PL1831202T3 - Pochodne pirolidyniowe jako receptory M3 muskarynowe - Google Patents
Pochodne pirolidyniowe jako receptory M3 muskarynoweInfo
- Publication number
- PL1831202T3 PL1831202T3 PL05850334T PL05850334T PL1831202T3 PL 1831202 T3 PL1831202 T3 PL 1831202T3 PL 05850334 T PL05850334 T PL 05850334T PL 05850334 T PL05850334 T PL 05850334T PL 1831202 T3 PL1831202 T3 PL 1831202T3
- Authority
- PL
- Poland
- Prior art keywords
- pyrrolinidium
- derivatives
- muscarinic receptors
- compounds
- muscarinic
- Prior art date
Links
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 title 1
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000007202 Muscarinic M3 Receptor Human genes 0.000 abstract 1
- 108010008405 Muscarinic M3 Receptor Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0428416.2A GB0428416D0 (en) | 2004-12-24 | 2004-12-24 | Organic compounds |
| EP05850334A EP1831202B1 (en) | 2004-12-24 | 2005-12-22 | Pyrrolinidium derivatives as m3 muscarinic receptors |
| PCT/EP2005/013896 WO2006066928A1 (en) | 2004-12-24 | 2005-12-22 | Pyrrolinidium derivatives as m3 muscarinic receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1831202T3 true PL1831202T3 (pl) | 2012-06-29 |
Family
ID=34130966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05850334T PL1831202T3 (pl) | 2004-12-24 | 2005-12-22 | Pochodne pirolidyniowe jako receptory M3 muskarynowe |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8383625B2 (pl) |
| EP (1) | EP1831202B1 (pl) |
| JP (1) | JP2008525358A (pl) |
| KR (1) | KR101256242B1 (pl) |
| CN (1) | CN101087777B (pl) |
| AT (1) | ATE541839T1 (pl) |
| AU (1) | AU2005318423B2 (pl) |
| BR (1) | BRPI0519208A2 (pl) |
| CA (1) | CA2589744C (pl) |
| ES (1) | ES2377486T3 (pl) |
| GB (1) | GB0428416D0 (pl) |
| MX (1) | MX2007007720A (pl) |
| PL (1) | PL1831202T3 (pl) |
| PT (1) | PT1831202E (pl) |
| RU (1) | RU2412183C2 (pl) |
| WO (1) | WO2006066928A1 (pl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1957451B1 (en) | 2005-11-10 | 2011-10-19 | Nicholas S. Bodor | Soft anticholinergic zwitterions |
| JP5257073B2 (ja) * | 2005-11-10 | 2013-08-07 | ボーダー、ニコラス・エス | ソフト型抗コリン作動性エステル |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| AU2008218962B2 (en) | 2007-02-23 | 2013-03-14 | Theravance Biopharma R&D Ip, Llc | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
| PT2197841E (pt) | 2007-09-07 | 2012-01-02 | Theravance Inc | Compostos contendo guanidina úteis como antagonistas do receptor muscarínico |
| EP2222637A1 (en) | 2007-12-14 | 2010-09-01 | Theravance, Inc. | Amidine-containing compounds useful as muscarinic receptor antagonists |
| NZ589091A (en) | 2008-05-13 | 2011-07-29 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic m3 receptor antagonists |
| AU2013365742B2 (en) | 2012-12-19 | 2016-11-24 | Novartis Ag | Autotaxin inhibitors |
| EP2968267B1 (en) | 2013-03-15 | 2018-04-25 | Bodor Laboratories, Inc. | Soft anticholinergic esters for the treatment of hyperhidrosis |
| US20150259283A1 (en) | 2014-03-13 | 2015-09-17 | Brickell Biotech, Inc. | Formulation for soft anticholinergic analogs |
