CL2015002124A1 - Moduladores de receptores nmda de espiro-lactama y sus usos - Google Patents

Moduladores de receptores nmda de espiro-lactama y sus usos

Info

Publication number
CL2015002124A1
CL2015002124A1 CL2015002124A CL2015002124A CL2015002124A1 CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1 CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1
Authority
CL
Chile
Prior art keywords
modulators
nmda receptors
spiro
lactam nmda
lactam
Prior art date
Application number
CL2015002124A
Other languages
English (en)
Spanish (es)
Inventor
M Amin Khan
John A Lowe Iii
Original Assignee
Aptinyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50097881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015002124(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aptinyx Inc filed Critical Aptinyx Inc
Publication of CL2015002124A1 publication Critical patent/CL2015002124A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
CL2015002124A 2013-01-29 2015-07-29 Moduladores de receptores nmda de espiro-lactama y sus usos CL2015002124A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361757939P 2013-01-29 2013-01-29

Publications (1)

Publication Number Publication Date
CL2015002124A1 true CL2015002124A1 (es) 2015-12-04

Family

ID=50097881

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002124A CL2015002124A1 (es) 2013-01-29 2015-07-29 Moduladores de receptores nmda de espiro-lactama y sus usos

Country Status (16)

Country Link
US (2) US9738650B2 (enExample)
EP (1) EP2951186B1 (enExample)
JP (1) JP2016506961A (enExample)
KR (1) KR20150110586A (enExample)
CN (1) CN105026401A (enExample)
AU (1) AU2014212490A1 (enExample)
BR (1) BR112015018095A2 (enExample)
CA (1) CA2899010A1 (enExample)
CL (1) CL2015002124A1 (enExample)
EA (1) EA201591404A1 (enExample)
IL (1) IL240165A0 (enExample)
MX (1) MX2015009778A (enExample)
PE (1) PE20151438A1 (enExample)
PH (1) PH12015501600A1 (enExample)
SG (1) SG11201505937SA (enExample)
WO (1) WO2014120789A1 (enExample)

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CA2740628C (en) 2008-09-18 2018-05-01 Naurex, Inc. Nmda receptor modulators and uses thereof
EA031905B1 (ru) 2013-01-29 2019-03-29 Аптиникс Инк. Спиролактамные модуляторы рецептора nmda и их применение
EP3514158B1 (en) 2013-01-29 2022-10-12 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
CA2899010A1 (en) 2013-01-29 2014-08-07 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
US9708335B2 (en) 2013-01-29 2017-07-18 Apytinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CA2898774C (en) 2013-01-29 2021-07-13 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
MX378566B (es) * 2016-05-19 2025-03-11 Aptinyx Inc Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos.
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
KR102462288B1 (ko) * 2016-08-01 2022-11-01 앱티닉스 인크. 스피로-락탐 및 비스-스피로-락탐 nmda 수용체 조정제 및 그의 용도
JP2019527233A (ja) * 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用
EP3490974B1 (en) 2016-08-01 2023-12-06 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam nmda receptor modulators and uses thereof
EP3490990B1 (en) 2016-08-01 2023-12-06 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam nmda modulators and methods of using same
JP7032378B2 (ja) 2016-08-01 2022-03-08 アプティニックス インコーポレイテッド スピロ－ラクタムｎｍｄａ受容体修飾因子及びその使用
AU2019215058A1 (en) * 2018-01-31 2020-09-17 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
CN112218866A (zh) * 2018-01-31 2021-01-12 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
CN109485598A (zh) * 2018-11-29 2019-03-19 河南师范大学 一种去除氨基上喹啉保护基的新方法
CN114269338B (zh) * 2019-06-24 2025-02-18 诺雷克斯股份有限公司 生产二氮杂螺内酰胺化合物的方法和中间体
AU2020323543A1 (en) * 2019-08-01 2022-02-24 Aptinyx Inc. Methods of treating disorders associated with elevated levels of antibodies that interact with the NMDA receptor
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

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Also Published As

Publication number Publication date
CN105026401A (zh) 2015-11-04
EP2951186B1 (en) 2018-07-25
AU2014212490A1 (en) 2015-07-30
BR112015018095A2 (pt) 2017-07-18
JP2016506961A (ja) 2016-03-07
PH12015501600A1 (en) 2015-10-19
EP2951186A1 (en) 2015-12-09
KR20150110586A (ko) 2015-10-02
WO2014120789A1 (en) 2014-08-07
EA201591404A1 (ru) 2016-01-29
US20180155354A1 (en) 2018-06-07
SG11201505937SA (en) 2015-09-29
US9738650B2 (en) 2017-08-22
US10253032B2 (en) 2019-04-09
CA2899010A1 (en) 2014-08-07
PE20151438A1 (es) 2015-10-10
IL240165A0 (en) 2015-09-24
US20150376195A1 (en) 2015-12-31
MX2015009778A (es) 2016-02-09

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