BRPI0815547B8 - composição farmacêutica compreendendo depsipeptídeos cíclicos, e seus usos - Google Patents

composição farmacêutica compreendendo depsipeptídeos cíclicos, e seus usos

Info

Publication number
BRPI0815547B8
BRPI0815547B8 BRPI0815547A BRPI0815547A BRPI0815547B8 BR PI0815547 B8 BRPI0815547 B8 BR PI0815547B8 BR PI0815547 A BRPI0815547 A BR PI0815547A BR PI0815547 A BRPI0815547 A BR PI0815547A BR PI0815547 B8 BRPI0815547 B8 BR PI0815547B8
Authority
BR
Brazil
Prior art keywords
cyclic depsipeptides
pharmaceutical composition
depsipeptides
cyclic
pharmaceutical
Prior art date
Application number
BRPI0815547A
Other languages
English (en)
Inventor
Liechty Brigitta-Maria
Schmitt Esther
Paul Schreiner Erwin
Gottfried Meingassner Josef
Krastel Philipp
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38805728&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0815547(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0815547A2 publication Critical patent/BRPI0815547A2/pt
Publication of BRPI0815547B1 publication Critical patent/BRPI0815547B1/pt
Publication of BRPI0815547B8 publication Critical patent/BRPI0815547B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

depsipeptídeos cíclicos, seu uso e processo de produção, bem como disposição farmacêutica compreendendo os referidos depsipeptídeos cíclicos. a presente invenção refere-se a depsipeptídeos cíclicos, ou derivados destes, possuindo a estrutura de fórmula (i), e usos destes, por exemplo, como inibidores de calicreína 7 e elastase de neutrófilo humano.
BRPI0815547A 2007-08-17 2008-08-14 composição farmacêutica compreendendo depsipeptídeos cíclicos, e seus usos BRPI0815547B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07114507.2 2007-08-17
EP07114507 2007-08-17
PCT/EP2008/060689 WO2009024527A1 (en) 2007-08-17 2008-08-14 Cyclic depsipeptides

Publications (3)

Publication Number Publication Date
BRPI0815547A2 BRPI0815547A2 (pt) 2015-02-10
BRPI0815547B1 BRPI0815547B1 (pt) 2020-09-15
BRPI0815547B8 true BRPI0815547B8 (pt) 2021-05-25

Family

ID=38805728

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815547A BRPI0815547B8 (pt) 2007-08-17 2008-08-14 composição farmacêutica compreendendo depsipeptídeos cíclicos, e seus usos

Country Status (30)

Country Link
US (2) US8178650B2 (pt)
EP (1) EP2183273B1 (pt)
JP (1) JP5520824B2 (pt)
KR (2) KR20120123579A (pt)
CN (1) CN103298827B (pt)
AR (1) AR068343A1 (pt)
AU (1) AU2008290567B2 (pt)
BR (1) BRPI0815547B8 (pt)
CA (1) CA2696570C (pt)
CL (1) CL2008002394A1 (pt)
CO (1) CO6260099A2 (pt)
CR (1) CR11251A (pt)
CU (2) CU23943B1 (pt)
EA (1) EA017735B1 (pt)
EC (1) ECSP109968A (pt)
ES (1) ES2632392T3 (pt)
GT (1) GT201000037A (pt)
MA (1) MA31701B1 (pt)
MX (1) MX2010001849A (pt)
MY (1) MY151973A (pt)
NZ (1) NZ583284A (pt)
PE (2) PE20091007A1 (pt)
PL (1) PL2183273T3 (pt)
PT (1) PT2183273T (pt)
SV (1) SV2010003485A (pt)
TN (1) TN2010000074A1 (pt)
TW (1) TW200922613A (pt)
UA (1) UA98658C2 (pt)
WO (1) WO2009024527A1 (pt)
ZA (1) ZA201000776B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2183273B1 (en) 2007-08-17 2017-04-05 Novartis AG Cyclic depsipeptides
EP2183270B1 (en) 2007-08-17 2014-12-17 Novartis AG Use of cyclic depsipeptides to inhibit kallikrein 7
WO2010092109A2 (en) 2009-02-13 2010-08-19 Novartis Ag Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof
US8680054B2 (en) * 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8614289B2 (en) * 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) * 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) * 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
AU2015209759B2 (en) 2014-01-23 2018-11-29 Sixera Pharma Ab New kallikrein 7 inhibitors
WO2015114144A1 (en) * 2014-02-03 2015-08-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of netherton syndrome
US20170022254A1 (en) 2014-04-08 2017-01-26 Novartis Ag Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates
KR101729848B1 (ko) 2015-06-30 2017-04-24 영남대학교 산학협력단 신규한 해양 바실러스속 균주, 이로부터 분리한 화합물 및 상기 화합물의 약제학적 용도
CN106518880B (zh) * 2015-11-04 2018-10-19 衡阳师范学院 激肽释放酶7小分子抑制剂及其制备方法与用途
WO2020018888A1 (en) 2018-07-20 2020-01-23 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use

