PH26556A - 3-aryloxy-3-substituted propanamines - Google Patents
3-aryloxy-3-substituted propanamines Download PDFInfo
- Publication number
- PH26556A PH26556A PH36267A PH36267A PH26556A PH 26556 A PH26556 A PH 26556A PH 36267 A PH36267 A PH 36267A PH 36267 A PH36267 A PH 36267A PH 26556 A PH26556 A PH 26556A
- Authority
- PH
- Philippines
- Prior art keywords
- thienyl
- methyl
- propanamine
- naphthalenyloxy
- compound
- Prior art date
Links
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical class CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 title claims description 60
- 150000001875 compounds Chemical class 0.000 claims description 70
- 125000001544 thienyl group Chemical group 0.000 claims description 26
- 239000002253 acid Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 9
- 125000002541 furyl group Chemical group 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000003085 diluting agent Substances 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 125000004076 pyridyl group Chemical group 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000000335 thiazolyl group Chemical group 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
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- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 description 3
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- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940071104 xylenesulfonate Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94512286A | 1986-12-22 | 1986-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26556A true PH26556A (en) | 1992-08-19 |
Family
ID=25482649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH36267A PH26556A (en) | 1986-12-22 | 1987-12-18 | 3-aryloxy-3-substituted propanamines |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0273658B1 (da) |
| JP (1) | JP2549681B2 (da) |
| KR (2) | KR880007433A (da) |
| CN (1) | CN1019113B (da) |
| AR (1) | AR243868A1 (da) |
| AT (1) | ATE57924T1 (da) |
| AU (1) | AU591007B2 (da) |
| CA (1) | CA1302421C (da) |
| CY (2) | CY1682A (da) |
| DE (3) | DE3765919D1 (da) |
| DK (1) | DK174599B1 (da) |
| EG (1) | EG18230A (da) |
| ES (1) | ES2019949B3 (da) |
| GR (1) | GR3001207T3 (da) |
| HK (1) | HK69693A (da) |
| HU (1) | HU206309B (da) |
| IE (1) | IE873449L (da) |
| IL (1) | IL84863A (da) |
| LU (1) | LU91131I2 (da) |
| MX (1) | MX9845A (da) |
| NL (1) | NL300171I2 (da) |
| NZ (1) | NZ222980A (da) |
| PH (1) | PH26556A (da) |
| PT (1) | PT86389B (da) |
| SG (1) | SG114992G (da) |
| SU (1) | SU1598865A3 (da) |
| ZA (1) | ZA879472B (da) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902710A (en) * | 1988-12-14 | 1990-02-20 | Eli Lilly And Company | Serotonin and norepinephrine uptake inhibitors |
| CA2042346A1 (en) * | 1990-05-17 | 1991-11-18 | Michael Alexander Staszak | Chiral synthesis of 1-aryl-3-aminopropan-1-ols |
| EP0571685A1 (en) * | 1992-05-27 | 1993-12-01 | Novo Nordisk A/S | Aryloxyheteroarylpropylamines, their preparation and use |
| US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| GB0004151D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004153D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004149D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0004152D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| SE0102640D0 (sv) | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| MXPA04000979A (es) * | 2001-07-31 | 2005-02-17 | Upjohn Co | Tratamiento de dolor cronico con 3-ariloxi-3-fenilpropanaminas. |
| IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
| AU2003221028A1 (en) * | 2002-03-19 | 2003-09-29 | Mitsubishi Chemical Corporation | 3-hydroxy-3-(2-thienyl)propionamide compound, process for producing the same, and process for producing 3-amino-1-(2-thienyl)-1-propanol compound therefrom |
| US7659409B2 (en) | 2002-03-19 | 2010-02-09 | Mitsubishi Chemical Corporation | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same |
| EP1506965A4 (en) * | 2002-05-20 | 2010-11-03 | Mitsubishi Rayon Co | PROPANOLAMINE DERIVATIVES, PROCESS FOR THE PREPARATION OF 3-N-METHYLAMINO-1- (2-THIENYL) -1-PROPANOLS AND PROCESS FOR THE PREPARATION OF PROPANOLAMINE DERIVATIVES |
