PE20170680A1 - Tratamientos conjuntos con anticuerpos anti cd40 - Google Patents
Tratamientos conjuntos con anticuerpos anti cd40Info
- Publication number
- PE20170680A1 PE20170680A1 PE2017000203A PE2017000203A PE20170680A1 PE 20170680 A1 PE20170680 A1 PE 20170680A1 PE 2017000203 A PE2017000203 A PE 2017000203A PE 2017000203 A PE2017000203 A PE 2017000203A PE 20170680 A1 PE20170680 A1 PE 20170680A1
- Authority
- PE
- Peru
- Prior art keywords
- treatments
- antibodies
- antigen
- antibody
- joint
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 5
- 101150013553 CD40 gene Proteins 0.000 title abstract 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1414270.7A GB201414270D0 (en) | 2014-08-12 | 2014-08-12 | Antibodies |
| GB201422614 | 2014-12-18 | ||
| GBGB1507541.9A GB201507541D0 (en) | 2015-05-01 | 2015-05-01 | Antibodies |
| PCT/EP2015/068598 WO2016023960A1 (en) | 2014-08-12 | 2015-08-12 | Combination therapies with anti cd40 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20170680A1 true PE20170680A1 (es) | 2017-06-14 |
Family
ID=53836090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2017000203A PE20170680A1 (es) | 2014-08-12 | 2015-08-12 | Tratamientos conjuntos con anticuerpos anti cd40 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US11149090B2 (enExample) |
| EP (3) | EP3552665A3 (enExample) |
| JP (1) | JP6654187B2 (enExample) |
| KR (1) | KR102443258B1 (enExample) |
| CN (3) | CN114099671A (enExample) |
| AU (1) | AU2015303164B2 (enExample) |
| CA (1) | CA2957146A1 (enExample) |
| CL (1) | CL2017000335A1 (enExample) |
| CO (1) | CO2017001317A2 (enExample) |
| CR (1) | CR20170096A (enExample) |
| DK (1) | DK3180087T3 (enExample) |
| EA (1) | EA201790339A1 (enExample) |
| EC (1) | ECSP17008984A (enExample) |
| ES (1) | ES2725463T3 (enExample) |
| IL (1) | IL250512B (enExample) |
| MA (1) | MA47472A (enExample) |
| MX (1) | MX382549B (enExample) |
| NI (1) | NI201700015A (enExample) |
| PE (1) | PE20170680A1 (enExample) |
| PH (1) | PH12017500229A1 (enExample) |
| SG (1) | SG11201701070WA (enExample) |
| SV (1) | SV2017005380A (enExample) |
| UA (1) | UA119783C2 (enExample) |
| WO (1) | WO2016023960A1 (enExample) |
| ZA (1) | ZA201701126B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190122889A (ko) | 2011-04-29 | 2019-10-30 | 아펙시젠, 인코포레이티드 | 항-cd40 항체 및 사용 방법 |
| ES2885423T3 (es) | 2013-02-07 | 2021-12-13 | Massachusetts Gen Hospital | Procedimientos para la expansión o el empobrecimiento de células T reguladoras |
| AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| MX370449B (es) | 2013-12-12 | 2019-12-13 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de unión al antígeno de este y uso médico de este. |
| CA2985816A1 (en) | 2015-05-15 | 2016-11-24 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
| WO2017040312A1 (en) | 2015-08-28 | 2017-03-09 | The General Hospital Corporation | Agonistic anti-tumor necrosis factor receptor 2 antibodies |
| IL300122A (en) | 2015-11-18 | 2023-03-01 | Merck Sharp ַ& Dohme Llc | Substances that bind to PD1 and/or LAG3 |
| CN108367069B (zh) | 2015-12-14 | 2022-08-23 | 宏观基因有限公司 | 对于pd-1和ctla-4具有免疫反应性的双特异性分子及其使用方法 |
| CN109476745B (zh) * | 2016-05-13 | 2023-11-24 | 综合医院公司 | 拮抗性抗肿瘤坏死因子受体超家族抗体 |
| IL263834B2 (en) | 2016-06-20 | 2024-01-01 | Kymab Ltd | Anti-pd-l1 antibodies |
| KR20250097987A (ko) | 2016-07-14 | 2025-06-30 | 젠맵 에이/에스 | Cd40 및 cd137에 대한 다중특이적 항체 |
