PE20141199A1 - Depsipeptidos ciclicos como moduladores de calicreina 7 - Google Patents

Depsipeptidos ciclicos como moduladores de calicreina 7

Info

Publication number
PE20141199A1
PE20141199A1 PE2014000462A PE2014000462A PE20141199A1 PE 20141199 A1 PE20141199 A1 PE 20141199A1 PE 2014000462 A PE2014000462 A PE 2014000462A PE 2014000462 A PE2014000462 A PE 2014000462A PE 20141199 A1 PE20141199 A1 PE 20141199A1
Authority
PE
Peru
Prior art keywords
calicrein
modulators
amino acid
side chain
depsipeptides
Prior art date
Application number
PE2014000462A
Other languages
English (en)
Inventor
Philipp Krastel
Brigitta-Maria Liechty
Josef Gottfried Meingassner
Esther Schmitt
Erwin Paul Schreiner
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38805728&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141199(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20141199A1 publication Critical patent/PE20141199A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A DEPSIPEPTIDOS CICLICOS DE FORMULA (I') DONDE X ES H, UN RESIDUO ACILO, ENTRE OTROS; A1 ES GLUTAMINA, ACIDO GLUTAMICO, ENTRE OTROS; R2 ES H O METILO; R3 ES LA CADENA LATERAL DE UN AMINOACIDO NO BASICO; R5 ES LA CADENA LATERAL DEL AMINOACIDO ISOLEUCINA O VALINA; R6 ES LA CADENA LATERAL DE TIROSINA; R7 ES LA CADENA LATERAL DEL AMINOACIDO LEUCINA, ISOLEUCINA O VALINA; Y ES H O METILO. SON COMPUESTOS PREFERIDOS LOS DE FORMULA (II), (III), ENTRE OTROS. DICHOS DEPSIPEPTIDOS PRODUCIDOS POR CHONDROMYCES SON MODULADORES DE LA CALICREINA 7 SIENDO UTILES EN EL TRATAMIENTO DE CANCER, ENFERMEDADES INFLAMATORIAS, HIPERPROLIFERATIVAS
PE2014000462A 2007-08-17 2008-08-15 Depsipeptidos ciclicos como moduladores de calicreina 7 PE20141199A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07114507 2007-08-17

Publications (1)

Publication Number Publication Date
PE20141199A1 true PE20141199A1 (es) 2014-09-24

Family

ID=38805728

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2008001396A PE20091007A1 (es) 2007-08-17 2008-08-15 Depsipeptidos ciclicos como moduladores de calicreina 7
PE2014000462A PE20141199A1 (es) 2007-08-17 2008-08-15 Depsipeptidos ciclicos como moduladores de calicreina 7

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2008001396A PE20091007A1 (es) 2007-08-17 2008-08-15 Depsipeptidos ciclicos como moduladores de calicreina 7

Country Status (30)

Country Link
US (2) US8178650B2 (es)
EP (1) EP2183273B1 (es)
JP (1) JP5520824B2 (es)
KR (2) KR20120123579A (es)
CN (1) CN103298827B (es)
AR (1) AR068343A1 (es)
AU (1) AU2008290567B2 (es)
BR (1) BRPI0815547B8 (es)
CA (1) CA2696570C (es)
CL (1) CL2008002394A1 (es)
CO (1) CO6260099A2 (es)
CR (1) CR11251A (es)
CU (2) CU23943B1 (es)
EA (1) EA017735B1 (es)
EC (1) ECSP109968A (es)
ES (1) ES2632392T3 (es)
GT (1) GT201000037A (es)
MA (1) MA31701B1 (es)
MX (1) MX2010001849A (es)
MY (1) MY151973A (es)
NZ (1) NZ583284A (es)
PE (2) PE20091007A1 (es)
PL (1) PL2183273T3 (es)
PT (1) PT2183273T (es)
SV (1) SV2010003485A (es)
TN (1) TN2010000074A1 (es)
TW (1) TW200922613A (es)
UA (1) UA98658C2 (es)
WO (1) WO2009024527A1 (es)
ZA (1) ZA201000776B (es)

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* Cited by examiner, † Cited by third party
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EP2183270B1 (en) 2007-08-17 2014-12-17 Novartis AG Use of cyclic depsipeptides to inhibit kallikrein 7
PT2183273T (pt) 2007-08-17 2017-05-22 Novartis Ag Depsipéptidos cíclicos
WO2010092109A2 (en) 2009-02-13 2010-08-19 Novartis Ag Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof
AR086168A1 (es) * 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8680054B2 (en) * 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
HUE052990T2 (hu) 2014-01-23 2021-05-28 Sixera Pharma Ab Új kallikrein 7 gátlók
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US20170022254A1 (en) 2014-04-08 2017-01-26 Novartis Ag Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates
KR101729848B1 (ko) 2015-06-30 2017-04-24 영남대학교 산학협력단 신규한 해양 바실러스속 균주, 이로부터 분리한 화합물 및 상기 화합물의 약제학적 용도
CN106518868B (zh) * 2015-11-04 2018-02-23 衡阳师范学院 激肽释放酶7小分子抑制剂及其制备方法、用途
US11643438B2 (en) 2018-07-20 2023-05-09 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use

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DE4421113A1 (de) * 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
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EP2183270B1 (en) * 2007-08-17 2014-12-17 Novartis AG Use of cyclic depsipeptides to inhibit kallikrein 7
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AR086168A1 (es) 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Also Published As

Publication number Publication date
ES2632392T3 (es) 2017-09-12
NZ583284A (en) 2012-04-27
EP2183273B1 (en) 2017-04-05
CO6260099A2 (es) 2011-03-22
US20120196790A1 (en) 2012-08-02
UA98658C2 (uk) 2012-06-11
JP2010536731A (ja) 2010-12-02
CN103298827B (zh) 2017-05-31
US9127044B2 (en) 2015-09-08
KR20120123579A (ko) 2012-11-08
TN2010000074A1 (en) 2011-09-26
CN103298827A (zh) 2013-09-11
PL2183273T3 (pl) 2017-09-29
CA2696570C (en) 2020-12-29
CL2008002394A1 (es) 2009-05-15
TW200922613A (en) 2009-06-01
SV2010003485A (es) 2011-03-23
EA201000329A1 (ru) 2010-08-30
ECSP109968A (es) 2010-03-31
PE20091007A1 (es) 2009-08-14
MA31701B1 (fr) 2010-09-01
EP2183273A1 (en) 2010-05-12
MY151973A (en) 2014-07-31
WO2009024527A1 (en) 2009-02-26
BRPI0815547A2 (pt) 2015-02-10
US8178650B2 (en) 2012-05-15
CA2696570A1 (en) 2009-02-26
AR068343A1 (es) 2009-11-11
BRPI0815547B8 (pt) 2021-05-25
AU2008290567B2 (en) 2011-05-12
BRPI0815547B1 (pt) 2020-09-15
CU20130063A7 (es) 2013-06-28
KR20100044893A (ko) 2010-04-30
CU23943B1 (es) 2013-09-27
PT2183273T (pt) 2017-05-22
GT201000037A (es) 2012-04-30
JP5520824B2 (ja) 2014-06-11
AU2008290567A1 (en) 2009-02-26
CR11251A (es) 2010-03-08
CU20100032A7 (es) 2011-10-05
KR101227231B1 (ko) 2013-01-28
MX2010001849A (es) 2010-03-10
ZA201000776B (en) 2010-10-27
US20090156472A1 (en) 2009-06-18
EA017735B1 (ru) 2013-02-28

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