NO20081862L - Alkylsulfoksidkinoliner som NK-3-reseptorligander - Google Patents
Alkylsulfoksidkinoliner som NK-3-reseptorliganderInfo
- Publication number
- NO20081862L NO20081862L NO20081862A NO20081862A NO20081862L NO 20081862 L NO20081862 L NO 20081862L NO 20081862 A NO20081862 A NO 20081862A NO 20081862 A NO20081862 A NO 20081862A NO 20081862 L NO20081862 L NO 20081862L
- Authority
- NO
- Norway
- Prior art keywords
- alkylsulfoxide
- quinolines
- receptor ligands
- compounds
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Forbindelser med formel (I) hvori R1, A, R2, R3, R4, R5, n, m og q er som beskrevet i beskrivelsen, farmasøytisk akseptable salter, fremgangsmåter for fremstilling, farmasøytiske sammensetninger som inneholder dem og fremgangsmåter for anvendelse av samme.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71927505P | 2005-09-21 | 2005-09-21 | |
US71928605P | 2005-09-21 | 2005-09-21 | |
PCT/SE2006/001068 WO2007035158A1 (en) | 2005-09-21 | 2006-09-19 | Alkyl sulfoxide quinolines as nk-3 receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20081862L true NO20081862L (no) | 2008-06-16 |
Family
ID=37889114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20081862A NO20081862L (no) | 2005-09-21 | 2008-04-17 | Alkylsulfoksidkinoliner som NK-3-reseptorligander |
Country Status (17)
Country | Link |
---|---|
US (1) | US7964733B2 (no) |
EP (1) | EP1928835B1 (no) |
JP (1) | JP2009508946A (no) |
KR (1) | KR20080046669A (no) |
AR (1) | AR057130A1 (no) |
AT (1) | ATE506350T1 (no) |
AU (1) | AU2006292849A1 (no) |
BR (1) | BRPI0616136A2 (no) |
CA (1) | CA2621062A1 (no) |
DE (1) | DE602006021440D1 (no) |
EC (1) | ECSP088375A (no) |
IL (1) | IL189857A0 (no) |
NO (1) | NO20081862L (no) |
RU (1) | RU2008110914A (no) |
TW (1) | TW200800902A (no) |
UY (1) | UY29805A1 (no) |
WO (1) | WO2007035158A1 (no) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101268052A (zh) * | 2005-09-21 | 2008-09-17 | 阿斯利康(瑞典)有限公司 | 作为nk-3受体配体的n-氧代-杂环和n-氧代-烷基喹啉-4-甲酰胺 |
CA2681466A1 (en) * | 2007-03-19 | 2008-09-25 | Astrazeneca Ab | Quinoline derivatives, pharmaceutical compositions comprising them, and their use in treating central nervous system and peripheral diseases |
CA2680853C (en) * | 2007-03-23 | 2012-07-17 | Amgen Inc. | 3- substituted quinoline or quinoxaline derivatives and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT940391E (pt) * | 1994-05-27 | 2004-12-31 | Glaxosmithkline Spa | Derivados de quinolina como antagonistas do receptor de taquicinina nk3 |
IT1270615B (it) | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
GB9502644D0 (en) | 1995-02-10 | 1995-03-29 | Zeneca Ltd | Heterocyclic derivatives |
GB9513118D0 (en) | 1995-06-28 | 1995-08-30 | Merck Sharp & Dohme | Therapeutic agents |
AR004735A1 (es) | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
GB9524137D0 (en) * | 1995-11-24 | 1996-01-24 | Smithkline Beecham Spa | Novel compounds |
SK66798A3 (en) | 1995-11-24 | 1999-01-11 | Smithkline Beecham Spa | Quinoline derivative, preparation method thereof, pharmaceutical composition containing the same and its use |
EP0983262B1 (en) | 1997-05-23 | 2003-07-09 | GlaxoSmithKline S.p.A. | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
AP1201A (en) * | 1997-09-17 | 2003-09-01 | Smithkline Beecham Corp | Method for the synthesis of quinoline derivatives. |
AR021354A1 (es) | 1998-11-20 | 2002-07-17 | Smithkline Beecham Spa | Procedimiento para la preparacion de un compuesto derivado de quinolina y un procedimiento para preparar una composicion farmaceutica |
