PE20221168A1 - Agonistas del receptor npy2 - Google Patents
Agonistas del receptor npy2Info
- Publication number
- PE20221168A1 PE20221168A1 PE2022000757A PE2022000757A PE20221168A1 PE 20221168 A1 PE20221168 A1 PE 20221168A1 PE 2022000757 A PE2022000757 A PE 2022000757A PE 2022000757 A PE2022000757 A PE 2022000757A PE 20221168 A1 PE20221168 A1 PE 20221168A1
- Authority
- PE
- Peru
- Prior art keywords
- analogs
- obesity
- prevention
- pyy
- receptor agonists
- Prior art date
Links
- 102000029748 Neuropeptide Y2 receptor Human genes 0.000 title 1
- 108010089579 neuropeptide Y2 receptor Proteins 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 208000008589 Obesity Diseases 0.000 abstract 2
- 230000037396 body weight Effects 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 235000012631 food intake Nutrition 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2271—Neuropeptide Y
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19208394 | 2019-11-11 | ||
| PCT/EP2020/081513 WO2021094259A1 (en) | 2019-11-11 | 2020-11-09 | Npy2 receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20221168A1 true PE20221168A1 (es) | 2022-07-25 |
Family
ID=68531488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2022000757A PE20221168A1 (es) | 2019-11-11 | 2020-11-09 | Agonistas del receptor npy2 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20210139548A1 (https=) |
| EP (1) | EP4058047A1 (https=) |
| JP (2) | JP7821393B2 (https=) |
| KR (1) | KR20220100925A (https=) |
| CN (1) | CN114641303A (https=) |
| AR (1) | AR120440A1 (https=) |
| AU (1) | AU2020384729A1 (https=) |
| CA (1) | CA3156452A1 (https=) |
| CL (1) | CL2022001227A1 (https=) |
| CO (1) | CO2022006046A2 (https=) |
| CR (1) | CR20220206A (https=) |
| DO (1) | DOP2022000097A (https=) |
| EC (1) | ECSP22037660A (https=) |
| IL (1) | IL292601A (https=) |
| JO (1) | JOP20220110A1 (https=) |
| MX (1) | MX2022005661A (https=) |
| PE (1) | PE20221168A1 (https=) |
| PH (1) | PH12022551101A1 (https=) |
| TW (1) | TWI864155B (https=) |
| WO (1) | WO2021094259A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20220206A (es) | 2019-11-11 | 2022-06-16 | Boehringer Ingelheim Int | Agonistas del receptor npy2 |
| JP7661478B2 (ja) * | 2020-08-07 | 2025-04-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性ｎｐｙ２受容体アゴニスト |
| JP2025526148A (ja) * | 2022-08-18 | 2025-08-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 長時間作用型ｇｌｐ－１／グルカゴン受容体アゴニスト及びｎｐｙ２受容体アゴニストを含む組合せ治療 |
| CN120865433A (zh) * | 2022-12-21 | 2025-10-31 | 勃林格殷格翰国际有限公司 | Glp1/gip/npy2受体的三重激动剂 |
| EP4670741A1 (en) | 2023-04-28 | 2025-12-31 | Pinotbio, Inc. | ANTIBODY-DRUG CONJUGATE IN WHICH ONE OR MORE DRUG-BINDER CONJUGATES ARE LINKED TO AN ANTIBODY AND ITS PREPARATION METHOD |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005053726A1 (en) | 2003-11-25 | 2005-06-16 | Bayer Pharmaceuticals Corporation | Selective neuropeptide y2 receptor agonists |
| NZ579621A (en) | 2004-02-11 | 2011-03-31 | Amylin Pharmaceuticals Inc | Hybrid polypeptides with selectable properties |
| EA011860B1 (ru) | 2004-03-17 | 2009-06-30 | 7ТиЭм ФАРМА А/С | Селективные агонисты рецептора y2 для терапевтического воздействия |
| WO2006049681A2 (en) | 2004-08-30 | 2006-05-11 | Bayer Pharmaceuticals Corporation | Selective neuropeptide y2 receptor agonists |
| US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| EP2360180A3 (en) | 2004-12-13 | 2012-02-08 | Amylin Pharmaceuticals Inc. | Pancreatic polypeptide family motifs, polypeptides and methods comprising the same |
