PE20130203A1 - Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf) - Google Patents
Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf)Info
- Publication number
- PE20130203A1 PE20130203A1 PE2012001560A PE2012001560A PE20130203A1 PE 20130203 A1 PE20130203 A1 PE 20130203A1 PE 2012001560 A PE2012001560 A PE 2012001560A PE 2012001560 A PE2012001560 A PE 2012001560A PE 20130203 A1 PE20130203 A1 PE 20130203A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- ngf
- growth factor
- concentration
- antibody
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: a) UN ANTICUERPO CONTRA EL FACTOR DE CRECIMIENTO NERVIOSO (NGF) O UN FRAGMENTO DE UNION EN UNA CONCENTRACION DE 1 A 240 mg/ml; b) UN AMORTIGUADOR DE HISTIDINA EN UNA CONCENTRACION DE 5 A 60 mM; c) POLISORBATO 80 EN UNA CONCENTRACION DE 0,01% A 0,1%; CON pH ENTRE 5,0 A 6,0; TAMBIEN PUEDE COMPRENDER POLIOL Y AZUCAR. EL ANTICUERPO O FRAGMENTO DE UNION COMPRENDE UNA REGION VARIABLE DE CADENA PESADA DE SEQ ID Nº 1, CON CDRs 1, 2 Y 3 DE SEQ ID Nº 3, 4 Y 5 RESPECTIVAMENTE Y UNA REGION VARIABLE DE CADENA LIVIANA DE SEQ ID Nº 2, CON CDRs 1, 2 Y 3 DE SEQ ID Nº 6, 7 Y 8 RESPECTIVAMENTE, ADEMAS EL ANTICUERPO O FRAGMENTO COMPRENDE UNA MUTACION EN LA REGION DE BISAGRA EN LA POSICION DEL AMINOACIDO 108 DE LA SEQ ID Nº 9. DICHA COMPOSICION INHIBE LA ACTIVIDAD DEL NGF SIENDO UTIL PARA LA PREVENCION Y/O TRATAMIENTO DE LOS TRASTORNOS DE DOLOR
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31498410P | 2010-03-17 | 2010-03-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20130203A1 true PE20130203A1 (es) | 2013-03-24 |
Family
ID=44114427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2012001560A PE20130203A1 (es) | 2010-03-17 | 2011-03-16 | Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf) |
Country Status (24)
Country | Link |
---|---|
US (1) | US20110256135A1 (es) |
EP (1) | EP2547365A1 (es) |
JP (1) | JP2013522313A (es) |
KR (1) | KR20130031247A (es) |
CN (1) | CN102892430A (es) |
AR (1) | AR080685A1 (es) |
AU (1) | AU2011227335B2 (es) |
BR (1) | BR112012023895A2 (es) |
CA (1) | CA2790699A1 (es) |
CL (1) | CL2012002536A1 (es) |
CO (1) | CO6640289A2 (es) |
CR (1) | CR20120490A (es) |
DO (1) | DOP2012000246A (es) |
EC (1) | ECSP12012211A (es) |
GT (1) | GT201200258A (es) |
MX (1) | MX2012010728A (es) |
NZ (1) | NZ602054A (es) |
PE (1) | PE20130203A1 (es) |
RU (1) | RU2012144017A (es) |
SG (2) | SG10201504808XA (es) |
TW (1) | TW201201835A (es) |
UY (1) | UY33280A (es) |
WO (1) | WO2011116090A1 (es) |
ZA (1) | ZA201206761B (es) |
Families Citing this family (33)
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ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
PL2448970T3 (pl) | 2009-05-04 | 2014-12-31 | Abbvie Res B V | Przeciwciało przeciwko czynnikowi wzrostu nerwów (NGF) ze zwiększoną stabilnością in vivo |
JOP20190250A1 (ar) * | 2010-07-14 | 2017-06-16 | Regeneron Pharma | صيغ مستقرة تحتوي على الأجسام المضادة لمضاد عامل نمو الأعصاب |
AR083035A1 (es) | 2010-09-17 | 2013-01-30 | Baxter Int | ESTABILIZACION DE INMUNOGLOBULINAS MEDIANTE UNA FORMULACION ACUOSA CON HISTIDINA A pH ACIDO DEBIL A NEUTRO, COMPOSICION ACUOSA DE INMUNOGLOBULINA |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
WO2012075340A2 (en) | 2010-12-01 | 2012-06-07 | Alderbio Holdings Llc | Anti-ngf compositions and use thereof |
LT2691112T (lt) | 2011-03-31 | 2018-07-25 | Merck Sharp & Dohme Corp. | Stabilios antikūnų kompozicijos prieš žmogaus programuojamos mirties receptorių pd-1 ir susiję gydymo būdai |
CN104364264B (zh) | 2012-06-06 | 2018-07-24 | 硕腾服务有限责任公司 | 犬源化抗ngf抗体和其方法 |
KR102305226B1 (ko) * | 2013-03-15 | 2021-09-29 | 아비에 도이치란트 게엠베하 운트 콤파니 카게 | 항-egfr 항체 약물 접합체 제형 |
TWI679019B (zh) * | 2013-04-29 | 2019-12-11 | 法商賽諾菲公司 | 抗il-4/抗il-13之雙特異性抗體調配物 |
EP3043775B1 (en) | 2013-09-11 | 2020-11-04 | Eagle Biologics, Inc. | Liquid protein formulations containing viscosity-lowering agents |
CN111402950B (zh) * | 2013-11-29 | 2024-03-19 | 豪夫迈·罗氏有限公司 | 抗体选择装置和方法 |
KR102497368B1 (ko) | 2014-10-01 | 2023-02-10 | 이글 바이올로직스 인코포레이티드 | 점도-저하제를 함유하는 폴리삭카라이드 및 핵산 제형 |
