PH26686A - Antibacterial antiplaque oral composition - Google Patents
Antibacterial antiplaque oral composition Download PDFInfo
- Publication number
- PH26686A PH26686A PH39826A PH39826A PH26686A PH 26686 A PH26686 A PH 26686A PH 39826 A PH39826 A PH 39826A PH 39826 A PH39826 A PH 39826A PH 26686 A PH26686 A PH 26686A
- Authority
- PH
- Philippines
- Prior art keywords
- oral composition
- weight
- agent
- water
- oral
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 68
- 230000002882 anti-plaque Effects 0.000 title claims description 11
- 230000000844 anti-bacterial effect Effects 0.000 title description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 96
- 239000000551 dentifrice Substances 0.000 claims description 42
- 235000013772 propylene glycol Nutrition 0.000 claims description 33
- 239000000463 material Substances 0.000 claims description 30
- 239000003795 chemical substances by application Substances 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 239000003242 anti bacterial agent Substances 0.000 claims description 26
- 239000003906 humectant Substances 0.000 claims description 26
- 229920005646 polycarboxylate Polymers 0.000 claims description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 23
- -1 vinyl methyl Chemical group 0.000 claims description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 17
- 238000005498 polishing Methods 0.000 claims description 17
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 125000000129 anionic group Chemical group 0.000 claims description 15
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 14
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- 239000002324 mouth wash Substances 0.000 claims description 10
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- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 4
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- 230000009897 systematic effect Effects 0.000 claims 1
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- 230000001580 bacterial effect Effects 0.000 description 7
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 7
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- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
- 229910000400 magnesium phosphate tribasic Inorganic materials 0.000 description 1
- 150000002689 maleic acids Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- ASHGTJPOSUFTGB-UHFFFAOYSA-N methyl resorcinol Natural products COC1=CC=CC(O)=C1 ASHGTJPOSUFTGB-UHFFFAOYSA-N 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- HXDOZKJGKXYMEW-UHFFFAOYSA-N para-ethyl phenol Natural products CCC1=CC=C(O)C=C1 HXDOZKJGKXYMEW-UHFFFAOYSA-N 0.000 description 1
- IWDCLRJOBJJRNH-UHFFFAOYSA-N para-hydroxytoluene Natural products CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 229940106025 phenylethyl resorcinol Drugs 0.000 description 1
- 125000004344 phenylpropyl group Chemical group 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229940057847 polyethylene glycol 600 Drugs 0.000 description 1
- 229920001444 polymaleic acid Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 229940071089 sarcosinate Drugs 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical class [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- AZJYLVAUMGUUBL-UHFFFAOYSA-A u1qj22mc8e Chemical group [F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 AZJYLVAUMGUUBL-UHFFFAOYSA-A 0.000 description 1
- 229940117958 vinyl acetate Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0037—Containers
- B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
- B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
- B05B11/00446—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means the means being located at the bottom of the container or of an enclosure surrounding the container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1042—Components or details
