DE602006021440D1 - Alkylsulfoxidchinoline als nk-3-rezeptorliganden - Google Patents
Alkylsulfoxidchinoline als nk-3-rezeptorligandenInfo
- Publication number
- DE602006021440D1 DE602006021440D1 DE602006021440T DE602006021440T DE602006021440D1 DE 602006021440 D1 DE602006021440 D1 DE 602006021440D1 DE 602006021440 T DE602006021440 T DE 602006021440T DE 602006021440 T DE602006021440 T DE 602006021440T DE 602006021440 D1 DE602006021440 D1 DE 602006021440D1
- Authority
- DE
- Germany
- Prior art keywords
- alkylsulfoxid
- chinolines
- receptor ligands
- ligands
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71928605P | 2005-09-21 | 2005-09-21 | |
US71927505P | 2005-09-21 | 2005-09-21 | |
PCT/SE2006/001068 WO2007035158A1 (en) | 2005-09-21 | 2006-09-19 | Alkyl sulfoxide quinolines as nk-3 receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006021440D1 true DE602006021440D1 (de) | 2011-06-01 |
Family
ID=37889114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006021440T Active DE602006021440D1 (de) | 2005-09-21 | 2006-09-19 | Alkylsulfoxidchinoline als nk-3-rezeptorliganden |
Country Status (17)
Country | Link |
---|---|
US (1) | US7964733B2 (de) |
EP (1) | EP1928835B1 (de) |
JP (1) | JP2009508946A (de) |
KR (1) | KR20080046669A (de) |
AR (1) | AR057130A1 (de) |
AT (1) | ATE506350T1 (de) |
AU (1) | AU2006292849A1 (de) |
BR (1) | BRPI0616136A2 (de) |
CA (1) | CA2621062A1 (de) |
DE (1) | DE602006021440D1 (de) |
EC (1) | ECSP088375A (de) |
IL (1) | IL189857A0 (de) |
NO (1) | NO20081862L (de) |
RU (1) | RU2008110914A (de) |
TW (1) | TW200800902A (de) |
UY (1) | UY29805A1 (de) |
WO (1) | WO2007035158A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1940795A1 (de) * | 2005-09-21 | 2008-07-09 | AstraZeneca AB | N-oxo-heterocyclyl- und n-oxo-alkylchinolin-4-carbonsäureamide als liganden des nk-3-rezeptors |
CN101679271A (zh) * | 2007-03-19 | 2010-03-24 | 阿斯利康(瑞典)有限公司 | 喹啉衍生物、包含它们的药物组合物以及它们在治疗中枢神经系统和外周疾病中的用途 |
EP2139882B1 (de) * | 2007-03-23 | 2013-12-25 | Amgen Inc. | 3- substituierte chinolin- oder chinoxalin- derivate und ihre verwendung als phosphatidylinositol 3-kinase (pi3k) inhibitoren |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0804419T3 (da) * | 1994-05-27 | 2003-11-24 | Glaxosmithkline Spa | Quinolinderivater som tachykinin NK 3-receptor-antagonister |
IT1270615B (it) | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
GB9502644D0 (en) | 1995-02-10 | 1995-03-29 | Zeneca Ltd | Heterocyclic derivatives |
GB9513118D0 (en) | 1995-06-28 | 1995-08-30 | Merck Sharp & Dohme | Therapeutic agents |
GB9524137D0 (en) * | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
AR004735A1 (es) | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
CA2238298A1 (en) | 1995-11-24 | 1997-06-19 | Luca Francesco Raveglia | Quinoline derivatives |
AP9901695A0 (en) | 1997-05-23 | 1999-12-31 | Smithkline Beecham Spa | Quinoline-4-carbaoxamide derivatives as NK-2 and NK-3 receptor antagonists. |
AP1201A (en) * | 1997-09-17 | 2003-09-01 | Smithkline Beecham Corp | Method for the synthesis of quinoline derivatives. |
NZ511777A (en) | 1998-11-20 | 2003-12-19 | Smithkline Beecham S | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists |
AU4802500A (en) | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
GB0027701D0 (en) | 2000-11-13 | 2000-12-27 | Smithkline Beecham Spa | Novel compounds |
