CN114641303A - Npy2受体激动剂 - Google Patents

Npy2受体激动剂 Download PDF

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Publication number
CN114641303A
CN114641303A CN202080078045.4A CN202080078045A CN114641303A CN 114641303 A CN114641303 A CN 114641303A CN 202080078045 A CN202080078045 A CN 202080078045A CN 114641303 A CN114641303 A CN 114641303A
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CN
China
Prior art keywords
ethoxy
group
hpyy
ala
glu
Prior art date
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Pending
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CN202080078045.4A
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English (en)
Chinese (zh)
Inventor
P·W·海贝尔
A·布伦瑙尔
C·S·马德森
S·L·彼得森
S·彼得斯
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Publication of CN114641303A publication Critical patent/CN114641303A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2271—Neuropeptide Y

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202080078045.4A 2019-11-11 2020-11-09 Npy2受体激动剂 Pending CN114641303A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19208394 2019-11-11
EP19208394.7 2019-11-11
PCT/EP2020/081513 WO2021094259A1 (en) 2019-11-11 2020-11-09 Npy2 receptor agonists

Publications (1)

Publication Number Publication Date
CN114641303A true CN114641303A (zh) 2022-06-17

Family

ID=68531488

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080078045.4A Pending CN114641303A (zh) 2019-11-11 2020-11-09 Npy2受体激动剂

Country Status (20)

Country Link
US (3) US20210139548A1 (https=)
EP (1) EP4058047A1 (https=)
JP (2) JP7821393B2 (https=)
KR (1) KR20220100925A (https=)
CN (1) CN114641303A (https=)
AR (1) AR120440A1 (https=)
AU (1) AU2020384729A1 (https=)
CA (1) CA3156452A1 (https=)
CL (1) CL2022001227A1 (https=)
CO (1) CO2022006046A2 (https=)
CR (1) CR20220206A (https=)
DO (1) DOP2022000097A (https=)
EC (1) ECSP22037660A (https=)
IL (1) IL292601A (https=)
JO (1) JOP20220110A1 (https=)
MX (1) MX2022005661A (https=)
PE (1) PE20221168A1 (https=)
PH (1) PH12022551101A1 (https=)
TW (1) TWI864155B (https=)
WO (1) WO2021094259A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20220206A (es) 2019-11-11 2022-06-16 Boehringer Ingelheim Int Agonistas del receptor npy2
JP7661478B2 (ja) * 2020-08-07 2025-04-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 可溶性ｎｐｙ２受容体アゴニスト
JP2025526148A (ja) * 2022-08-18 2025-08-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 長時間作用型ｇｌｐ－１／グルカゴン受容体アゴニスト及びｎｐｙ２受容体アゴニストを含む組合せ治療
CN120865433A (zh) * 2022-12-21 2025-10-31 勃林格殷格翰国际有限公司 Glp1/gip/npy2受体的三重激动剂
EP4670741A1 (en) 2023-04-28 2025-12-31 Pinotbio, Inc. ANTIBODY-DRUG CONJUGATE IN WHICH ONE OR MORE DRUG-BINDER CONJUGATES ARE LINKED TO AN ANTIBODY AND ITS PREPARATION METHOD

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US20210139548A1 (en) 2021-05-13
JP2023500895A (ja) 2023-01-11
AU2020384729A1 (en) 2022-04-14
TWI864155B (zh) 2024-12-01
AR120440A1 (es) 2022-02-16
JOP20220110A1 (ar) 2023-01-30
CO2022006046A2 (es) 2022-05-20
TW202134263A (zh) 2021-09-16
CR20220206A (es) 2022-06-16
JP7821393B2 (ja) 2026-02-27
ECSP22037660A (es) 2022-06-30
JP2026026081A (ja) 2026-02-16
PE20221168A1 (es) 2022-07-25
KR20220100925A (ko) 2022-07-18
PH12022551101A1 (en) 2023-11-13
US12559529B2 (en) 2026-02-24
EP4058047A1 (en) 2022-09-21
CL2022001227A1 (es) 2023-02-03
US20230340039A1 (en) 2023-10-26
US12054525B2 (en) 2024-08-06
US20250002544A1 (en) 2025-01-02
IL292601A (en) 2022-07-01
MX2022005661A (es) 2022-09-07
DOP2022000097A (es) 2022-06-15
WO2021094259A1 (en) 2021-05-20
CA3156452A1 (en) 2021-05-20

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