- B05B11/1052—Actuation means
- B05B11/1053—Actuation means combined with means, other than pressure, for automatically opening a valve during actuation; combined with means for automatically removing closures or covers from the discharge nozzle during actuation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/291,712 US4894220A (en) | 1987-01-30 | 1988-12-29 | Antibacterial antiplaque oral composition |
Publications (1)
Publication Number | Publication Date |
---|---|
PH26686A true PH26686A (en) | 1992-09-15 |
Family
ID=23121503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH39826A PH26686A (en) | 1988-12-29 | 1989-12-29 | Antibacterial antiplaque oral composition |
Country Status (9)
Country | Link |
---|---|
US (1) | US4894220A (de) |
KR (2) | KR0155985B1 (de) |
AU (1) | AU654874B2 (de) |
CA (1) | CA2006719C (de) |
DD (2) | DD291245A5 (de) |
IT (1) | IT1238355B (de) |
PH (1) | PH26686A (de) |
ZA (2) | ZA899972B (de) |
ZM (1) | ZM5289A1 (de) |
Families Citing this family (191)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4931273A (en) * | 1985-09-13 | 1990-06-05 | Colgate-Palmolive Company | Anticalculus oral composition |
US4966777A (en) * | 1985-09-13 | 1990-10-30 | Colgate-Palmolive Company | Anticalculus oral composition |
US5057310A (en) * | 1986-11-06 | 1991-10-15 | Hill Ira D | Method of manufacturing oral hygiene preparations containing active SnF.sub. |
US5057307A (en) * | 1986-11-06 | 1991-10-15 | Hill Ira D | Method of relieving gum discomfort |
US5057308A (en) * | 1986-11-06 | 1991-10-15 | Hill Ira D | Method of treating the oral cavity with oral hygiene preparations containing active SnF2 |
US5057309A (en) * | 1986-11-06 | 1991-10-15 | Hill Ira D | Oral hygiene preparations |
US5453265A (en) * | 1987-01-30 | 1995-09-26 | Colgate Palmolive Company | Antibacterial antiplaque oral composition |
US5256401A (en) * | 1987-01-30 | 1993-10-26 | Colgate-Palmolive Company | Antibacterial antiplaque mouthwash composition |
US5531982A (en) | 1987-01-30 | 1996-07-02 | Colgate Palmolive Company | Antimicrobial oral composition |
US5294431A (en) * | 1987-01-30 | 1994-03-15 | Colgate-Palmolive Co. | Antibacterial antiplaque oral composition mouthwash or liquid dentifrice |
US5180578A (en) * | 1987-01-30 | 1993-01-19 | Colgate-Palmolive Company | Antibacterial antiplaque anticalculus oral composition |
US5192530A (en) * | 1987-01-30 | 1993-03-09 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
US5312618A (en) * | 1988-12-29 | 1994-05-17 | Colgate-Palmolive Co. | Antibacterial antiplaque oral composition |
US5043154A (en) * | 1987-01-30 | 1991-08-27 | Colgate-Palmolive Co. | Antibacterial, antiplaque, anticalculus oral composition |
US5344641A (en) * | 1987-01-30 | 1994-09-06 | Colgate-Palmolive Co. | Antibacterial antiplaque oral composition |
US5192531A (en) * | 1988-12-29 | 1993-03-09 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
US5178851A (en) * | 1987-01-30 | 1993-01-12 | Colgate-Palmolive Company | Antiplaque antibacterial oral composition |
US5288480A (en) * | 1987-01-30 | 1994-02-22 | Colgate-Palmolive Co. | Antiplaque antibacterial oral composition |
IN168400B (de) * | 1987-01-30 | 1991-03-23 | Colgate Palmolive Co | |
US5080887A (en) * | 1987-01-30 | 1992-01-14 | Colgate-Palmolive Company | Antibacterial antiplaque, anticalculus oral composition |
US5156835A (en) * | 1987-01-30 | 1992-10-20 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
US5188821A (en) * | 1987-01-30 | 1993-02-23 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition mouthwash or liquid dentifrice |
US5334375A (en) * | 1988-12-29 | 1994-08-02 | Colgate Palmolive Company | Antibacterial antiplaque oral composition |
