PE20181040A1 - Formulacion solida oral que contiene irinotecan y metodo de preparacion de la misma - Google Patents
Formulacion solida oral que contiene irinotecan y metodo de preparacion de la mismaInfo
- Publication number
- PE20181040A1 PE20181040A1 PE2017002882A PE2017002882A PE20181040A1 PE 20181040 A1 PE20181040 A1 PE 20181040A1 PE 2017002882 A PE2017002882 A PE 2017002882A PE 2017002882 A PE2017002882 A PE 2017002882A PE 20181040 A1 PE20181040 A1 PE 20181040A1
- Authority
- PE
- Peru
- Prior art keywords
- preparing
- same
- formulation containing
- solid oral
- oral formulation
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
Se refiere a una formulacion solida oral que comprende irinotecan o una sal farmaceuticamente aceptable del mismo y un agente acidificante tal como acido acetico, acido citrico, acido lactico, entre otros. La formulacion solida comprende adicionalmente un aditivo aceptable farmaceuticamente seleccionado del grupo que consiste en un diluyente, un aglutinante, un disgregante, un lubricante y combinaciones de los mismos. Dicha formulacion es util para el tratamiento de diversos tipos de cancer
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020150093413A KR102293907B1 (ko) | 2015-06-30 | 2015-06-30 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20181040A1 true PE20181040A1 (es) | 2018-07-03 |
Family
ID=57608859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017002882A PE20181040A1 (es) | 2015-06-30 | 2016-06-20 | Formulacion solida oral que contiene irinotecan y metodo de preparacion de la misma |
Country Status (32)
Country | Link |
---|---|
US (2) | US11090299B2 (es) |
EP (1) | EP3300483B1 (es) |
JP (2) | JP6835746B2 (es) |
KR (2) | KR102293907B1 (es) |
CN (1) | CN107949375B (es) |
AR (1) | AR105203A1 (es) |
AU (2) | AU2016286804B2 (es) |
BR (1) | BR112017028468B1 (es) |
CA (1) | CA2988079C (es) |
CL (1) | CL2017003437A1 (es) |
CO (1) | CO2017013317A2 (es) |
CR (1) | CR20170604A (es) |
DO (1) | DOP2017000307A (es) |
EC (1) | ECSP17085443A (es) |
ES (1) | ES2930663T3 (es) |
GT (1) | GT201700280A (es) |
HK (1) | HK1246656A1 (es) |
IL (1) | IL256278B (es) |
JO (1) | JO3683B1 (es) |
MX (2) | MX2017014994A (es) |
MY (1) | MY191297A (es) |
NZ (1) | NZ737238A (es) |
PE (1) | PE20181040A1 (es) |
PH (1) | PH12017502376B1 (es) |
RU (1) | RU2716595C2 (es) |
SA (1) | SA517390602B1 (es) |
SG (1) | SG10201913274VA (es) |
SV (1) | SV2017005603A (es) |
TW (2) | TWI750125B (es) |
UY (1) | UY36761A (es) |
WO (1) | WO2017003120A1 (es) |
ZA (1) | ZA201708429B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102293907B1 (ko) * | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
KR102066402B1 (ko) * | 2017-12-22 | 2020-01-15 | 대화제약 주식회사 | 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물 |
KR102185475B1 (ko) * | 2019-06-20 | 2020-12-02 | 대화제약 주식회사 | 이리노테칸 자유 염기를 포함하는 경구투여용 약학 조성물 |
KR102444073B1 (ko) * | 2020-01-06 | 2022-09-16 | (주)휴온스 | 안정성이 향상된 메틸에르고메트린말레산염 함유 약제학적 제제 및 이의 제조방법 |
KR20220006776A (ko) * | 2020-07-09 | 2022-01-18 | 주식회사유한양행 | 다이아미노피리미딘 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 약학 조성물 및 이의 제조방법 |
MX2023001525A (es) * | 2020-08-06 | 2023-03-06 | Sk Biopharmaceuticals Co Ltd | Composicion oral solida que comprende compuesto de carbamato y metodo de preparacion para la misma. |
TW202233593A (zh) | 2020-10-07 | 2022-09-01 | 美商亞瑟尼克斯公司 | 乙醯胺基-苯基四唑衍生物及其使用方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
AU764370B2 (en) | 1998-06-18 | 2003-08-14 | George Washington University, The | Methods of administering camptothecin compounds for the treatment of cancer with reduced side effects |
GB9925127D0 (en) | 1999-10-22 | 1999-12-22 | Pharmacia & Upjohn Spa | Oral formulations for anti-tumor compounds |
US6881420B2 (en) * | 2000-06-23 | 2005-04-19 | Teva Pharmaceutical Industries Ltd. | Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation |
JP2002154963A (ja) * | 2000-11-14 | 2002-05-28 | Yakult Honsha Co Ltd | 徐放性抗腫瘍剤 |
US6476068B1 (en) | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
KR20040091083A (ko) | 2002-03-01 | 2004-10-27 | 파마시아 이탈리아 에스.피.에이. | 이리노테칸 히드로클로라이드의 결정성 다형체 |