| WO2018036852A1 (en) | 2016-08-25 | 2018-03-01 | F. Hoffmann-La Roche Ag | Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent |
| WO2018078620A1 (en) | 2016-10-25 | 2018-05-03 | Urogen Pharma Ltd. | Immunomodulating treatments of body cavities |
| EP3534951A4 (en) * | 2016-11-02 | 2020-09-23 | Apexigen, Inc. | ANTI-CD40 ANTIBODIES IN COMBINATION AND METHOD OF USES |
| JP7304287B2 (ja) | 2016-12-22 | 2023-07-06 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗pd-l1/pd1治療の不成功後の、抗pd-l1抗体との組み合わせでの抗csf-1r抗体を用いた腫瘍の治療 |
| ES2902670T3 (es) * | 2017-01-13 | 2022-03-29 | Taizhou Hanzhong Biopharmaceutics Inc | Anticuerpo monoclonal contra PD-1 y aplicaciones del mismo |
| US10857230B2 (en) * | 2017-03-03 | 2020-12-08 | Janssen Biotech, Inc. | Co-therapy comprising a small molecule CSF-1R inhibitor and an agonistic antibody that specifically binds CD40 for the treatment of cancer |
| WO2019043170A1 (en) | 2017-08-31 | 2019-03-07 | Multimmune Gmbh | POLY THERAPY BASED ON HSP70 |
| CA3093820A1 (en) * | 2018-03-13 | 2019-09-19 | Hibercell, Inc. | Beta glucan and cd40 agonist combination immunotherapy |
| WO2019241306A2 (en) * | 2018-06-12 | 2019-12-19 | Neon Therapeutics, Inc. | Combination therapy with neoantigen vaccine |
| US20210251994A1 (en) | 2018-06-15 | 2021-08-19 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
| PE20211412A1 (es) * | 2018-08-20 | 2021-08-02 | Pfizer | Anticuerpos anti-gdf15, composiciones y metodos de uso |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP3883600B1 (en) * | 2018-11-23 | 2025-03-12 | Strike Pharma AB | Bi-specific conjugates |
| AU2019389354A1 (en) * | 2018-11-30 | 2021-07-15 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-CD40 antibody, antigen binding fragment and pharmaceutical use thereof |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| MA56027A (fr) * | 2019-05-28 | 2022-04-06 | Janssen Biotech Inc | Procédé de fourniture d'une administration sûre d'un anticorps anti-cd40 |
| WO2021048135A1 (en) | 2019-09-09 | 2021-03-18 | Basilea Pharmaceutica International AG | Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| AU2020414184A1 (en) * | 2019-12-27 | 2022-07-14 | Interoligo Corporation. | Anti-cancer immunotherapeutic composition for treating cancer |
| GB202008003D0 (en) | 2020-05-28 | 2020-07-15 | Quine Medical Ab | Anti-CD40 antibody |
| CN116096906A (zh) | 2020-06-29 | 2023-05-09 | 旗舰创业创新五公司 | 工程化以促进萨诺传递的病毒及其在治疗癌症中的用途 |
| CN113861292A (zh) * | 2020-06-30 | 2021-12-31 | 百奥泰生物制药股份有限公司 | 抗cd40抗体或抗原结合片段及其应用 |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| WO2022212784A1 (en) | 2021-03-31 | 2022-10-06 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
| US20240316104A1 (en) | 2021-06-29 | 2024-09-26 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| US20240400706A1 (en) * | 2021-10-15 | 2024-12-05 | The Rockefeller University | Combination of anti-cd40 antibody and il-15 for treating cancer |
| JP2024539940A (ja) * | 2021-10-26 | 2024-10-31 | ナビキュア バイオファーマシューティカルズ リミテッド | がん及び感染症に対する組み合わせ療法 |
| JP2025521028A (ja) | 2022-06-23 | 2025-07-04 | アリゲーター・バイオサイエンス・アーベー | 併用療法 |
| EP4598946A1 (en) | 2022-10-05 | 2025-08-13 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| SE459005B (sv) | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| WO1996006641A1 (en) | 1994-08-29 | 1996-03-07 | Prizm Pharmaceuticals, Inc. | Conjugates of vascular endothelial growth factor with targeted agents |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| US6051228A (en) | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