US5424059A (en) * | 1988-12-29 | 1995-06-13 | Colgate Palmolive Company | Antibacterial antiplaque dentifrice |
GB8901587D0 (en) * | 1989-01-25 | 1989-03-15 | Unilever Plc | Dentifrices |
GB9007074D0 (en) * | 1990-03-29 | 1990-05-30 | Beecham Inc | Novel compositions |
US5188820A (en) * | 1989-10-05 | 1993-02-23 | Chesebrough-Pond's Usa Co., Dividion Of Conopco, Inc. | Method of inhibiting plaque on teeth by applying an oral composition |
US5356615A (en) * | 1991-01-30 | 1994-10-18 | Colgate Palmolive Company | Antiplaque oral compositions |
US5108734A (en) * | 1991-07-01 | 1992-04-28 | Colgate-Palmolive Company | Prophy mouthfeel dentifrice having low RDA value |
US5240697A (en) * | 1991-10-17 | 1993-08-31 | Colgate-Palmolive Company | Desensitizing anti-tartar dentifrice |
JP2979446B2 (ja) * | 1991-11-06 | 1999-11-15 | ライオン株式会社 | 口腔用組成物 |
US5252313A (en) * | 1991-12-20 | 1993-10-12 | Colgate-Palmolive Company | Visually clear gel dentifrice |
US5290541A (en) * | 1992-06-18 | 1994-03-01 | The Procter & Gamble Company | Methods for making oral compositions |
NZ247712A (en) * | 1992-06-19 | 1995-04-27 | Colgate Palmolive Co | Oral composition comprising an anti-bacterial compound, a water-insoluble biodegradable polymer, and an organic solvent |
AU682489B2 (en) * | 1993-01-27 | 1997-10-09 | Warner-Lambert Company | Reduced alcohol mouthwash antiseptic and antiseptic preparations |
US5290542A (en) * | 1993-04-08 | 1994-03-01 | The Procter & Gamble Company | Oral compositions for treating plaque and gingivitis |
US5474761A (en) * | 1993-04-08 | 1995-12-12 | The Procter & Gamble Company | Oral compositions for treating plaque and gingivitis |
WO1995008332A1 (en) * | 1993-09-20 | 1995-03-30 | The Procter & Gamble Company | Use of triclosan phosphates for the treatment of gastrointestinal disorders due to heliobacter infection |
US5451401A (en) * | 1993-09-29 | 1995-09-19 | The Procter & Gamble Company | Diphosphonic acid esters as tartar control agents |
US5407665A (en) * | 1993-12-22 | 1995-04-18 | The Procter & Gamble Company | Ethanol substitutes |
CA2177680C (en) * | 1993-12-29 | 2000-12-05 | Lori Ann Bacca | Tartar control dentifrice composition containing thymol |
US5505933A (en) * | 1994-06-27 | 1996-04-09 | Colgate Palmolive Company | Desensitizing anti-tartar dentifrice |
US6136298A (en) * | 1994-07-14 | 2000-10-24 | Colgate-Palmolive Company | Process for inhibiting S. mutans and caries |
US5681548A (en) * | 1994-07-15 | 1997-10-28 | Colgate Palmolive Company | Oral formulations |
AU689580B2 (en) | 1994-07-15 | 1998-04-02 | Colgate-Palmolive Company, The | Oral compositions |
US5599527A (en) * | 1994-11-14 | 1997-02-04 | Colgate-Palmolive Company | Dentifrice compositions having improved anticalculus properties |
US5578295A (en) * | 1995-04-28 | 1996-11-26 | The Procter & Gamble Company | Oral care compositions comprising certain substituted diphenyl ethers |
US5599526A (en) * | 1995-06-01 | 1997-02-04 | Viscio; David B. | Visually clear gel dentifrice |
US5582816A (en) * | 1995-06-01 | 1996-12-10 | Colgate Palmolive Company | Preparation of a visually clear gel dentifrice |
US5733529A (en) * | 1995-06-05 | 1998-03-31 | Whitehill Oral Technologies, Inc. | Ultramulsion based antigingivitis toothpaste compositions |
US5645841A (en) * | 1995-06-05 | 1997-07-08 | Whitehill Oral Technologies, Inc. | Ultramulsion based oral care rinse compositions |
US5651959A (en) * | 1995-06-05 | 1997-07-29 | Whitehill Oral Technologies, Inc. | Ultramulsion based oral care compositions |
US5665374A (en) * | 1995-06-05 | 1997-09-09 | Whitehill Oral Technologies, Inc. | Ultramulsion containing interdental delivery devices |
