PE20230608A1 - Quimioterapicos de eter macrociclico heteroaromatico - Google Patents

Quimioterapicos de eter macrociclico heteroaromatico

Info

Publication number
PE20230608A1
PE20230608A1 PE2022002535A PE2022002535A PE20230608A1 PE 20230608 A1 PE20230608 A1 PE 20230608A1 PE 2022002535 A PE2022002535 A PE 2022002535A PE 2022002535 A PE2022002535 A PE 2022002535A PE 20230608 A1 PE20230608 A1 PE 20230608A1
Authority
PE
Peru
Prior art keywords
heteroaromatic
chemotherapy
macrocyclic ether
macrocyclic
ether
Prior art date
Application number
PE2022002535A
Other languages
English (en)
Inventor
Xinxing Tang
Joshua Courtney Horan
Scot Richard Mente
Henry Efrem Pelish
Matthew D Shair
Anupong Tangpeerachaikul
Original Assignee
Nuvalent Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuvalent Inc filed Critical Nuvalent Inc
Publication of PE20230608A1 publication Critical patent/PE20230608A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Esta referido a derivados de eter macrociclico heteroaromatico heterociclicos de Formula I, en donde: X es un heteroarileno de 5 eslabones, que comprende de 1 a 3 heteroatomos; Y es un heteroarileno de 5 o 6 eslabones, que comprende de 1 a 3 heteroatomos; Q es CH o N; Z es CR5 o N; R1 es H, metilo e hidroximetilo; y, R4 es H o F. Estos compuestos se emplean en el tratamiento o prevencion del cancer.
PE2022002535A 2020-05-05 2021-05-05 Quimioterapicos de eter macrociclico heteroaromatico PE20230608A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020088590 2020-05-05
US202063125733P 2020-12-15 2020-12-15
PCT/US2021/030842 WO2021226208A2 (en) 2020-05-05 2021-05-05 Heteroaromatic macrocyclic ether chemotherapeutic agents

Publications (1)

Publication Number Publication Date
PE20230608A1 true PE20230608A1 (es) 2023-04-13

Family

ID=78468784

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022002535A PE20230608A1 (es) 2020-05-05 2021-05-05 Quimioterapicos de eter macrociclico heteroaromatico

Country Status (13)

Country Link
US (2) US11542278B1 (es)
EP (1) EP4146626A2 (es)
JP (1) JP2023525038A (es)
KR (1) KR20230019833A (es)
CN (1) CN115916754A (es)
AU (1) AU2021268664A1 (es)
BR (1) BR112022022535A2 (es)
CA (1) CA3179700A1 (es)
CL (1) CL2022003045A1 (es)
IL (1) IL297832A (es)
MX (1) MX2022013657A (es)
PE (1) PE20230608A1 (es)
WO (1) WO2021226208A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115916754A (zh) 2020-05-05 2023-04-04 纽威伦特公司 杂芳族大环醚化学治疗剂
JP2023525040A (ja) 2020-05-05 2023-06-14 ヌバレント， インク． ヘテロ芳香族大環状エーテル化学療法剤
WO2023056431A1 (en) * 2021-10-01 2023-04-06 Nuvalent, Inc. Methods of treating solid tumor using heteroaromatic macrocyclic ether compounds
TW202320768A (zh) * 2021-10-01 2023-06-01 美商努法倫特公司 雜芳族大環醚化合物之固體形式、醫藥組成物及製備
WO2023179600A1 (zh) * 2022-03-21 2023-09-28 杭州德睿智药科技有限公司 新型取代大杂环类新化合物及其应用
WO2024036098A1 (en) 2022-08-12 2024-02-15 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds
WO2024036097A1 (en) 2022-08-12 2024-02-15 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds and isotopologues thereof

