CO6420347A2 - Derivados de imidazotiazol que tienen estructura de anillo de prolina - Google Patents

Derivados de imidazotiazol que tienen estructura de anillo de prolina

Info

Publication number
CO6420347A2
CO6420347A2 CO11102791A CO11102791A CO6420347A2 CO 6420347 A2 CO6420347 A2 CO 6420347A2 CO 11102791 A CO11102791 A CO 11102791A CO 11102791 A CO11102791 A CO 11102791A CO 6420347 A2 CO6420347 A2 CO 6420347A2
Authority
CO
Colombia
Prior art keywords
protein
imidazotiazol
prolina
derivatives
ring structure
Prior art date
Application number
CO11102791A
Other languages
English (en)
Inventor
Kouichi Uoto
Yuuichi Sugimoto
Masashi Aonuma
Keisuke Yoshida
Masaki Miyazaki
Hiroyuki Naito
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CO6420347A2 publication Critical patent/CO6420347A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se proporciona un compuesto novedoso que inhibe la interacción entre la proteína doble minuto rnurino 2 (Mdm2) y la proteína p53 y exhibe actividad anti-tumoral; la presente invención provee un derivado de imidazotiazol representado por la siguiente fórmula (1) que tiene varios sustituyentes que inhiben la interacción entre la proteína Mdm2 y la proteína p53 y exhibe actividad anti-tumoral:en donde R1, R2, R3, R4, R5, R6, R7, Ar1, y Ar2 en la fórmula (1) respectivamente tienen los mismos significados como se definen en la especificación.
CO11102791A 2009-01-16 2011-08-12 Derivados de imidazotiazol que tienen estructura de anillo de prolina CO6420347A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009007536 2009-01-16

Publications (1)

Publication Number Publication Date
CO6420347A2 true CO6420347A2 (es) 2012-04-16

Family

ID=42339866

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11102791A CO6420347A2 (es) 2009-01-16 2011-08-12 Derivados de imidazotiazol que tienen estructura de anillo de prolina

Country Status (24)

Country Link
US (2) US8404691B2 (es)
EP (1) EP2380892B1 (es)
JP (1) JP5520236B2 (es)
KR (1) KR20110119641A (es)
CN (1) CN102356085A (es)
AU (1) AU2010205201A1 (es)
BR (1) BRPI1007334A2 (es)
CA (1) CA2750009A1 (es)
CO (1) CO6420347A2 (es)
CY (1) CY1115234T1 (es)
DK (1) DK2380892T3 (es)
ES (1) ES2463820T3 (es)
HR (1) HRP20140409T1 (es)
IL (1) IL214117A0 (es)
MX (1) MX2011007598A (es)
PL (1) PL2380892T3 (es)
PT (1) PT2380892E (es)
RU (1) RU2011134283A (es)
SG (1) SG173028A1 (es)
SI (1) SI2380892T1 (es)
SM (1) SMT201400082B (es)
TW (1) TW201030011A (es)
WO (1) WO2010082612A1 (es)
ZA (1) ZA201105132B (es)

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JPWO2009151069A1 (ja) * 2008-06-12 2011-11-17 第一三共株式会社 ４，７−ジアザスピロ［２．５］オクタン環構造を有するイミダゾチアゾール誘導体
WO2012121361A1 (ja) 2011-03-10 2012-09-13 第一三共株式会社 ジスピロピロリジン誘導体
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
JP2017532959A (ja) * 2014-10-09 2017-11-09 第一三共株式会社 Ｍｄｍ２阻害剤に対する感受性の遺伝子シグネチャーに基づく予測因子に関するアルゴリズム
EP3458101B1 (en) 2016-05-20 2020-12-30 H. Hoffnabb-La Roche Ag Protac antibody conjugates and methods of use
EP3360865A1 (en) 2017-02-13 2018-08-15 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of cyclopropyldiketopiperazines, and of a key intermediate of ds-5272
CN111943894A (zh) * 2019-05-17 2020-11-17 南京爱德程医药科技有限公司 一种4,7-二氮杂螺[2.5]辛烷类化合物的合成方法
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

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US6740495B1 (en) 2000-04-03 2004-05-25 Rigel Pharmaceuticals, Inc. Ubiquitin ligase assay
US6979551B2 (en) 2000-04-03 2005-12-27 Rigel Pharmaceuticals, Inc. Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
CN100486969C (zh) 2001-12-18 2009-05-13 霍夫曼-拉罗奇有限公司 顺式-2,4,5-三苯基-咪唑啉及其在肿瘤治疗中的应用
CA2468783A1 (en) 2001-12-18 2003-06-26 F. Hoffmann-La Roche Ag Cis-imidazolines as mdm2 inhibitors
CN100465163C (zh) 2003-06-17 2009-03-04 霍夫曼-拉罗奇有限公司 顺式-2,4,5-三芳基-咪唑啉类化合物
US7132421B2 (en) 2003-06-17 2006-11-07 Hoffmann-La Roche Inc. CIS-imidazoles
AU2004253245B2 (en) 2003-06-17 2010-02-11 F. Hoffmann-La Roche Ag CIS-imidazolines as MDM2 inhibitors
US7425638B2 (en) 2003-06-17 2008-09-16 Hoffmann-La Roche Inc. Cis-imidazolines
GB0324498D0 (en) 2003-07-21 2003-11-26 Aventis Pharma Inc Heterocyclic compounds as P2X7 ion channel blockers
JP2005075754A (ja) 2003-08-29 2005-03-24 Mitsui Chemicals Inc トランス−１，２−ビス（３，５−ジメチルフェニル）−１，２−エタンジアミンの光学分割方法
KR100832277B1 (ko) 2004-05-18 2008-05-26 에프. 호프만-라 로슈 아게 신규 ｃｉｓ-이미다졸린
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WO2007063013A1 (en) 2005-12-01 2007-06-07 F. Hoffmann-La Roche Ag 2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between p53 and mdm2 proteins for use as anticancer agents
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Also Published As

Publication number Publication date
SMT201400082B (it) 2014-09-08
DK2380892T3 (da) 2014-06-30
RU2011134283A (ru) 2013-02-27
KR20110119641A (ko) 2011-11-02
CN102356085A (zh) 2012-02-15
EP2380892B1 (en) 2014-04-02
CY1115234T1 (el) 2017-01-04
PT2380892E (pt) 2014-06-09
WO2010082612A1 (ja) 2010-07-22
IL214117A0 (en) 2011-08-31
SG173028A1 (en) 2011-08-29
US8404691B2 (en) 2013-03-26
US20110301176A1 (en) 2011-12-08
JPWO2010082612A1 (ja) 2012-07-05
HRP20140409T1 (hr) 2014-06-06
AU2010205201A1 (en) 2011-08-04
EP2380892A4 (en) 2012-08-29
MX2011007598A (es) 2011-08-08
CA2750009A1 (en) 2010-07-22
US20130172362A1 (en) 2013-07-04
JP5520236B2 (ja) 2014-06-11
BRPI1007334A2 (pt) 2016-02-10
SI2380892T1 (sl) 2014-05-30
TW201030011A (en) 2010-08-16
ZA201105132B (en) 2012-03-28
EP2380892A1 (en) 2011-10-26
ES2463820T3 (es) 2014-05-29
PL2380892T3 (pl) 2014-08-29

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