US5891422A (en) * | 1996-10-10 | 1999-04-06 | Warner-Lambert Company | Antimicrobial composition containing a C3 -C6 alcohol |
US20030206874A1 (en) * | 1996-11-21 | 2003-11-06 | The Proctor & Gamble Company | Promoting whole body health |
US6713049B1 (en) | 1999-11-12 | 2004-03-30 | The Procter & Gamble Company | Oral compositions providing optimal surface conditioning |
US6350436B1 (en) | 1996-11-21 | 2002-02-26 | The Procter & Gamble Company | Method of reducing staining of stannous in dentifrice compositions |
US20060171907A1 (en) * | 1996-11-21 | 2006-08-03 | The Procter & Gamble Company | Oral care compositions providing enhanced whitening and stain prevention |
US5885554A (en) * | 1997-01-10 | 1999-03-23 | The Procter & Gamble Company | Hydrophobic agents and polymeric surfactants |
US5885553A (en) * | 1997-01-10 | 1999-03-23 | The Procter & Gamble Company | Hydrophobic agents for use in oral care products |
US5800803A (en) * | 1997-02-10 | 1998-09-01 | Colgate-Palmolive Company | Oral composition exhibiting enhanced uptake by dental tissue of noncationic antibacterial agents |
US6248309B1 (en) | 1997-04-04 | 2001-06-19 | Optiva Corporation | Gums containing antimicrobial agents |
US5939050A (en) * | 1997-04-04 | 1999-08-17 | Optiva Corp. | Antimicrobial compositions |
US6280707B1 (en) | 1998-12-15 | 2001-08-28 | Dentsply International Inc. | Oral prophalaxis paste |
US6592912B1 (en) * | 1997-12-30 | 2003-07-15 | Wm. Wrigley Jr. Company | Method of controlling release of antimicrobial agents from chewing gum and gum produced thereby |
EP1056430A2 (de) | 1998-02-19 | 2000-12-06 | Oraceutical, LLC | Härtbare zusammensetzungen mit antimikrobiellen eigenschaften |
AU6448598A (en) * | 1998-03-06 | 1999-09-20 | Fmc Corporation | Non-stringy gel toothpaste comprising kappa carrageenan and cellulose as binders |
JP3967077B2 (ja) * | 1998-03-06 | 2007-08-29 | エフ エム シー コーポレーション | 高水分歯磨 |
US6165447A (en) * | 1999-06-15 | 2000-12-26 | Colgate-Palmolive Company | Synergistic antibacterial combination |
US6129907A (en) * | 1999-08-04 | 2000-10-10 | Colgate Palmolive Company | Stable hydrogenated lupulone antibacterial oral compositions |
ES2156569B1 (es) * | 1999-10-05 | 2002-05-16 | Biocosmetics Sl | Empleo del aceite de oliva en la elaboracion de una pasta dentifrica para la eliminacion o reduccion de la placa bacteriana y/o bacterias presentes en la cavidad bucal. |
US20070025928A1 (en) * | 1999-11-12 | 2007-02-01 | The Procter & Gamble Company | Stannous oral care compositions |
US6685920B2 (en) | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
US20040146466A1 (en) | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
US10470985B2 (en) | 1999-11-12 | 2019-11-12 | The Procter & Gamble Company | Method of protecting teeth against erosion |
EP2238965A1 (de) | 1999-11-12 | 2010-10-13 | The Procter & Gamble Company | Orale Zusammensetzungen enthaltend Zinn-ionen |
EP1227789B1 (de) | 1999-11-12 | 2004-09-22 | The Procter & Gamble Company | Verbesserte zweikomponente orale zusammensetzungen die zinn-derivate enthalten |
US6861060B1 (en) * | 2000-04-21 | 2005-03-01 | Elena Luriya | Personal care formulations |
US8283135B2 (en) * | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
EP1294383B1 (de) * | 2000-06-30 | 2008-07-16 | The Procter & Gamble Company | Orale zubereitungen, die antimikrobielle wirkstoffe enthalten zur prävention von systemischen erkrankungen |
JP2004511506A (ja) * | 2000-10-16 | 2004-04-15 | バイオコスメティックス・ソシエダッド・リミターダ | 口腔内のバクテリアによるプラークおよび/またはバクテリアを除去または低減するための口内衛生製品の調製におけるオリーブオイルの用途 |
KR20020066060A (ko) * | 2001-02-08 | 2002-08-14 | 주식회사옥시 | 칫솔의 살균을 위한 살균제 조성물, 그 제조방법 및 그를이용한 칫솔의 살균방법 |
KR20030016131A (ko) * | 2001-08-20 | 2003-02-26 | 오희숙 | 기능성 치약 조성물 |
US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
