PH26276A - Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances - Google Patents
Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances Download PDFInfo
- Publication number
- PH26276A PH26276A PH40155A PH40155A PH26276A PH 26276 A PH26276 A PH 26276A PH 40155 A PH40155 A PH 40155A PH 40155 A PH40155 A PH 40155A PH 26276 A PH26276 A PH 26276A
- Authority
- PH
- Philippines
- Prior art keywords
- reservoir
- transdermal system
- substances
- membrane
- active substance
- Prior art date
Links
- 229940100640 transdermal system Drugs 0.000 title claims abstract description 37
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 239000013543 active substance Substances 0.000 title claims description 98
- 229940079593 drug Drugs 0.000 title claims description 13
- 230000001747 exhibiting effect Effects 0.000 title claims description 4
- 238000007910 systemic administration Methods 0.000 title 1
- 230000002500 effect on skin Effects 0.000 claims abstract description 3
- 230000009885 systemic effect Effects 0.000 claims abstract description 3
- 239000012528 membrane Substances 0.000 claims description 94
- 239000010410 layer Substances 0.000 claims description 29
- 230000035699 permeability Effects 0.000 claims description 19
- 239000000126 substance Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 15
- 238000012423 maintenance Methods 0.000 claims description 8
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 6
- 239000011241 protective layer Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 230000000063 preceeding effect Effects 0.000 claims 3
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 210000004379 membrane Anatomy 0.000 description 78
- 239000011888 foil Substances 0.000 description 11
- 239000011159 matrix material Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 7
- 230000004907 flux Effects 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- -1 e.g. Substances 0.000 description 6
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 5
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 5
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 5
- 229960002646 scopolamine Drugs 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 230000036470 plasma concentration Effects 0.000 description 4
- 239000011505 plaster Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000001955 cumulated effect Effects 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002557 soporific effect Effects 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 239000002830 appetite depressant Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019439 ethyl acetate Nutrition 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000003152 motion sickness Diseases 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 230000001003 psychopharmacologic effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- External Artificial Organs (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3908431A DE3908431A1 (de) | 1989-03-15 | 1989-03-15 | Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung |
Publications (1)
Publication Number | Publication Date |
---|---|
PH26276A true PH26276A (en) | 1992-04-10 |
Family
ID=6376396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH40155A PH26276A (en) | 1989-03-15 | 1990-03-07 | Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0387693B1 (pt) |
JP (1) | JPH0693921B2 (pt) |
KR (1) | KR960005148B1 (pt) |
AT (1) | ATE143276T1 (pt) |
AU (1) | AU625402B2 (pt) |
CA (1) | CA2012123C (pt) |
CZ (1) | CZ284770B6 (pt) |
DD (1) | DD292383A5 (pt) |
DE (2) | DE3908431A1 (pt) |
DK (1) | DK0387693T3 (pt) |
ES (1) | ES2095216T3 (pt) |
FI (1) | FI901290A0 (pt) |
GR (1) | GR3022033T3 (pt) |
HR (1) | HRP930662A2 (pt) |
HU (1) | HU206991B (pt) |
IL (1) | IL93678A (pt) |
MY (1) | MY107420A (pt) |
NO (1) | NO300087B1 (pt) |
NZ (1) | NZ232895A (pt) |
PH (1) | PH26276A (pt) |
PL (1) | PL162693B1 (pt) |
PT (1) | PT93430B (pt) |
SI (1) | SI9010493B (pt) |
SK (1) | SK279357B6 (pt) |
YU (1) | YU48228B (pt) |
ZA (1) | ZA901941B (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4341444C2 (de) * | 1993-12-04 | 1996-03-14 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster und Verfahren zu seiner Herstellung |
AU3512595A (en) * | 1994-09-13 | 1996-03-29 | Magainin Pharmaceuticals, Inc. | Method for inhibiting sexually transmitted diseases using magaining antimicrobials or squalamine compounds |
US5714162A (en) * | 1994-09-16 | 1998-02-03 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Scopolamine patch |
DE4438989C2 (de) * | 1994-09-16 | 1999-02-25 | Lohmann Therapie Syst Lts | Scopolaminpflaster |
DE19705138A1 (de) * | 1997-02-11 | 1998-08-13 | Lohmann Therapie Syst Lts | Dehnbares transdermales therapeutisches System |
DE19733981A1 (de) * | 1997-08-06 | 1999-02-11 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System (TTS) zur Abgabe von Wirkstoff durch die Haut an einen Organismus und Verfahren zur Applikation auf der Haut |
DE19738643C2 (de) * | 1997-09-04 | 2001-10-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung |
DE10056012A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Flexible Barrierefolie für ein Trägermaterial für medizinische Zwecke |