| WO2015162558A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Autotaxin inhibitors |
| KR20230151061A (ko) | 2015-07-21 | 2023-10-31 | 보도르 라보래토리즈, 인크. | 연성 항콜린제 유사체를 위한 제제 |
| TWI767507B (zh) | 2016-07-21 | 2022-06-11 | 美商波德實驗股份有限公司 | 軟性抗膽鹼類似物之製劑 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001504459A (ja) * | 1996-11-11 | 2001-04-03 | ノエ・クリスティアン・エル | 対掌体純粋な、塩基性アリール―シクロアルキル―ヒドロキシカルボン酸エステル、その製造方法及びこれを薬剤に使用する方法 |
| AU2001271027B2 (en) | 2000-07-11 | 2005-07-07 | Msd K.K. | Ester derivatives |
| ES2206021B1 (es) * | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| AR044134A1 (es) * | 2003-05-02 | 2005-08-24 | Novartis Ag | Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas. |
| PE20050231A1 (es) | 2003-06-24 | 2005-05-20 | Novartis Ag | Derivados de piperidinium y pirrolidinium como antagonistas del receptor muscarinico m3 |
| GB0428418D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| WO2009050707A1 (en) * | 2007-10-15 | 2009-04-23 | Can-Fite Biopharma Ltd. | Method for inducing hepatocyte proliferation and uses thereof |
-
2004
- 2004-12-24 GB GBGB0428416.2A patent/GB0428416D0/en not_active Ceased
-
2005
- 2005-12-22 RU RU2007128080/04A patent/RU2412183C2/ru not_active IP Right Cessation
- 2005-12-22 JP JP2007547367A patent/JP2008525358A/ja active Pending
- 2005-12-22 BR BRPI0519208-0A patent/BRPI0519208A2/pt not_active IP Right Cessation
- 2005-12-22 AU AU2005318423A patent/AU2005318423B2/en not_active Ceased
- 2005-12-22 EP EP05850334A patent/EP1831202B1/en not_active Not-in-force
- 2005-12-22 PL PL05850334T patent/PL1831202T3/pl unknown
- 2005-12-22 ES ES05850334T patent/ES2377486T3/es active Active
- 2005-12-22 WO PCT/EP2005/013896 patent/WO2006066928A1/en active Application Filing
- 2005-12-22 MX MX2007007720A patent/MX2007007720A/es active IP Right Grant
- 2005-12-22 PT PT05850334T patent/PT1831202E/pt unknown
- 2005-12-22 US US11/721,058 patent/US8383625B2/en not_active Expired - Fee Related
- 2005-12-22 CN CN2005800447368A patent/CN101087777B/zh not_active Expired - Fee Related
- 2005-12-22 KR KR1020077014263A patent/KR101256242B1/ko not_active IP Right Cessation
- 2005-12-22 AT AT05850334T patent/ATE541839T1/de active
- 2005-12-22 CA CA2589744A patent/CA2589744C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005318423B2 (en) | 2009-12-03 |
| EP1831202B1 (en) | 2012-01-18 |
| ES2377486T3 (es) | 2012-03-28 |
| PT1831202E (pt) | 2012-04-11 |
| CN101087777A (zh) | 2007-12-12 |
| BRPI0519208A2 (pt) | 2008-12-30 |
| JP2008525358A (ja) | 2008-07-17 |
| CN101087777B (zh) | 2010-12-08 |
| RU2007128080A (ru) | 2009-01-27 |
| MX2007007720A (es) | 2007-08-14 |
| WO2006066928A1 (en) | 2006-06-29 |
| ATE541839T1 (de) | 2012-02-15 |
| RU2412183C2 (ru) | 2011-02-20 |
| AU2005318423A1 (en) | 2006-06-29 |
| KR20070088730A (ko) | 2007-08-29 |
| CA2589744A1 (en) | 2006-06-29 |
| KR101256242B1 (ko) | 2013-04-17 |
| GB0428416D0 (en) | 2005-02-02 |
| US8383625B2 (en) | 2013-02-26 |
| US20090291960A1 (en) | 2009-11-26 |
| EP1831202A1 (en) | 2007-09-12 |
| CA2589744C (en) | 2012-08-28 |
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