JP2004519432A (ja) | 2000-11-28 | 2004-07-02 | グラクソスミスクライン・ソシエタ・ペル・アチオニ | 新規化合物 |
AU2002226356A1 (en) | 2000-11-28 | 2002-06-11 | Glaxosmithkline S.P.A. | Quinoline derivatives as nk-3 antagonists |
WO2002083663A1 (en) | 2001-04-11 | 2002-10-24 | Glaxosmithkline S.P.A. | Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists |
GB0109122D0 (en) | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
GB0318727D0 (en) | 2003-08-08 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
GB0425077D0 (en) | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425075D0 (en) | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425076D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
CN101208304A (zh) | 2005-06-23 | 2008-06-25 | 阿斯利康(瑞典)有限公司 | 作为nk3受体调节剂的喹啉3-磺酸酯 |
EP1940795A1 (de) * | 2005-09-21 | 2008-07-09 | AstraZeneca AB | N-oxo-heterocyclyl- und n-oxo-alkylchinolin-4-carbonsäureamide als liganden des nk-3-rezeptors |
AR058051A1 (es) * | 2005-09-21 | 2008-01-23 | Astrazeneca Ab | Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas. |
WO2007039123A2 (en) | 2005-09-22 | 2007-04-12 | Smithkline Beecham Corporation | Combination therapy comprising an nk-3 antagonist and an antipsychotic agent |
EP1940357A2 (de) | 2005-09-30 | 2008-07-09 | SmithKline Beecham Corporation | Pharmazeutische zusammensetzungen |
-
2006
- 2006-09-15 AR ARP060104049A patent/AR057130A1/es not_active Application Discontinuation
- 2006-09-19 US US12/067,572 patent/US7964733B2/en not_active Expired - Fee Related
- 2006-09-19 CA CA002621062A patent/CA2621062A1/en not_active Abandoned
- 2006-09-19 RU RU2008110914/04A patent/RU2008110914A/ru not_active Application Discontinuation
- 2006-09-19 JP JP2008532190A patent/JP2009508946A/ja active Pending
- 2006-09-19 AT AT06784189T patent/ATE506350T1/de not_active IP Right Cessation
- 2006-09-19 WO PCT/SE2006/001068 patent/WO2007035158A1/en active Application Filing
- 2006-09-19 DE DE602006021440T patent/DE602006021440D1/de active Active
- 2006-09-19 BR BRPI0616136-7A patent/BRPI0616136A2/pt not_active IP Right Cessation
- 2006-09-19 KR KR1020087006742A patent/KR20080046669A/ko not_active Application Discontinuation
- 2006-09-19 EP EP06784189A patent/EP1928835B1/de active Active
- 2006-09-19 AU AU2006292849A patent/AU2006292849A1/en not_active Abandoned
- 2006-09-20 UY UY29805A patent/UY29805A1/es unknown
- 2006-09-21 TW TW095134992A patent/TW200800902A/zh unknown
-
2008
- 2008-02-28 IL IL189857A patent/IL189857A0/en unknown
- 2008-04-16 EC EC2008008375A patent/ECSP088375A/es unknown
- 2008-04-17 NO NO20081862A patent/NO20081862L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200800902A (en) | 2008-01-01 |
IL189857A0 (en) | 2008-08-07 |
ECSP088375A (es) | 2008-05-30 |
RU2008110914A (ru) | 2009-10-27 |
BRPI0616136A2 (pt) | 2011-06-07 |
US20080214605A1 (en) | 2008-09-04 |
NO20081862L (no) | 2008-06-16 |
UY29805A1 (es) | 2007-04-30 |
KR20080046669A (ko) | 2008-05-27 |
US7964733B2 (en) | 2011-06-21 |
AR057130A1 (es) | 2007-11-14 |
JP2009508946A (ja) | 2009-03-05 |
EP1928835A1 (de) | 2008-06-11 |
ATE506350T1 (de) | 2011-05-15 |
EP1928835B1 (de) | 2011-04-20 |
WO2007035158A1 (en) | 2007-03-29 |
CA2621062A1 (en) | 2007-03-29 |
AU2006292849A1 (en) | 2007-03-29 |
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