ES468173A1 - Un procedimiento para la preparacion de derivados de morfina - Google Patents

Un procedimiento para la preparacion de derivados de morfina

Info

Publication number
ES468173A1
ES468173A1 ES468173A ES468173A ES468173A1 ES 468173 A1 ES468173 A1 ES 468173A1 ES 468173 A ES468173 A ES 468173A ES 468173 A ES468173 A ES 468173A ES 468173 A1 ES468173 A1 ES 468173A1
Authority
ES
Spain
Prior art keywords
morphine
making
methods
compositions containing
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES468173A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt Benckiser Healthcare UK Ltd
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Publication of ES468173A1 publication Critical patent/ES468173A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES468173A 1977-03-23 1978-03-22 Un procedimiento para la preparacion de derivados de morfina Expired ES468173A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12325/77A GB1593191A (en) 1977-03-23 1977-03-23 Derivatives of morphine

Publications (1)

Publication Number Publication Date
ES468173A1 true ES468173A1 (es) 1979-09-16

Family

ID=10002423

Family Applications (1)

Application Number Title Priority Date Filing Date
ES468173A Expired ES468173A1 (es) 1977-03-23 1978-03-22 Un procedimiento para la preparacion de derivados de morfina

Country Status (24)

Country Link
US (1) US4241066A (enExample)
JP (1) JPS53119899A (enExample)
AT (1) AT361139B (enExample)
AU (1) AU519643B2 (enExample)
BE (1) BE865183A (enExample)
CA (1) CA1089456A (enExample)
CH (1) CH629809A5 (enExample)
CS (1) CS200542B2 (enExample)
DD (1) DD133950A5 (enExample)
DE (1) DE2812580A1 (enExample)
DK (1) DK149858C (enExample)
ES (1) ES468173A1 (enExample)
FI (1) FI68236C (enExample)
FR (1) FR2384774A1 (enExample)
GB (1) GB1593191A (enExample)
IE (1) IE46443B1 (enExample)
IT (1) IT1105176B (enExample)
LU (1) LU79294A1 (enExample)
NL (1) NL7803083A (enExample)
NZ (1) NZ186692A (enExample)
PL (1) PL114723B1 (enExample)
SE (1) SE436131B (enExample)
SU (1) SU921467A3 (enExample)
ZA (1) ZA781527B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
WO1983003197A1 (en) * 1982-03-16 1983-09-29 Univ Rockefeller Method for controlling gastrointestinal dysmotility
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
DK0577847T3 (da) * 1992-01-23 1999-06-23 Toray Industries Morphinanderivat og medicinsk anvendelse deraf
IT1269826B (it) * 1994-05-24 1997-04-15 Paolo Minoia Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate
CN104383542B (zh) 2003-04-08 2017-09-26 普罗热尼奇制药公司 包含甲基纳曲酮的药物配方
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
US8067597B2 (en) 2005-06-16 2011-11-29 Mallinckrodt Llc Synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
US8183376B2 (en) * 2006-04-21 2012-05-22 Nektar Therapeutics Stereoselective reduction of a morphinone
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
PL2137191T3 (pl) 2007-03-29 2016-12-30 Antagoniści obwodowego receptora opioidowego i ich zastosowania
DK2139890T3 (da) 2007-03-29 2014-08-25 Wyeth Llc Perifere opioidreceptor-antagonister og anvendelser deraf
WO2008121352A2 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms of (r) -n-methylnaltrexone bromide and uses thereof
KR101581480B1 (ko) 2008-02-06 2015-12-30 프로제닉스 파머슈티컬스, 인코포레이티드 (ｒ),(ｒ)-2,2'-비스-메틸날트렉손의 제조법 및 용도
WO2010039220A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the production of buprenorphine with reduced impurity formation
ES2560877T3 (es) 2008-09-30 2016-02-23 Mallinckrodt Llc Procesos para la alquilación de norbuprenorfina con menor formación de impurezas
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
EP3077398B1 (en) 2013-12-05 2020-03-11 The University of Bath Novel opioid compounds and their uses
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322771A (en) * 1967-05-30 Intermediates for preparing thebaine derivatives
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby

Also Published As

Publication number Publication date
CS200542B2 (en) 1980-09-15
IT1105176B (it) 1985-10-28
CH629809A5 (fr) 1982-05-14
ZA781527B (en) 1979-04-25
IT7848544A0 (it) 1978-03-22
IE46443B1 (en) 1983-06-15
DK149858B (da) 1986-10-13
NZ186692A (en) 1980-02-21
DK130078A (da) 1978-09-24
US4241066A (en) 1980-12-23
NL7803083A (nl) 1978-09-26
GB1593191A (en) 1981-07-15
FI68236C (fi) 1985-08-12
SE436131B (sv) 1984-11-12
BE865183A (fr) 1978-09-22
AU3435778A (en) 1979-09-27
FR2384774B1 (enExample) 1981-10-16
DD133950A5 (de) 1979-01-31
CA1089456A (en) 1980-11-11
PL114723B1 (en) 1981-02-28
FI68236B (fi) 1985-04-30
IE780515L (en) 1978-09-23
AT361139B (de) 1981-02-25
DE2812580A1 (de) 1978-10-05
DK149858C (da) 1987-06-29
JPH0112755B2 (enExample) 1989-03-02
ATA204278A (de) 1980-07-15
SE7803328L (sv) 1978-09-24
SU921467A3 (ru) 1982-04-15
FR2384774A1 (fr) 1978-10-20
PL205498A1 (pl) 1979-04-09
LU79294A1 (fr) 1979-10-29
AU519643B2 (en) 1981-12-17
JPS53119899A (en) 1978-10-19
FI780882A7 (fi) 1978-09-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990201