PH26694A - Mixtures for treating hyper-cholesterolemia - Google Patents
Mixtures for treating hyper-cholesterolemia Download PDFInfo
- Publication number
- PH26694A PH26694A PH36678A PH36678A PH26694A PH 26694 A PH26694 A PH 26694A PH 36678 A PH36678 A PH 36678A PH 36678 A PH36678 A PH 36678A PH 26694 A PH26694 A PH 26694A
- Authority
- PH
- Philippines
- Prior art keywords
- polyol
- psyllium
- ingestion
- component
- fatty acid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 28
- 208000035150 Hypercholesterolemia Diseases 0.000 title description 3
- 229920005862 polyol Polymers 0.000 claims abstract description 40
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 38
- 229920000728 polyester Polymers 0.000 claims abstract description 37
- 150000003077 polyols Chemical class 0.000 claims abstract description 28
- 210000004369 blood Anatomy 0.000 claims abstract description 14
- 239000008280 blood Substances 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims description 17
- -1 polyol poly- ester Chemical class 0.000 claims description 16
- 230000037406 food intake Effects 0.000 claims description 12
- 244000090599 Plantago psyllium Species 0.000 claims description 10
- 235000010451 Plantago psyllium Nutrition 0.000 claims description 10
- 230000001603 reducing effect Effects 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 3
- 230000001684 chronic effect Effects 0.000 claims description 2
- 239000000306 component Substances 0.000 claims 6
- 235000003421 Plantago ovata Nutrition 0.000 abstract description 19
- 239000009223 Psyllium Substances 0.000 abstract description 18
- 229940070687 psyllium Drugs 0.000 abstract description 18
- 241001499741 Plantago arenaria Species 0.000 abstract description 6
- 239000000194 fatty acid Substances 0.000 description 50
- 235000014113 dietary fatty acids Nutrition 0.000 description 47
- 229930195729 fatty acid Natural products 0.000 description 47
- 150000004665 fatty acids Chemical class 0.000 description 30
- 229930003231 vitamin Natural products 0.000 description 25
- 239000011782 vitamin Substances 0.000 description 25
- 229940088594 vitamin Drugs 0.000 description 25
- 235000013343 vitamin Nutrition 0.000 description 25
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 24
- 229930006000 Sucrose Natural products 0.000 description 24
- 239000005720 sucrose Substances 0.000 description 24
- 244000134552 Plantago ovata Species 0.000 description 15
- 229940107161 cholesterol Drugs 0.000 description 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 12
- 239000000463 material Substances 0.000 description 12
- 150000003722 vitamin derivatives Chemical class 0.000 description 9
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 7
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- 239000000811 xylitol Substances 0.000 description 7
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 7
- 235000010447 xylitol Nutrition 0.000 description 7
- 229960002675 xylitol Drugs 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- 230000002475 laxative effect Effects 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 239000004386 Erythritol Substances 0.000 description 4
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 4
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 4
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 4
- 229940009714 erythritol Drugs 0.000 description 4
- 235000019414 erythritol Nutrition 0.000 description 4
- 239000003925 fat Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000010903 husk Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 150000002772 monosaccharides Chemical class 0.000 description 4
- 239000004006 olive oil Substances 0.000 description 4
- 235000008390 olive oil Nutrition 0.000 description 4