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5569655A (en) 1993-09-14 1996-10-29 Sterling Winthrop Inc. Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof
TW401301B (en) 1994-10-07 2000-08-11 Takeda Chemical Industries Ltd Antihypertriglyceridemic composition
AR002459A1 (es) 1995-01-17 1998-03-25 American Cyanamid Co Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
US5849735A (en) 1995-01-17 1998-12-15 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
AU1745102A (en) 2000-12-20 2002-07-01 Kyowa Hakko Kogyo Kk Metal complex type squarylium compounds and optical recording media made by using the same
DE10239042A1 (de) * 2002-08-21 2004-03-04 Schering Ag Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
US8012603B2 (en) 2002-10-30 2011-09-06 Sumitomo Chemical Company, Limited Polymer compound and polymer light-emitting device using the same
US7514466B2 (en) 2004-04-27 2009-04-07 Wyeth Purification of progesterone receptor modulators
AR049631A1 (es) 2004-04-27 2006-08-23 Wyeth Corp Proceso de acoplamiento para la generacion de derivados reactivos de pirrol -2- carbonitrilo n- sustituidos con contenido de boro para producir biarilos
ES2366193T3 (es) 2004-09-20 2011-10-18 Janssen Pharmaceutica Nv Nuevos derivados que contienen heteroátomos tetracíclicos útiles como moduladores de receptores de hormonas esteroideas sexuales.
US7445211B1 (en) 2005-03-11 2008-11-04 Walton Daniel J Wall decoration and game apparatus
US20070116984A1 (en) 2005-09-21 2007-05-24 Doosan Corporation Spiro-compound for electroluminescent display device and electroluminescent display device comprising the same
US20090022694A1 (en) 2005-10-18 2009-01-22 Distefano Peter Sirt1 inhibition
US20070213526A1 (en) 2006-03-07 2007-09-13 Wyeth Purification of progesterone receptor modulators
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
US7915414B2 (en) 2006-11-24 2011-03-29 Yun Chi Blue-emitting organometallic complexes and their application
FR2913882B1 (fr) 2007-03-20 2009-05-01 Oreal Utilisation pour la coloration des fibres keratiniques d'une composition comprenant un compose halochromique et/ou le colorant correspondant a ce compose
JP5492769B2 (ja) 2007-06-26 2014-05-14 サノフイ 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成
EP2193132A2 (en) 2007-07-02 2010-06-09 AstraZeneca AB 3-spiropyrimidinetrione-quinoline derivatives and their use as antibacterial agents
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
JP2009234928A (ja) 2008-03-25 2009-10-15 Kyoto Univ 縮合多環芳香族化合物、およびその製造方法
JP5304010B2 (ja) 2008-04-23 2013-10-02 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子、表示装置及び照明装置
JP5499519B2 (ja) 2009-05-27 2014-05-21 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子、表示装置及び照明装置
WO2011016582A1 (ja) 2009-08-04 2011-02-10 株式会社トクヤマ クロメン化合物
JP4599469B1 (ja) 2009-08-31 2010-12-15 富士フイルム株式会社 有機電界発光素子用材料及び有機電界発光素子
