PE20151438A1 - Moduladores de receptores nmda de espiro-lactama y sus usos - Google Patents

Moduladores de receptores nmda de espiro-lactama y sus usos

Info

Publication number
PE20151438A1
PE20151438A1 PE2015001565A PE2015001565A PE20151438A1 PE 20151438 A1 PE20151438 A1 PE 20151438A1 PE 2015001565 A PE2015001565 A PE 2015001565A PE 2015001565 A PE2015001565 A PE 2015001565A PE 20151438 A1 PE20151438 A1 PE 20151438A1
Authority
PE
Peru
Prior art keywords
lactama
spiro
compounds
receiver modulators
nmda
Prior art date
Application number
PE2015001565A
Other languages
English (en)
Spanish (es)
Inventor
Lowe John A Iii
M Amin Khan
Original Assignee
Naurex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50097881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20151438(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Naurex Inc filed Critical Naurex Inc
Publication of PE20151438A1 publication Critical patent/PE20151438A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
PE2015001565A 2013-01-29 2014-01-29 Moduladores de receptores nmda de espiro-lactama y sus usos PE20151438A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361757939P 2013-01-29 2013-01-29

Publications (1)

Publication Number Publication Date
PE20151438A1 true PE20151438A1 (es) 2015-10-10

Family

ID=50097881

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015001565A PE20151438A1 (es) 2013-01-29 2014-01-29 Moduladores de receptores nmda de espiro-lactama y sus usos

Country Status (16)

Country Link
US (2) US9738650B2 (enExample)
EP (1) EP2951186B1 (enExample)
JP (1) JP2016506961A (enExample)
KR (1) KR20150110586A (enExample)
CN (1) CN105026401A (enExample)
AU (1) AU2014212490A1 (enExample)
BR (1) BR112015018095A2 (enExample)
CA (1) CA2899010A1 (enExample)
CL (1) CL2015002124A1 (enExample)
EA (1) EA201591404A1 (enExample)
IL (1) IL240165A0 (enExample)
MX (1) MX2015009778A (enExample)
PE (1) PE20151438A1 (enExample)
PH (1) PH12015501600A1 (enExample)
SG (1) SG11201505937SA (enExample)
WO (1) WO2014120789A1 (enExample)

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Publication number Priority date Publication date Assignee Title
JP5702288B2 (ja) 2008-09-18 2015-04-15 ノースウエスタン ユニバーシティ Ｎｍｄａレセプターモジュレータ及びその用途
CA2898863A1 (en) 2013-01-29 2014-08-07 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
AU2014212501A1 (en) 2013-01-29 2015-07-30 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CA2899010A1 (en) 2013-01-29 2014-08-07 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
LT2951183T (lt) 2013-01-29 2019-05-27 Aptinyx Inc. Spiro-laktamo nmda receptorių moduliatoriai ir jų panaudojimas
MX375286B (es) 2013-01-29 2025-03-06 Aptinyx Inc Moduladores de receptores nmda de espiro-lactama y sus usos.
JP6823083B2 (ja) * 2016-05-19 2021-01-27 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
PE20190504A1 (es) 2016-08-01 2019-04-10 Aptinyx Inc Moduladores del receptor nmda espiro-lactam y uso de los mismos
MX385336B (es) 2016-08-01 2025-03-18 Aptinyx Inc Moduladores del receptor nmda espiro-lactam y uso de los mismos.
AU2017306158B2 (en) * 2016-08-01 2021-10-14 Aptinyx Inc. Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
EA201990424A1 (ru) * 2016-08-01 2019-08-30 Аптиникс Инк. Спиролактамовые модуляторы nmda-рецептора и их применение
ES2974090T3 (es) 2016-08-01 2024-06-25 Tenacia Biotechnology Hong Kong Co Ltd Moduladores de NMDA de espirolactama y métodos de uso de los mismos
JP7210599B2 (ja) * 2018-01-31 2023-01-23 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用
WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
AU2019215049A1 (en) * 2018-01-31 2020-09-17 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CN109485598A (zh) * 2018-11-29 2019-03-19 河南师范大学 一种去除氨基上喹啉保护基的新方法
ES2991258T3 (es) * 2019-06-24 2024-12-03 Naurex Inc Procedimientos y productos intermedios para producir compuestos de diazaespiro-lactama
JP2022543772A (ja) * 2019-08-01 2022-10-14 アプティニックス インコーポレイテッド Ｎｍｄａ受容体と相互作用する抗体のレベル上昇に関連する障害を治療する方法
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

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Also Published As

Publication number Publication date
US9738650B2 (en) 2017-08-22
BR112015018095A2 (pt) 2017-07-18
SG11201505937SA (en) 2015-09-29
MX2015009778A (es) 2016-02-09
IL240165A0 (en) 2015-09-24
AU2014212490A1 (en) 2015-07-30
EP2951186B1 (en) 2018-07-25
EA201591404A1 (ru) 2016-01-29
US20180155354A1 (en) 2018-06-07
US20150376195A1 (en) 2015-12-31
KR20150110586A (ko) 2015-10-02
PH12015501600A1 (en) 2015-10-19
US10253032B2 (en) 2019-04-09
EP2951186A1 (en) 2015-12-09
JP2016506961A (ja) 2016-03-07
WO2014120789A1 (en) 2014-08-07
CL2015002124A1 (es) 2015-12-04
CN105026401A (zh) 2015-11-04
CA2899010A1 (en) 2014-08-07

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