| DE10235206A1 (de) * | 2002-08-01 | 2004-02-19 | Basf Ag | Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| GB0229583D0 (en) * | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
| DE10302595A1 (de) | 2003-01-22 | 2004-07-29 | Basf Ag | 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung |
| DE10345772A1 (de) | 2003-10-01 | 2005-04-21 | Basf Ag | Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol |
| DE102004004719A1 (de) | 2004-01-29 | 2005-08-18 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen |
| CN102627572A (zh) * | 2004-02-19 | 2012-08-08 | 隆萨股份公司 | 对映异构体纯的1-取代-3-氨基醇的制备方法 |
| DE102004022686A1 (de) | 2004-05-05 | 2005-11-24 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
| GB0410470D0 (en) * | 2004-05-11 | 2004-06-16 | Cipla Ltd | Pharmaceutical compound and polymorphs thereof |
| AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| WO2006021564A1 (en) * | 2004-08-26 | 2006-03-02 | Neurosearch A/S | Novel substituted aryloxy alkylamines and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2006071868A2 (en) * | 2004-12-23 | 2006-07-06 | Teva Pharmaceutical Industries Ltd. | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
| TW200639162A (en) | 2005-03-14 | 2006-11-16 | Teva Pharma | Pure duloxetine hydrochloride |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| KR101589551B1 (ko) | 2005-07-15 | 2016-02-02 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| DE102005044736A1 (de) | 2005-09-19 | 2007-03-22 | Basf Ag | Neue Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von optisch aktiven Alkanolen |
| WO2007038253A2 (en) * | 2005-09-22 | 2007-04-05 | Teva Pharmaceutical Industries Ltd. | Dnt-maleate and methods of preparation thereof |
| ITMI20051970A1 (it) * | 2005-10-18 | 2007-04-19 | Solmag S P A | Processo per la preparazione di eteri misti derivanti dall'inaftolo e intermedi di forme cristalline definite di + e - duloxetina |
| WO2007062998A1 (en) * | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 3-amino-2-arylpropyl azaindoles and uses thereof |
| WO2007067581A1 (en) | 2005-12-05 | 2007-06-14 | Teva Pharmaceutical Industries Ltd. | 2-(n-methyl-propanamine)-3-(2-naphthol) thiophene, an impurity of duloxetine hydrochloride |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| DE102005062662A1 (de) | 2005-12-23 | 2007-06-28 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
| DE102005062661A1 (de) | 2005-12-23 | 2007-08-16 | Basf Ag | Verfahren zur Herstellung von optisch aktivem (1S)-3-Chlor-(-thien-2-yl)-propan-1-ol |
| CZ299270B6 (cs) | 2006-01-04 | 2008-06-04 | Zentiva, A. S. | Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu |
| EP1976844A4 (en) | 2006-01-06 | 2010-11-03 | Msn Lab Ltd | IMPROVED METHOD FOR PURE DULOXETIN HYDROCHLORIDE |
| ATE552250T1 (de) | 2006-12-22 | 2012-04-15 | Synthon Bv | Verfahren zur herstellung von duloxetin und verwandten verbindungen |
| CN101998866A (zh) * | 2008-04-11 | 2011-03-30 | 尼克塔治疗公司 | 低聚物-芳氧基-取代的丙胺共轭物 |
| EP2133072A1 (en) | 2008-06-13 | 2009-12-16 | KRKA, D.D., Novo Mesto | Gastro-resistant pharmaceutical oral compositions comprising duloxetine or its pharmaceutically acceptable derivatives |
| CN101613347B (zh) * | 2008-06-23 | 2012-07-04 | 中国人民解放军军事医学科学院毒物药物研究所 | 胺类化合物及其医药用途 |
| HU230480B1 (hu) * | 2008-07-25 | 2016-07-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Eljárás N-metil-ariloxi-propánamin származékok előállítására |
| EP2329013B1 (en) | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| AU2010247735B2 (en) | 2009-05-12 | 2015-07-16 | Albany Molecular Research, Inc. | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof |
| US8802696B2 (en) | 2009-05-12 | 2014-08-12 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof |
| CZ304602B6 (cs) | 2009-09-02 | 2014-07-30 | Zentiva, K. S. | Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu) |
| EP2377525A1 (en) | 2010-03-26 | 2011-10-19 | Laboratorios del Dr. Esteve S.A. | Duloxetine enteric pellets |
| SI2558455T1 (sl) | 2010-04-13 | 2017-12-29 | Krka, D.D., Novo Mesto | Sinteza duloksetina in/ali njegovih farmacevtsko sprejemljivih soli |
