PE20230733A1 - Sintesis de compuestos de quinazolina - Google Patents
Sintesis de compuestos de quinazolinaInfo
- Publication number
- PE20230733A1 PE20230733A1 PE2023000241A PE2023000241A PE20230733A1 PE 20230733 A1 PE20230733 A1 PE 20230733A1 PE 2023000241 A PE2023000241 A PE 2023000241A PE 2023000241 A PE2023000241 A PE 2023000241A PE 20230733 A1 PE20230733 A1 PE 20230733A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- formula
- synthesis
- contacting
- quinazoline compounds
- Prior art date
Links
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 239000012685 metal catalyst precursor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002901 organomagnesium compounds Chemical class 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Esta referido a un proceso para la obtencion de un compuesto derivado de quinazolina de Formula I, el cual comprende: (a) poner en contacto un compuesto de formula (II) con un compuesto de organomagnesio y un complejo de zinc; y (b) poner en contacto la mezcla de la etapa (a) con un compuesto de formula (III), un precursor de catalizador de metal de transicion y un ligando quiral, y, de esta manera, sintetizar un compuesto de formula (I). Estos son procesos sinteticos atroposelectivos en donde, los compuestos asi obtenidos, se emplean en el tratamiento de diversos tipos de cancer de pulmon
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063064746P | 2020-08-12 | 2020-08-12 | |
| PCT/US2021/045297 WO2022035790A1 (en) | 2020-08-12 | 2021-08-10 | Synthesis of quinazoline compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20230733A1 true PE20230733A1 (es) | 2023-05-03 |
Family
ID=77543703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023000241A PE20230733A1 (es) | 2020-08-12 | 2021-08-10 | Sintesis de compuestos de quinazolina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20220081413A1 (es) |
| EP (1) | EP4196470A1 (es) |
| JP (1) | JP2023537999A (es) |
| KR (1) | KR20230049679A (es) |
| CN (1) | CN116057052A (es) |
| AR (1) | AR123200A1 (es) |
| AU (2) | AU2021325869B2 (es) |
| BR (1) | BR112023002591A2 (es) |
| CA (1) | CA3191001A1 (es) |
| CL (1) | CL2023000395A1 (es) |
| CR (1) | CR20230123A (es) |
| IL (1) | IL300309A (es) |
| MX (1) | MX2023001682A (es) |
| PE (1) | PE20230733A1 (es) |
| TW (1) | TWI829003B (es) |
| WO (1) | WO2022035790A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023150706A1 (en) * | 2022-02-07 | 2023-08-10 | Genentech, Inc. | Solid forms of 1-((s)-4-((r)-7-(6-amino-4-methyl-3- (trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((s)-1- methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3- methylpiperazin-1-yl)prop-2-en-1-one |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5512665B2 (ja) | 2008-06-20 | 2014-06-04 | ジェネンテック， インコーポレイテッド | トリアゾロピリジンｊａｋ阻害剤化合物と方法 |
| CN105037333A (zh) * | 2009-12-21 | 2015-11-11 | 张强 | 新的喹唑啉衍生物 |
| JP2013107855A (ja) * | 2011-11-22 | 2013-06-06 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
| CN106488910B (zh) * | 2013-10-10 | 2020-07-31 | 亚瑞克西斯制药公司 | Kras g12c的抑制剂 |
| US9988357B2 (en) * | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| AU2019377130B2 (en) * | 2018-11-09 | 2022-03-17 | F. Hoffmann-La Roche Ag | Fused ring compounds |
-
2021
- 2021-08-10 WO PCT/US2021/045297 patent/WO2022035790A1/en active Application Filing
- 2021-08-10 CR CR20230123A patent/CR20230123A/es unknown
- 2021-08-10 JP JP2023509849A patent/JP2023537999A/ja active Pending
- 2021-08-10 CN CN202180056371.XA patent/CN116057052A/zh active Pending
- 2021-08-10 KR KR1020237007998A patent/KR20230049679A/ko unknown
- 2021-08-10 US US17/398,345 patent/US20220081413A1/en active Pending
- 2021-08-10 IL IL300309A patent/IL300309A/en unknown
- 2021-08-10 BR BR112023002591A patent/BR112023002591A2/pt unknown
- 2021-08-10 AR ARP210102232A patent/AR123200A1/es unknown
- 2021-08-10 AU AU2021325869A patent/AU2021325869B2/en active Active
- 2021-08-10 CA CA3191001A patent/CA3191001A1/en active Pending
- 2021-08-10 MX MX2023001682A patent/MX2023001682A/es unknown
- 2021-08-10 PE PE2023000241A patent/PE20230733A1/es unknown
- 2021-08-10 EP EP21762952.6A patent/EP4196470A1/en active Pending
- 2021-08-10 TW TW110129429A patent/TWI829003B/zh active
-
2023
- 2023-02-07 CL CL2023000395A patent/CL2023000395A1/es unknown
-
2024
- 2024-01-12 AU AU2024200220A patent/AU2024200220A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112023002591A2 (pt) | 2023-04-04 |
| WO2022035790A1 (en) | 2022-02-17 |
| CN116057052A (zh) | 2023-05-02 |
| CL2023000395A1 (es) | 2023-07-28 |
| AU2021325869B2 (en) | 2024-02-15 |
| KR20230049679A (ko) | 2023-04-13 |
| US20220081413A1 (en) | 2022-03-17 |
| IL300309A (en) | 2023-04-01 |
| TW202214596A (zh) | 2022-04-16 |
| EP4196470A1 (en) | 2023-06-21 |
| AU2024200220A1 (en) | 2024-02-01 |
| MX2023001682A (es) | 2023-02-22 |
| CR20230123A (es) | 2023-04-19 |
| AU2021325869A1 (en) | 2023-02-23 |
| TWI829003B (zh) | 2024-01-11 |
| AR123200A1 (es) | 2022-11-09 |
| JP2023537999A (ja) | 2023-09-06 |
| CA3191001A1 (en) | 2022-02-17 |
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