PE20091967A1 - Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras - Google Patents

Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras

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Publication number
PE20091967A1
PE20091967A1 PE2009000635A PE2009000635A PE20091967A1 PE 20091967 A1 PE20091967 A1 PE 20091967A1 PE 2009000635 A PE2009000635 A PE 2009000635A PE 2009000635 A PE2009000635 A PE 2009000635A PE 20091967 A1 PE20091967 A1 PE 20091967A1
Authority
PE
Peru
Prior art keywords
hil
regulatory
prevention
cells
treatment
Prior art date
Application number
PE2009000635A
Other languages
English (en)
Inventor
Daniela Paulsen
Nina Brunner
Dorothy Bray
Original Assignee
Aicuris Gmbh And Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41152787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091967(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Gmbh And Co Kg filed Critical Aicuris Gmbh And Co Kg
Publication of PE20091967A1 publication Critical patent/PE20091967A1/es

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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
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  • Rheumatology (AREA)

Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE; A) UNA MUTEINA DE INTERLEUQUINA-2 HUMANA (MUTEINA DE hIL-2) QUE PRESENTA UNA SUSTITUCION DE AMINOACIDO CONSERVATIVA EN AL MENOS UNA DE LAS POSICIONES 20, 88 O 126, DONDE: EN POSICION 20 SE INTERCAMBIA UN ACIDO ASPARTICO POR UNA HISTIDINA (hIL-2-D2OH), O ISOLEUCINA (hIL-2-D2OH) O TIROSINA (hIL-2-D2OY), EN POSICION 88 SE INTERCAMBIA UNA ASPARAGINA POR UNA ARGININA (hIL-2-N88R), O UNA GLICINA (hIL-2-N88G) O ISOLEUCINA (hIL-2-N88I), Y EN POSICION 126 SE INTERCAMBIA UNA GLUTAMINA POR UNA LEUCINA (hIL-2-Q126L); B) UN INMUNOSUPRESOR SELECCIONADO DE DECORTINA, PREDNISOL, AZATIOPRINA, ENTRE OTROS. DICHA MUTEINA SE PONE EN CONTACTO CON GLOBULOS ROJOS MONONUCLEARES PERIFERICOS PARA OBTENER UNA POBLACION DE CELULAS T REGULADORAS EN UN SER VIVO, SIENDO UTIL PARA EL TRATAMIENTO Y/O PREVENCION DE ENFERMEDADES AUTOINMUNES
PE2009000635A 2008-05-08 2009-05-07 Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras PE20091967A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102008023820A DE102008023820A1 (de) 2008-05-08 2008-05-08 Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen

Publications (1)

Publication Number Publication Date
PE20091967A1 true PE20091967A1 (es) 2010-02-05

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ID=41152787

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000635A PE20091967A1 (es) 2008-05-08 2009-05-07 Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras

Country Status (28)

Country Link
US (4) US20110150826A1 (es)
EP (1) EP2288372B1 (es)
JP (2) JP5651583B2 (es)
KR (3) KR101554056B1 (es)
CN (2) CN102088996A (es)
AR (1) AR071756A1 (es)
AT (1) ATE544465T1 (es)
AU (1) AU2009244039B2 (es)
BR (1) BRPI0912411B8 (es)
CA (1) CA2723761C (es)
CL (1) CL2009001099A1 (es)
CY (1) CY1112469T1 (es)
DE (1) DE102008023820A1 (es)
DK (1) DK2288372T3 (es)
ES (1) ES2378957T3 (es)
HR (1) HRP20120296T1 (es)
IL (3) IL209128A (es)
MX (1) MX2010012214A (es)
PE (1) PE20091967A1 (es)
PL (1) PL2288372T3 (es)
PT (1) PT2288372E (es)
RU (1) RU2531936C2 (es)
SI (1) SI2288372T1 (es)
TW (1) TWI510622B (es)
UA (1) UA102099C2 (es)
UY (1) UY31816A (es)
WO (1) WO2009135615A2 (es)
ZA (1) ZA201008129B (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008023820A1 (de) 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
MX2011007647A (es) 2009-01-21 2011-09-01 Amgen Inc Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes.
US11090363B2 (en) 2009-07-10 2021-08-17 University of Pittsburgh—of the Commonwealth System of Higher Education Vasoactive intestinal peptide release from microparticles
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