MX2023006606A - Derivados biciclicos. - Google Patents

Derivados biciclicos.

Info

Publication number
MX2023006606A
MX2023006606A MX2023006606A MX2023006606A MX2023006606A MX 2023006606 A MX2023006606 A MX 2023006606A MX 2023006606 A MX2023006606 A MX 2023006606A MX 2023006606 A MX2023006606 A MX 2023006606A MX 2023006606 A MX2023006606 A MX 2023006606A
Authority
MX
Mexico
Prior art keywords
bicyclic derivatives
bicyclic
derivatives
endoparasites
warm
Prior art date
Application number
MX2023006606A
Other languages
English (en)
Inventor
Chouaib Tahtaoui
Francois Pautrat
Pierre Ducray
Denise Rageot
Original Assignee
Elanco Tiergesundheit Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elanco Tiergesundheit Ag filed Critical Elanco Tiergesundheit Ag
Publication of MX2023006606A publication Critical patent/MX2023006606A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención proporciona compuestos de fórmula (I'): (ver Fórmula) (I') los cuales son útiles en el control de endoparásitos, por ejemplo los gusanos del corazón, en animales de sangre caliente.
MX2023006606A 2020-12-04 2021-12-03 Derivados biciclicos. MX2023006606A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063121498P 2020-12-04 2020-12-04
US202063123269P 2020-12-09 2020-12-09
PCT/EP2021/084090 WO2022117783A1 (en) 2020-12-04 2021-12-03 Bicyclic derivatives

Publications (1)

Publication Number Publication Date
MX2023006606A true MX2023006606A (es) 2023-06-19

Family

ID=78827915

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023006606A MX2023006606A (es) 2020-12-04 2021-12-03 Derivados biciclicos.

Country Status (7)

Country Link
EP (1) EP4255911A1 (es)
JP (1) JP2023551550A (es)
AU (1) AU2021390173A1 (es)
CA (1) CA3204171A1 (es)
MX (1) MX2023006606A (es)
TW (1) TW202237600A (es)
WO (1) WO2022117783A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220002890A (ko) 2019-03-19 2022-01-07 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물
KR20230028268A (ko) 2020-05-29 2023-02-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 헤테로시클릭 화합물
AR127495A1 (es) 2021-11-01 2024-01-31 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelmínticos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3442974B8 (en) 2016-04-15 2023-07-12 Elanco Animal Health GmbH Pyrazolopyrimidine derivatives
CA3043298A1 (en) 2016-11-11 2018-05-17 Bayer Animal Health Gmbh Anthelmintic quinoline-3-carboxamide derivatives
JP7261747B2 (ja) 2017-04-27 2023-04-20 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新規二環式ピラゾール誘導体
KR20200020911A (ko) 2017-06-30 2020-02-26 바이엘 애니멀 헬스 게엠베하 새로운 아자퀴놀린 유도체
SG11202000266VA (en) 2017-08-04 2020-02-27 Bayer Animal Health Gmbh Quinoline derivatives for treating infections with helminths
SG11202012922VA (en) 2018-07-09 2021-01-28 Boehringer Ingelheim Animal Health Usa Inc Anthelminthic heterocyclic compounds
WO2020131629A1 (en) 2018-12-18 2020-06-25 Elanco Tiergesundheit Ag Bicyclic derivatives
BR112021012021A2 (pt) 2018-12-18 2021-09-21 Elanco Tiergesundheit Ag Derivados bicíclicos
KR20220002890A (ko) 2019-03-19 2022-01-07 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물

Also Published As

Publication number Publication date
AU2021390173A9 (en) 2024-05-09
EP4255911A1 (en) 2023-10-11
AU2021390173A1 (en) 2023-07-20
WO2022117783A1 (en) 2022-06-09
JP2023551550A (ja) 2023-12-08
CA3204171A1 (en) 2022-06-09
TW202237600A (zh) 2022-10-01

Similar Documents

Publication Publication Date Title
MX2021007538A (es) Derivados biciclicos.
MX2021007540A (es) Derivados biciclicos.
MX2023006606A (es) Derivados biciclicos.
PH12021500014A1 (en) Fused ring compounds
EA202091506A1 (ru) Триазол n-связанные карбамоил циклогексильные кислоты в качестве антагонистов lpa
MY195782A (en) Carbamoyloxymethyl Triazole Cyclohexyl Acids as LPA Antagonists
PH12021551065A1 (en) Fused ring compounds
BR112021024726A2 (pt) Novos derivados bicíclicos
CA3139348A1 (en) Heterocyclic compounds for inhibiting ras and uses thereof
MX2021004624A (es) Derivados de 2-(2-acriloil-2,6-diazaspiro[3.4]octan-6-il)-6-(1h-in dazol-4-il)-benzonitrilo y compuestos relacionados como inhibidores de la proteina kras mutante g12c para inhibir metastasis de tumor.
CR20200421A (es) Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida y compuestos relacionados como inhibidores hpki para tratar el càncer
MX2020005323A (es) Triazol azinas de acido ciclohexilo como antagonistas de acido lisofosfatidico (lpa).
CY1112117T1 (el) Υδροξυλιωμενες και μεθοξυλιωμενες κυκλοπεντα[d]πυριμιδινες ως αναστολεις ακτ πρωτεϊνικης κινασης
ATE522509T1 (de) Pyrimidylcyclopentane als inhibitoren der akt- proteinkinase
ATE493418T1 (de) Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren
UA99597C2 (ru) Пиримидилциклопентаны как ингибиторы акт протеинкиназ
EA201100311A1 (ru) Амидные производные гетероарилов и их применение в качестве активаторов глюкокиназы
ATE532789T1 (de) Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
BR112022009390A2 (pt) Síntese melhorada de composto inibidor de kras g12c
WO2020081410A3 (en) Radioligands for imaging the lpa1 receptor
MX2021004659A (es) Derivados de aminopirimidina/pirazina como inhibidores de ctps1.
EA202091475A1 (ru) ПРОИЗВОДНЫЕ 5-(2-(2,5-ДИФТОРФЕНИЛ)ПИРРОЛИДИН-1-ИЛ)-3-(1H-ПИРАЗОЛ-1-ИЛ)ПИРАЗОЛО[1,5-а]ПИРИМИДИНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Trk КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ РАКА
TW200519096A (en) Quinazoline analogs as receptor tyrosine kinase inhibitors
ZA202201503B (en) Urea compound for antagonizing lpa1 receptor
WO2021011713A8 (en) Imidazopyrimidines as eed inhibitors and the use thereof