PE25091A1 - Eteres de 1-bencil-3-hidroximetil-indazol con 2-hidroxiacidos alifaticos - Google Patents

Eteres de 1-bencil-3-hidroximetil-indazol con 2-hidroxiacidos alifaticos

Info

Publication number
PE25091A1
PE25091A1 PE1990164654A PE16465490A PE25091A1 PE 25091 A1 PE25091 A1 PE 25091A1 PE 1990164654 A PE1990164654 A PE 1990164654A PE 16465490 A PE16465490 A PE 16465490A PE 25091 A1 PE25091 A1 PE 25091A1
Authority
PE
Peru
Prior art keywords
formula
indazol
ether
compound
rent
Prior art date
Application number
PE1990164654A
Other languages
English (en)
Spanish (es)
Inventor
Bruno Silvestrini
Leandro Baiocchi
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of PE25091A1 publication Critical patent/PE25091A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PE1990164654A 1989-02-07 1990-01-30 Eteres de 1-bencil-3-hidroximetil-indazol con 2-hidroxiacidos alifaticos PE25091A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8947620A IT1230441B (it) 1989-02-07 1989-02-07 Eteri della serie dell'indazolo

Publications (1)

Publication Number Publication Date
PE25091A1 true PE25091A1 (es) 1991-08-17

Family

ID=11261479

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1990164654A PE25091A1 (es) 1989-02-07 1990-01-30 Eteres de 1-bencil-3-hidroximetil-indazol con 2-hidroxiacidos alifaticos

Country Status (36)

Country Link
US (2) US4999367A (enExample)
EP (1) EP0382276B1 (enExample)
JP (1) JP2870925B2 (enExample)
KR (1) KR0145525B1 (enExample)
CN (2) CN1046505C (enExample)
AR (1) AR247386A1 (enExample)
AT (1) ATE127115T1 (enExample)
AU (1) AU624895B2 (enExample)
BG (1) BG50273A3 (enExample)
CA (1) CA2009503C (enExample)
CZ (1) CZ280121B6 (enExample)
DD (2) DD295363A5 (enExample)
DE (2) DE69021902T2 (enExample)
DK (1) DK0382276T3 (enExample)
EG (1) EG19170A (enExample)
ES (1) ES2020171T3 (enExample)
FI (1) FI102678B1 (enExample)
GE (1) GEP19971030B (enExample)
GR (2) GR910300073T1 (enExample)
HU (1) HU204793B (enExample)
IL (1) IL93132A (enExample)
IN (1) IN170957B (enExample)
IT (1) IT1230441B (enExample)
LT (1) LT3604B (enExample)
LV (1) LV10612B (enExample)
NZ (1) NZ232258A (enExample)
PE (1) PE25091A1 (enExample)
PH (1) PH26552A (enExample)
PL (2) PL163720B1 (enExample)
PT (1) PT93067B (enExample)
RO (1) RO106252B1 (enExample)
RU (3) RU2066318C1 (enExample)
SK (1) SK278441B6 (enExample)
UA (1) UA26852C2 (enExample)
YU (1) YU47943B (enExample)
ZA (1) ZA90644B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1253703B (it) * 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it) * 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) * 1997-11-26 1999-08-24 Intel Corporation Two-transistor DRAM cell for logic process technology
US7514463B2 (en) * 2004-08-20 2009-04-07 University Of Kansas Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it) * 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
EA018185B1 (ru) 2008-03-07 2013-06-28 Ацьенде Кимике Рьюните Анджелини Франческо A.К.P.A.Ф. С.П.А. Новые производные 1-бензил-3-гидроксиметилиндазола и их применение при лечении заболеваний, обусловленных экспрессией mcp-1 или cx3cr1
DK2254869T3 (en) 2008-03-07 2017-09-04 Acraf 1-BENZYL-3-HYDROXYMETHYL INDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF CX3CR1 AND P40
MX2010009625A (es) 2008-03-07 2010-09-28 Acraf Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40.
BR112012002130A2 (pt) * 2009-08-03 2015-09-15 Aziende Chimique Riunite Angelini Francesco A C R A F S P A processo para a preparação de composto,e, composto intermediário
UA108742C2 (uk) * 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
CA3095012C (en) 2012-05-01 2023-02-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
JP2015521183A (ja) 2012-05-18 2015-07-27 サノフイ ピリジン誘導体および病理学的血栓形成に関連する状態の治療へのその使用
DK2882715T3 (en) 2012-05-18 2017-02-13 Sanofi Sa PYRAZOL DERIVATIVES AND USE THEREOF AS LPAR5 ANTAGONISTS
CN108047136B (zh) * 2017-12-20 2021-07-09 长春普华制药股份有限公司 一种苄达酸的精制方法
AU2019441740B2 (en) 2019-04-18 2025-12-18 Tracery Ophthalmics Inc. Detection, prediction, and classification for ocular disease
EP3990433B1 (en) * 2019-06-25 2026-05-20 Translatum Medicus Inc. PROCESSES FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL28032A (en) * 1966-08-29 1971-08-25 Acraf Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3470298A (en) * 1969-01-29 1969-09-30 Acraf Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
IT1131779B (it) 1980-07-29 1986-06-25 Acraf Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1189052B (it) 1981-11-27 1988-01-28 Acraf Trattamento della cataratta
IT1194564B (it) 1983-04-18 1988-09-22 Acraf Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
IT1197805B (it) 1986-08-01 1988-12-06 Acraf Metodo per il tratamento di lenti a contatto

