ECSP088375A - Alquil sulfóxido quinolinas como ligandos del receptor nk-3 - Google Patents
Alquil sulfóxido quinolinas como ligandos del receptor nk-3Info
- Publication number
- ECSP088375A ECSP088375A EC2008008375A ECSP088375A ECSP088375A EC SP088375 A ECSP088375 A EC SP088375A EC 2008008375 A EC2008008375 A EC 2008008375A EC SP088375 A ECSP088375 A EC SP088375A EC SP088375 A ECSP088375 A EC SP088375A
- Authority
- EC
- Ecuador
- Prior art keywords
- sulfóxido
- quinolinas
- legandos
- rent
- del receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Compuestos de la Fórmula (I), en donde R1, A, R2, R3, R4, R5, n, m y q son tal como se indica en la descripción, sales farmacéuticamente aceptables, métodos para su preparación, composiciones farmacéuticas que los contienen y métodos para utilizarlos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71928605P | 2005-09-21 | 2005-09-21 | |
US71927505P | 2005-09-21 | 2005-09-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP088375A true ECSP088375A (es) | 2008-05-30 |
Family
ID=37889114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008008375A ECSP088375A (es) | 2005-09-21 | 2008-04-16 | Alquil sulfóxido quinolinas como ligandos del receptor nk-3 |
Country Status (17)
Country | Link |
---|---|
US (1) | US7964733B2 (es) |
EP (1) | EP1928835B1 (es) |
JP (1) | JP2009508946A (es) |
KR (1) | KR20080046669A (es) |
AR (1) | AR057130A1 (es) |
AT (1) | ATE506350T1 (es) |
AU (1) | AU2006292849A1 (es) |
BR (1) | BRPI0616136A2 (es) |
CA (1) | CA2621062A1 (es) |
DE (1) | DE602006021440D1 (es) |
EC (1) | ECSP088375A (es) |
IL (1) | IL189857A0 (es) |
NO (1) | NO20081862L (es) |
RU (1) | RU2008110914A (es) |
TW (1) | TW200800902A (es) |
UY (1) | UY29805A1 (es) |
WO (1) | WO2007035158A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1940795A1 (en) * | 2005-09-21 | 2008-07-09 | AstraZeneca AB | N-oxo-heterocycle and n-oxo-alkyl quinoline-4-carboxamides as nk-3 receptor ligands |
KR20090122253A (ko) * | 2007-03-19 | 2009-11-26 | 아스트라제네카 아베 | 퀴놀린 유도체, 이를 포함하는 제약 조성물, 및 중추신경계 및 말초 질환의 치료에서의 이의 용도 |
DK2139882T3 (en) * | 2007-03-23 | 2014-03-10 | Amgen Inc | 3-substituted quinoline or quinoxaline derivatives and their use as inhibitors of phosphatidylinositol 3-kinase (PI3K) |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU699319B2 (en) | 1994-05-27 | 1998-12-03 | Smithkline Beecham Farmaceutici S.P.A. | Quinoline derivatives as tachykinin nk3 receptor antagonists |
IT1270615B (it) | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
GB9502644D0 (en) | 1995-02-10 | 1995-03-29 | Zeneca Ltd | Heterocyclic derivatives |
GB9513118D0 (en) | 1995-06-28 | 1995-08-30 | Merck Sharp & Dohme | Therapeutic agents |
GB9524137D0 (en) * | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
SK66798A3 (en) | 1995-11-24 | 1999-01-11 | Smithkline Beecham Spa | Quinoline derivative, preparation method thereof, pharmaceutical composition containing the same and its use |
AR004735A1 (es) | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
PL336942A1 (en) | 1997-05-23 | 2000-07-17 | Smithkline Beecham Spa | Derivatives of quinoline-4-carboxamide as antagonists of nk-2 and nk-3 receptor |
AP1201A (en) * | 1997-09-17 | 2003-09-01 | Smithkline Beecham Corp | Method for the synthesis of quinoline derivatives. |
BR9915475A (pt) | 1998-11-20 | 2001-12-18 | Smithkline Beecham Spa | Derivados da quinolina-4-carboxamida comoantagonistas dos receptores de nk-3 e nk-2 |
