CN113365665A - 抗Her2抗体药物偶联物药物制剂 - Google Patents

抗Her2抗体药物偶联物药物制剂 Download PDF

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CN113365665A
CN113365665A CN202080009504.3A CN202080009504A CN113365665A CN 113365665 A CN113365665 A CN 113365665A CN 202080009504 A CN202080009504 A CN 202080009504A CN 113365665 A CN113365665 A CN 113365665A
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pharmaceutical formulation
antibody
cancer
amino acid
concentration
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李壮林
徐巧玉
姚雪静
鲍倩婧
房健民
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Rongchang Biopharmaceutical Yantai Co Ltd
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Rongchang Biopharmaceutical Yantai Co Ltd
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Abstract

本发明涉及一种包含非还原糖、重组人源化抗Her2单抗‑MMAE偶联物和一种表面活性剂的混合物的药物制剂。所述药物制剂具有减少颗粒物、减少聚集体形成、提高偶联物稳定性、改善冻干粉外观等特性。

Description

PCT国内申请，说明书已公开。

Claims (19)

  1. PCT国内申请，权利要求书已公开。
CN202080009504.3A 2019-03-26 2020-03-25 抗Her2抗体药物偶联物药物制剂 Pending CN113365665A (zh)

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CN201910231203 2019-03-26
CN2019102312034 2019-03-26
PCT/CN2020/081138 WO2020192693A1 (zh) 2019-03-26 2020-03-25 抗Her2抗体药物偶联物药物制剂

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CN113365665A true CN113365665A (zh) 2021-09-07

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US (1) US20210154314A1 (zh)
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AU (2) AU2020239621B2 (zh)
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CN113474360A (zh) 2019-02-18 2021-10-01 伊莱利利公司 治疗性抗体制剂
WO2023000171A1 (zh) * 2021-07-20 2023-01-26 浙江新码生物医药有限公司 一种含有抗her2-药物偶联物的冻干组合物、冻干制剂及其制备方法和用途
EP4353220A1 (en) * 2022-10-12 2024-04-17 Pierre Fabre Medicament Use of a liquid aqueous composition for solubilization and stabilization of an antibody-drug conjugate

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CN107847449A (zh) * 2015-07-10 2018-03-27 斯索恩生物制药有限公司 包含抗体‑倍癌霉素药物缀合物的组合物
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EP3197500A1 (en) * 2014-09-17 2017-08-02 Genentech, Inc. Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines
CN106729743B (zh) * 2015-11-23 2021-09-21 四川科伦博泰生物医药股份有限公司 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用
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CN102892430A (zh) * 2010-03-17 2013-01-23 雅培研究有限公司 抗神经生长因子（ngf）抗体组合物
CN105163763A (zh) * 2013-03-15 2015-12-16 阿布维德国有限责任两合公司 抗egfr抗体药物偶联物制剂
WO2015074528A1 (zh) * 2013-11-19 2015-05-28 烟台荣昌生物工程有限公司 抗her2抗体及其缀合物
CN107847449A (zh) * 2015-07-10 2018-03-27 斯索恩生物制药有限公司 包含抗体‑倍癌霉素药物缀合物的组合物
WO2019039483A1 (ja) * 2017-08-23 2019-02-28 第一三共株式会社 抗体－薬物コンジュゲートの製剤及びその凍結乾燥方法

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JP7264986B2 (ja) 2023-04-25
EP4316521A3 (en) 2024-04-10
SG11202104269PA (en) 2021-05-28
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PT3811979T (pt) 2024-01-02
AU2020239621A1 (en) 2020-10-22
BR112021002290A2 (pt) 2021-05-04
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AU2023282237A1 (en) 2024-01-18
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