PH12015501204B1 - Tobacco specific nitrosamine reduction in plants - Google Patents
Tobacco specific nitrosamine reduction in plantsInfo
- Publication number
- PH12015501204B1 PH12015501204B1 PH1/2015/501204A PH12015501204A PH12015501204B1 PH 12015501204 B1 PH12015501204 B1 PH 12015501204B1 PH 12015501204 A PH12015501204 A PH 12015501204A PH 12015501204 B1 PH12015501204 B1 PH 12015501204B1
- Authority
- PH
- Philippines
- Prior art keywords
- seq
- mutant
- naturally occurring
- plants
- polynucleotide
- Prior art date
Links
- 241000196324 Embryophyta Species 0.000 title 1
- 244000061176 Nicotiana tabacum Species 0.000 title 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 title 1
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 230000009261 transgenic effect Effects 0.000 abstract 3
- 108010062745 Chloride Channels Proteins 0.000 abstract 2
- 102000011045 Chloride Channels Human genes 0.000 abstract 2
- 108091064523 Clc family Proteins 0.000 abstract 2
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/245—Nitrosamines
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B3/00—Preparing tobacco in the factory
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Manufacture Of Tobacco Products (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12198966 | 2012-12-21 | ||
| PCT/EP2013/077532 WO2014096283A2 (en) | 2012-12-21 | 2013-12-19 | Tobacco specific nitrosamine reduction in plants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12015501204A1 PH12015501204A1 (en) | 2015-08-17 |
| PH12015501204B1 true PH12015501204B1 (en) | 2022-07-15 |
Family
ID=47559184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2015/501204A PH12015501204B1 (en) | 2012-12-21 | 2013-12-19 | Tobacco specific nitrosamine reduction in plants |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10563215B2 (enExample) |
| EP (1) | EP2935588A2 (enExample) |
| JP (1) | JP6693747B2 (enExample) |
| KR (1) | KR102253223B1 (enExample) |
| CN (1) | CN105247053B (enExample) |
| AP (1) | AP2015008563A0 (enExample) |
| CA (1) | CA2894955C (enExample) |
| MX (2) | MX2015008084A (enExample) |
| PH (1) | PH12015501204B1 (enExample) |
| RU (1) | RU2735254C2 (enExample) |
| WO (1) | WO2014096283A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9980509B2 (en) | 2013-04-05 | 2018-05-29 | R.J. Reynolds Tobacco Company | Modification of bacterial profile of tobacco |
| US20170145431A1 (en) * | 2014-06-25 | 2017-05-25 | Philip Morris Products S.A. | Modulation of nitrate content in plants |
| GB201501941D0 (en) * | 2015-02-05 | 2015-03-25 | British American Tobacco Co | Method |
| BR112017023719A2 (pt) * | 2015-05-05 | 2018-07-17 | Univ North Carolina State | planta de tabaco, parte de planta e/ou célula de planta, semente, cultura de planta, produto de tabaco, método para reduzir pon e/ou nnk, método de produção de uma planta e método para produzir um produto de tabaco |
| CN117089525A (zh) * | 2016-03-11 | 2023-11-21 | 奥驰亚客户服务有限公司 | 用于生产烟杈减少或消除的烟草植物和制品的组合物和方法 |
| EP3661354A1 (en) | 2017-07-31 | 2020-06-10 | R. J. Reynolds Tobacco Company | Methods and compositions for viral-based gene editing in plants |
