PH23014A - Novel insulin derivatives,their use and pharmaceutical agents for the treatment of diabetes mellitus - Google Patents

Novel insulin derivatives,their use and pharmaceutical agents for the treatment of diabetes mellitus

Info

Publication number
PH23014A
PH23014A PH31009A PH31009A PH23014A PH 23014 A PH23014 A PH 23014A PH 31009 A PH31009 A PH 31009A PH 31009 A PH31009 A PH 31009A PH 23014 A PH23014 A PH 23014A
Authority
PH
Philippines
Prior art keywords
treatment
diabetes mellitus
pharmaceutical agents
insulin derivatives
novel insulin
Prior art date
Application number
PH31009A
Other languages
English (en)
Inventor
Ulrich Grau
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PH23014A publication Critical patent/PH23014A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/622—Insulins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PH31009A 1983-07-22 1984-07-20 Novel insulin derivatives,their use and pharmaceutical agents for the treatment of diabetes mellitus PH23014A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833326472 DE3326472A1 (de) 1983-07-22 1983-07-22 Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus

Publications (1)

Publication Number Publication Date
PH23014A true PH23014A (en) 1989-03-03

Family

ID=6204660

Family Applications (1)

Application Number Title Priority Date Filing Date
PH31009A PH23014A (en) 1983-07-22 1984-07-20 Novel insulin derivatives,their use and pharmaceutical agents for the treatment of diabetes mellitus

Country Status (20)

Country Link
US (1) US4701440A (enExample)
EP (1) EP0132770B1 (enExample)
JP (2) JPS6042397A (enExample)
AR (1) AR241864A1 (enExample)
AT (1) ATE29729T1 (enExample)
AU (1) AU569097B2 (enExample)
CA (1) CA1246548A (enExample)
DE (2) DE3326472A1 (enExample)
DK (2) DK172211B1 (enExample)
ES (2) ES534487A0 (enExample)
FI (1) FI79854C (enExample)
GR (1) GR81551B (enExample)
HU (1) HUT37805A (enExample)
IE (1) IE57709B1 (enExample)
IL (1) IL72469A (enExample)
NO (1) NO167810C (enExample)
NZ (1) NZ208959A (enExample)
PH (1) PH23014A (enExample)
PT (1) PT78940A (enExample)
ZA (1) ZA845620B (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
HUT56857A (en) * 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
YU66892A (sh) * 1991-08-20 1995-10-24 Hoechst Ag. Fosfoinositolglikan - peptid sa delovanjem kao insulin
TW224471B (enExample) * 1991-11-26 1994-06-01 Lilly Co Eli
DK0545198T3 (da) * 1991-11-29 2000-03-20 Hoechst Ag Peptider med insulinagtig virkning
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
PT821006E (pt) 1996-07-26 2004-09-30 Aventis Pharma Gmbh Derivados de insulina com ligacao a zinco aumentada
DE19649350A1 (de) * 1996-11-28 1998-06-04 Hoechst Ag Inositolglykane mit insulinartiger Wirkung
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
JP4969002B2 (ja) 1999-06-08 2012-07-04 ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン ｒＡＡＶ形質導入を増加するための化合物および方法
WO2002067969A2 (en) 2001-02-21 2002-09-06 Medtronic Minimed, Inc. Stabilized insulin formulations
US6605155B2 (en) * 2001-02-21 2003-08-12 Seiwa Pro Co., Ltd. Remover for scale deposited on titanium material
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
WO2004089423A2 (en) 2003-03-31 2004-10-21 University Of Iowa Research Foundation Pharmico-gene theraphy of epithelial sodium channel associated disoders
JP2008500006A (ja) * 2003-05-21 2008-01-10 バイオテック トゥールス ソシエテ アノニム ペプチド複合体
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
PH12011502708B1 (en) 2009-07-06 2017-11-10 Sanofi Aventis Deutschland Insulin preparations containing methionine
JP5832439B2 (ja) 2009-11-13 2015-12-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物
SG10201500871TA (en) 2009-11-13 2015-04-29 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
CN103179978A (zh) 2010-08-30 2013-06-26 赛诺菲-安万特德国有限公司 Ave0010用于制造供治疗2型糖尿病用的药物的用途
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
JP6367115B2 (ja) 2011-08-29 2018-08-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病患者の血糖コントロールに使用する組合せ医薬
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
WO2017139381A1 (en) 2016-02-08 2017-08-17 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
WO2017155973A1 (en) 2016-03-07 2017-09-14 University Of Iowa Research Foundation Aav-mediated expression using a synthetic promoter and enhancer
US12173305B2 (en) 2016-05-26 2024-12-24 University Of Iowa Research Foundation cis and trans requirements for terminal resolution of human bocavirus 1
US11142775B2 (en) 2017-01-13 2021-10-12 University Of Iowa Research Foundation Bocaparvovirus small noncoding RNA and uses thereof
EP3852873A1 (en) 2018-09-19 2021-07-28 Ziylo Ltd Glucose sensitive insulins and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2256215C3 (de) * 1972-11-16 1981-01-08 Hoechst Ag, 6000 Frankfurt Insulin-Zubereitung mit einem Gehalt an kristallinem Insulin und amorphem Desphenylalanin8' -insulin
DE2460753A1 (de) * 1974-12-21 1976-06-24 Hoechst Ag Verfahren zur herstellung von humaninsulin
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) * 1983-09-23 1985-04-04 Hoechst Ag, 6230 Frankfurt In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
JPH118546A (ja) * 1997-04-24 1999-01-12 Hitachi Ltd Ｃｍｏｓ回路