- 239000003549 soybean oil Substances 0.000 description 4
- 235000012424 soybean oil Nutrition 0.000 description 4
- 150000005846 sugar alcohols Chemical class 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241001127637 Plantago Species 0.000 description 3
- SRBFZHDQGSBBOR-IOVATXLUSA-N Xylose Natural products O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 235000012343 cottonseed oil Nutrition 0.000 description 3
- 239000002385 cottonseed oil Substances 0.000 description 3
- 229930182830 galactose Natural products 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000008141 laxative Substances 0.000 description 3
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000003760 tallow Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- SECPZKHBENQXJG-FPLPWBNLSA-N (Z)-Palmitoleic acid Natural products CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N Behenic acid Natural products CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- YTBSYETUWUMLBZ-UHFFFAOYSA-N D-Erythrose Natural products OCC(O)C(O)C=O YTBSYETUWUMLBZ-UHFFFAOYSA-N 0.000 description 2
- YTBSYETUWUMLBZ-IUYQGCFVSA-N D-erythrose Chemical compound OC[C@@H](O)[C@@H](O)C=O YTBSYETUWUMLBZ-IUYQGCFVSA-N 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 206010056474 Erythrosis Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- YWWVWXASSLXJHU-AATRIKPKSA-N Myristoleic acid Natural products CCCC\C=C\CCCCCCCC(O)=O YWWVWXASSLXJHU-AATRIKPKSA-N 0.000 description 2
- 235000019483 Peanut oil Nutrition 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 229930003448 Vitamin K Natural products 0.000 description 2
- WJPZXFWMBSJTPE-PISRTDAGSA-N [(2r,3r,4s,5r,6r)-6-[(2s,3s,4r,5r)-3,4-di(hexadecanoyloxy)-2,5-bis(hexadecanoyloxymethyl)oxolan-2-yl]oxy-3,4,5-tri(hexadecanoyloxy)oxan-2-yl]methyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@H]1[C@H](OC(=O)CCCCCCCCCCCCCCC)[C@@H](COC(=O)CCCCCCCCCCCCCCC)O[C@@]1(COC(=O)CCCCCCCCCCCCCCC)O[C@@H]1[C@H](OC(=O)CCCCCCCCCCCCCCC)[C@@H](OC(=O)CCCCCCCCCCCCCCC)[C@H](OC(=O)CCCCCCCCCCCCCCC)[C@@H](COC(=O)CCCCCCCCCCCCCCC)O1 WJPZXFWMBSJTPE-PISRTDAGSA-N 0.000 description 2
- 230000010933 acylation Effects 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Natural products CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000005687 corn oil Nutrition 0.000 description 2
- 239000002285 corn oil Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N ethyl stearic acid Natural products CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 2
- 229940073769 methyl oleate Drugs 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N methyl undecanoic acid Natural products CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- AOHAPDDBNAPPIN-UHFFFAOYSA-N myristicinic acid Natural products COC1=CC(C(O)=O)=CC2=C1OCO2 AOHAPDDBNAPPIN-UHFFFAOYSA-N 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000000312 peanut oil Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 235000019168 vitamin K Nutrition 0.000 description 2
- 239000011712 vitamin K Substances 0.000 description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 229940046010 vitamin k Drugs 0.000 description 2
- CUXYLFPMQMFGPL-UHFFFAOYSA-N (9Z,11E,13E)-9,11,13-Octadecatrienoic acid Natural products CCCCC=CC=CC=CCCCCCCCC(O)=O CUXYLFPMQMFGPL-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- URSCRKIYUPROKB-PHHCKKAISA-N (Z)-octadec-9-enoic acid (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O URSCRKIYUPROKB-PHHCKKAISA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- YWWVWXASSLXJHU-UHFFFAOYSA-N 9E-tetradecenoic acid Natural products CCCCC=CCCCCCCCC(O)=O YWWVWXASSLXJHU-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 description 1