AU4802500A (en) | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
GB0027701D0 (en) | 2000-11-13 | 2000-12-27 | Smithkline Beecham Spa | Novel compounds |
AU2002226356A1 (en) | 2000-11-28 | 2002-06-11 | Glaxosmithkline S.P.A. | Quinoline derivatives as nk-3 antagonists |
JP2004519432A (ja) | 2000-11-28 | 2004-07-02 | グラクソスミスクライン・ソシエタ・ペル・アチオニ | 新規化合物 |
EP1659120A1 (en) | 2001-04-11 | 2006-05-24 | GlaxoSmithKline S.p.A. | 3-substituted quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists |
GB0109122D0 (en) | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
GB0318727D0 (en) | 2003-08-08 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
GB0425077D0 (en) | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425075D0 (en) | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425076D0 (en) | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
WO2006137789A1 (en) | 2005-06-23 | 2006-12-28 | Astrazeneca Ab | Quinoline 3 -sulfonate esters as NK3 receptor modulators |
EP1940795A1 (en) * | 2005-09-21 | 2008-07-09 | AstraZeneca AB | N-oxo-heterocycle and n-oxo-alkyl quinoline-4-carboxamides as nk-3 receptor ligands |
AR058051A1 (es) * | 2005-09-21 | 2008-01-23 | Astrazeneca Ab | Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas. |
WO2007039123A2 (en) | 2005-09-22 | 2007-04-12 | Smithkline Beecham Corporation | Combination therapy comprising an nk-3 antagonist and an antipsychotic agent |
US20080275082A1 (en) | 2005-09-30 | 2008-11-06 | Jeffrey Brum | Pharmaceutical Composition |
-
2006
- 2006-09-15 AR ARP060104049A patent/AR057130A1/es not_active Application Discontinuation
- 2006-09-19 KR KR1020087006742A patent/KR20080046669A/ko not_active Application Discontinuation
- 2006-09-19 CA CA002621062A patent/CA2621062A1/en not_active Abandoned
- 2006-09-19 AU AU2006292849A patent/AU2006292849A1/en not_active Abandoned
- 2006-09-19 JP JP2008532190A patent/JP2009508946A/ja active Pending
- 2006-09-19 EP EP06784189A patent/EP1928835B1/en active Active
- 2006-09-19 RU RU2008110914/04A patent/RU2008110914A/ru not_active Application Discontinuation
- 2006-09-19 WO PCT/SE2006/001068 patent/WO2007035158A1/en active Application Filing
- 2006-09-19 AT AT06784189T patent/ATE506350T1/de not_active IP Right Cessation
- 2006-09-19 US US12/067,572 patent/US7964733B2/en not_active Expired - Fee Related
- 2006-09-19 BR BRPI0616136-7A patent/BRPI0616136A2/pt not_active IP Right Cessation
- 2006-09-19 DE DE602006021440T patent/DE602006021440D1/de active Active
- 2006-09-20 UY UY29805A patent/UY29805A1/es unknown
- 2006-09-21 TW TW095134992A patent/TW200800902A/zh unknown
-
2008
- 2008-02-28 IL IL189857A patent/IL189857A0/en unknown
- 2008-04-16 EC EC2008008375A patent/ECSP088375A/es unknown
- 2008-04-17 NO NO20081862A patent/NO20081862L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
UY29805A1 (es) | 2007-04-30 |
AR057130A1 (es) | 2007-11-14 |
RU2008110914A (ru) | 2009-10-27 |
NO20081862L (no) | 2008-06-16 |
BRPI0616136A2 (pt) | 2011-06-07 |
ATE506350T1 (de) | 2011-05-15 |
AU2006292849A1 (en) | 2007-03-29 |
US20080214605A1 (en) | 2008-09-04 |
IL189857A0 (en) | 2008-08-07 |
EP1928835A1 (en) | 2008-06-11 |
EP1928835B1 (en) | 2011-04-20 |
US7964733B2 (en) | 2011-06-21 |
WO2007035158A1 (en) | 2007-03-29 |
JP2009508946A (ja) | 2009-03-05 |
CA2621062A1 (en) | 2007-03-29 |
DE602006021440D1 (de) | 2011-06-01 |
TW200800902A (en) | 2008-01-01 |
KR20080046669A (ko) | 2008-05-27 |
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