BR112023002591A2 - Processo para a preparação de um composto e composto - Google Patents
Processo para a preparação de um composto e compostoInfo
- Publication number
- BR112023002591A2 BR112023002591A2 BR112023002591A BR112023002591A BR112023002591A2 BR 112023002591 A2 BR112023002591 A2 BR 112023002591A2 BR 112023002591 A BR112023002591 A BR 112023002591A BR 112023002591 A BR112023002591 A BR 112023002591A BR 112023002591 A2 BR112023002591 A2 BR 112023002591A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparation
- atropisomeric
- preparing
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCESSO PARA A PREPARAÇÃO DE UM COMPOSTO E COMPOSTO. São fornecidos neste documento métodos para sintetizar compostos de quinazolina compreendendo pelo menos um centro atropisomérico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063064746P | 2020-08-12 | 2020-08-12 | |
| PCT/US2021/045297 WO2022035790A1 (en) | 2020-08-12 | 2021-08-10 | Synthesis of quinazoline compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023002591A2 true BR112023002591A2 (pt) | 2023-04-04 |
Family
ID=77543703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023002591A BR112023002591A2 (pt) | 2020-08-12 | 2021-08-10 | Processo para a preparação de um composto e composto |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20220081413A1 (pt) |
| EP (1) | EP4196470A1 (pt) |
| JP (1) | JP2023537999A (pt) |
| KR (1) | KR20230049679A (pt) |
| CN (1) | CN116057052A (pt) |
| AR (1) | AR123200A1 (pt) |
| AU (2) | AU2021325869C1 (pt) |
| BR (1) | BR112023002591A2 (pt) |
| CA (1) | CA3191001A1 (pt) |
| CL (1) | CL2023000395A1 (pt) |
| CR (1) | CR20230123A (pt) |
| IL (1) | IL300309A (pt) |
| MX (1) | MX2023001682A (pt) |
| PE (1) | PE20230733A1 (pt) |
| TW (1) | TWI829003B (pt) |
| WO (1) | WO2022035790A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023150706A1 (en) * | 2022-02-07 | 2023-08-10 | Genentech, Inc. | Solid forms of 1-((s)-4-((r)-7-(6-amino-4-methyl-3- (trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((s)-1- methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3- methylpiperazin-1-yl)prop-2-en-1-one |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010014005A (es) | 2008-06-20 | 2011-02-15 | Genentech Inc | Compuestos de triazolopiridina inhibidores de jak y los metodos. |
| CN102686581B (zh) * | 2009-12-21 | 2015-08-26 | 张强 | 喹唑啉衍生物 |
| JP2013107855A (ja) * | 2011-11-22 | 2013-06-06 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
| KR20160076519A (ko) * | 2013-10-10 | 2016-06-30 | 아락세스 파마 엘엘씨 | Kras g12c 억제제 |
| US9988357B2 (en) * | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| IL282916B1 (en) * | 2018-11-09 | 2024-05-01 | Hoffmann La Roche | United Cyclic Chemical Compounds and Their Uses in the Treatment of RAS-Mediated Disorders |
-
2021
- 2021-08-10 CN CN202180056371.XA patent/CN116057052A/zh active Pending
- 2021-08-10 JP JP2023509849A patent/JP2023537999A/ja active Pending
- 2021-08-10 US US17/398,345 patent/US20220081413A1/en active Pending
- 2021-08-10 MX MX2023001682A patent/MX2023001682A/es unknown
- 2021-08-10 CA CA3191001A patent/CA3191001A1/en active Pending
- 2021-08-10 KR KR1020237007998A patent/KR20230049679A/ko unknown
- 2021-08-10 TW TW110129429A patent/TWI829003B/zh active
- 2021-08-10 PE PE2023000241A patent/PE20230733A1/es unknown
- 2021-08-10 AR ARP210102232A patent/AR123200A1/es unknown
