PH27181A - New histidyl amino acid derivatives and pharmaceutical composition comprising the same - Google Patents

New histidyl amino acid derivatives and pharmaceutical composition comprising the same Download PDF

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Publication number
PH27181A
PH27181A PH37089A PH37089A PH27181A PH 27181 A PH27181 A PH 27181A PH 37089 A PH37089 A PH 37089A PH 37089 A PH37089 A PH 37089A PH 27181 A PH27181 A PH 27181A
Authority
PH
Philippines
Prior art keywords
methyl
methanol
chloroform
group
amino
Prior art date
Application number
PH37089A
Other languages
English (en)
Inventor
Keiji Hemmi
Masahiro Neya
Hiroshi Marusawa
Natsuko Kayakiri
Masashi Hashimoto
Keisuke Imai
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878714597A external-priority patent/GB8714597D0/en
Priority claimed from GB878725511A external-priority patent/GB8725511D0/en
Priority claimed from GB888805389A external-priority patent/GB8805389D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of PH27181A publication Critical patent/PH27181A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PH37089A 1987-06-22 1988-06-17 New histidyl amino acid derivatives and pharmaceutical composition comprising the same PH27181A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878714597A GB8714597D0 (en) 1987-06-22 1987-06-22 Peptide compounds
GB878725511A GB8725511D0 (en) 1987-10-30 1987-10-30 Peptide compounds
GB888805389A GB8805389D0 (en) 1988-03-07 1988-03-07 New peptide compounds process for preparation thereof & pharmaceutical composition comprising same

Publications (1)

Publication Number Publication Date
PH27181A true PH27181A (en) 1993-04-16

Family

ID=27263470

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37089A PH27181A (en) 1987-06-22 1988-06-17 New histidyl amino acid derivatives and pharmaceutical composition comprising the same

Country Status (20)

Country Link
US (2) US4921855A (de)
EP (1) EP0300189B1 (de)
JP (1) JPH0625147B2 (de)
KR (1) KR950003926B1 (de)
CN (1) CN1026892C (de)
AR (1) AR247733A1 (de)
AT (1) ATE113585T1 (de)
AU (1) AU617674B2 (de)
DE (1) DE3851986T2 (de)
DK (1) DK340088A (de)
ES (1) ES2067456T3 (de)
FI (1) FI96202C (de)
HK (1) HK18796A (de)
HU (2) HU202212B (de)
IE (1) IE65807B1 (de)
IL (1) IL86782A (de)
NO (1) NO175371C (de)
PH (1) PH27181A (de)
PT (1) PT87754B (de)
RU (1) RU1801107C (de)