| CA2630649A1 (en) | 2005-12-07 | 2007-06-14 | F. Hoffmann-La Roche Ag | Neuropeptide-2 receptor-agonists |
| CA2677932A1 (en) | 2007-02-15 | 2008-08-21 | Indiana University Research And Technology Corporation | Glucagon/glp-1 receptor co-agonists |
| EP2158214B1 (en) | 2007-06-15 | 2011-08-17 | Zealand Pharma A/S | Glucagon analogues |
| UA97707C2 (ru) | 2007-11-14 | 2012-03-12 | Амилин Фармасьютикалз, Инк. | Способы лечения ожирения и заболеваний, расстройств, связанных с ожирением |
| FR2934058B1 (fr) | 2008-07-15 | 2010-09-24 | Centre Nat Rech Scient | Dispositif de projection interferometrique a trois ouvertures pour produire une tache constituee de structures fines |
| EP2370462B1 (en) | 2008-12-15 | 2014-07-16 | Zealand Pharma A/S | Glucagon analogues |
| JP5635531B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| ES2477880T3 (es) | 2008-12-15 | 2014-07-18 | Zealand Pharma A/S | Análogos del glucagón |
| CN102282167B (zh) | 2008-12-15 | 2014-08-13 | 西兰制药公司 | 胰高血糖素类似物 |
| AU2010272944B2 (en) | 2009-07-13 | 2015-11-19 | Zealand Pharma A/S | Acylated glucagon analogues |
| WO2011033068A1 (en) | 2009-09-18 | 2011-03-24 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| EP2498800A1 (en) | 2009-11-13 | 2012-09-19 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| CN102946875A (zh) | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| US9169310B2 (en) | 2010-06-24 | 2015-10-27 | Zealand Pharma A/S | Glucagon analogues |
| JP6121992B2 (ja) | 2011-06-10 | 2017-04-26 | ノヴォ ノルディスク アー／エス | ポリペプチド |
| IN2014CN04401A (https=) | 2011-12-23 | 2015-09-04 | Zealand Pharma As | |
| IN2014MN02304A (https=) | 2012-05-03 | 2015-08-07 | Zealand Pharma As | |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| AU2014261111B2 (en) | 2013-05-02 | 2017-03-16 | Glaxosmithkline Intellectual Property Development Limited | Therapeutic peptides |
| AR097701A1 (es) | 2013-09-19 | 2016-04-13 | Zealand Pharma As | Análogos de amilina |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| PL3057984T3 (pl) | 2013-10-17 | 2018-12-31 | Zealand Pharma A/S | Acylowane analogi glukagonu |
| CN105829339B (zh) | 2013-11-06 | 2021-03-12 | 西兰制药公司 | 胰高血糖素-glp-1-gip三重激动剂化合物 |
| CN105722854B (zh) | 2013-11-14 | 2020-08-04 | 关键生物科学有限公司 | 用于治疗疾病和病症的降钙素模拟物 |
| EP3068795B1 (en) * | 2013-11-15 | 2019-03-06 | Novo Nordisk A/S | Hpyy(1-36) having a beta-homoarginine substitution at position 35 |
| CN105722526B (zh) * | 2013-11-15 | 2020-12-08 | 诺和诺德股份有限公司 | 选择性pyy化合物及其用途 |
| BR112017019378A2 (pt) | 2015-03-18 | 2019-02-19 | Zealand Pharma A/S | análogos de amilina |
| DK3283507T3 (da) | 2015-04-16 | 2020-01-02 | Zealand Pharma As | Acyleret glucagonanalog |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| TWI694082B (zh) * | 2015-06-12 | 2020-05-21 | 丹麥商諾佛 儂迪克股份有限公司 | 選擇性ｐｙｙ化合物及其用途 |
| SG11201805586SA (en) | 2015-12-31 | 2018-07-30 | Hanmi Pharmaceutical Co Ltd | Triple glucagon/glp-1/gip receptor agonist |
| EP3452088A4 (en) | 2016-05-03 | 2020-04-15 | The Scripps Research Institute | TRKB AGONIST ANTIBODIES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| US10071140B2 (en) | 2016-09-09 | 2018-09-11 | Zealand Pharma A/S | Amylin analogues |
| JOP20190095A1 (ar) | 2016-10-27 | 2019-04-28 | Janssen Pharmaceutica Nv | مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y |
| TW201833131A (zh) | 2016-12-02 | 2018-09-16 | 法商賽諾菲公司 | 作為胜肽類ｇｌｐ１／升糖素／ｇｉｐ受體促效劑之新化合物 |
| AR110300A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Compuestos como agonistas peptídicos trigonales de los receptores de glp1 / glucagón / gip |
| CN108289005B (zh) | 2017-01-09 | 2021-06-29 | 中兴通讯股份有限公司 | 信令发送、接收方法及装置 |