- 2021-08-10 EP EP21762952.6A patent/EP4196470A1/en active Pending
- 2021-08-10 CR CR20230123A patent/CR20230123A/es unknown
- 2021-08-10 AU AU2021325869A patent/AU2021325869C1/en active Active
- 2021-08-10 IL IL300309A patent/IL300309A/en unknown
- 2021-08-10 BR BR112023002591A patent/BR112023002591A2/pt unknown
- 2021-08-10 WO PCT/US2021/045297 patent/WO2022035790A1/en active Application Filing
-
2023
- 2023-02-07 CL CL2023000395A patent/CL2023000395A1/es unknown
-
2024
- 2024-01-12 AU AU2024200220A patent/AU2024200220A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PE20230733A1 (es) | 2023-05-03 |
| KR20230049679A (ko) | 2023-04-13 |
| WO2022035790A1 (en) | 2022-02-17 |
| TWI829003B (zh) | 2024-01-11 |
| CL2023000395A1 (es) | 2023-07-28 |
| IL300309A (en) | 2023-04-01 |
| US20220081413A1 (en) | 2022-03-17 |
| AU2024200220A1 (en) | 2024-02-01 |
| JP2023537999A (ja) | 2023-09-06 |
| AU2021325869C1 (en) | 2024-05-30 |
| AR123200A1 (es) | 2022-11-09 |
| CA3191001A1 (en) | 2022-02-17 |
| AU2021325869A1 (en) | 2023-02-23 |
| CR20230123A (es) | 2023-04-19 |
| CN116057052A (zh) | 2023-05-02 |
| EP4196470A1 (en) | 2023-06-21 |
| MX2023001682A (es) | 2023-02-22 |
| TW202214596A (zh) | 2022-04-16 |
| AU2021325869B2 (en) | 2024-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2021002382A2 (es) | Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasa | |
| PE20181803A1 (es) | Inhibidores de mcl-1 macrociclicos para tratar el cancer | |
| BR112017019287A2 (pt) | composto, composição farmaceuticamente aceitável, método de tratamento de câncer, processo para preparar o composto da fórmula i, método para tratar câncer, e kit | |
| BR112023017763A2 (pt) | Inibidores kras g12d | |
| BR112022009390A2 (pt) | Síntese melhorada de composto inibidor de kras g12c | |
| BR112022026981A2 (pt) | Processos para a preparação de um composto e processo para a síntese de um composto | |
| CL2020002103A1 (es) | Anticuerpos anti-htra1 y metodos de uso de los mismos. (divisional solicitud 201801139) | |
| BR112022003357A2 (pt) | Compostos heterocíclicos | |
| CL2021001859A1 (es) | Inhibidores de la pcsk9 y métodos de uso de los mismos | |
| BR112023017661A2 (pt) | Inibidores de kras | |
| BR112023002591A2 (pt) | Processo para a preparação de um composto e composto | |
| BR112021026899A2 (pt) | Compostos heterocíclicos | |
| BR112022012731A2 (pt) | Anticorpo anti-ox40 e uso do mesmo | |
| CL2020001589A1 (es) | Proceso para la preparación de derivados de quinolina. | |
| CL2021001607A1 (es) | Anticuerpos anti-pmel17 y conjugados de los mismos | |
| BR112022001336A2 (pt) | Anticorpo biespecífico anti-her2/anti-4-1bb e uso do mesmo | |
| CO2023018064A2 (es) | Anticuerpos anti-ccr8 y usos de los mismos | |
| BR112023002055A2 (pt) | Processo | |
| EA202192840A1 (ru) | Способ получения соединений карбамоилоксиметилтриазолциклогексиловой кислоты | |
| CU20220019A7 (es) | Proteínas de fusión nkg2d | |
| MX2021015301A (es) | Métodos de cultivo celular y composiciones para la producción de anticuerpos. | |
| BR112021017710A2 (pt) | Composto, composição farmacêutica, método de tratamento | |
| BR112017017209A2 (pt) | processo para inibir incrustação. | |
| CL2023000084A1 (es) | Anticuerpos anti-betacelulina, fragmentos de los mismos, y moléculas de unión multiespecíficas | |
| AR111318A1 (es) | Proceso para preparar 2-exo-(2-metilbenciloxi)-1-metil-4-isopropil-7-oxabiciclo[2.2.1]heptano |