| CN111801423A (zh) | 2018-03-28 | 2020-10-20 | 菲利普莫里斯生产公司 | 调节植物中的氨基酸含量 |
| BR112020017430A2 (pt) | 2018-03-28 | 2021-01-19 | Philip Morris Products S.A. | Modulação do teor de açúcar redutor em uma planta |
| CN113271768B (zh) * | 2018-12-30 | 2024-02-06 | 菲利普莫里斯生产公司 | 经由硝酸盐还原酶的突变来调节植物中的硝酸盐水平 |
| EP3979839A4 (en) * | 2019-06-05 | 2023-06-28 | R. J. Reynolds Tobacco Company | Bzip transcription factors regulate conversion of nicotine to nornicotine and reduce levels of tobacco specific (tsna) precursors |
| CN110499388B (zh) * | 2019-09-29 | 2023-03-24 | 云南省烟草农业科学研究院 | 鉴别烟草抗斑萎病位点rtsw等位基因类型的共显性标记引物组、鉴别方法及其应用 |
| BR112022005552A2 (pt) | 2019-10-01 | 2022-06-28 | Philip Morris Products Sa | Modulação da redução do teor de açúcar em uma planta (inv) |
| US12419264B2 (en) | 2019-10-01 | 2025-09-23 | Philip Morris Products S.A. | Modulating sugar and amino acid content in a plant (SULTR3) |
| CN111690661A (zh) * | 2020-06-01 | 2020-09-22 | 云南省烟草农业科学研究院 | 一种烟草NtbHLH13基因突变体及分子鉴定方法和应用 |
| WO2023036691A1 (en) | 2021-09-10 | 2023-03-16 | Philip Morris Products S.A. | Modulating alkaloid profiles in nicotiana tabacum |
| WO2023117661A1 (en) | 2021-12-20 | 2023-06-29 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
| WO2023117701A1 (en) | 2021-12-21 | 2023-06-29 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
| EP4458140A4 (en) * | 2021-12-27 | 2025-10-15 | Japan Tobacco Inc | TOBACCO PLANT |
| JP2025533986A (ja) | 2022-10-13 | 2025-10-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Ｎｔｐ２を調節することによって葉バイオマスおよび窒素利用効率を増加させる |
| KR20250139371A (ko) | 2023-02-02 | 2025-09-23 | 필립모리스 프로덕츠 에스.에이. | 당 수송체의 조절 |
| CN120476136A (zh) | 2023-02-02 | 2025-08-12 | 菲利普莫里斯生产公司 | 编码赖氨酸酮戊二酸还原酶的基因的调节 |
| CN117025627B (zh) * | 2023-06-29 | 2024-11-01 | 中国烟草总公司郑州烟草研究院 | 烟草氯离子通道蛋白NtCLC13及其编码基因和应用 |
| WO2025003105A1 (en) | 2023-06-29 | 2025-01-02 | Philip Morris Products S.A. | Modulation of genes coding for glutamate dehydrogenase |
| CN117025626B (zh) * | 2023-06-29 | 2025-02-14 | 中国烟草总公司郑州烟草研究院 | 烟草硝酸盐转运蛋白NtNPF7.4及其编码基因、基因编辑载体和应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5810020A (en) | 1993-09-07 | 1998-09-22 | Osmotek, Inc. | Process for removing nitrogen-containing anions and tobacco-specific nitrosamines from tobacco products |
| US6202649B1 (en) | 1996-12-02 | 2001-03-20 | Regent Court Technologies | Method of treating tobacco to reduce nitrosamine content, and products produced thereby |
| US6586661B1 (en) * | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
| IL154166A (en) | 1997-06-20 | 2005-09-25 | Regent Court Technologies | Tobacco products having low nitrosamine content |
| US7700834B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
| RU2191529C1 (ru) | 2001-12-21 | 2002-10-27 | Романенко Александр Павлович | Устройство для курения |
| RU2310353C2 (ru) * | 2003-05-06 | 2007-11-20 | Джапан Тобакко Инк. | Способ производства восстановленного табачного материала |
| JP4160868B2 (ja) * | 2003-07-10 | 2008-10-08 | 日本たばこ産業株式会社 | 葉タバコ中のニトロソアミン含量の低減方法 |
| KR20060128821A (ko) * | 2003-08-19 | 2006-12-14 | 22엔디 센츄리 리미티드, 엘엘씨 | 감소된 노출 담배 제품 |