US20050084551A1 (en) | 2003-09-26 | 2005-04-21 | Jensen Claude J. | Morinda citrifolia-based oral care compositions and methods |
KR100555300B1 (ko) * | 2003-10-29 | 2006-03-03 | 유재현 | 섬유치약 |
US7135449B2 (en) * | 2004-02-20 | 2006-11-14 | Milliken & Company | Composition for removal of odors and contaminants from textiles and method |
US20050271601A1 (en) * | 2004-06-02 | 2005-12-08 | Nebojsa Milanovich | Anti-staining antibacterial dentifrice |
US9028852B2 (en) * | 2004-09-07 | 2015-05-12 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
US20060051384A1 (en) * | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Antiseptic compositions and methods of use |
US8198326B2 (en) * | 2004-09-07 | 2012-06-12 | 3M Innovative Properties Company | Phenolic antiseptic compositions and methods of use |
EP1634948A1 (de) | 2004-09-10 | 2006-03-15 | Basf Aktiengesellschaft | Mittel und Verfahren zur Vorbeugung und/oder Behandlung von Karies |
TWI404545B (zh) * | 2004-12-22 | 2013-08-11 | Colgate Palmolive Co | 含有黃酮類化合物及黃烷之口腔護理組合物 |
US20060140881A1 (en) * | 2004-12-22 | 2006-06-29 | Guofeng Xu | Oral care compositions containing flavonoids and flavans |
US20060141039A1 (en) * | 2004-12-23 | 2006-06-29 | Colgate-Palmolive Company | Oral compositions containing oxidized camellia |
US8895084B2 (en) | 2004-12-23 | 2014-11-25 | Colgate-Palmolive Company | Oral care composition containing extract of unoxidized Camellia |
US20060140883A1 (en) * | 2004-12-29 | 2006-06-29 | Colgate-Palmolive Company | Oral care compositions containing a eucalyptus extract |
NZ560448A (en) * | 2005-02-16 | 2009-08-28 | Anacor Pharmaceuticals Inc | Boron-containing small molecules |
US10918618B2 (en) | 2005-03-10 | 2021-02-16 | 3M Innovative Properties Company | Methods of reducing microbial contamination |
ATE511838T1 (de) * | 2005-03-10 | 2011-06-15 | 3M Innovative Properties Co | Antimikrobielle zusammensetzungen mit hydroxycarboxylsäureestern |
EP1858506A2 (de) * | 2005-03-10 | 2007-11-28 | 3M Innovative Properties Company | Verfahren zur behandlung von ohrinfektionen |
BRPI0620265B8 (pt) * | 2005-12-21 | 2021-05-25 | Colgate Palmolive Co | composição oral anti-placa e dessensibilizante |
JP5657206B2 (ja) | 2005-12-21 | 2015-01-21 | コルゲート・パーモリブ・カンパニーColgate−Palmolive Company | 清浄及び/又は光沢組成物とその使用の方法 |
RU2396938C2 (ru) * | 2005-12-21 | 2010-08-20 | Колгейт-Палмолив Компани | Абразивная система для композиций для ухода за полостью рта |
US20070140990A1 (en) * | 2005-12-21 | 2007-06-21 | Nataly Fetissova | Oral Compositions Comprising Propolis |
CN106008571A (zh) * | 2005-12-30 | 2016-10-12 | 安纳考尔医药公司 | 含硼的小分子 |
SI2719388T1 (sl) | 2006-02-16 | 2019-06-28 | Anacor Pharmaceuticals, Inc. | Majhne molekule, polnjene z borom, kot učinkovine proti vnetjem |
US9649513B2 (en) * | 2006-03-24 | 2017-05-16 | Colgate—Palmolive Company | Aerosol dispenser |
CA2649955C (en) * | 2006-05-09 | 2013-04-02 | Colgate-Palmolive Company | Oral care regimen |
US20080274065A1 (en) * | 2006-05-09 | 2008-11-06 | Richard Scott Robinson | Oral Care Regimen |
US20070286822A1 (en) * | 2006-06-12 | 2007-12-13 | Anacor Pharmaceuticals Inc. | Compounds for the Treatment of Periodontal Disease |
WO2007146956A2 (en) * | 2006-06-12 | 2007-12-21 | Rhodia Inc. | Hydrophilized substrate and method for hydrophilizing a hydrophobic surface of a substrate |
US9682256B2 (en) * | 2006-07-14 | 2017-06-20 | Colgate-Palmolive Company | Methods of making compositions comprising films |
US8084050B2 (en) | 2006-10-11 | 2011-12-27 | Colgate-Palmolive Company | Compositions comprising combinations of sensates |
CA2667307C (en) | 2006-10-27 | 2015-12-01 | 3M Innovative Properties Company | Antimicrobial compositions comprising a c2-c5 lower alcohol, a cationic antimicrobial agent, and a fatty component containing free hydroxyl groups |