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FI89058C (fi) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
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US5151513A (en) * 1988-04-29 1992-09-29 E. R. Squibb & Sons, Inc. N-heterocyclic alcohol derivatives
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US4902706A (en) * 1988-07-01 1990-02-20 G. D. Searle & Co. Aminoalkylaminocarbonyl aminodiol amino acid derivatives as antihypertensive agents
US5229369A (en) * 1988-07-01 1993-07-20 G. D. Searle & Co. Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
US5229420A (en) * 1988-07-01 1993-07-20 G. D. Searle & Co. Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents
US4900745A (en) * 1988-07-01 1990-02-13 G. D. Searle & Co. Poly(aminoalkyl)aminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
US4900746A (en) * 1988-07-01 1990-02-13 G. D. Searle & Co. Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents
AU615313B2 (en) * 1988-07-01 1991-09-26 G.D. Searle & Co. Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
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EP0355331A3 (de) * 1988-07-01 1991-08-14 G.D. Searle & Co. Poly(aminoalkyl)aminocarbonylaminoacylaminodiolaminosäure als antihypertensive Agenzien
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US5223514A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Quinolinyl/quinolinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5217988A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydroxyβ-amino acid derivatives
US5215996A (en) * 1989-12-04 1993-06-01 G. D. Searle & Co. Naphthyridinyl/naphthyridinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5180725A (en) * 1989-12-04 1993-01-19 G. D. Searle & Co. Quinoxalinyl/quinoxaliy; alkyl-N-terminal amino hydroxy
US5175181A (en) * 1989-12-04 1992-12-29 G. D. Searle & Co. Imidazolyl/imidazolylalkyl-N-terminal amino hydroxy
US5223532A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino derivatives
US5217991A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5216013A (en) * 1989-12-04 1993-06-01 G. D. Searle & Co. Aralkyl-N-terminal cycloalkoxy-C terminal amino hydroxy β-amino acid derivatives
US5175170A (en) * 1989-12-04 1992-12-29 G. D. Searle & Co. β-amino acid derivatives
US5180744A (en) * 1989-12-04 1993-01-19 G. D. Searle & Co. Aralkyl-N-terminal amino hydroxy
US5179102A (en) * 1989-12-04 1993-01-12 G. D. Searle & Co. Naphthyridinyl/naphthyridinylalkyl-n-terminal anino hydroxy β-amino acid derivatives
US5147888A (en) * 1989-12-04 1992-09-15 G. D. Searle & Co. N-terminal indolyy indolylalkylaminodiol β-amino acid derivatives
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US5217989A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Benothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
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US5231111A (en) * 1989-12-04 1993-07-27 G. D. Searle & Co. Imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5171751A (en) * 1989-12-04 1992-12-15 G. D. Searle & Co. Benzofuran/benzofuranalkyl-N-terminal amino hydroxy
US5223534A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Benzofuuranyl/benofuranylaklyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5210095A (en) * 1989-12-04 1993-05-11 G. D. Searle & Co. Chromonyl/chromonylalkyl-N-terminal amino hydroxy
US5194605A (en) * 1989-12-08 1993-03-16 Merck & Co., Inc. Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs
US5254682A (en) * 1989-12-08 1993-10-19 Merck & Co., Inc. Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs
DE4008403A1 (de) * 1990-03-16 1991-09-19 Merck Patent Gmbh Glykolsaeurederivate
US5430022A (en) * 1990-05-14 1995-07-04 Fujisawa Pharmaceutical Co., Ltd. Peptide compound and its preparation
US5278161A (en) * 1990-06-28 1994-01-11 Hoffmann-La Roche Inc. Amino acid derivatives useful as renin inhibitors
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IL99389A0 (en) * 1990-09-17 1992-08-18 Fujisawa Pharmaceutical Co Amino acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ZA921381B (en) * 1991-03-01 1992-11-25 Fujisawa Pharmaceutical Co New use of amino acid derivatives
WO1992017456A1 (en) * 1991-03-26 1992-10-15 Fujisawa Pharmaceutical Co., Ltd. Amino acid derivative and salt thereof
US5223535A (en) * 1991-10-29 1993-06-29 G. D. Searle & Co. Propargyl glycine amino propargyl diol compounds for treatment of hypertension
US5330996A (en) * 1991-10-29 1994-07-19 G. D. Searle & Co. Amino acyl amino propargyl diol compounds for treatment of hypertension
US5227401A (en) * 1991-10-29 1993-07-13 G. D. Searle & Co. Ethynyl alanine amino diol compounds for treatment of hypertension
GB9127041D0 (en) * 1991-12-20 1992-02-19 Fujisawa Pharmaceutical Co New use
JP2578044B2 (ja) * 1992-03-14 1997-02-05 呉羽化学工業株式会社 フェニルアラニン−グリシン誘導体、その製造方法、及びその誘導体を含有する抗腫瘍剤
EP0648747A4 (de) * 1992-07-02 1996-07-31 Fujisawa Pharmaceutical Co Neue zwischenprodukte zur synthese und produktion von aminosäure derivaten.
US5314920A (en) * 1992-07-20 1994-05-24 G. D. Searle & Co. Ethynyl-alanine aryl/alkylsulfonyl-terminated amino-diol compounds for treatment of hypertension
US5268391A (en) * 1992-07-20 1993-12-07 C. D. Searle & Co. Propargyl-terminated cycloalkylalkyl-P2-site substituted aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension
US5317039A (en) * 1992-07-20 1994-05-31 G. D. Searle & Co. Cyclopropyl-alanine aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension
US5246969A (en) * 1992-07-20 1993-09-21 G. D. Searle & Co. Di-propargyl-containing aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension
US5422349A (en) * 1992-08-14 1995-06-06 G. D. Seale & Co. Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5373017A (en) * 1992-08-14 1994-12-13 G. D. Searle & Co. Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5252591A (en) * 1992-08-14 1993-10-12 G. D. Searle & Company Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5212185A (en) * 1992-08-14 1993-05-18 G. D. Searle & Co. Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5298505A (en) * 1992-08-14 1994-03-29 G. D. Searle & Co. Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension
US5312838A (en) * 1992-09-21 1994-05-17 G. D. Searle & Co. β-alanineamide aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension
JP3134936B2 (ja) * 1992-10-16 2001-02-13 沖電気工業株式会社 衝撃センサ
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US5383540A (en) * 1993-10-04 1995-01-24 Ford Motor Company Torque converter bypass clutch piston-pump drive for an automatic transmission
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CA2997471C (en) 2010-11-16 2020-12-01 Texas Heart Institute Agonists that enhance binding of integrin-expressing cells to integrin receptors
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Also Published As

Publication number Publication date
US5142048A (en) 1992-08-25
JPH0625147B2 (ja) 1994-04-06
CN1026892C (zh) 1994-12-07
CN1030411A (zh) 1989-01-18
FI96202B (fi) 1996-02-15
IL86782A (en) 1993-04-04
HU202212B (en) 1991-02-28
NO882732L (no) 1988-12-23
NO882732D0 (no) 1988-06-21
KR950003926B1 (ko) 1995-04-20
ATE113585T1 (de) 1994-11-15
DE3851986D1 (de) 1994-12-08
DK340088A (da) 1988-12-23
AR247733A1 (es) 1995-03-31
JPS6419071A (en) 1989-01-23
ES2067456T3 (es) 1995-04-01
FI96202C (fi) 1996-05-27
IE881778L (en) 1988-12-22
DK340088D0 (da) 1988-06-21
IL86782A0 (en) 1988-11-30
NO175371B (no) 1994-06-27
HUT47917A (en) 1989-04-28
EP0300189A3 (en) 1990-08-22
PT87754A (pt) 1988-07-01
IE65807B1 (en) 1995-11-15
AU617674B2 (en) 1991-12-05
HK18796A (en) 1996-02-09
KR890000434A (ko) 1989-03-14
EP0300189A2 (de) 1989-01-25
PT87754B (pt) 1992-10-30
FI882875A0 (fi) 1988-06-16
NO175371C (no) 1994-10-05
HU211977A9 (en) 1996-01-29
US4921855A (en) 1990-05-01
DE3851986T2 (de) 1995-03-09
AU1819088A (en) 1988-12-22
EP0300189B1 (de) 1994-11-02
FI882875A (fi) 1988-12-23
RU1801107C (ru) 1993-03-07

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