| EP1851317B1 (en) | 2005-02-23 | 2011-10-26 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| EP2087123B1 (en) | 2006-10-13 | 2011-08-10 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| RU2324737C1 (ru) * | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
| ES2716864T3 (es) | 2007-06-06 | 2019-06-17 | Monsanto Technology Llc | Genes y usos para la mejora de plantas |
| BRPI0820042B1 (pt) | 2007-11-12 | 2020-05-19 | North Carolina State University | método de obtenção de uma planta de tabaco, ou célula ou parte desta, tendo níveis reduzidos de nornicotina, produto de tabaco, método para fabricar um produto de tabaco, polinucleotídeo isolado, cassete de expressão, polipetpídeo isolado e método de obtenção de uma planta, ou parte de planta desta, do gênero nicotiana |
| EP2231861B1 (en) | 2007-12-13 | 2014-10-29 | Philip Morris Products S.A. | Transgenic plants modified for reduced cadmium transport, derivative products, and related methods |
| WO2009091518A2 (en) * | 2008-01-15 | 2009-07-23 | Monsanto Technology, Llc | Isolated novel nucleic acid and protein molecules from corn and methods of using those molecules to generate transgenic plant with enhanced agronomic traits |
| WO2011048009A1 (en) * | 2009-10-22 | 2011-04-28 | Basf Plant Science Company Gmbh | Plants having enhanced yield-related traits and a method for making the same |
| PH12012501393B1 (en) | 2010-01-15 | 2017-10-25 | Univ North Carolina State | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| EP3447065A1 (en) | 2010-09-03 | 2019-02-27 | Philip Morris Products S.A. | Heavy metal reduction in planta |
-
2013
- 2013-12-19 JP JP2015548608A patent/JP6693747B2/ja active Active
- 2013-12-19 KR KR1020157018188A patent/KR102253223B1/ko active Active
- 2013-12-19 CA CA2894955A patent/CA2894955C/en active Active
- 2013-12-19 RU RU2015126909A patent/RU2735254C2/ru active
- 2013-12-19 CN CN201380073174.4A patent/CN105247053B/zh active Active
- 2013-12-19 AP AP2015008563A patent/AP2015008563A0/xx unknown
- 2013-12-19 WO PCT/EP2013/077532 patent/WO2014096283A2/en not_active Ceased
- 2013-12-19 MX MX2015008084A patent/MX2015008084A/es unknown
- 2013-12-19 US US14/653,924 patent/US10563215B2/en active Active
- 2013-12-19 PH PH1/2015/501204A patent/PH12015501204B1/en unknown
- 2013-12-19 EP EP13817681.3A patent/EP2935588A2/en active Pending
-
2015
- 2015-06-19 MX MX2019001598A patent/MX2019001598A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AP2015008563A0 (en) | 2015-06-30 |
| CN105247053B (zh) | 2020-07-31 |
| EP2935588A2 (en) | 2015-10-28 |
| US10563215B2 (en) | 2020-02-18 |
| US20150315603A1 (en) | 2015-11-05 |
| WO2014096283A2 (en) | 2014-06-26 |
| RU2015126909A (ru) | 2017-01-27 |
| JP2016508032A (ja) | 2016-03-17 |
| KR102253223B1 (ko) | 2021-05-21 |
| MX2015008084A (es) | 2016-03-31 |
| JP6693747B2 (ja) | 2020-05-13 |
| CN105247053A (zh) | 2016-01-13 |
| CA2894955C (en) | 2023-10-31 |
| WO2014096283A3 (en) | 2014-08-14 |
| RU2735254C2 (ru) | 2020-10-29 |
| MX2019001598A (es) | 2019-07-01 |
| PH12015501204A1 (en) | 2015-08-17 |
| KR20150096451A (ko) | 2015-08-24 |
| CA2894955A1 (en) | 2014-06-26 |
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