CO2017013317A2 - Formulación sólida oral que contiene irinotecán y método de preparación de la misma - Google Patents

Formulación sólida oral que contiene irinotecán y método de preparación de la misma

Info

Publication number
CO2017013317A2
CO2017013317A2 CONC2017/0013317A CO2017013317A CO2017013317A2 CO 2017013317 A2 CO2017013317 A2 CO 2017013317A2 CO 2017013317 A CO2017013317 A CO 2017013317A CO 2017013317 A2 CO2017013317 A2 CO 2017013317A2
Authority
CO
Colombia
Prior art keywords
preparation
formulation containing
solid oral
oral formulation
containing irinotecan
Prior art date
Application number
CONC2017/0013317A
Other languages
English (en)
Inventor
Jae Hyun Park
Jong Soo Woo
Caleb Hyung Min Park
Myeong Ki Jung
Jin Cheul Kim
Yong Il Kim
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of CO2017013317A2 publication Critical patent/CO2017013317A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

Una formulación sólida oral incluye irinotecán o una sal aceptable farmacéuticamente del mismo como un ingrediente activo y un agente acidificante.
CONC2017/0013317A 2015-06-30 2017-12-22 Formulación sólida oral que contiene irinotecán y método de preparación de la misma CO2017013317A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020150093413A KR102293907B1 (ko) 2015-06-30 2015-06-30 이리노테칸 함유 경구용 고형제제 및 그 제조방법
PCT/KR2016/006513 WO2017003120A1 (en) 2015-06-30 2016-06-20 Oral solid formulation containing irinotecan and method of preparing the same

Publications (1)

Publication Number Publication Date
CO2017013317A2 true CO2017013317A2 (es) 2018-03-28

Family

ID=57608859

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0013317A CO2017013317A2 (es) 2015-06-30 2017-12-22 Formulación sólida oral que contiene irinotecán y método de preparación de la misma

Country Status (32)

Country Link
US (2) US11090299B2 (es)
EP (1) EP3300483B1 (es)
JP (2) JP6835746B2 (es)
KR (2) KR102293907B1 (es)
CN (1) CN107949375B (es)
AR (1) AR105203A1 (es)
AU (2) AU2016286804B2 (es)
BR (1) BR112017028468B1 (es)
CA (1) CA2988079C (es)
CL (1) CL2017003437A1 (es)
CO (1) CO2017013317A2 (es)
CR (1) CR20170604A (es)
DO (1) DOP2017000307A (es)
EC (1) ECSP17085443A (es)
ES (1) ES2930663T3 (es)
GT (1) GT201700280A (es)
HK (1) HK1246656A1 (es)
IL (1) IL256278B (es)
JO (1) JO3683B1 (es)
MX (2) MX2017014994A (es)
MY (1) MY191297A (es)
NZ (1) NZ737238A (es)
PE (1) PE20181040A1 (es)
PH (1) PH12017502376A1 (es)
RU (1) RU2716595C2 (es)
SA (1) SA517390602B1 (es)
SG (1) SG10201913274VA (es)
SV (1) SV2017005603A (es)
TW (2) TW202137985A (es)
UY (1) UY36761A (es)
WO (1) WO2017003120A1 (es)
ZA (1) ZA201708429B (es)

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KR102293907B1 (ko) * 2015-06-30 2021-08-26 한미약품 주식회사 이리노테칸 함유 경구용 고형제제 및 그 제조방법
KR102066402B1 (ko) * 2017-12-22 2020-01-15 대화제약 주식회사 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물
KR102185475B1 (ko) * 2019-06-20 2020-12-02 대화제약 주식회사 이리노테칸 자유 염기를 포함하는 경구투여용 약학 조성물
KR102444073B1 (ko) * 2020-01-06 2022-09-16 (주)휴온스 안정성이 향상된 메틸에르고메트린말레산염 함유 약제학적 제제 및 이의 제조방법
KR20220006776A (ko) * 2020-07-09 2022-01-18 주식회사유한양행 다이아미노피리미딘 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 약학 조성물 및 이의 제조방법
WO2022031099A1 (ko) * 2020-08-06 2022-02-10 에스케이바이오팜 주식회사 카바메이트 화합물을 포함하는 경구용 고형 제제 및 이의 제조방법
AU2021358074A1 (en) 2020-10-07 2023-04-27 Athenex, Inc. Acetamido-phenyltetrazole derivatives and methods of using the same