| WO2001083755A2 (en) | 2000-04-28 | 2001-11-08 | La Jolla Institute For Allergy And Immunology | Human anti-cd40 antibodies and methods of making and using same |
| CA2430582C (en) | 2000-12-12 | 2012-12-04 | Alligator Bioscience Ab | A method for in vitro molecular evolution of protein function |
| ATE374214T1 (de) | 2001-04-27 | 2007-10-15 | Kirin Brewery | Monoklonaler anti-cd-40-antikörper |
| WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
| AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| ES2285118T5 (es) | 2002-05-17 | 2012-09-21 | Alligator Bioscience Ab | Un método para el desarrollo molecular in vitro de una función proteica. |
| CN101001872A (zh) * | 2004-04-16 | 2007-07-18 | 宏观基因有限公司 | FcγRIIB-特异性抗体及其使用方法 |
| AU2005323515A1 (en) | 2004-04-27 | 2006-07-13 | Novartis Vaccines And Diagnostics, Inc. | Antagonist anti-CD40 monoclonal antibodies and methods for their use |
| PL2161336T5 (pl) | 2005-05-09 | 2017-10-31 | Ono Pharmaceutical Co | Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi |
| ATE485057T1 (de) | 2005-05-26 | 2010-11-15 | Seattle Genetics Inc | Humanisierte antikörper gegen cd40 und verfahren zu ihrer anwendung |
| GB0620894D0 (en) | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
| EP2245065A1 (en) | 2008-01-23 | 2010-11-03 | Xencor, Inc. | Optimized cd40 antibodies and methods of using the same |
| EP2323690A1 (en) * | 2008-08-29 | 2011-05-25 | Academisch Ziekenhuis Leiden h.o.d.n. LUMC | Delivery of a cd40 agonist to a tumor draining lymph node of a subject |
| CN102695772B (zh) * | 2009-09-16 | 2015-09-16 | 纳幕尔杜邦公司 | 装有反式-1,1,1,4,4,4-六氟-2-丁烯的冷却器设备以及在其中制冷的方法 |
| GB201006096D0 (en) | 2010-04-13 | 2010-05-26 | Alligator Bioscience Ab | Novel compositions and uses thereof |
| CA2843595C (en) | 2011-08-01 | 2022-10-18 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
| GB201115280D0 (en) * | 2011-09-05 | 2011-10-19 | Alligator Bioscience Ab | Antibodies, uses and methods |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| EP2951209A4 (en) * | 2013-01-31 | 2016-06-22 | Univ Jefferson | CD40 OX40 AGONIST FUSION PROTEIN AND USES THEREOF |
| PE20160753A1 (es) | 2013-12-20 | 2016-08-01 | Hoffmann La Roche | Terapia combinada con un anticuerpo anti-ang2 y un agonista de cd40 |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| RS60753B1 (sr) | 2015-04-17 | 2020-10-30 | Bristol Myers Squibb Co | Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba |
| DK3303395T3 (da) | 2015-05-29 | 2020-01-27 | Abbvie Inc | Anti-cd40-antistoffer og anvendelser deraf |
| ES3039629T3 (en) | 2015-06-29 | 2025-10-23 | Bristol Myers Squibb Co | Antibodies to cd40 |
| WO2017004016A1 (en) | 2015-06-29 | 2017-01-05 | The Rockefeller University | Antibodies to cd40 with enhanced agonist activity |
-
2015
- 2015-08-12 WO PCT/EP2015/068598 patent/WO2016023960A1/en not_active Ceased
- 2015-08-12 EP EP19161728.1A patent/EP3552665A3/en active Pending
- 2015-08-12 EP EP25194883.2A patent/EP4653463A2/en active Pending
- 2015-08-12 AU AU2015303164A patent/AU2015303164B2/en active Active
- 2015-08-12 MA MA047472A patent/MA47472A/fr unknown
- 2015-08-12 CN CN202111420044.6A patent/CN114099671A/zh active Pending