| GB201704429D0 (en) | 2017-03-21 | 2017-05-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
| US10793634B2 (en) | 2017-06-09 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Anti-TrkB antibodies |
| GB201720188D0 (en) | 2017-12-04 | 2018-01-17 | Imperial Innovations Ltd | Analogues of PYY |
| US10581312B2 (en) | 2017-12-29 | 2020-03-03 | Texas Instruments Incorporated | Multilevel converter using node voltage track and control |
| WO2019147650A1 (en) | 2018-01-23 | 2019-08-01 | Gila Therapeutics, Inc. | Peptide yy pharmaceutical formulations, compositions, and methods |
| TWI847981B (zh) | 2018-04-25 | 2024-07-11 | 比利時商健生藥品公司 | 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途 |
| TW202535916A (zh) * | 2018-11-01 | 2025-09-16 | 美商美國禮來大藥廠 | 蛋白質酪胺酸-酪胺酸類似物及其使用方法 |
| CR20220206A (es) | 2019-11-11 | 2022-06-16 | Boehringer Ingelheim Int | Agonistas del receptor npy2 |
| JP7661478B2 (ja) | 2020-08-07 | 2025-04-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性ｎｐｙ２受容体アゴニスト |
-
2020
- 2020-11-09 CR CR20220206A patent/CR20220206A/es unknown
- 2020-11-09 KR KR1020227019823A patent/KR20220100925A/ko active Pending
- 2020-11-09 EP EP20800693.2A patent/EP4058047A1/en active Pending
- 2020-11-09 CA CA3156452A patent/CA3156452A1/en active Pending
- 2020-11-09 MX MX2022005661A patent/MX2022005661A/es unknown
- 2020-11-09 JP JP2022526028A patent/JP7821393B2/ja active Active
- 2020-11-09 JO JOP/2022/0110A patent/JOP20220110A1/ar unknown
- 2020-11-09 WO PCT/EP2020/081513 patent/WO2021094259A1/en not_active Ceased
- 2020-11-09 PH PH1/2022/551101A patent/PH12022551101A1/en unknown
- 2020-11-09 CN CN202080078045.4A patent/CN114641303A/zh active Pending
- 2020-11-09 AU AU2020384729A patent/AU2020384729A1/en active Pending
- 2020-11-09 PE PE2022000757A patent/PE20221168A1/es unknown
- 2020-11-10 US US17/093,680 patent/US20210139548A1/en not_active Abandoned
- 2020-11-10 AR ARP200103125A patent/AR120440A1/es unknown
- 2020-11-10 TW TW109139134A patent/TWI864155B/zh active
-
2022
- 2022-04-28 IL IL292601A patent/IL292601A/en unknown
- 2022-05-09 CO CONC2022/0006046A patent/CO2022006046A2/es unknown
- 2022-05-09 DO DO2022000097A patent/DOP2022000097A/es unknown
- 2022-05-10 CL CL2022001227A patent/CL2022001227A1/es unknown
- 2022-05-11 EC ECSENADI202237660A patent/ECSP22037660A/es unknown
- 2022-12-20 US US18/068,641 patent/US12054525B2/en active Active
-
2024
- 2024-06-24 US US18/751,723 patent/US12559529B2/en active Active
-
2025
- 2025-10-23 JP JP2025178353A patent/JP2026026081A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210139548A1 (en) | 2021-05-13 |
| JP2023500895A (ja) | 2023-01-11 |
| AU2020384729A1 (en) | 2022-04-14 |
| TWI864155B (zh) | 2024-12-01 |
| AR120440A1 (es) | 2022-02-16 |
| JOP20220110A1 (ar) | 2023-01-30 |
| CO2022006046A2 (es) | 2022-05-20 |
| TW202134263A (zh) | 2021-09-16 |
| CR20220206A (es) | 2022-06-16 |
| JP7821393B2 (ja) | 2026-02-27 |
| ECSP22037660A (es) | 2022-06-30 |
| JP2026026081A (ja) | 2026-02-16 |
| KR20220100925A (ko) | 2022-07-18 |
| PH12022551101A1 (en) | 2023-11-13 |
| US12559529B2 (en) | 2026-02-24 |
| EP4058047A1 (en) | 2022-09-21 |
| CL2022001227A1 (es) | 2023-02-03 |
| US20230340039A1 (en) | 2023-10-26 |
| US12054525B2 (en) | 2024-08-06 |
| US20250002544A1 (en) | 2025-01-02 |
| IL292601A (en) | 2022-07-01 |
| MX2022005661A (es) | 2022-09-07 |
| DOP2022000097A (es) | 2022-06-15 |
| WO2021094259A1 (en) | 2021-05-20 |
| CA3156452A1 (en) | 2021-05-20 |
| CN114641303A (zh) | 2022-06-17 |
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