CN101563447A (zh) | 2006-12-19 | 2009-10-21 | 巴斯夫欧洲公司 | 用于预防和/或治疗变形链球菌群引起的龋的用途和方法 |
CN101679915B (zh) * | 2007-06-12 | 2013-01-23 | 罗迪亚公司 | 具有亲水剂的硬质表面清洁组合物以及清洁硬质表面的方法 |
EP2152844B1 (de) | 2007-06-12 | 2019-04-24 | Solvay USA Inc. | Mono-di- und polyole phosphatester in körperpflegeformulierungen |
AU2008261634B2 (en) * | 2007-06-12 | 2014-04-24 | Rhodia Inc. | Detergent composition with hydrophilizing soil-release agent and methods for using same |
EP2164455B1 (de) * | 2007-06-12 | 2018-08-15 | Solvay USA Inc. | Mono-, di- und polyol-alkoxylatephosphatester in mundpflegeformulierungen und verfahren zu ihrer anwendung |
MX2009013365A (es) * | 2007-07-20 | 2010-01-25 | Rhodia | Metodo para recuperar petroleo crudo de una formacion subterranea. |
US20090202452A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care regimen |
US8039450B2 (en) | 2008-03-06 | 2011-10-18 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
EP2285384A4 (de) * | 2008-05-12 | 2012-04-25 | Anacor Pharmaceuticals Inc | Borhaltige kleine moleküle |
US10213627B2 (en) | 2008-05-16 | 2019-02-26 | Colgate-Palmolive Company | Oral compositions and uses therof |
EP2133414A1 (de) | 2008-06-11 | 2009-12-16 | Basf Se | Anwendungen und Verfahren zur Vorbeugung und/oder Behandlung von Mundgeruch |
WO2010027975A1 (en) * | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
WO2010028005A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
US9493489B2 (en) * | 2008-10-15 | 2016-11-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
EA201190034A1 (ru) * | 2008-12-17 | 2012-02-28 | Анакор Фармасьютикалс, Инк. | Полиморфы (s)-3-аминометил-7-(3-гидроксипропокси)-3н-бензо[c][1,2]оксаборол-1-ола |
TWI405565B (zh) | 2009-04-01 | 2013-08-21 | Colgate Palmolive Co | 口腔用組成物之抗-骨質流失及抗-牙周附連喪失之功效 |
US8778312B2 (en) | 2009-04-01 | 2014-07-15 | Colgate-Palmolive Company | Densensitizing dentifrice exhibiting dental tissue antibacterial agent uptake |
MX2011008671A (es) | 2009-04-01 | 2011-09-06 | Colgate Palmolive Co | Composiciones dentifricas y metodos para el tratamiento y prevencion del deterioro de las superficies dentales. |
TWI396554B (zh) | 2009-05-26 | 2013-05-21 | Colgate Palmolive Co | 增進可溶性鋅的量之口腔保健調配物 |
TW201109022A (en) | 2009-06-03 | 2011-03-16 | Colgate Palmolive Co | Borinic compositions |
EP2458995A1 (de) * | 2009-07-28 | 2012-06-06 | Anacor Pharmaceuticals, Inc. | Trisubstituierte borhaltige moleküle |
MX2012001359A (es) | 2009-07-30 | 2012-02-17 | Procter & Gamble | Articulos para el cuidado oral. |
WO2011019618A1 (en) * | 2009-08-14 | 2011-02-17 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
MX2012002031A (es) * | 2009-08-19 | 2012-07-04 | Anacor Pharmaceuticals Inc | Moleculas pequeñas que contienen boro como agentes antiprotozoarios. |
US20110124597A1 (en) * | 2009-09-25 | 2011-05-26 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules |
US9346834B2 (en) | 2009-10-20 | 2016-05-24 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
BR112012009305B8 (pt) | 2009-10-29 | 2017-08-08 | Colgate Palmolive Co | composição de dentifrício e método para a fabricação de uma composição de dentifrício |
WO2011060196A1 (en) * | 2009-11-11 | 2011-05-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
AR079508A1 (es) | 2009-12-17 | 2012-02-01 | Colgate Palmolive Co | Formulacion dentifrica |
WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
WO2011116348A1 (en) | 2010-03-19 | 2011-09-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agent |
AU2011235154B2 (en) | 2010-04-01 | 2014-06-05 | The Procter & Gamble Company | Whole mouth malodor control by a combination of antibacterial and deodorizing agents |
US20120003162A1 (en) | 2010-06-30 | 2012-01-05 | Mcneil-Ppc, Inc. | Methods of Preparing Non-Alcohol Bioactive Esential Oil Mouth Rinses |
