CL2015002124A1 - Moduladores de receptores nmda de espiro-lactama y sus usos - Google Patents

Moduladores de receptores nmda de espiro-lactama y sus usos

Info

Publication number
CL2015002124A1
CL2015002124A1 CL2015002124A CL2015002124A CL2015002124A1 CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1 CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1
Authority
CL
Chile
Prior art keywords
modulators
nmda receptors
spiro
lactam nmda
lactam
Prior art date
Application number
CL2015002124A
Other languages
English (en)
Spanish (es)
Inventor
M Amin Khan
John A Lowe Iii
Original Assignee
Aptinyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50097881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015002124(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aptinyx Inc filed Critical Aptinyx Inc
Publication of CL2015002124A1 publication Critical patent/CL2015002124A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
CL2015002124A 2013-01-29 2015-07-29 Moduladores de receptores nmda de espiro-lactama y sus usos CL2015002124A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361757939P 2013-01-29 2013-01-29

Publications (1)

Publication Number Publication Date
CL2015002124A1 true CL2015002124A1 (es) 2015-12-04

Family

ID=50097881

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002124A CL2015002124A1 (es) 2013-01-29 2015-07-29 Moduladores de receptores nmda de espiro-lactama y sus usos

Country Status (16)

Country Link
US (2) US9738650B2 (enExample)
EP (1) EP2951186B1 (enExample)
JP (1) JP2016506961A (enExample)
KR (1) KR20150110586A (enExample)
CN (1) CN105026401A (enExample)
AU (1) AU2014212490A1 (enExample)
BR (1) BR112015018095A2 (enExample)
CA (1) CA2899010A1 (enExample)
CL (1) CL2015002124A1 (enExample)
EA (1) EA201591404A1 (enExample)
IL (1) IL240165A0 (enExample)
MX (1) MX2015009778A (enExample)
PE (1) PE20151438A1 (enExample)
PH (1) PH12015501600A1 (enExample)
SG (1) SG11201505937SA (enExample)
WO (1) WO2014120789A1 (enExample)

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JP6419087B2 (ja) * 2013-01-29 2018-11-07 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
US9828384B2 (en) 2013-01-29 2017-11-28 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
AU2014212490A1 (en) 2013-01-29 2015-07-30 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
KR102280616B1 (ko) 2013-01-29 2021-07-21 앱티닉스 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
JP6823083B2 (ja) 2016-05-19 2021-01-27 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
BR112019001768A2 (pt) 2016-08-01 2019-06-11 Aptinyx Inc moduladores do receptor de spiro-lactamas nmda e usos dos mesmos
SG11201900558RA (en) 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof
EA201990425A1 (ru) * 2016-08-01 2019-08-30 Аптиникс Инк. Спиролактамовые и бис-спиролактамовые модуляторы nmda-рецептора и их применение
KR102465757B1 (ko) * 2016-08-01 2022-11-09 앱티닉스 인크. 스피로-락탐 nmda 수용체 조정제 및 그의 용도
CN109843889B (zh) 2016-08-01 2022-03-15 阿普廷伊克斯股份有限公司 螺-内酰胺nmda调节剂和使用其的方法
PE20210455A1 (es) * 2018-01-31 2021-03-08 Aptinyx Inc Moduladores del receptor nmda espiro-lactama y usos de los mismos
WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
BR112020015666A2 (pt) * 2018-01-31 2021-02-23 Aptinyx Inc. moduladores de espiro-lactamas de receptores nmda e usos dos mesmos
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
CN109485598A (zh) * 2018-11-29 2019-03-19 河南师范大学 一种去除氨基上喹啉保护基的新方法
EP4484431A3 (en) * 2019-06-24 2025-03-26 Naurex Inc. Processes and intermediates for producing diazaspiro lactam compounds
JP2022543772A (ja) * 2019-08-01 2022-10-14 アプティニックス インコーポレイテッド Ｎｍｄａ受容体と相互作用する抗体のレベル上昇に関連する障害を治療する方法
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

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AU2014212490A1 (en) 2013-01-29 2015-07-30 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
KR20150110784A (ko) 2013-01-29 2015-10-02 노렉스, 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
JP6419087B2 (ja) 2013-01-29 2018-11-07 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用

Also Published As

Publication number Publication date
MX2015009778A (es) 2016-02-09
CN105026401A (zh) 2015-11-04
US10253032B2 (en) 2019-04-09
KR20150110586A (ko) 2015-10-02
AU2014212490A1 (en) 2015-07-30
US20180155354A1 (en) 2018-06-07
EP2951186B1 (en) 2018-07-25
US9738650B2 (en) 2017-08-22
JP2016506961A (ja) 2016-03-07
PH12015501600A1 (en) 2015-10-19
US20150376195A1 (en) 2015-12-31
CA2899010A1 (en) 2014-08-07
IL240165A0 (en) 2015-09-24
EP2951186A1 (en) 2015-12-09
BR112015018095A2 (pt) 2017-07-18
SG11201505937SA (en) 2015-09-29
EA201591404A1 (ru) 2016-01-29
PE20151438A1 (es) 2015-10-10
WO2014120789A1 (en) 2014-08-07

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