CA2774266A1 (en) 2009-09-16 2011-03-24 Cylene Pharmaceuticals, Inc. Novel tricyclic protein kinase modulators
WO2011138751A2 (en) 2010-05-04 2011-11-10 Pfizer Inc. Heterocyclic derivatives as alk inhibitors
JP2013532691A (ja) 2010-07-30 2013-08-19 ドクター レディズ ラボラトリーズ リミテッド 選択的非対称ヒドロホルミル化のための配位子
TW201307357A (zh) 2010-11-22 2013-02-16 Array Biopharma Inc 治療神經退化性疾病之化合物
ES2559519T3 (es) 2010-12-22 2016-02-12 Université Catholique de Louvain Nuevos derivados de fenazina y su uso
FR2969611B1 (fr) 2010-12-28 2013-02-08 Sanofi Aventis Nouveaux derives de thiazoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
LT2658844T (lt) 2010-12-28 2017-02-10 Sanofi Nauji pirimidino dariniai, jų gamyba ir jų farmacinis panaudojimas kaip akt (pkb) fosforilinimo slopiklių
WO2012102409A1 (ja) 2011-01-27 2012-08-02 株式会社トクヤマ クロメン化合物
TW201311689A (zh) 2011-08-05 2013-03-16 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之新穎巨環化合物
CN102977150B (zh) 2011-09-06 2016-07-06 郑建鸿 含有碳烯配位基的过渡金属错合物结构及其在发光材料的应用
ES2621220T3 (es) 2012-03-06 2017-07-03 Pfizer Inc. Derivados macrocíclicos para el tratamiento de enfermedades proliferativas
KR20140032823A (ko) 2012-09-07 2014-03-17 롬엔드하스전자재료코리아유한회사 유기 전계 발광 소자
US9502667B2 (en) 2013-01-24 2016-11-22 Idemitsu Kosan Co., Ltd. Organic electroluminescence
WO2014138912A1 (en) 2013-03-13 2014-09-18 Queen's University At Kingston Luminescent compounds and methods of using same
EP3013835B1 (en) 2013-06-28 2017-12-13 Pfizer Inc Solid forms of a macrocyclic kinase inhibitor
KR102100929B1 (ko) 2013-09-04 2020-04-14 삼성전자주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
CN104513253A (zh) 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 用于治疗增殖性疾病的大环化合物
KR102167048B1 (ko) 2013-12-03 2020-10-19 삼성디스플레이 주식회사 화합물 및 이를 포함한 유기 발광 소자
EP3091999B1 (en) 2014-01-09 2021-10-20 Hadasit Medical Research Services and Development Ltd. Improved cell compositions and methods for cancer therapy
KR102191992B1 (ko) 2014-01-22 2020-12-17 삼성디스플레이 주식회사 유기 발광 소자
KR102253441B1 (ko) 2014-03-10 2021-05-20 삼성디스플레이 주식회사 화합물 및 이를 포함한 유기 발광 소자
KR101793335B1 (ko) 2014-09-30 2017-11-02 주식회사 엘지화학 헤테로고리 화합물 및 이를 포함하는 유기 발광 소자
US20160140491A1 (en) 2014-11-17 2016-05-19 Gregory Forgatch System and method for integrating intermediary and end-user online retail experiences
US9887372B2 (en) 2015-06-11 2018-02-06 Samsung Display Co., Ltd. Amine-based compound and organic light-emitting device including the same
CN108137609B (zh) 2015-08-03 2021-07-16 百时美施贵宝公司 用作TNFα的调节剂的环状化合物
CA3004680A1 (en) 2015-11-13 2017-05-18 Mavalon Therapeutics Limited Substituted tricyclic 1,4-benzodiazepinone derivatives as allosteric modulators of group ii metabotropic glutamate receptors
ES2812336T3 (es) 2016-03-03 2021-03-16 Shenzhen Targetrx Inc Macrocíclico y composición que comprende el mismo