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JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
EP1003516A4 (en) 1998-06-18 2006-07-12 Univ George Washington METHOD FOR THE ADMINISTRATION OF CAMPTOTHECIN COMPOSITIONS FOR CANCER TREATMENT WITH REDUCED SIDE EFFECTS
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JP2002154963A (ja) 2000-11-14 2002-05-28 Yakult Honsha Co Ltd 徐放性抗腫瘍剤
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JP4245384B2 (ja) * 2003-03-18 2009-03-25 株式会社ヤクルト本社 カンプトテシン類含有医薬組成物
US20050208146A1 (en) 2003-10-30 2005-09-22 Pfizer Inc Novel dosage and administration method for oral camptosar
EP1798235B1 (en) * 2004-10-01 2015-04-01 Kabushiki Kaisha Yakult Honsha Acid addition salt of irinotecan
MX2007006635A (es) 2004-12-03 2007-06-19 Merck & Co Inc Formulacion farmaceutica de inhibidores dela carboxamida vih integrasa que contienen una composicion que controla la velocidad de liberacion.
EP2270000B1 (en) 2005-05-23 2015-07-29 Novartis AG Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts
CN101283983A (zh) * 2007-10-26 2008-10-15 南京长澳医药科技有限公司 一种稳定的喜树碱类药物脂质体组合物
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CN102617584B (zh) 2012-03-14 2013-10-16 海南锦瑞制药股份有限公司 一种盐酸伊立替康化合物及其药物组合物
EA028246B1 (ru) 2012-11-30 2017-10-31 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Фармацевтическая композиция
ES2680444T3 (es) * 2014-01-17 2018-09-07 Oncoral Pharma Aps Forma de dosificación oral sólida de irinotecán para el tratamiento del cáncer
KR102293907B1 (ko) * 2015-06-30 2021-08-26 한미약품 주식회사 이리노테칸 함유 경구용 고형제제 및 그 제조방법

Also Published As

Publication number Publication date
CL2017003437A1 (es) 2018-06-22
US20210330666A1 (en) 2021-10-28
JP2018519279A (ja) 2018-07-19
KR102317664B1 (ko) 2021-10-26
AU2016286804B2 (en) 2021-03-25
SA517390602B1 (ar) 2022-11-09
UY36761A (es) 2016-12-30
MX2017014994A (es) 2018-08-15
DOP2017000307A (es) 2018-03-15
BR112017028468B1 (pt) 2023-03-28
WO2017003120A1 (en) 2017-01-05
PE20181040A1 (es) 2018-07-03
ECSP17085443A (es) 2018-01-31
US11090299B2 (en) 2021-08-17
HK1246656A1 (zh) 2018-09-14
EP3300483A4 (en) 2018-12-12
SG10201913274VA (en) 2020-03-30
IL256278A (en) 2018-02-28
AU2021204259A1 (en) 2021-07-22
KR20210106946A (ko) 2021-08-31
JO3683B1 (ar) 2020-08-27
KR20170003143A (ko) 2017-01-09
CA2988079C (en) 2023-09-26
GT201700280A (es) 2019-10-10
CR20170604A (es) 2018-04-27
AR105203A1 (es) 2017-09-13
PH12017502376B1 (en) 2018-06-25
BR112017028468A2 (pt) 2018-08-28
US20180153878A1 (en) 2018-06-07
MY191297A (en) 2022-06-14
CN107949375A (zh) 2018-04-20
EP3300483B1 (en) 2022-11-09
TW201713339A (zh) 2017-04-16
IL256278B (en) 2020-11-30
MX2021004439A (es) 2021-05-27
RU2017143849A (ru) 2019-08-01
JP2021070705A (ja) 2021-05-06
CN107949375B (zh) 2023-04-21
JP6835746B2 (ja) 2021-02-24
AU2016286804A1 (en) 2017-11-30
NZ737238A (en) 2024-03-22
RU2716595C2 (ru) 2020-03-13
ES2930663T3 (es) 2022-12-20
KR102293907B1 (ko) 2021-08-26
CA2988079A1 (en) 2017-01-05
RU2017143849A3 (es) 2019-09-25
TW202137985A (zh) 2021-10-16
EP3300483A1 (en) 2018-04-04
TWI750125B (zh) 2021-12-21
ZA201708429B (en) 2019-06-26
PH12017502376A1 (en) 2018-06-25
SV2017005603A (es) 2018-03-12

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