US20060030578A1 (en) | 2002-08-20 | 2006-02-09 | Neopharm, Inc. | Pharmaceutically active lipid based formulation of irinotecan |
JP4245384B2 (ja) * | 2003-03-18 | 2009-03-25 | 株式会社ヤクルト本社 | カンプトテシン類含有医薬組成物 |
US20050208146A1 (en) | 2003-10-30 | 2005-09-22 | Pfizer Inc | Novel dosage and administration method for oral camptosar |
JP4829120B2 (ja) * | 2004-10-01 | 2011-12-07 | 株式会社ヤクルト本社 | イリノテカン酸付加塩 |
NZ555120A (en) | 2004-12-03 | 2009-11-27 | Merck & Co Inc | Pharmaceutical formulation of carboxamide HIV integrase inhibitors containing a release rate controlling composition |
WO2006127926A2 (en) | 2005-05-23 | 2006-11-30 | Novartis Ag | Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts |
CN101283983A (zh) * | 2007-10-26 | 2008-10-15 | 南京长澳医药科技有限公司 | 一种稳定的喜树碱类药物脂质体组合物 |
US7880591B2 (en) | 2008-02-01 | 2011-02-01 | Apple Inc. | Consumer abuse detection system and method |
EP2153821A1 (en) | 2008-08-06 | 2010-02-17 | BioAlliance Pharma | Oral formulations of camptothecin derivatives |
CN102617584B (zh) * | 2012-03-14 | 2013-10-16 | 海南锦瑞制药股份有限公司 | 一种盐酸伊立替康化合物及其药物组合物 |
ES2686730T3 (es) | 2012-11-30 | 2018-10-19 | Novartis Ag | Composición farmacéutica novedosa |
US10143657B2 (en) * | 2014-01-17 | 2018-12-04 | Oncoral Pharma Aps | Solid oral dosage form of irinotecan for the treatment of cancer |
KR102293907B1 (ko) * | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
-
2015
- 2015-06-30 KR KR1020150093413A patent/KR102293907B1/ko active IP Right Grant
-
2016
- 2016-06-20 CR CR20170604A patent/CR20170604A/es unknown
- 2016-06-20 US US15/735,313 patent/US11090299B2/en active Active
- 2016-06-20 AU AU2016286804A patent/AU2016286804B2/en active Active
- 2016-06-20 WO PCT/KR2016/006513 patent/WO2017003120A1/en active Application Filing
- 2016-06-20 ES ES16818153T patent/ES2930663T3/es active Active
- 2016-06-20 JP JP2017564664A patent/JP6835746B2/ja active Active
- 2016-06-20 MY MYPI2017001682A patent/MY191297A/en unknown
- 2016-06-20 SG SG10201913274VA patent/SG10201913274VA/en unknown
- 2016-06-20 CA CA2988079A patent/CA2988079C/en active Active
- 2016-06-20 NZ NZ737238A patent/NZ737238A/en unknown
- 2016-06-20 EP EP16818153.5A patent/EP3300483B1/en active Active
- 2016-06-20 RU RU2017143849A patent/RU2716595C2/ru active
- 2016-06-20 MX MX2017014994A patent/MX2017014994A/es unknown
- 2016-06-20 PE PE2017002882A patent/PE20181040A1/es unknown
- 2016-06-20 CN CN201680036424.0A patent/CN107949375B/zh active Active
- 2016-06-20 BR BR112017028468-5A patent/BR112017028468B1/pt active IP Right Grant
- 2016-06-28 JO JOP/2016/0133A patent/JO3683B1/ar active
- 2016-06-29 TW TW105120541A patent/TWI750125B/zh active
- 2016-06-29 TW TW110123753A patent/TW202137985A/zh unknown
- 2016-06-30 AR ARP160101985A patent/AR105203A1/es unknown
- 2016-06-30 UY UY0001036761A patent/UY36761A/es not_active Application Discontinuation
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2017
- 2017-11-21 MX MX2021004439A patent/MX2021004439A/es unknown
- 2017-12-12 IL IL256278A patent/IL256278B/en active IP Right Grant
- 2017-12-12 ZA ZA2017/08429A patent/ZA201708429B/en unknown
- 2017-12-20 PH PH12017502376A patent/PH12017502376B1/en unknown
- 2017-12-21 DO DO2017000307A patent/DOP2017000307A/es unknown
- 2017-12-21 GT GT201700280A patent/GT201700280A/es unknown
- 2017-12-21 SV SV2017005603A patent/SV2017005603A/es unknown
- 2017-12-22 CO CONC2017/0013317A patent/CO2017013317A2/es unknown
- 2017-12-24 SA SA517390602A patent/SA517390602B1/ar unknown
- 2017-12-28 EC ECIEPI201785443A patent/ECSP17085443A/es unknown
- 2017-12-28 CL CL2017003437A patent/CL2017003437A1/es unknown
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2018
- 2018-05-11 HK HK18106185.2A patent/HK1246656A1/zh unknown
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2021
- 2021-02-04 JP JP2021016485A patent/JP2021070705A/ja active Pending
- 2021-06-23 AU AU2021204259A patent/AU2021204259A1/en not_active Abandoned
- 2021-07-08 US US17/370,709 patent/US20210330666A1/en not_active Abandoned
- 2021-08-19 KR KR1020210109641A patent/KR102317664B1/ko active IP Right Grant
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