US9084902B2 (en) | 2010-06-30 | 2015-07-21 | Mcneil-Ppc, Inc. | Non-alchohol bioactive essential oil mouth rinses |
CN103153272A (zh) | 2010-07-19 | 2013-06-12 | 宝洁公司 | 包含精油化合物的衍生物的组合物以及在个人护理产品中的用途 |
ES2898695T3 (es) | 2010-09-07 | 2022-03-08 | Anacor Pharmaceuticals Inc | Derivados de benzoxaborol para el tratamiento de infecciones bacterianas |
PL2621466T3 (pl) | 2010-10-01 | 2018-11-30 | The Procter & Gamble Company | Kompozycje do pielęgnacji jamy ustnej o ulepszonej słodkości |
WO2012044728A1 (en) | 2010-10-01 | 2012-04-05 | The Procter & Gamble Company | Oral care compositions with improved flavor |
US9259377B2 (en) | 2010-12-13 | 2016-02-16 | Colgate-Palmolive Company | Oral compositions and method for producing thereof |
CA2819995A1 (en) | 2010-12-13 | 2012-06-21 | Colgate-Palmolive Company | Oral flavored compositions comprising polymer matrix films and hydrophobic/lipophilic additives and alcohol-free method for producing thereof |
WO2012082101A1 (en) | 2010-12-13 | 2012-06-21 | Colgate-Palmolive Company | Oral compositions and method for producing thereof |
AU2011341455B2 (en) | 2010-12-13 | 2015-07-23 | Colgate-Palmolive Company | Oral compositions |
US8900557B2 (en) | 2010-12-30 | 2014-12-02 | Jr Chem, Llc | Dental cleaning composition |
EP2667883A1 (de) | 2011-01-24 | 2013-12-04 | Basf Se | Zusammensetzungen zur verbesserung der mundgesundheit |
MX338801B (es) | 2011-05-16 | 2016-05-02 | Colgate Palmolive Co | Composiciones de cuidado oral. |
SG194607A1 (en) | 2011-06-02 | 2013-12-30 | Colgate Palmolive Co | Low water metal ion dentifrice |
MX344234B (es) | 2011-09-01 | 2016-12-01 | Procter & Gamble | Composiciones para el cuidado bucal con reologia mejorada. |
ITCZ20120007A1 (it) * | 2012-05-25 | 2013-11-26 | Giuseppe Alfi | Pasta dentifiricia sbiancante, lucidante e remineralizzante |
US10123953B2 (en) | 2012-06-21 | 2018-11-13 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
CA2906184A1 (en) | 2013-03-15 | 2014-09-18 | Api Genesis, Llc | Polyphenol/flavonoid compositions and methods of formulating oral hygienic products |
US10751260B2 (en) | 2013-10-22 | 2020-08-25 | Jag Mayer Pty Ltd | Dispenser |
WO2015171837A1 (en) | 2014-05-09 | 2015-11-12 | The Procter & Gamble Company | Oral compositions containing zinc |
WO2015171836A1 (en) | 2014-05-09 | 2015-11-12 | The Procter & Gamble Company | Oral compositions containing stannous |
BR112016028543B1 (pt) | 2014-06-20 | 2020-12-15 | Colgate-Palmolive Company | Composições orais contendo íons de metal |
MX359754B (es) | 2014-06-20 | 2018-10-01 | Colgate Palmolive Co | Composiciones orales que contienen fuentes de ion de zinc, estaño y fluoruro. |
EP3193822A2 (de) | 2014-09-15 | 2017-07-26 | Vizuri Health Sciences LLC | Polyphenol-/flavonoidzusammensetzungen und verfahren zur formulierung von mundhygieneprodukten |
EP3233036B1 (de) | 2014-12-15 | 2023-01-25 | 3M Innovative Properties Company | Kits zur entfernung von zahnstein |
EP3586925B1 (de) | 2014-12-26 | 2021-02-24 | Colgate-Palmolive Company | Zink-phosphat-komplex |
US9951295B2 (en) | 2015-02-19 | 2018-04-24 | The Procter & Gamble Company | Compositions for deposition on biological surfaces |
CA2991917A1 (en) | 2015-07-17 | 2017-01-26 | Colgate-Palmolive Company | Oral care compositions |
ES2913120T3 (es) | 2015-08-04 | 2022-05-31 | Isp Investments Llc | Polímeros derivados de éteres de alcohol vinílico aminofuncionales y aplicaciones de los mismos |
WO2017048617A1 (en) | 2015-09-15 | 2017-03-23 | Vizuri Health Sciences Llc | Polyphenol/flavonoid compositions and methods of formulating oral hygienic products |
US11447506B2 (en) | 2016-05-09 | 2022-09-20 | Anacor Pharmaceuticals, Inc. | Crystal forms of crisaborole in free form and preparation method and use thereof |