| EP2606049A4 (en) | 2010-08-17 | 2014-01-08 | Albany Molecular Res Inc | 2,5-METHANO- AND 2,5-ETHANO-TETRAHYDROBENZAZEPINE DERIVATIVES AND USES THEREOF FOR BLOCKING NOREPINEPHRINE, DOPAMINE, AND SEROTONIN REUPTAKE |
| EP2508519A1 (en) * | 2011-04-07 | 2012-10-10 | Bioindustria Laboratorio Italiano Medicinali S.p.A In forma abbreviata Bioindustria L.I.M. S.p.A. | "Process for the preparation of duloxetine and its hydrochloride salt" |
| GR1007725B (el) | 2011-10-17 | 2012-10-18 | Φαρματεν Αβεε, | Μεθοδος δια την παρασκευη υδροχλωρικης ντουλοξετινης υψηλης καθαροτητας |
| PL224543B1 (pl) | 2013-08-21 | 2017-01-31 | Pabianickie Zakłady Farm Polfa Spółka Akcyjna | Dojelitowa tabletka duloksetyny |
| US9668975B2 (en) | 2014-10-14 | 2017-06-06 | PharmaDax Inc. | Method of preparing drug agglomerate |
| CN105777706B (zh) | 2014-12-25 | 2019-08-23 | 江苏恩华药业股份有限公司 | 一种3-[(苯并[d][1, 3]二氧戊环-4-基)-氧基]-3-芳基丙胺类化合物及其应用 |
| JP2016222628A (ja) * | 2015-06-03 | 2016-12-28 | 株式会社トクヤマ | デュロキセチン塩酸塩の製造方法 |
| JP6182183B2 (ja) * | 2015-07-07 | 2017-08-16 | 東和薬品株式会社 | デュロキセチン塩基及びデュロキセチン塩酸塩の製造方法 |
| CN106349211B (zh) * | 2016-08-26 | 2020-10-16 | 江苏恩华药业股份有限公司 | 2-甲基-3-芳氧基-3-杂芳基丙胺类化合物及应用 |
| EP3339304A1 (en) | 2016-12-20 | 2018-06-27 | Laboratorios del Dr. Esteve, S.A. | Quinoline and isoquinoline derivatives for treating pain and pain related conditions |
| WO2020228789A1 (zh) * | 2019-05-16 | 2020-11-19 | 上海璃道医药科技有限公司 | 3-芳氧基-3-五元杂芳基-丙胺类化合物及其晶型和用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2842555A (en) * | 1954-07-27 | 1958-07-08 | Burroughs Wellcome Co | Method of preparing quaternary salts of amino carbinols |
| AT255400B (de) * | 1965-03-22 | 1967-07-10 | Chemie Linz Ag | Verfahren zur Herstellung von neuen basischen Äthern |
| US3423510A (en) * | 1966-08-31 | 1969-01-21 | Geigy Chem Corp | 3-(p-halophenyl) - 3 - (2'-pyridyl-n-methylpropylamine for the treatment of depression |
| US4018895A (en) * | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
| FR2482956A1 (fr) * | 1980-05-22 | 1981-11-27 | Synthelabo | Cyclohexylalkylamines, leurs procedes de preparation et leur application en therapeutique |
-
1986
- 1986-12-18 KR KR860014449A patent/KR880007433A/ko unknown
-
1987
- 1987-12-17 CA CA000554601A patent/CA1302421C/en not_active Expired - Lifetime
- 1987-12-17 ZA ZA879472A patent/ZA879472B/xx unknown
- 1987-12-17 DK DK198706648A patent/DK174599B1/da not_active IP Right Cessation
- 1987-12-17 SU SU874203804A patent/SU1598865A3/ru active
- 1987-12-17 EG EG731/87A patent/EG18230A/xx active
- 1987-12-17 IL IL84863A patent/IL84863A/xx not_active IP Right Cessation
- 1987-12-17 AU AU82660/87A patent/AU591007B2/en not_active Expired
- 1987-12-17 PT PT86389A patent/PT86389B/pt unknown
- 1987-12-18 KR KR1019870014449A patent/KR960003808B1/ko not_active IP Right Cessation
- 1987-12-18 PH PH36267A patent/PH26556A/en unknown
- 1987-12-18 JP JP62322617A patent/JP2549681B2/ja not_active Expired - Lifetime
- 1987-12-18 EP EP87311181A patent/EP0273658B1/en not_active Expired - Lifetime
- 1987-12-18 HU HU875863A patent/HU206309B/hu unknown
- 1987-12-18 NZ NZ222980A patent/NZ222980A/xx unknown
- 1987-12-18 AR AR87309638A patent/AR243868A1/es active
- 1987-12-18 IE IE873449A patent/IE873449L/xx not_active IP Right Cessation
- 1987-12-18 MX MX984587A patent/MX9845A/es unknown
- 1987-12-18 DE DE8787311181T patent/DE3765919D1/de not_active Expired - Lifetime
- 1987-12-18 DE DE19873765919 patent/DE122005000002I2/de active Active
- 1987-12-18 DE DE200512000002 patent/DE122005000002I1/de active Pending
- 1987-12-18 CN CN87108175A patent/CN1019113B/zh not_active Expired
- 1987-12-18 ES ES87311181T patent/ES2019949B3/es not_active Expired - Lifetime
- 1987-12-18 AT AT87311181T patent/ATE57924T1/de active
-
1990
- 1990-12-18 GR GR90401079T patent/GR3001207T3/el unknown
-
1992
- 1992-11-04 SG SG1149/92A patent/SG114992G/en unknown
-
1993
- 1993-07-22 HK HK696/93A patent/HK69693A/xx not_active IP Right Cessation
- 1993-10-10 CY CY1682A patent/CY1682A/xx unknown
-
2005
- 2005-01-26 LU LU91131C patent/LU91131I2/fr unknown
- 2005-01-27 CY CY200500001C patent/CY2005001I1/el unknown
- 2005-01-31 NL NL300171C patent/NL300171I2/nl unknown
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