- DLQDPUCZIABCES-VZBBZXSKSA-N CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)C=O Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)C=O DLQDPUCZIABCES-VZBBZXSKSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 101100114416 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) con-10 gene Proteins 0.000 description 1
- MKXYXDWCASGLJG-NSLUQPGISA-N OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O MKXYXDWCASGLJG-NSLUQPGISA-N 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 244000010922 Plantago major Species 0.000 description 1
- 241001460377 Plantago rugelii Species 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 244000000231 Sesamum indicum Species 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 241000011102 Thera Species 0.000 description 1
- 206010048215 Xanthomatosis Diseases 0.000 description 1
- GQPAMKBZEBGASK-LVVDDXEGSA-N [(2r,3s)-2,3,4-tris[[(z)-octadec-9-enoyl]oxy]butyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC GQPAMKBZEBGASK-LVVDDXEGSA-N 0.000 description 1
- RKZXQQPEDGMHBJ-LIGJGSPWSA-N [(2s,3r,4r,5r)-2,3,4,5,6-pentakis[[(z)-octadec-9-enoyl]oxy]hexyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC RKZXQQPEDGMHBJ-LIGJGSPWSA-N 0.000 description 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- CUXYLFPMQMFGPL-SUTYWZMXSA-N all-trans-octadeca-9,11,13-trienoic acid Chemical compound CCCC\C=C\C=C\C=C\CCCCCCCC(O)=O CUXYLFPMQMFGPL-SUTYWZMXSA-N 0.000 description 1
- 239000003529 anticholesteremic agent Substances 0.000 description 1
- 229940127226 anticholesterol agent Drugs 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 239000010480 babassu oil Substances 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000018823 dietary intake Nutrition 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000012632 extractable Substances 0.000 description 1
- 125000002899 fatty ester group Chemical group 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229940042003 metamucil Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000002888 oleic acid derivatives Chemical class 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000005471 saturated fatty acid group Chemical group 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 125000000969 xylosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)CO1)* 0.000 description 1
- DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/029,825 US4849222A (en) | 1987-03-24 | 1987-03-24 | Mixtures for treating hypercholesterolemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26694A true PH26694A (en) | 1992-09-15 |
Family
ID=21851092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH36678A PH26694A (en) | 1987-03-24 | 1988-03-23 | Mixtures for treating hyper-cholesterolemia |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4849222A (de) |
| EP (1) | EP0285201B1 (de) |
| JP (1) | JP2581737B2 (de) |
| KR (1) | KR970004956B1 (de) |
| AT (1) | ATE79544T1 (de) |
| AU (1) | AU620541B2 (de) |
| CA (1) | CA1314230C (de) |
| DE (1) | DE3873800T2 (de) |
| DK (1) | DK167847B1 (de) |
| IE (1) | IE61404B1 (de) |
| IL (1) | IL85689A (de) |
| NZ (1) | NZ223947A (de) |
| PH (1) | PH26694A (de) |
| ZA (1) | ZA882061B (de) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4579752A (en) * | 1984-10-29 | 1986-04-01 | At&T Bell Laboratories | Enhanced corrosion resistance of metal surfaces |
| JPH0788318B2 (ja) * | 1986-08-06 | 1995-09-27 | 三菱レイヨン株式会社 | イソブチレンの製造法 |
| US5095008A (en) * | 1987-09-14 | 1992-03-10 | The Procter & Gamble Company | Cookies containing psyllium |
| US4950140A (en) * | 1987-09-14 | 1990-08-21 | The Procter & Gamble Company | Cookies containing psyllium |
| US5910317A (en) * | 1988-01-11 | 1999-06-08 | The Procter & Gamble Company | Mixed compositions for treating hypercholesterolemia |
| US4978529A (en) * | 1988-05-25 | 1990-12-18 | Denick Jr John | Easily dispersible psyllium compositions |