WO2000064877A1 (en) | 1999-04-26 | 2000-11-02 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
GB0027701D0 (en) | 2000-11-13 | 2000-12-27 | Smithkline Beecham Spa | Novel compounds |
EP1351953A1 (en) | 2000-11-28 | 2003-10-15 | GlaxoSmithKline S.p.A. | Quinoline derivatives as nk-3 antagonists |
WO2002043734A1 (en) | 2000-11-28 | 2002-06-06 | Glaxosmithkline Spa | Novel compounds |
JP2004525183A (ja) | 2001-04-11 | 2004-08-19 | グラクソスミスクライン・ソシエタ・ペル・アチオニ | Nk−3およびnk−2受容体アンタゴニストとしてのキノリン−4−カルボキサミド誘導体 |
GB0109122D0 (en) | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
GB0318727D0 (en) | 2003-08-08 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
GB0425077D0 (en) | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425076D0 (en) | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0425075D0 (en) | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
KR20080031871A (ko) | 2005-06-23 | 2008-04-11 | 아스트라제네카 아베 | Nk3 수용체 조절제로서의 퀴놀린 3-술포네이트 에스테르 |
CN101268052A (zh) * | 2005-09-21 | 2008-09-17 | 阿斯利康(瑞典)有限公司 | 作为nk-3受体配体的n-氧代-杂环和n-氧代-烷基喹啉-4-甲酰胺 |
AR058051A1 (es) * | 2005-09-21 | 2008-01-23 | Astrazeneca Ab | Quinolinas de alquilnitrilo.proceso de obtencion y composiciones farmaceuticas. |
WO2007039123A2 (en) | 2005-09-22 | 2007-04-12 | Smithkline Beecham Corporation | Combination therapy comprising an nk-3 antagonist and an antipsychotic agent |
WO2007044251A2 (en) | 2005-09-30 | 2007-04-19 | Smithkline Beecham Corporation | Pharmaceutical compositions |
-
2006
- 2006-09-15 AR ARP060104049A patent/AR057130A1/es not_active Application Discontinuation
- 2006-09-19 BR BRPI0616136-7A patent/BRPI0616136A2/pt not_active IP Right Cessation
- 2006-09-19 WO PCT/SE2006/001068 patent/WO2007035158A1/en active Application Filing
- 2006-09-19 RU RU2008110914/04A patent/RU2008110914A/ru not_active Application Discontinuation
- 2006-09-19 JP JP2008532190A patent/JP2009508946A/ja active Pending
- 2006-09-19 DE DE602006021440T patent/DE602006021440D1/de active Active
- 2006-09-19 EP EP06784189A patent/EP1928835B1/en active Active
- 2006-09-19 KR KR1020087006742A patent/KR20080046669A/ko not_active Application Discontinuation
- 2006-09-19 US US12/067,572 patent/US7964733B2/en not_active Expired - Fee Related
- 2006-09-19 CA CA002621062A patent/CA2621062A1/en not_active Abandoned
- 2006-09-19 AT AT06784189T patent/ATE506350T1/de not_active IP Right Cessation
- 2006-09-19 AU AU2006292849A patent/AU2006292849A1/en not_active Abandoned
- 2006-09-20 UY UY29805A patent/UY29805A1/es unknown
- 2006-09-21 TW TW095134992A patent/TW200800902A/zh unknown
-
2008
- 2008-02-28 IL IL189857A patent/IL189857A0/en unknown
- 2008-04-16 EC EC2008008375A patent/ECSP088375A/es unknown
- 2008-04-17 NO NO20081862A patent/NO20081862L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2009508946A (ja) | 2009-03-05 |
US20080214605A1 (en) | 2008-09-04 |
EP1928835A1 (en) | 2008-06-11 |
KR20080046669A (ko) | 2008-05-27 |
DE602006021440D1 (de) | 2011-06-01 |
CA2621062A1 (en) | 2007-03-29 |
EP1928835B1 (en) | 2011-04-20 |
US7964733B2 (en) | 2011-06-21 |
BRPI0616136A2 (pt) | 2011-06-07 |
AU2006292849A1 (en) | 2007-03-29 |
IL189857A0 (en) | 2008-08-07 |
UY29805A1 (es) | 2007-04-30 |
TW200800902A (en) | 2008-01-01 |
WO2007035158A1 (en) | 2007-03-29 |
ECSP088375A (es) | 2008-05-30 |
AR057130A1 (es) | 2007-11-14 |
ATE506350T1 (de) | 2011-05-15 |
RU2008110914A (ru) | 2009-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |