CL2023000395A1 - Síntesis de compuestos de quinazolina. - Google Patents
Síntesis de compuestos de quinazolina.Info
- Publication number
- CL2023000395A1 CL2023000395A1 CL2023000395A CL2023000395A CL2023000395A1 CL 2023000395 A1 CL2023000395 A1 CL 2023000395A1 CL 2023000395 A CL2023000395 A CL 2023000395A CL 2023000395 A CL2023000395 A CL 2023000395A CL 2023000395 A1 CL2023000395 A1 CL 2023000395A1
- Authority
- CL
- Chile
- Prior art keywords
- synthesis
- quinazoline compounds
- compounds
- quinazoline
- atropisomeric
- Prior art date
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
En la presente se proporcionan métodos para sintetizar compuestos de quinazolina que comprenden al menos un centro atropisomérico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063064746P | 2020-08-12 | 2020-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2023000395A1 true CL2023000395A1 (es) | 2023-07-28 |
Family
ID=77543703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2023000395A CL2023000395A1 (es) | 2020-08-12 | 2023-02-07 | Síntesis de compuestos de quinazolina. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20220081413A1 (es) |
| EP (1) | EP4196470A1 (es) |
| JP (1) | JP2023537999A (es) |
| KR (1) | KR20230049679A (es) |
| CN (1) | CN116057052B (es) |
| AR (1) | AR123200A1 (es) |
| AU (2) | AU2021325869C1 (es) |
| BR (1) | BR112023002591A2 (es) |
| CA (1) | CA3191001A1 (es) |
| CL (1) | CL2023000395A1 (es) |
| CR (1) | CR20230123A (es) |
| IL (1) | IL300309A (es) |
| MX (1) | MX2023001682A (es) |
| PE (1) | PE20230733A1 (es) |
| TW (2) | TW202423916A (es) |
| WO (1) | WO2022035790A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023143623A1 (zh) | 2022-01-30 | 2023-08-03 | 上海医药集团股份有限公司 | 一种喹啉类化合物及其应用 |
| MX2024009215A (es) | 2022-02-07 | 2024-08-30 | F Hoffmann La Roche Ag | Proceso para la sintesis de compuestos de quinazolina. |
| IL314606A (en) * | 2022-02-07 | 2024-09-01 | Genentech Inc | Solid forms of 1-((S)-4-((R)-7-(6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2- (((S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102131389A (zh) | 2008-06-20 | 2011-07-20 | 健泰科生物技术公司 | 三唑并吡啶jak抑制剂化合物和方法 |
| US8735409B2 (en) * | 2009-12-21 | 2014-05-27 | Qiang Zhang | Quinazoline derivatives |
| JP2013107855A (ja) * | 2011-11-22 | 2013-06-06 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
| KR20160076519A (ko) * | 2013-10-10 | 2016-06-30 | 아락세스 파마 엘엘씨 | Kras g12c 억제제 |
| US9988357B2 (en) * | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| TWI784209B (zh) * | 2018-11-09 | 2022-11-21 | 瑞士商赫孚孟拉羅股份公司 | 稠環化合物 |
-
2021
- 2021-08-10 AU AU2021325869A patent/AU2021325869C1/en active Active
- 2021-08-10 PE PE2023000241A patent/PE20230733A1/es unknown
- 2021-08-10 WO PCT/US2021/045297 patent/WO2022035790A1/en active Application Filing
- 2021-08-10 TW TW112148077A patent/TW202423916A/zh unknown
- 2021-08-10 BR BR112023002591A patent/BR112023002591A2/pt unknown
- 2021-08-10 AR ARP210102232A patent/AR123200A1/es unknown
- 2021-08-10 EP EP21762952.6A patent/EP4196470A1/en active Pending
- 2021-08-10 CN CN202180056371.XA patent/CN116057052B/zh active Active
- 2021-08-10 US US17/398,345 patent/US20220081413A1/en active Pending
- 2021-08-10 KR KR1020237007998A patent/KR20230049679A/ko unknown
- 2021-08-10 CR CR20230123A patent/CR20230123A/es unknown
- 2021-08-10 MX MX2023001682A patent/MX2023001682A/es unknown
- 2021-08-10 CA CA3191001A patent/CA3191001A1/en active Pending
- 2021-08-10 JP JP2023509849A patent/JP2023537999A/ja active Pending
- 2021-08-10 IL IL300309A patent/IL300309A/en unknown
- 2021-08-10 TW TW110129429A patent/TWI829003B/zh active
-
2023
- 2023-02-07 CL CL2023000395A patent/CL2023000395A1/es unknown
-
2024
- 2024-01-12 AU AU2024200220A patent/AU2024200220A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PE20230733A1 (es) | 2023-05-03 |
| CN116057052A (zh) | 2023-05-02 |
| TWI829003B (zh) | 2024-01-11 |
| CR20230123A (es) | 2023-04-19 |
| AR123200A1 (es) | 2022-11-09 |
| IL300309A (en) | 2023-04-01 |
| JP2023537999A (ja) | 2023-09-06 |
| AU2024200220A1 (en) | 2024-02-01 |
| AU2021325869B2 (en) | 2024-02-15 |
| AU2021325869A1 (en) | 2023-02-23 |
| BR112023002591A2 (pt) | 2023-04-04 |
| CA3191001A1 (en) | 2022-02-17 |
| US20220081413A1 (en) | 2022-03-17 |
| TW202214596A (zh) | 2022-04-16 |
| KR20230049679A (ko) | 2023-04-13 |
| AU2021325869C1 (en) | 2024-05-30 |
| CN116057052B (zh) | 2024-09-03 |
| EP4196470A1 (en) | 2023-06-21 |
| WO2022035790A1 (en) | 2022-02-17 |
| TW202423916A (zh) | 2024-06-16 |
| MX2023001682A (es) | 2023-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2023000395A1 (es) | Síntesis de compuestos de quinazolina. | |
| CU20210080A7 (es) | Triazinas sustituidas como inhibidores de proteína tirosina fosfatasa | |
| ECSP22029777A (es) | Heterociclos bic?clicos como inhibidores de fgfr | |
| AR122789A2 (es) | Inhibidores de kras g12c y métodos para su uso | |
| BR112023017763A2 (pt) | Inibidores kras g12d | |
| BR112023017661A2 (pt) | Inibidores de kras | |
| CR10600A (es) | Ciclopenta (d) pirimidinas hidroxiladas y metoxiladas como inhibidores de akt proteina quinasa | |
| GT200200273A (es) | Moleculas pequeñas para el tratamiento del crecimiento celular anormal | |
| BR112022009390A2 (pt) | Síntese melhorada de composto inibidor de kras g12c | |
| EA201291246A1 (ru) | Конденсированные бициклические ингибиторы киназы | |
| BR112022012512A2 (pt) | Método para a preparação de l-glufosinato | |
| PA8807801A1 (es) | Inhibidores de cinesina como productos terapeuticos para el cancer | |
| AR122719A1 (es) | Moléculas agonistas de unión al antígeno cd28 que se dirigen a her2 | |
| CO2023006684A2 (es) | Anticuerpos contra sars-cov-2 y usos de los mismos | |
| CL2020001930A1 (es) | Compuestos para el tratamiento de trastornos dependientes de cinasas. | |
| CL2021003373A1 (es) | Nuevos inhibidores de egfr | |
| CO2023017156A2 (es) | Anticuerpos anti-sirp-alfa | |
| ECSP23051657A (es) | Nuevos compuestos como inhibidor dual del receptor de andrógenos y de la fosfodiesterasa | |
| CO2023002375A2 (es) | Anticuerpos contra ilt2 y uso de los mismos | |
| MX2023006606A (es) | Derivados biciclicos. | |
| CL2024000248A1 (es) | Composiciones y métodos para anticuerpos anti-pacap | |
| BR112023017834A2 (pt) | Inibidores de lrrk2 cinase macrocíclicos | |
| CU20220019A7 (es) | Proteínas de fusión nkg2d | |
| CL2023001565A1 (es) | Inhibidores de enzimas | |
| EA202192840A1 (ru) | Способ получения соединений карбамоилоксиметилтриазолциклогексиловой кислоты |