PE20080709A1 - Polipeptidos moduladores del receptor del peptido 1 tipo glucagon (glp-1) - Google Patents

Polipeptidos moduladores del receptor del peptido 1 tipo glucagon (glp-1)

Info

Publication number
PE20080709A1
PE20080709A1 PE2007000653A PE2007000653A PE20080709A1 PE 20080709 A1 PE20080709 A1 PE 20080709A1 PE 2007000653 A PE2007000653 A PE 2007000653A PE 2007000653 A PE2007000653 A PE 2007000653A PE 20080709 A1 PE20080709 A1 PE 20080709A1
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PE
Peru
Prior art keywords
glp
threonine
seq
formula
alkyl
Prior art date
Application number
PE2007000653A
Other languages
English (en)
Inventor
William R Ewing
Claudio Mapelli
Douglas James Riexinger
Richard B Sulsky
Yeheng Zhu
Ving G Lee
Original Assignee
Bristol Myers Squibb Co
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38085979&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080709(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20080709A1 publication Critical patent/PE20080709A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A UN POLIPEPTIDO AISLADO DE FORMULA (I), EN DONDE Xaa1 ES HISTIDINA O TIAZOLILALANINA, DONDE CUALQUIERA DE SUS CARBONOS ESTAN OPCIONALMENTE SUSTITUIDOS CON H, ALQUILO, HALO, ENTRE OTROS; Xaa2 ES ACIDO a-AMINO-ISOBUTIRICO, D-ALANINA, (L)-PROLINA, (L)-ALANINA, ENTRE OTROS; Xaa3 ES ACIDO ASPARTICO O GLUTAMICO; Xaa4 ES GLICINA; Xaa5 ES (L)-TREONINA, (L)-SERINA, (L)-NORVALINA, ENTRE OTROS; Xaa6 ES ALFA-METIL-FENILALANINA, ALFA-METIL-2-FLUOROFENILALANINA, ENTRE OTROS; Xaa7 ES L-TREONINA, L-ALLO-TREONINA, ENTRE OTROS; Xaa8 ES L-SERINA, L-HISTIDINA, ENTRE OTROS; Xaa9 ES ACIDO L-ASPARTICO, ACIDO L-GLUTAMICO, ENTRE OTROS; ADEMAS CUALQUIERA DE LOS CARBONOS DE LOS GRUPOS Xaa2-4 Y Xaa6-9 SE ENCUENTRAN OPCIONALMENTE SUSTITUIDOS CON ALQUILO O HALO Xaa10 ES DE LA FORMULA (II), (III) O (IV); Xaa11 ES DE LA FORMULA (IIa), (IIIa) y (IVa); EN EL C DEL CARBONILO TERMINAL C DEL Xaa11 SE ENLAZA A UN NITROGENO PARA FORMAR UNA CARBOXAMIDA, ALQUIL CARBOXAMIDA O UNA DIALQUILCARBOXAMIDA SON SELECCIONADOS: SEQ ID NO:9; SEQ ID NO:118, SEQ ID NO: 133, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MODULADORES DEL RECEPTOR PEPTIDO 1 DE TIPO GLUCAGON HUMANO (GLP-1) Y EXHIBEN ESTABILIDAD AL DESDOBLAMIENTO PROTEOLITICO PUDIENDO ADMINISTRARSE VIA ORAL O PARENTERAL; SIENDO UTILES EN EL TRATAMIENTO Y PREVENCION DE LA DIABETES TIPO II Y ENFERMEDADES ASOCIADOS CON LA ACTIVIDAD GLP
PE2007000653A 2006-05-26 2007-05-25 Polipeptidos moduladores del receptor del peptido 1 tipo glucagon (glp-1) PE20080709A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80913406P 2006-05-26 2006-05-26

Publications (1)

Publication Number Publication Date
PE20080709A1 true PE20080709A1 (es) 2008-06-14

Family

ID=38085979

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000653A PE20080709A1 (es) 2006-05-26 2007-05-25 Polipeptidos moduladores del receptor del peptido 1 tipo glucagon (glp-1)

Country Status (8)

Country Link
US (2) US20100022457A1 (es)
EP (2) EP2021014A1 (es)
JP (1) JP2009538360A (es)
CN (1) CN101495502A (es)
AR (1) AR061203A1 (es)
PE (1) PE20080709A1 (es)
TW (1) TW200813095A (es)
WO (2) WO2007139589A1 (es)

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US7960349B2 (en) 2011-06-14
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CN101495502A (zh) 2009-07-29

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