| US5149541A (en) * | 1988-10-03 | 1992-09-22 | The Procter & Gamble Company | Psyllium-containing produces with a distribution of particle size |
| US5024996A (en) * | 1989-12-05 | 1991-06-18 | General Mills, Inc. | R-T-E cereal with soluble fibers |
| US5026689A (en) * | 1989-03-29 | 1991-06-25 | General Mills, Inc. | R-T-E cereal with psyllium |
| US5219570A (en) * | 1989-08-10 | 1993-06-15 | The Procter & Gamble Company | Agglomerated psyllium husk containing edible acid |
| US6419911B1 (en) | 1993-09-17 | 2002-07-16 | Board Of Trustees Of Michigan State University | Psyllium containing snack bars, processes for making these, and uses thereof |
| US5126150A (en) * | 1990-10-01 | 1992-06-30 | The Procter & Gamble Company | Compositions containing psyllium |
| WO1992011019A1 (en) * | 1990-12-20 | 1992-07-09 | The Procter & Gamble Company | Psyllium and cholestyramine compositions with improved palatability |
| US5721221A (en) * | 1991-03-08 | 1998-02-24 | Regents Of The University Of Minnesota | Lowering blood cholesterol levels using water soluble cellulose ethers |
| WO1993013801A1 (en) * | 1992-01-17 | 1993-07-22 | The Procter & Gamble Company | Treatment for atherosclerosis |
| US5244887A (en) * | 1992-02-14 | 1993-09-14 | Straub Carl D | Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof |
| US5281584A (en) * | 1992-02-28 | 1994-01-25 | The Dow Chemical Company | Effect of particle-size distribution of cellulose ethers on palatability of compositions |
| US5258181A (en) * | 1992-03-02 | 1993-11-02 | The Procter & Gamble Company | Compositions containing psyllium |
| DE69303813T2 (de) | 1992-03-11 | 1997-01-16 | The Procter & Gamble Co., Cincinnati, Ohio | Gekörnte grundsätze enthaltende psyllium-getränkezusammenstellungen |
| AU3812893A (en) * | 1992-03-20 | 1993-10-21 | Procter & Gamble Company, The | Anion exchange resin compositions |
| US5234916A (en) * | 1992-06-12 | 1993-08-10 | The Proctor & Gamble Company | Psyllium drink mix compositions |
| US5232698A (en) * | 1992-06-12 | 1993-08-03 | The Proctor & Gamble Company | Psyllium drink mix compositions |
| US5338549A (en) * | 1992-12-21 | 1994-08-16 | The Procter & Gamble Company | Powdered psyllium drink mix compositions containing antioxidant |
| US5422101A (en) * | 1993-05-14 | 1995-06-06 | The Procter & Gamble Company | Cholesterol lowering drink mix compositions |
| US5384136A (en) * | 1993-09-17 | 1995-01-24 | Kellogg Company | Psyllium-enriched dough products and method for making the same |
| US5384144A (en) * | 1993-09-17 | 1995-01-24 | Kellogg Company | Psyllium enriched pasta products and method for making same |
| US5382443A (en) * | 1993-09-17 | 1995-01-17 | Kellogg Company | Ready-to-eat cereals containing extruded pre-wetted psyllium |
| US5955123A (en) * | 1996-10-21 | 1999-09-21 | The Procter & Gamble Company | Baked compositions comprising psyllium |
| US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| ATE418869T1 (de) | 1997-11-07 | 2009-01-15 | Univ Michigan State | Extrudierte vorprodukte enthaltend eine lösliche faser sowie dieseenthaltende lebensmittelprodukte |
| US6123978A (en) * | 1998-08-31 | 2000-09-26 | Mcneil-Ppc, Inc. | Stable salad dressings |
| US6248387B1 (en) | 1998-11-05 | 2001-06-19 | Kellogg Company | Psyllium enriched baked snack foods |
| US7115297B2 (en) * | 2000-02-22 | 2006-10-03 | Suzanne Jaffe Stillman | Nutritionally fortified liquid composition with added value delivery systems/elements/additives |
| US7892586B2 (en) | 2001-02-22 | 2011-02-22 | Suzanne Jaffe Stillman | Water containing soluble fiber |
| US7238380B2 (en) * | 2000-02-22 | 2007-07-03 | Suzanne Jaffe Stillman | Water containing soluble fiber |
| US8178150B2 (en) | 2000-02-22 | 2012-05-15 | Suzanne Jaffe Stillman | Water containing soluble fiber |