CA3018473A1 (en) | 2016-03-25 | 2017-09-28 | Astellas Pharma Inc. | Pharmaceutical composition comprising pegylated fab' fragment of anti-human ngf antibody |
PT3565844T (pt) * | 2017-01-09 | 2023-05-02 | Tesaro Inc | Métodos de tratamento de cancro com anticorpos anti-pd-1 |
US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
CN114751982B (zh) * | 2017-12-15 | 2023-06-23 | 安源医药科技(上海)有限公司 | 抗人ngf抗体及其制备方法和用途 |
US11472870B2 (en) | 2018-08-10 | 2022-10-18 | Regeneron Pharmaceuticals, Inc. | Pharmaceutical composition for safe and effective treatment of knee and/or hip pain |
IT201800009384A1 (it) | 2018-10-11 | 2020-04-11 | Cosmo Srl | Peptide for cosmetic application |
JP2020063244A (ja) | 2018-10-15 | 2020-04-23 | アヴェント インコーポレイテッド | 神経アブレーションのための組成物、システム、キット及び方法 |
CR20210435A (es) | 2019-02-18 | 2021-09-20 | Lilly Co Eli | Formulación de anticuerpos terapéuticos |
CN113365665A (zh) * | 2019-03-26 | 2021-09-07 | 荣昌生物制药(烟台)股份有限公司 | 抗Her2抗体药物偶联物药物制剂 |
CN111939267A (zh) * | 2019-05-17 | 2020-11-17 | 百奥泰生物制药股份有限公司 | 抗体-药物偶联物制剂、制备方法及应用 |
KR102265434B1 (ko) * | 2019-08-20 | 2021-06-15 | 주식회사 케어젠 | 피부 미백 활성을 갖는 펩타이드 및 이의 용도 |
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PT2270048E (pt) | 2002-12-24 | 2016-02-10 | Rinat Neuroscience Corp | Anticorpos anti-ngf e métodos de utilização dos mesmos |
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-
2011
- 2011-03-16 JP JP2013500181A patent/JP2013522313A/ja active Pending
- 2011-03-16 UY UY0001033280A patent/UY33280A/es not_active Application Discontinuation
- 2011-03-16 SG SG10201504808XA patent/SG10201504808XA/en unknown
- 2011-03-16 AU AU2011227335A patent/AU2011227335B2/en not_active Ceased
- 2011-03-16 US US13/049,473 patent/US20110256135A1/en not_active Abandoned
- 2011-03-16 EP EP11715322A patent/EP2547365A1/en not_active Withdrawn
- 2011-03-16 CA CA2790699A patent/CA2790699A1/en not_active Abandoned
- 2011-03-16 PE PE2012001560A patent/PE20130203A1/es not_active Application Discontinuation
- 2011-03-16 AR ARP110100852A patent/AR080685A1/es unknown
- 2011-03-16 KR KR1020127026996A patent/KR20130031247A/ko not_active Application Discontinuation
- 2011-03-16 NZ NZ602054A patent/NZ602054A/en not_active IP Right Cessation
- 2011-03-16 WO PCT/US2011/028659 patent/WO2011116090A1/en active Application Filing
- 2011-03-16 TW TW100109071A patent/TW201201835A/zh unknown
- 2011-03-16 SG SG2012066866A patent/SG183983A1/en unknown
- 2011-03-16 RU RU2012144017/10A patent/RU2012144017A/ru not_active Application Discontinuation
- 2011-03-16 BR BR112012023895A patent/BR112012023895A2/pt not_active IP Right Cessation
- 2011-03-16 CN CN201180023857XA patent/CN102892430A/zh active Pending
- 2011-03-16 MX MX2012010728A patent/MX2012010728A/es not_active Application Discontinuation
-
2012
- 2012-09-10 ZA ZA2012/06761A patent/ZA201206761B/en unknown
- 2012-09-13 GT GT201200258A patent/GT201200258A/es unknown
- 2012-09-13 CL CL2012002536A patent/CL2012002536A1/es unknown
- 2012-09-13 DO DO2012000246A patent/DOP2012000246A/es unknown
- 2012-09-27 CR CR20120490A patent/CR20120490A/es unknown
- 2012-10-02 EC EC2012012211A patent/ECSP12012211A/es unknown
- 2012-10-05 CO CO12175503A patent/CO6640289A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CO6640289A2 (es) | 2013-03-22 |
CN102892430A (zh) | 2013-01-23 |
CL2012002536A1 (es) | 2012-12-07 |
CA2790699A1 (en) | 2011-09-22 |
UY33280A (es) | 2011-10-31 |
JP2013522313A (ja) | 2013-06-13 |
CR20120490A (es) | 2013-04-09 |
TW201201835A (en) | 2012-01-16 |
NZ602054A (en) | 2014-10-31 |
BR112012023895A2 (pt) | 2016-11-29 |
DOP2012000246A (es) | 2012-11-15 |
ECSP12012211A (es) | 2012-10-30 |
MX2012010728A (es) | 2013-03-05 |
SG183983A1 (en) | 2012-10-30 |
US20110256135A1 (en) | 2011-10-20 |
KR20130031247A (ko) | 2013-03-28 |
AU2011227335B2 (en) | 2014-11-06 |
AR080685A1 (es) | 2012-05-02 |
EP2547365A1 (en) | 2013-01-23 |
GT201200258A (es) | 2014-02-21 |
RU2012144017A (ru) | 2014-04-27 |
SG10201504808XA (en) | 2015-07-30 |
ZA201206761B (en) | 2013-05-29 |
WO2011116090A1 (en) | 2011-09-22 |
AU2011227335A1 (en) | 2012-09-20 |
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