DE10056014A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Mehrschichtige Trägerkonstruktion für wirkstofhaltige Pflastersyteme |
DE102004020463A1 (de) * | 2004-04-26 | 2005-11-10 | Grünenthal GmbH | Wirkstoffabgabesystem aus einem wirkstoffhaltigen Pflaster und mindestens einem Wirkstoffabgaberegulierungsmittel |
MX355295B (es) | 2011-04-04 | 2018-04-12 | Procter & Gamble | Artículos para el cuidado personal. |
US9763547B2 (en) | 2011-08-15 | 2017-09-19 | The Procter & Gamble Company | Personal care articles having multi-zone compliant personal care compositions |
CN104202987B (zh) | 2011-08-15 | 2017-09-01 | 宝洁公司 | 个人护理方法 |
BR112015032340A2 (pt) | 2013-06-27 | 2017-07-25 | Procter & Gamble | composições e artigos para cuidados pessoais |
DE102018216244A1 (de) | 2018-09-24 | 2020-03-26 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Barriereschicht |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5755157A (en) * | 1980-09-19 | 1982-04-01 | Nitto Electric Ind Co | Drug member having transcataneous absorbing property |
IE53703B1 (en) * | 1982-12-13 | 1989-01-18 | Elan Corp Plc | Drug delivery device |
US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
US4666441A (en) * | 1985-12-17 | 1987-05-19 | Ciba-Geigy Corporation | Multicompartmentalized transdermal patches |
DE3634016A1 (de) * | 1986-04-17 | 1987-10-29 | Lohmann Gmbh & Co Kg | Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung |
DE3775830D1 (de) * | 1986-06-13 | 1992-02-20 | Alza Corp | Aktivierung eines transdermalen drogenabgabesystems durch feuchtigkeit. |
US4781924A (en) * | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device |
-
1989
- 1989-03-15 DE DE3908431A patent/DE3908431A1/de active Granted
-
1990
- 1990-03-07 MY MYPI90000358A patent/MY107420A/en unknown
- 1990-03-07 AU AU50765/90A patent/AU625402B2/en not_active Ceased
- 1990-03-07 PH PH40155A patent/PH26276A/en unknown
- 1990-03-08 SK SK1136-90A patent/SK279357B6/sk unknown
- 1990-03-08 IL IL9367890A patent/IL93678A/en not_active IP Right Cessation
- 1990-03-08 CZ CS901136A patent/CZ284770B6/cs unknown
- 1990-03-08 EP EP90104406A patent/EP0387693B1/de not_active Expired - Lifetime
- 1990-03-08 ES ES90104406T patent/ES2095216T3/es not_active Expired - Lifetime
- 1990-03-08 AT AT90104406T patent/ATE143276T1/de not_active IP Right Cessation
- 1990-03-08 DK DK90104406.5T patent/DK0387693T3/da active
- 1990-03-08 DE DE59010514T patent/DE59010514D1/de not_active Expired - Fee Related
- 1990-03-09 NO NO901128A patent/NO300087B1/no not_active IP Right Cessation
- 1990-03-12 JP JP2058241A patent/JPH0693921B2/ja not_active Expired - Fee Related
- 1990-03-13 NZ NZ232895A patent/NZ232895A/xx unknown
- 1990-03-13 HU HU901422A patent/HU206991B/hu not_active IP Right Cessation
- 1990-03-13 DD DD90338650A patent/DD292383A5/de unknown
- 1990-03-14 PT PT93430A patent/PT93430B/pt not_active IP Right Cessation
- 1990-03-14 ZA ZA901941A patent/ZA901941B/xx unknown
- 1990-03-14 SI SI9010493A patent/SI9010493B/sl unknown
- 1990-03-14 KR KR1019900003563A patent/KR960005148B1/ko not_active IP Right Cessation
- 1990-03-14 PL PL28430190A patent/PL162693B1/pl unknown
- 1990-03-14 CA CA002012123A patent/CA2012123C/en not_active Expired - Fee Related
- 1990-03-14 YU YU49390A patent/YU48228B/sh unknown
- 1990-03-15 FI FI901290A patent/FI901290A0/fi not_active Application Discontinuation
-
1993
- 1993-04-01 HR HR930662A patent/HRP930662A2/hr not_active Application Discontinuation
-
1996
- 1996-12-13 GR GR960403458T patent/GR3022033T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU678237B2 (en) | Active substance-containing plaster | |
CA1261267A (en) | Transdermal system for timolol | |
CA2012123C (en) | Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances | |
AU2018203157A1 (en) | Transdermal drug delivery device | |
AU2005324182B2 (en) | Transdermal, therapeutic system with activatable oversaturation and controlled permeation promotion | |
US20040101551A1 (en) | Transdermal therapeutic system for releasing venlafaxine | |
ES2836483T3 (es) | Sistema terapéutico transdérmico para la administración de un principio activo | |
IE61788B1 (en) | Transdermal therapeutic system | |
KR20010036685A (ko) | 펜타닐을 함유하는 매트릭스형 경피투여제 | |
IE912181A1 (en) | Patch with a high content of softening ingredients | |
AU2004260583A1 (en) | Transdermaltherapeutic system containing a pramipexol active agent | |
CA2216278A1 (en) | Transdermally administrable medicament with ace inhibitors | |
KR100624500B1 (ko) | 레리세트론 전달용 경피치료시스템 | |
US5176917A (en) | Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances | |
AU709288B2 (en) | Transdermal therapeutic system (tts) for the administration of drugs for treatment of drug dependency or drug addiction | |
KR20010084881A (ko) | 투명한 경피성 니코틴 전달 장치 | |
WO1989012470A1 (en) | Subsaturated transdermal delivery device | |
KR102710072B1 (ko) | 장기 투여용 리바스티그민 패취 | |
JPH10511972A (ja) | (s)−3−メチル−5−(1−メチル−2−ピロリデニル)−イソオキサゾールまたはその製薬上受け入れられる塩類の一つの投与のための経皮性治療系 | |
RU2246937C2 (ru) | Система для чрескожного введения никотина | |
KR910003107B1 (ko) | 에틸렌-비닐 아세테이트 기질 적층 구조의 방출 조절성 경피 흡수 제형 | |
KR20200025888A (ko) | 장기 투여용 리바스티그민 패취 | |
AU727267B2 (en) | Patch for transdermal application of pergolid |