| GEP20094759B (en) | 2002-10-24 | 2009-08-25 | Merz Pharma Gmbh & Co Kgaa | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
| MXPA05012493A (es) * | 2003-05-27 | 2006-05-25 | Forest Laboratories | Combinacion de un antagonista del receptor de nmda y un inhibidor selectivo de reabsorcion de serotonina para el tratamiento de depresion y otros trastornos de estado de animo. |
| JP2004352626A (ja) * | 2003-05-28 | 2004-12-16 | Asahi Breweries Ltd | 植物由来成分を含有する抗コレステロール剤 |
| CN1870984A (zh) * | 2003-10-22 | 2006-11-29 | 莫茨药物股份两合公司 | 1-氨基环己烷衍生物用于调节淀粉样病变中原纤维生成Aβ肽的沉积的用途 |
| TW200616608A (en) * | 2004-07-09 | 2006-06-01 | Forest Laboratories | Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients |
| EA012036B1 (ru) * | 2004-09-23 | 2009-06-30 | Мерц Фарма Гмбх Унд Ко. Кгаа | Мемантин для лечения расстройств поведения детского возраста |
| US20060205822A1 (en) * | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| KR100679290B1 (ko) * | 2005-06-30 | 2007-02-05 | 박정휘 | Hgdsj201 생약 복합제 추출물을 포함하는 비만의예방 및 치료용 조성물 |
| US8088382B2 (en) * | 2005-07-05 | 2012-01-03 | Cornell Research Foundation, Inc. | Methods of inhibiting transendothelial migration of neutrophils and monocytes with anti-CD99L2 antibodies |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| KR20100052557A (ko) | 2007-09-12 | 2010-05-19 | 메르츠 파마 게엠베하 운트 코. 카가아 | 이명 치료를 위한 간격 치료요법 |
| EP2085120A1 (de) | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Verwendung von Substanzen zur Behandlung zentraler und peripherer Insulinrezeptorbeeinträchtigung oder Insulinresistenz |
| JP5986745B2 (ja) | 2008-07-15 | 2016-09-06 | アカデミア シニカAcademia Sinica | Ptfe様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法 |
| KR101335118B1 (ko) | 2008-12-19 | 2013-12-05 | 메르츠 파마 게엠베하 운트 코. 카가아 | 비만 세포 매개 질환의 치료를 위한 1-아미노-알킬시클로헥산 유도체 |
| TWI432188B (zh) | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之1-胺基-烷基環己烷衍生物類 |
| WO2011000564A1 (en) | 2009-06-30 | 2011-01-06 | Merz Pharma Gmbh & Co. Kgaa | Eltoprazine for the treatment of drug addiction |
| WO2011000562A1 (en) | 2009-06-30 | 2011-01-06 | Merz Pharma Gmbh & Co. Kgaa | Eltoprazine for the treatment of certain movement disorders |
| EP2448580A1 (de) | 2009-06-30 | 2012-05-09 | Merz Pharma GmbH & Co. KGaA | Eltoprazin zur behandlung von angstzuständen |
| US20120190690A1 (en) | 2009-06-30 | 2012-07-26 | Merz Pharma Gmbh & Co. Kgaa | Eltoprazine for the treatment of weight disorders |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| US20110294890A1 (en) | 2010-05-28 | 2011-12-01 | Merz Pharma Gmbh & Co. Kgaa | Neramexane for the treatment or prevention of inner ear disorders |
| WO2012023033A2 (en) | 2010-08-18 | 2012-02-23 | Purdue Pharma L.P. | Improved peptide immunogens |
| WO2012098000A1 (en) | 2011-01-20 | 2012-07-26 | Merz Pharma Gmbh & Co. Kgaa | Neramexane for the treatment or prevention of tinnitus related with stress or acute hearing loss |
| WO2012171653A1 (en) | 2011-06-15 | 2012-12-20 | Merz Pharma Gmbh & Co. Kgaa | Sarizotan for use in the treatment of attention deficit hyperactivity disorder (adhd) |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| TW201412325A (zh) | 2012-06-20 | 2014-04-01 | 梅茲製藥有限兩合公司 | 用於治療患有青光眼及其他退化性眼疾之人類視力喪失的間隔醫療 |
| AU2013306098A1 (en) | 2012-08-18 | 2015-02-12 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| AU2014317889B2 (en) | 2013-09-06 | 2020-03-05 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
| BR112015032713B1 (pt) | 2013-09-17 | 2023-03-21 | Obi Pharma, Inc | Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| TW201620939A (zh) | 2014-01-16 | 2016-06-16 | 中央研究院 | 治療及檢測癌症之組合物及方法 |
| TWI687428B (zh) | 2014-03-27 | 2020-03-11 | 中央研究院 | 反應性標記化合物及其用途 |
| AU2015267047A1 (en) | 2014-05-27 | 2017-01-05 | Academia Sinica | Anti-CD20 glycoantibodies and uses thereof |