Also Published As

Publication number Publication date
NO167810C (no) 1991-12-18
JPH052654B2 (enExample) 1993-01-13
AR241864A1 (es) 1993-01-29
NZ208959A (en) 1989-02-24
DK172211B1 (da) 1998-01-05
IL72469A0 (en) 1984-11-30
DK1790D0 (da) 1990-01-04
ES8505646A1 (es) 1985-06-01
ES8504678A1 (es) 1985-04-16
FI842914L (fi) 1985-01-23
NO842977L (no) 1985-01-23
IL72469A (en) 1989-07-31
CA1246548A (en) 1988-12-13
ZA845620B (en) 1985-02-27
ES534487A0 (es) 1985-04-16
FI79854B (fi) 1989-11-30
PT78940A (de) 1984-08-01
DE3326472A1 (de) 1985-02-14
DK358284D0 (da) 1984-07-20
US4701440A (en) 1987-10-20
ATE29729T1 (de) 1987-10-15
FI842914A0 (fi) 1984-07-19
IE57709B1 (en) 1993-03-10
EP0132770B1 (de) 1987-09-16
HUT37805A (en) 1986-02-28
JPH01294634A (ja) 1989-11-28
JPH0357119B2 (enExample) 1991-08-30
ES535706A0 (es) 1985-06-01
DK358284A (da) 1985-01-23
AU569097B2 (en) 1988-01-21
NO167810B (no) 1991-09-02
JPS6042397A (ja) 1985-03-06
DE3466227D1 (en) 1987-10-22
AU3092284A (en) 1985-01-24
GR81551B (enExample) 1984-12-11
IE841889L (en) 1985-01-22
FI79854C (fi) 1990-03-12
DK172209B1 (da) 1998-01-05
DK1790A (da) 1990-01-04
EP0132770A1 (de) 1985-02-13

Similar Documents

Publication Publication Date Title
IL72469A0 (en) Novel insulin derivatives,processes for their preparation and their use,and pharmaceutical agents for the treatment of diabetes mellitus
GB2100605B (en) Bandage for administering drugs.
EG18268A (en) Medicament for the treatment of inflammation of the eye
GB2101482B (en) Pharmaceutical composition for the treatment of diabetes mellitus
HU912266D0 (en) Process for the production of solid medical preparations with controlled portioning of the active agents for oral use
GB8711564D0 (en) Medical syringe
IL62847A (en) Pharmaceutical composition for the treatment of juvenile diabetes mellitus comprising insulin and l-carnitine and/or an l-acylcarnitine
KR950005743B1 (en) Thiazole derivatives, their preparation and their use in the treatment of diabetes complications
EP0129478A3 (en) 2-sulfamoylbenzo (b) thiophene derivatives, their preparation and pharmaceutical composition for the treatment of elevated intraocular pressure
EP0278452A3 (en) 2,4- and 2,5-pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds
ZA855072B (en) Heterocyclic pharmaceutical compounds,preparation and use
ZA844539B (en) 3-phenyl-4-cyanopyrrole derivatives,the preparation thereof,and method of use thereof as microbicides
DE3479728D1 (en) Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure
PH16253A (en) Dibenzazepine derivatives,pharmaceutical composition containing them and use of the compound
EE03090B1 (et) Kinoliin-3-karboksamiidühendite kasutamine kompositsiooni valmistamiseks I tüüpi suhkurtõve raviks
ZA872972B (en) Benzothiazinone derivatives,processes for their preparation,medicaments containing them and their use
FI843695A7 (fi) Insuliini-johdannaisia, joissa B 30-asema on modifioitu, menetelmiä niiden valmistamiseksi ja niiden käyttö sekä sokeritaudin hoitoon tarkoitettuja lääkeaineita.
ZA825302B (en) Medicine for the treatment of diabetes
PH17582A (en) Pharmaceutical compositions for the treatment of diabetes
IL84012A0 (en) Pharmaceutical composition for the treatment of high blood pressure
IL91274A0 (en) New benzazole derivatives,processes for their preparation and pharmaceutical preparations containing such compounds and the use thereof
ZA876485B (en) 5-aminoethyloxazolidin-2-one derivatives,process for the preparation thereof and their therapeutic use
IL111361A0 (en) Pharmaceutical compositions for the treatment of insulin dependent diabetes mellitus (iddm)
EG19482A (en) Curative treatment for certain cases of diabetes mellitus in adults.
GB8510810D0 (en) Treatment of diabetes mellitus