PE20090485A1 - Proceso para la preparacion de 17-(3-hidroxipropil)-17-hidroxiesteroides - Google Patents

Proceso para la preparacion de 17-(3-hidroxipropil)-17-hidroxiesteroides

Info

Publication number
PE20090485A1
PE20090485A1 PE2008001102A PE2008001102A PE20090485A1 PE 20090485 A1 PE20090485 A1 PE 20090485A1 PE 2008001102 A PE2008001102 A PE 2008001102A PE 2008001102 A PE2008001102 A PE 2008001102A PE 20090485 A1 PE20090485 A1 PE 20090485A1
Authority
PE
Peru
Prior art keywords
alkyl
double link
hydroxyesteroids
formula
alcoxyl
Prior art date
Application number
PE2008001102A
Other languages
English (en)
Inventor
Claus-Christian Haeselhoff
Mike Petersen
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40029248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090485(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PE20090485A1 publication Critical patent/PE20090485A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR 17 ALFA-(3-HIDROXI-PROPIL)-17BETA-HIDROXIESTEROIDES DE FORMULA I, QUE COMPRENDE: A) CONVERTIR 17-CETOESTEROIDES DE FORMULA III, EN PRESENCIA DE UNA BASE CON UN PROP-1-IN-3-OLEOESTER DE FORMULA IV, DONDE R3 ES H O VI; R30, R31 Y R32 SON CADA UNO H, ALQUILO C1-C4, ALCOXILO C1-C4; R5 ES H, OH, JUNTO A R6 ES ENLACE DOBLE; R6 ES H, JUNTO CON R5 O R7 ES ENLACE DOBLE O JUNTO CON R7 ES -CH2; R7 ES H, ALQUILO C1-C4, ALCOXICARBONILO C1-C4, ENTRE OTROS; R10 ES H, METILO, ETILO; R13 ES METILO, ETILO; R15 ES H, ALQUILO C1-C4, ENTRE OTROS; R16 ES H, JUNTO CON R15 ES -CH2 O ENLACE DOBLE; R40, R41 Y R42 SON CADA UNO H, ALQUILO C1-C4, ALCOXILO C1-C4; B) EFECTUAR LA HIDROGENACION CATALITICA COMPLETA DE LA FUNCION ALQUINO DEL COMPUESTO FORMADO EN (A); C) ELIMINAR LOS GRUPOS PROTECTORES BENCILICOS. POR DICHO PROCEDIMIENTO SE OBTIENE DROSPIRENONA CON UN RENDIMIENTO Y GRADO DE PUREZA ELEVADOS
PE2008001102A 2007-06-28 2008-06-27 Proceso para la preparacion de 17-(3-hidroxipropil)-17-hidroxiesteroides PE20090485A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007030596A DE102007030596B3 (de) 2007-06-28 2007-06-28 Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden

Publications (1)

Publication Number Publication Date
PE20090485A1 true PE20090485A1 (es) 2009-05-24

Family

ID=40029248

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001102A PE20090485A1 (es) 2007-06-28 2008-06-27 Proceso para la preparacion de 17-(3-hidroxipropil)-17-hidroxiesteroides

Country Status (26)

Country Link
US (2) US8853431B2 (es)
EP (1) EP2170926B1 (es)
JP (2) JP5643087B2 (es)
KR (1) KR101547365B1 (es)
CN (1) CN101743248B (es)
AR (1) AR067194A1 (es)
AU (1) AU2008267145B2 (es)
BR (1) BRPI0813214A2 (es)
CA (1) CA2690177C (es)
CL (1) CL2008001908A1 (es)
DE (1) DE102007030596B3 (es)
DK (1) DK2170926T3 (es)
ES (1) ES2514516T3 (es)
HK (1) HK1144822A1 (es)
HR (1) HRP20140938T1 (es)
IL (1) IL202205A (es)
PA (1) PA8786201A1 (es)
PE (1) PE20090485A1 (es)
PL (1) PL2170926T3 (es)
PT (1) PT2170926E (es)
RU (1) RU2466137C2 (es)
SI (1) SI2170926T1 (es)
TW (1) TWI437006B (es)
UY (1) UY31188A1 (es)
WO (1) WO2009000923A2 (es)
ZA (1) ZA201000636B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007030596B3 (de) 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
CN105566032B (zh) * 2014-10-09 2017-12-22 中国石油化工股份有限公司 富炔碳四的选择加氢工艺

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3113953A (en) * 1958-11-28 1963-12-10 Sterling Drug Inc Esters of 17alpha-(3-hydroxy-1-propinyl) androst-5-ene-3beta, 17beta-diol and their preparation
FR2429056A1 (fr) * 1978-06-19 1980-01-18 Tournus Manuf Metallurg Procede de fabrication de bandes composites par coulee continue
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
DE3265852D1 (en) * 1981-09-21 1985-10-03 Schering Ag 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
US5106995A (en) * 1989-05-05 1992-04-21 Isp Investments Inc. Production of lactones from diols
US5693280A (en) 1996-07-31 1997-12-02 Owens-Corning Fiberglas Technology, Inc. Method of producing organic fibers from a rotary process
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
WO2001058919A2 (en) * 2000-02-11 2001-08-16 Sri International Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
ES2663399T3 (es) * 2005-07-21 2018-04-12 Bayer Intellectual Property Gmbh Procedimiento de producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación libre de metal de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos
US7319154B2 (en) * 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
CN100480256C (zh) * 2006-06-21 2009-04-22 上海迪赛诺医药发展有限公司 合成曲螺酮的方法
DE102007030596B3 (de) 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
ES2419663T3 (es) * 2010-08-03 2013-08-21 Newchem S.P.A. Métodos para la preparación de Drospirenona y productos intermedios de la misma

Also Published As

Publication number Publication date
EP2170926B1 (en) 2014-07-23
TW200918548A (en) 2009-05-01
US20150005488A1 (en) 2015-01-01
HRP20140938T1 (hr) 2014-12-05
RU2466137C2 (ru) 2012-11-10
CN101743248A (zh) 2010-06-16
EP2170926A2 (en) 2010-04-07
US20090012286A1 (en) 2009-01-08
US8853431B2 (en) 2014-10-07
CA2690177C (en) 2015-09-15
JP5643087B2 (ja) 2014-12-17
ZA201000636B (en) 2015-06-24
PA8786201A1 (es) 2009-01-23
AR067194A1 (es) 2009-09-30
JP2010531337A (ja) 2010-09-24
IL202205A (en) 2015-06-30
CA2690177A1 (en) 2008-12-31
CL2008001908A1 (es) 2009-01-02
KR101547365B1 (ko) 2015-08-25
WO2009000923A2 (en) 2008-12-31
AU2008267145A1 (en) 2008-12-31
TWI437006B (zh) 2014-05-11
BRPI0813214A2 (pt) 2014-12-23
SI2170926T1 (sl) 2014-11-28
HK1144822A1 (es) 2011-03-11
JP2014198724A (ja) 2014-10-23
AU2008267145B2 (en) 2013-10-24
CN101743248B (zh) 2013-01-02
DK2170926T3 (da) 2014-10-13
KR20100027158A (ko) 2010-03-10
RU2010102134A (ru) 2011-08-10
WO2009000923A3 (en) 2009-04-23
PT2170926E (pt) 2014-10-13
UY31188A1 (es) 2009-01-30
JP5898731B2 (ja) 2016-04-06
IL202205A0 (en) 2010-06-16
PL2170926T3 (pl) 2014-12-31
DE102007030596B3 (de) 2009-03-12
ES2514516T3 (es) 2014-10-28

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Legal Events

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