JP7018899B2 (ja) | 2016-05-26 | 2022-02-14 | スリーエム イノベイティブ プロパティズ カンパニー | 治療用歯科用ペースト並びに関連する方法及びキット |
BR112018076904B1 (pt) | 2016-06-22 | 2022-02-08 | 3M Innovative Properties Company | Método e kit de partes para a remoção de cálculo de um dente |
WO2018075149A1 (en) | 2016-10-20 | 2018-04-26 | 3M Innovative Properties Company | Methods and kits for removing calculus using a non-enzymatic, hydrogen peroxide decomposition catalyst |
HUE054497T2 (hu) | 2016-12-19 | 2021-09-28 | Evonik Operations Gmbh | Ónnal kompatibilis szilícium-dioxid |
US10328002B2 (en) | 2016-12-19 | 2019-06-25 | The Procter & Gamble Company | Dentifice compositions containing stannous compatible silica particles |
JP7368931B2 (ja) * | 2017-10-12 | 2023-10-25 | サンスター株式会社 | 口腔用組成物 |
CN107550763A (zh) * | 2017-10-20 | 2018-01-09 | 吴盼盼 | 一种预防治疗牙龈出血、牙龈萎缩的漱口精油组合物 |
EP3717608A1 (de) | 2017-11-30 | 2020-10-07 | 3M Innovative Properties Company | Reinigungszusammensetzungen, kits und verfahren mit glucaminderivaten |
MX2020007520A (es) | 2018-01-17 | 2021-05-31 | Procter & Gamble | Metodos y composiciones para aumentar la dureza y resistencia del esmalte. |
US11191709B2 (en) | 2019-04-26 | 2021-12-07 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
EP3972698A1 (de) | 2019-05-22 | 2022-03-30 | 3M Innovative Properties Company | Orale zusammensetzungen und verfahren zur verwendung |
WO2020234811A1 (en) | 2019-05-22 | 2020-11-26 | 3M Innovative Properties Company | Oral compositions and methods of use |
CN114173747A (zh) | 2019-07-08 | 2022-03-11 | 宝洁公司 | 用于提高釉质硬度和抵抗力的方法和组合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7600817A (en) * | 1975-02-13 | 1976-08-17 | Ciba Geigy | Disinfectant compsn. e.g. for use on skin - contg. triclosan, EDTA low alkanol and triethanol amine as pH adjuster |
GB8401965D0 (en) * | 1984-01-25 | 1984-02-29 | Beecham Group Plc | Composition |
GB8411731D0 (en) * | 1984-05-09 | 1984-06-13 | Unilever Plc | Oral compositions |
KR940010078B1 (ko) * | 1985-03-13 | 1994-10-21 | 안토니 그룩 브루노 | 소독액과 그의 도포구 |
EP0260859A1 (de) * | 1986-09-19 | 1988-03-23 | SMITH & NEPHEW UNITED, INC. | Medizinische Zubereitung für die Haut |
GB8629640D0 (en) * | 1986-12-11 | 1987-01-21 | Beecham Group Plc | Composition & method |
IN168400B (de) * | 1987-01-30 | 1991-03-23 | Colgate Palmolive Co |
-
1988
- 1988-12-29 US US07/291,712 patent/US4894220A/en not_active Expired - Lifetime
-
1989
- 1989-12-22 IT IT04869589A patent/IT1238355B/it active IP Right Grant
- 1989-12-27 CA CA002006719A patent/CA2006719C/en not_active Expired - Lifetime
- 1989-12-28 KR KR1019890020632A patent/KR0155985B1/ko not_active IP Right Cessation
- 1989-12-28 ZA ZA899972A patent/ZA899972B/xx unknown
- 1989-12-28 ZA ZA899971A patent/ZA899971B/xx unknown
- 1989-12-28 KR KR89020633A patent/KR0138911B1/ko not_active IP Right Cessation
- 1989-12-29 DD DD89336813A patent/DD291245A5/de not_active IP Right Cessation
- 1989-12-29 PH PH39826A patent/PH26686A/en unknown
- 1989-12-29 DD DD89336811A patent/DD291246A5/de unknown
-
1990
- 1990-06-18 ZM ZM52/89A patent/ZM5289A1/xx unknown
-
1992
- 1992-09-15 AU AU24519/92A patent/AU654874B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
US4894220A (en) | 1990-01-16 |
KR900009047A (ko) | 1990-07-02 |
DD291245A5 (de) | 1991-06-27 |
ZA899971B (en) | 1991-08-28 |
AU2451992A (en) | 1992-11-19 |
CA2006719A1 (en) | 1990-06-29 |
ZM5289A1 (en) | 1990-07-27 |
CA2006719C (en) | 2000-10-17 |
KR0138911B1 (en) | 1998-05-15 |
AU654874B2 (en) | 1994-11-24 |
IT1238355B (it) | 1993-07-13 |
ZA899972B (en) | 1991-11-27 |
KR900009048A (ko) | 1990-07-02 |
DD291246A5 (de) | 1991-06-27 |
IT8948695A0 (it) | 1989-12-22 |
IT8948695A1 (it) | 1991-06-22 |
KR0155985B1 (en) | 1998-11-16 |
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