| JP7062361B2 (ja) | 2014-05-27 | 2022-05-06 | アカデミア シニカ | 抗her2糖操作抗体群およびその使用 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| AU2015267051B2 (en) | 2014-05-27 | 2022-03-17 | Academia Sinica | Fucosidase from bacteroides and methods using the same |
| WO2015184001A1 (en) | 2014-05-28 | 2015-12-03 | Academia Sinica | Anti-tnf-alpha glycoantibodies and uses thereof |
| US9879042B2 (en) | 2014-09-08 | 2018-01-30 | Academia Sinica | Human iNKT cell activation using glycolipids |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| AU2015378564A1 (en) | 2015-01-24 | 2017-07-13 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| JP2018532990A (ja) | 2015-09-04 | 2018-11-08 | オービーアイ ファーマ,インコーポレイテッド | グリカンアレイおよび使用の方法 |
| CN109195996A (zh) | 2016-03-08 | 2019-01-11 | 中央研究院 | N-聚醣及其阵列的模组化合成方法 |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| KR20180121786A (ko) | 2016-03-29 | 2018-11-08 | 오비아이 파머 인코퍼레이티드 | 항체, 제약 조성물 및 방법 |
| KR20250048399A (ko) | 2016-04-22 | 2025-04-08 | 오비아이 파머 인코퍼레이티드 | 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법 |
| US11642400B2 (en) | 2016-07-27 | 2023-05-09 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| JP7121724B2 (ja) | 2016-07-29 | 2022-08-18 | オービーアイ ファーマ,インコーポレイテッド | ヒト抗体、医薬組成物及び方法 |
| KR102588027B1 (ko) | 2016-08-22 | 2023-10-12 | 초 파마 인크. | 항체, 결합 단편 및 사용 방법 |
| CA3044274A1 (en) | 2016-11-21 | 2018-05-24 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| EP3791873A1 (de) | 2019-09-16 | 2021-03-17 | Universite De Bordeaux | Verfahren zur behandlung und/oder vorbeugung von erkrankungen und symptomen im zusammenhang mit bkca- und/oder sk-kanalophathien |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2831854A (en) * | 1955-05-24 | 1958-04-22 | Procter & Gamble | Method for preparing fatty esters of non-reducing oligosaccharides in the presence of an amide |
| US3455714A (en) * | 1964-09-01 | 1969-07-15 | Hercules Inc | Cellulose derivatives of improved dispersibility and process |
| US3600186A (en) * | 1968-04-23 | 1971-08-17 | Procter & Gamble | Low calorie fat-containing food compositions |
| US3579548A (en) * | 1968-05-10 | 1971-05-18 | Procter & Gamble | Triglyceride esters of alpha-branched carboxylic acids |
| US3954976A (en) * | 1973-12-14 | 1976-05-04 | The Procter & Gamble Company | Pharmaceutical compositions for inhibiting absorption of cholesterol |
| US3963699A (en) * | 1974-01-10 | 1976-06-15 | The Procter & Gamble Company | Synthesis of higher polyol fatty acid polyesters |
| US4034083A (en) * | 1975-11-03 | 1977-07-05 | The Procter & Gamble Company | Compositions for inhibiting absorption of cholesterol |
| US4005196A (en) * | 1976-02-12 | 1977-01-25 | The Procter & Gamble Company | Vitaminized compositions for treating hypercholesterolemia |
| US4005195A (en) * | 1976-02-12 | 1977-01-25 | The Procter & Gamble Company | Compositions for treating hypercholesterolemia |
| IE44458B1 (en) * | 1976-02-12 | 1981-12-02 | Procter & Gamble | Compositions for treating hypercholesterolemia |
| US4241054A (en) * | 1978-12-08 | 1980-12-23 | The Procter & Gamble Company | Detoxifying lipophilic toxins |
| US4264583A (en) * | 1979-07-25 | 1981-04-28 | The Procter & Gamble Company | Gallstone dissolution compositions and method |
| US4382924A (en) * | 1980-06-25 | 1983-05-10 | The Procter & Gamble Company | Palatable composition containing oil or oil-like materials |
| DE3027611A1 (de) * | 1980-07-21 | 1982-02-18 | Bayer Ag, 5090 Leverkusen | Di- und oligo-1,2,4-triazolidin-3,5-dione und verfahren zu ihrer herstellung |
| US4321263A (en) * | 1980-09-30 | 1982-03-23 | Rowell Laboratories, Inc. | Psyllium compositions |
| US4461782A (en) * | 1982-02-16 | 1984-07-24 | The Procter & Gamble Company | Low calorie baked products |