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DE3043252C2 (de) 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
DE4421113A1 (de) * 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
DE19828043A1 (de) 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
JP2000154198A (ja) 1998-11-20 2000-06-06 Nisshin Flour Milling Co Ltd 環状デプシペプチドの固相合成方法及びその中間体
GB0108234D0 (en) 2001-04-02 2001-05-23 Pharma Mar Sa Process for producing trunkamide A compounds
US20040110228A1 (en) 2002-04-01 2004-06-10 Mcalpine Shelli R. Combinatorial organic synthesis of unique biologically active compounds
KR101099409B1 (ko) 2003-06-06 2011-12-27 아렉시스 악티에볼라그 피부 상태 또는 암 치료를 위한 ｓｃｃｅ 저해제로서의융합된 헤테로사이클 화합물의 용도
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
WO2005075667A1 (en) * 2004-02-03 2005-08-18 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7)
AU2007220042A1 (en) * 2006-02-27 2007-09-07 Arizona Board Of Regents For And On Behalf Of Arizona State University Identification and use of novopeptides for the treatment of cancer
EP2183273B1 (en) 2007-08-17 2017-04-05 Novartis AG Cyclic depsipeptides
EP2183270B1 (en) * 2007-08-17 2014-12-17 Novartis AG Use of cyclic depsipeptides to inhibit kallikrein 7
US20110112121A1 (en) 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
US20120064013A1 (en) 2010-02-03 2012-03-15 David Marcos Foamable topical composition
KR101004362B1 (ko) 2010-03-19 2010-12-28 가톨릭대학교 산학협력단 자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제
US20120064136A1 (en) 2010-09-10 2012-03-15 Nanobio Corporation Anti-aging and wrinkle treatment methods using nanoemulsion compositions
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
ES2720648T3 (es) 2011-01-24 2019-07-23 Anterios Inc Composiciones de nanopartículas
WO2012103038A2 (en) 2011-01-24 2012-08-02 Anterios, Inc. Nanoparticle compositions, formulations thereof, and uses therefor
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8614289B2 (en) 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Also Published As

Publication number Publication date
TW200922613A (en) 2009-06-01
US8178650B2 (en) 2012-05-15
KR20120123579A (ko) 2012-11-08
KR20100044893A (ko) 2010-04-30
PL2183273T3 (pl) 2017-09-29
AR068343A1 (es) 2009-11-11
SV2010003485A (es) 2011-03-23
MX2010001849A (es) 2010-03-10
WO2009024527A1 (en) 2009-02-26
CN103298827B (zh) 2017-05-31
CO6260099A2 (es) 2011-03-22
AU2008290567A1 (en) 2009-02-26
EP2183273A1 (en) 2010-05-12
CU20130063A7 (es) 2013-06-28
PT2183273T (pt) 2017-05-22
EA017735B1 (ru) 2013-02-28
CA2696570A1 (en) 2009-02-26
MY151973A (en) 2014-07-31
ES2632392T3 (es) 2017-09-12
US20120196790A1 (en) 2012-08-02
JP5520824B2 (ja) 2014-06-11
BRPI0815547A2 (pt) 2015-02-10
PE20091007A1 (es) 2009-08-14
JP2010536731A (ja) 2010-12-02
CR11251A (es) 2010-03-08
CN103298827A (zh) 2013-09-11
EA201000329A1 (ru) 2010-08-30
EP2183273B1 (en) 2017-04-05
ZA201000776B (en) 2010-10-27
US9127044B2 (en) 2015-09-08
BRPI0815547B1 (pt) 2020-09-15
MA31701B1 (fr) 2010-09-01
CU23943B1 (es) 2013-09-27
US20090156472A1 (en) 2009-06-18
PE20141199A1 (es) 2014-09-24
CA2696570C (en) 2020-12-29
UA98658C2 (uk) 2012-06-11
GT201000037A (es) 2012-04-30
TN2010000074A1 (en) 2011-09-26
KR101227231B1 (ko) 2013-01-28
AU2008290567B2 (en) 2011-05-12
ECSP109968A (es) 2010-03-31
CL2008002394A1 (es) 2009-05-15
NZ583284A (en) 2012-04-27
CU20100032A7 (es) 2011-10-05

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
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Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/09/2020, OBSERVADAS AS CONDICOES LEGAIS.

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