Also Published As

Publication number Publication date
UA26852C2 (uk) 1999-12-29
RU2044729C1 (ru) 1995-09-27
CA2009503A1 (en) 1990-08-07
CA2009503C (en) 2000-04-11
DE69021902T2 (de) 1996-05-23
ATE127115T1 (de) 1995-09-15
DK0382276T3 (da) 1996-01-15
SK56390A3 (en) 1997-05-07
KR0145525B1 (ko) 1998-08-17
PL163720B1 (pl) 1994-04-29
IL93132A (en) 1994-05-30
SK278441B6 (en) 1997-05-07
BG50273A3 (en) 1992-06-15
AU4906690A (en) 1990-08-16
US5112986A (en) 1992-05-12
EG19170A (en) 1994-11-30
DD295363A5 (de) 1991-10-31
PL163730B1 (pl) 1994-04-29
EP0382276B1 (en) 1995-08-30
ES2020171A4 (es) 1991-08-01
PT93067A (pt) 1990-08-31
DD291995A5 (de) 1991-07-18
HU204793B (en) 1992-02-28
RO106252B1 (ro) 1993-03-31
LT3604B (en) 1995-12-27
PH26552A (en) 1992-08-19
CN1046505C (zh) 1999-11-17
IN170957B (enExample) 1992-06-20
YU47943B (sh) 1996-07-24
CZ280121B6 (cs) 1995-11-15
JP2870925B2 (ja) 1999-03-17
FI900577A0 (fi) 1990-02-06
JPH02240065A (ja) 1990-09-25
RU2066318C1 (ru) 1996-09-10
EP0382276A3 (en) 1990-12-12
US4999367A (en) 1991-03-12
LTIP872A (en) 1995-03-27
DE69021902D1 (de) 1995-10-05
GR910300073T1 (en) 1991-11-15
HUT53088A (en) 1990-09-28
PT93067B (pt) 1995-12-29
YU20690A (sh) 1992-07-20
LV10612A (lv) 1995-04-20
IT1230441B (it) 1991-10-23
CN1088201A (zh) 1994-06-22
FI102678B (fi) 1999-01-29
EP0382276A2 (en) 1990-08-16
CZ56390A3 (en) 1995-06-14
ZA90644B (en) 1991-01-30
RU2055071C1 (ru) 1996-02-27
HU900689D0 (en) 1990-04-28
DE382276T1 (de) 1991-11-28
NZ232258A (en) 1991-06-25
KR900012913A (ko) 1990-09-03
AU624895B2 (en) 1992-06-25
IT8947620A0 (it) 1989-02-07
AR247386A1 (es) 1994-12-29
CN1034016C (zh) 1997-02-12
CN1044810A (zh) 1990-08-22
GR3018165T3 (en) 1996-02-29
IL93132A0 (en) 1990-11-05
ES2020171T3 (es) 1995-12-01
FI102678B1 (fi) 1999-01-29
GEP19971030B (en) 1997-06-13
LV10612B (en) 1995-08-20

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