| US4518772A (en) * | 1983-06-23 | 1985-05-21 | The Proctor & Gamble Company | Synthesis of higher polyol fatty acid polyesters using high soap:polyol ratios |
| US4517360A (en) * | 1983-06-23 | 1985-05-14 | The Procter & Gamble Company | Synthesis of higher polyol fatty acid polyesters using carbonate catalysts |
-
1987
- 1987-03-24 US US07/029,825 patent/US4849222A/en not_active Expired - Fee Related
-
1988
- 1988-03-10 IL IL85689A patent/IL85689A/xx not_active IP Right Cessation
- 1988-03-14 EP EP88200479A patent/EP0285201B1/de not_active Expired - Lifetime
- 1988-03-14 AT AT88200479T patent/ATE79544T1/de not_active IP Right Cessation
- 1988-03-14 DE DE8888200479T patent/DE3873800T2/de not_active Expired - Fee Related
- 1988-03-18 NZ NZ223947A patent/NZ223947A/xx unknown
- 1988-03-23 PH PH36678A patent/PH26694A/en unknown
- 1988-03-23 CA CA000562187A patent/CA1314230C/en not_active Expired - Fee Related
- 1988-03-23 ZA ZA882061A patent/ZA882061B/xx unknown
- 1988-03-23 IE IE87088A patent/IE61404B1/en not_active IP Right Cessation
- 1988-03-23 JP JP63069220A patent/JP2581737B2/ja not_active Expired - Lifetime
- 1988-03-23 AU AU13521/88A patent/AU620541B2/en not_active Ceased
- 1988-03-24 KR KR1019880003150A patent/KR970004956B1/ko not_active Expired - Fee Related
- 1988-03-24 DK DK162488A patent/DK167847B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2581737B2 (ja) | 1997-02-12 |
| NZ223947A (en) | 1991-02-26 |
| AU620541B2 (en) | 1992-02-20 |
| DE3873800D1 (de) | 1992-09-24 |
| ATE79544T1 (de) | 1992-09-15 |
| IE61404B1 (en) | 1994-11-02 |
| EP0285201A2 (de) | 1988-10-05 |
| EP0285201B1 (de) | 1992-08-19 |
| DK162488A (da) | 1988-09-25 |
| US4849222A (en) | 1989-07-18 |
| ZA882061B (en) | 1988-09-14 |
| JPS6426A (en) | 1989-01-05 |
| DK162488D0 (da) | 1988-03-24 |
| KR970004956B1 (ko) | 1997-04-10 |
| CA1314230C (en) | 1993-03-09 |
| IL85689A (en) | 1993-05-13 |
| AU1352188A (en) | 1988-09-22 |
| DE3873800T2 (de) | 1993-01-14 |
| KR880010764A (ko) | 1988-10-24 |
| IE880870L (en) | 1988-09-24 |
| DK167847B1 (da) | 1993-12-27 |
| EP0285201A3 (en) | 1990-01-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH26694A (en) | Mixtures for treating hyper-cholesterolemia | |
| US3954976A (en) | Pharmaceutical compositions for inhibiting absorption of cholesterol | |
| JPH0126A (ja) | 高コレステロール血症治療用混合物 | |
| CA1083043A (en) | Compositions for treating hypercholesterolemia | |
| US4005196A (en) | Vitaminized compositions for treating hypercholesterolemia | |
| US4034083A (en) | Compositions for inhibiting absorption of cholesterol | |
| EP0323666B1 (de) | Mischung zur Behandlung von Hypercholesterolemie | |
| JP4376977B2 (ja) | リパーゼ阻害剤、食品添加物及び食品 | |
| KR19980702533A (ko) | 프로시아니딘을 유효성분으로 하는 항비만제 | |
| JPH04504847A (ja) | インスリン抵抗性糖尿病のための食事用補添物 | |
| EP0309029A1 (de) | Psyllium enthaltende Kuchen | |
| IE50026B1 (en) | Gall-stone dissolution compositions | |
| JP4510289B2 (ja) | 筋萎縮性側索硬化症の治療薬を製造するためのイチョウ抽出物の使用 | |
| CN1280498A (zh) | 葡萄提取物的膦脂复合物作为抗动脉粥样硬化剂的应用 | |
| US20110142971A1 (en) | Use of an onion extract for making a composition to control weight gain | |
| USRE33996E (en) | Compositions for treating hypercholesterolemia | |
| US20060135444A1 (en) | Combination of flavonoid and procyanidin for the reduction of the mammalian appetite | |
| US20120195987A1 (en) | Substances for reducing occurrence of major cardiac events comprising epa or derivatives thereof, optionally, dha or derivatives thereof and monacolin k | |
| US5910317A (en) | Mixed compositions for treating hypercholesterolemia | |
| JPS6339568B2 (de) | ||
| WO1993013801A1 (en) | Treatment for atherosclerosis | |
| US20030004116A1 (en) | Noni extract for prevention of disease | |
| HK1033267B (en) | The use of phospholipid complexes of extracts of vitis vinifera as anti-atherosclerotic agents |