- 2015-08-12 KR KR1020177005821A patent/KR102443258B1/ko active Active
- 2015-08-12 SG SG11201701070WA patent/SG11201701070WA/en unknown
- 2015-08-12 PE PE2017000203A patent/PE20170680A1/es unknown
- 2015-08-12 EA EA201790339A patent/EA201790339A1/ru unknown
- 2015-08-12 US US15/329,402 patent/US11149090B2/en active Active
- 2015-08-12 DK DK15750051.3T patent/DK3180087T3/da active
- 2015-08-12 CA CA2957146A patent/CA2957146A1/en active Pending
- 2015-08-12 UA UAA201701452A patent/UA119783C2/uk unknown
- 2015-08-12 CN CN201580043161.1A patent/CN106573981A/zh active Pending
- 2015-08-12 CR CR20170096A patent/CR20170096A/es unknown
- 2015-08-12 JP JP2017507739A patent/JP6654187B2/ja active Active
- 2015-08-12 CN CN202411444693.3A patent/CN119280407A/zh active Pending
- 2015-08-12 MX MX2017001864A patent/MX382549B/es unknown
- 2015-08-12 ES ES15750051T patent/ES2725463T3/es active Active
- 2015-08-12 EP EP15750051.3A patent/EP3180087B1/en active Active
-
2017
- 2017-02-07 PH PH12017500229A patent/PH12017500229A1/en unknown
- 2017-02-07 SV SV2017005380A patent/SV2017005380A/es unknown
- 2017-02-08 IL IL250512A patent/IL250512B/en unknown
- 2017-02-09 CL CL2017000335A patent/CL2017000335A1/es unknown
- 2017-02-09 NI NI201700015A patent/NI201700015A/es unknown
- 2017-02-10 CO CONC2017/0001317A patent/CO2017001317A2/es unknown
- 2017-02-10 EC ECIEPI20178984A patent/ECSP17008984A/es unknown
- 2017-02-15 ZA ZA2017/01126A patent/ZA201701126B/en unknown
-
2021
- 2021-09-15 US US17/475,592 patent/US20210403589A1/en not_active Abandoned
-
2023
- 2023-12-13 US US18/538,429 patent/US20240228643A9/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP17008984A (es) | Tratamientos conjuntos con anticuerpos anti cd40 | |
| CL2022001189A1 (es) | Anticuerpos para cd40. (divisional de solicitud n° 2017003427) | |
| PH12021550023A1 (en) | Humanized anti-tau antibodies | |
| EA201990296A1 (ru) | Антитела против siglec-7 для лечения рака | |
| MX2018012468A (es) | Construcciones de union a antigeno multiespecificas dirigidas a agentes inmunoterapeuticos. | |
| MX2016002826A (es) | Anticuerpos anti-b7-h1 para tratar tumores. | |
| MX2018008995A (es) | Combinacion de un agonista de ox40 y un agonista de 4-1bb para tratar el cancer. | |
| MX2016014189A (es) | Anticuerpos anti ligando 1 de muerte programada (b7-h1) y anti antigeno 4 de linfocito t citotoxico (anti-ctla-4) para tratar el cancer de pulmon no microcitico. | |
| MX2017004715A (es) | Anticuerpos anti-ox40 humanizados y usos de los mismos. | |
| CL2017002983A1 (es) | Terapia combinada de un anticuerpo anti-cd-20 con un inhibidor de bcl-2 y un inhibidor de mdm2 | |
| MX2017004526A (es) | Terapia combinada de anticuerpos biespecificos especificos para fap y dr5 y agentes quimioterapeuticos. | |
| CL2017000558A1 (es) | Terapia de combinación | |
| CL2025000404A1 (es) | Anticuerpo anti-lilrb1 y usos del mismo | |
| MX2018015350A (es) | Anticuerpos anti-gitr y sus usos. | |
| CL2019002735A1 (es) | Anticuerpos que se unen a steap-1. | |
| EA201791970A1 (ru) | Способ лечения первичного склерозирующего холангита | |
| MX386543B (es) | Anticuerpo de anti-esclerostina, fragmento de unión a antigeno y uso médico del mismo. | |
| EA202090453A3 (ru) | Антитела к cd40 | |
| EA202191382A1 (ru) | Белки, связывающие калликреин плазмы, и их применение для лечения наследственного ангионевротического отека |