CN106243096B (zh) 2016-07-29 2019-11-29 上海璃道医药科技有限公司 三环类药物的新用途
JP6798851B2 (ja) 2016-10-14 2020-12-09 株式会社トクヤマ クロメン化合物、及び該クロメン化合物を含む硬化性組成物
CN109528717B (zh) 2017-09-21 2021-08-17 中国科学院分子细胞科学卓越创新中心 治疗或预防肥胖或其相关疾病的化合物及其应用
WO2019113071A1 (en) 2017-12-05 2019-06-13 Icahn School Of Medicine At Mount Sinai Compositions and methods for treating alk-mediated cancer
US11680059B2 (en) 2017-12-21 2023-06-20 Guangzhou Chinaray Optoelectronic Materials Ltd. Organic mixture and application thereof in organic electronic devices
WO2019164301A1 (ko) 2018-02-21 2019-08-29 주식회사 엘지화학 화합물 및 이를 포함하는 유기 발광 소자
KR102192368B1 (ko) 2018-02-28 2020-12-17 주식회사 엘지화학 유기 발광 소자
CN110357905B (zh) 2018-03-26 2021-10-01 武汉誉祥医药科技有限公司 作为蛋白激酶抑制剂的大环类衍生物及其制备方法和用途
CN108912175A (zh) 2018-06-05 2018-11-30 长春海谱润斯科技有限公司 一种金属铱配合物及其有机发光器件
CN112771035A (zh) 2018-07-26 2021-05-07 恩特姆生物科学公司 用于制备甘露糖衍生物的方法
US10593889B1 (en) 2018-09-26 2020-03-17 Idemitsu Kosan Co., Ltd. Compound and organic electroluminescence device
WO2020069106A1 (en) 2018-09-27 2020-04-02 Dana-Farber Cancer Institute, Inc. Degraders that target alk and therapeutic uses thereof
CN109912433B (zh) 2019-03-07 2022-04-08 石家庄诚志永华显示材料有限公司 化合物、有机电致发光材料、有机电致发光器件、电子装置
KR20200111577A (ko) 2019-03-19 2020-09-29 삼성전자주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
CN112533927A (zh) 2019-05-14 2021-03-19 苏州韬略生物科技有限公司 可用作激酶抑制剂的被取代的大环
CN114207861A (zh) 2019-08-02 2022-03-18 德山新勒克斯有限公司 有机电子器件
CN112321604A (zh) 2019-08-05 2021-02-05 华东理工大学 大环类jak2抑制剂及其应用
GB201913756D0 (en) 2019-09-24 2019-11-06 Chromatwist Ltd Contrast agent
CN112812128B (zh) 2019-11-18 2024-04-02 正大天晴药业集团股份有限公司 作为alk和ros调节剂的大环化合物
KR102610156B1 (ko) 2019-12-16 2023-12-05 주식회사 아이센스 C-n 리간드를 갖는 신규 전이금속 전자전달 착체 및 이를 이용한 전기화학적 바이오센서
TW202136246A (zh) 2019-12-19 2021-10-01 德商麥克專利有限公司 電子裝置用化合物
CN113121607B (zh) 2019-12-31 2023-07-04 马鞍山南大高新技术研究院有限公司 一种主配体含喹啉/喹唑啉的红光铱配合物与应用
CN111362967B (zh) 2020-04-28 2021-09-07 南京雷正医药科技有限公司 苯并氧杂二氮杂十四碳烯衍生物及其用途
CN115916754A (zh) 2020-05-05 2023-04-04 纽威伦特公司 杂芳族大环醚化学治疗剂
JP2023525040A (ja) 2020-05-05 2023-06-14 ヌバレント， インク． ヘテロ芳香族大環状エーテル化学療法剤
WO2022017408A1 (zh) 2020-07-22 2022-01-27 中国医药研究开发中心有限公司 芳胺类衍生物及其制备方法和医药用途
CN111808147B (zh) 2020-07-28 2023-04-18 奥来德(上海)光电材料科技有限公司 一种有机磷光材料及其制备方法和电致发光器件
CN113105440B (zh) 2021-04-15 2022-10-04 吉林奥来德光电材料股份有限公司 一种有机电致发光化合物及其制备方法和应用

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AU2021268664A1 (en) 2022-10-20
CN115916754A (zh) 2023-04-04
IL297832A (en) 2023-01-01
WO2021226208A2 (en) 2021-11-11
CA3179700A1 (en) 2021-11-11
CL2022003045A1 (es) 2023-10-06
BR112022022535A2 (pt) 2023-04-25
JP2023525038A (ja) 2023-06-14
KR20230019833A (ko) 2023-02-09
WO2021226208A3 (en) 2021-12-16
US11542278B1 (en) 2023-01-03
EP4146626A2 (en) 2023-03-15
US20230107663A1 (en) 2023-04-06
MX2022013657A (es) 2023-02-01

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