498A 1977-03-23 1978-03-22 Proces for preparing novel derivatives of morphine PL114723B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12325/77A GB1593191A (en) 1977-03-23 1977-03-23 Derivatives of morphine

Publications (2)

Publication Number Publication Date
PL205498A1 PL205498A1 (pl) 1979-04-09
PL114723B1 true PL114723B1 (en) 1981-02-28

Family

ID=10002423

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1978205498A PL114723B1 (en) 1977-03-23 1978-03-22 Proces for preparing novel derivatives of morphine

Country Status (24)

Country Link
US (1) US4241066A (enExample)
JP (1) JPS53119899A (enExample)
AT (1) AT361139B (enExample)
AU (1) AU519643B2 (enExample)
BE (1) BE865183A (enExample)
CA (1) CA1089456A (enExample)
CH (1) CH629809A5 (enExample)
CS (1) CS200542B2 (enExample)
DD (1) DD133950A5 (enExample)
DE (1) DE2812580A1 (enExample)
DK (1) DK149858C (enExample)
ES (1) ES468173A1 (enExample)
FI (1) FI68236C (enExample)
FR (1) FR2384774A1 (enExample)
GB (1) GB1593191A (enExample)
IE (1) IE46443B1 (enExample)
IT (1) IT1105176B (enExample)
LU (1) LU79294A1 (enExample)
NL (1) NL7803083A (enExample)
NZ (1) NZ186692A (enExample)
PL (1) PL114723B1 (enExample)
SE (1) SE436131B (enExample)
SU (1) SU921467A3 (enExample)
ZA (1) ZA781527B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
JPS59500418A (ja) * 1982-03-16 1984-03-15 ザ　ロツクフエラ−　ユニバ−シテイ 胃腸能動作用障害を回復する方法
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
WO1993015081A1 (en) * 1992-01-23 1993-08-05 Toray Industries, Inc. Morphinan derivative and medicinal use
IT1269826B (it) * 1994-05-24 1997-04-15 Paolo Minoia Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate
CA2521379C (en) 2003-04-08 2013-07-02 Progenics Pharmaceuticals, Inc. Pharmaceutical formulations containing methylnaltrexone
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AU2006259780B2 (en) 2005-06-16 2012-04-12 SpecGx LLC A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
MX2008013594A (es) * 2006-04-21 2009-01-16 Nektar Therapeutics Al Corp Reduccion estereoselectiva de una morfinona.
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
TWI466671B (zh) 2007-03-29 2015-01-01 Progenics Pharm Inc 末梢性類鴉片受體拮抗劑及其用途
CA2682550C (en) 2007-03-29 2016-05-17 Wyeth Peripheral opioid receptor antagonists and uses thereof
ES2765811T5 (es) 2007-03-29 2024-02-27 Progenics Pharm Inc Forma cristalina de bromuro de (R)-n-metilnaltrexona y sus usos
CA2713568C (en) 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
AU2009300386B2 (en) 2008-09-30 2015-07-02 SpecGx LLC Processes for the alkylation of norbuprenorphine with reduced impurity formation
US8232397B2 (en) 2008-09-30 2012-07-31 Mallinckrodt Llc Processes for the production of buprenorphine with reduced impurity formation
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
US9969746B2 (en) 2013-12-05 2018-05-15 The University Of Bath Opioid compounds and their uses
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322771A (en) * 1967-05-30 Intermediates for preparing thebaine derivatives
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby

Also Published As

Publication number Publication date
ZA781527B (en) 1979-04-25
FI68236C (fi) 1985-08-12
IE780515L (en) 1978-09-23
SU921467A3 (ru) 1982-04-15
AT361139B (de) 1981-02-25
SE436131B (sv) 1984-11-12
AU519643B2 (en) 1981-12-17
ATA204278A (de) 1980-07-15
FI68236B (fi) 1985-04-30
CA1089456A (en) 1980-11-11
JPS53119899A (en) 1978-10-19
AU3435778A (en) 1979-09-27
IT1105176B (it) 1985-10-28
DE2812580A1 (de) 1978-10-05
FI780882A7 (fi) 1978-09-24
DK149858C (da) 1987-06-29
LU79294A1 (fr) 1979-10-29
FR2384774A1 (fr) 1978-10-20
NZ186692A (en) 1980-02-21
CS200542B2 (en) 1980-09-15
IT7848544A0 (it) 1978-03-22
FR2384774B1 (enExample) 1981-10-16
SE7803328L (sv) 1978-09-24
NL7803083A (nl) 1978-09-26
BE865183A (fr) 1978-09-22
DK130078A (da) 1978-09-24
CH629809A5 (fr) 1982-05-14
GB1593191A (en) 1981-07-15
DD133950A5 (de) 1979-01-31
US4241066A (en) 1980-12-23
IE46443B1 (en) 1983-06-15
JPH0112755B2 (enExample) 1989-03-02
DK149858B (da) 1986-10-13
ES468173A1 (es) 1979-09-16
PL205498A1 (pl) 1979-04-09

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Legal Events

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LICE Declarations of willingness to grant licence

Effective date: 20100119