JP2016506961A - スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 - Google Patents
スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 Download PDFInfo
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- JP2016506961A JP2016506961A JP2015556102A JP2015556102A JP2016506961A JP 2016506961 A JP2016506961 A JP 2016506961A JP 2015556102 A JP2015556102 A JP 2015556102A JP 2015556102 A JP2015556102 A JP 2015556102A JP 2016506961 A JP2016506961 A JP 2016506961A
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Nitrogen Condensed Heterocyclic Rings (AREA)
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| JP2019516735A (ja) * | 2016-05-19 | 2019-06-20 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
| JP2021512098A (ja) * | 2018-01-31 | 2021-05-13 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用 |
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| CN105308049A (zh) | 2013-01-29 | 2016-02-03 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| SG11201505937SA (en) | 2013-01-29 | 2015-09-29 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| WO2014120784A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| JP6419087B2 (ja) | 2013-01-29 | 2018-11-07 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
| CA2898861C (en) | 2013-01-29 | 2021-07-20 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| JP2019527235A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用 |
| PE20190501A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores nmda espiro-lactam y metodos de uso de los mismos |
| CN109890825B (zh) | 2016-08-01 | 2022-03-11 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| EP3490992B1 (en) * | 2016-08-01 | 2023-03-22 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| CA3031534C (en) | 2016-08-01 | 2023-10-17 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| JP2021512109A (ja) * | 2018-01-31 | 2021-05-13 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用 |
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| CN109485598A (zh) * | 2018-11-29 | 2019-03-19 | 河南师范大学 | 一种去除氨基上喹啉保护基的新方法 |
| TWI887245B (zh) * | 2019-06-24 | 2025-06-21 | 美商諾雷克斯股份有限公司 | 用於產生二氮雜螺內醯胺化合物之方法及中間物 |
| AU2020323543A1 (en) * | 2019-08-01 | 2022-02-24 | Aptinyx Inc. | Methods of treating disorders associated with elevated levels of antibodies that interact with the NMDA receptor |
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2014
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- 2014-01-29 KR KR1020157021534A patent/KR20150110586A/ko not_active Withdrawn
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- 2014-01-29 CA CA2899010A patent/CA2899010A1/en not_active Abandoned
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- 2014-01-29 MX MX2015009778A patent/MX2015009778A/es unknown
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- 2014-01-29 US US14/764,419 patent/US9738650B2/en not_active Expired - Fee Related
- 2014-01-29 EA EA201591404A patent/EA201591404A1/ru unknown
- 2014-01-29 JP JP2015556102A patent/JP2016506961A/ja not_active Withdrawn
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019516735A (ja) * | 2016-05-19 | 2019-06-20 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
| JP2021512098A (ja) * | 2018-01-31 | 2021-05-13 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用 |
| JP7210599B2 (ja) | 2018-01-31 | 2023-01-23 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用 |
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| Publication number | Publication date |
|---|---|
| CN105026401A (zh) | 2015-11-04 |
| WO2014120789A1 (en) | 2014-08-07 |
| CA2899010A1 (en) | 2014-08-07 |
| CL2015002124A1 (es) | 2015-12-04 |
| SG11201505937SA (en) | 2015-09-29 |
| US9738650B2 (en) | 2017-08-22 |
| KR20150110586A (ko) | 2015-10-02 |
| AU2014212490A1 (en) | 2015-07-30 |
| EA201591404A1 (ru) | 2016-01-29 |
| EP2951186A1 (en) | 2015-12-09 |
| BR112015018095A2 (pt) | 2017-07-18 |
| EP2951186B1 (en) | 2018-07-25 |
| PH12015501600A1 (en) | 2015-10-19 |
| US20150376195A1 (en) | 2015-12-31 |
| IL240165A0 (en) | 2015-09-24 |
| US10253032B2 (en) | 2019-04-09 |
| PE20151438A1 (es) | 2015-10-10 |
| MX2015009778A (es) | 2016-02-09 |
| US20180155354A1 (en) | 2018-06-07 |
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