PE20080522A1 - Derivados de indol como inhibidores de los transportadores de glucosa dependientes de sodio (sglt) - Google Patents

Derivados de indol como inhibidores de los transportadores de glucosa dependientes de sodio (sglt)

Info

Publication number
PE20080522A1
PE20080522A1 PE2007000981A PE2007000981A PE20080522A1 PE 20080522 A1 PE20080522 A1 PE 20080522A1 PE 2007000981 A PE2007000981 A PE 2007000981A PE 2007000981 A PE2007000981 A PE 2007000981A PE 20080522 A1 PE20080522 A1 PE 20080522A1
Authority
PE
Peru
Prior art keywords
inhibitors
sglt
dependent glucose
glucose transporters
gluco
Prior art date
Application number
PE2007000981A
Other languages
English (en)
Inventor
Sumihiro Nomura
Shigeki Sakamaki
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38515468&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080522(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of PE20080522A1 publication Critical patent/PE20080522A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE INDOL DE FORMULA (I) DONDE R1 ES FLUOR O CLORO; R2 ES H O FLUOR. SON COMPUESTOS PREFERIDOS: 4-CLORO-3-(4-CICLOPROPILFENILMETIL)-1-(B-D-GLUCO-PIRANOSIL)INDOL, 3-(4-CICLOPROPILFENILMETIL)-4-FLUORO-1-(B-D-GLUCO-PIRANOSIL)INDOL, 4-CLORO-3-(4-CICLOPROPILFENILMETIL)-6-FLUORO-1-(B-D-GLUCO-PIRANOSIL)INDOL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LOS TRANSPORTADORES DE GLUCOSA DEPENDIENTES DE SODIO (SGLT) SIENDO UTILES EN EL TRATAMIENTO DE DIABETES MELLITUS TIPO 1 Y 2, HIPERGLUCEMIA, OBESIDAD, ATEROSCLEROSIS
PE2007000981A 2006-07-27 2007-07-26 Derivados de indol como inhibidores de los transportadores de glucosa dependientes de sodio (sglt) PE20080522A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82060406P 2006-07-27 2006-07-27
US88617807P 2007-01-23 2007-01-23

Publications (1)

Publication Number Publication Date
PE20080522A1 true PE20080522A1 (es) 2008-06-13

Family

ID=38515468

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000981A PE20080522A1 (es) 2006-07-27 2007-07-26 Derivados de indol como inhibidores de los transportadores de glucosa dependientes de sodio (sglt)

Country Status (31)

Country Link
US (1) US7851617B2 (es)
EP (1) EP2049557B1 (es)
JP (1) JP5102294B2 (es)
KR (1) KR101179312B1 (es)
CN (1) CN101501053B (es)
AR (1) AR062111A1 (es)
AT (1) ATE501159T1 (es)
AU (1) AU2007277662B2 (es)
BR (1) BRPI0715369A2 (es)
CA (1) CA2658116C (es)
CL (1) CL2007002197A1 (es)
CO (1) CO6150170A2 (es)
CR (1) CR10583A (es)
DE (1) DE602007013056D1 (es)
DK (1) DK2049557T3 (es)
EA (1) EA016819B1 (es)
GT (1) GT200900014A (es)
HN (1) HN2009000161A (es)
IL (1) IL196267A0 (es)
JO (1) JO2681B1 (es)
MX (1) MX2009000995A (es)
MY (1) MY145106A (es)
NO (1) NO20085337L (es)
NZ (1) NZ574072A (es)
PE (1) PE20080522A1 (es)
PL (1) PL2049557T3 (es)
PT (1) PT2049557E (es)
TW (1) TWI418556B (es)
UA (1) UA92100C2 (es)
UY (1) UY30506A1 (es)
WO (1) WO2008013322A1 (es)

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Also Published As

Publication number Publication date
HN2009000161A (es) 2011-05-25
NZ574072A (en) 2011-05-27
MX2009000995A (es) 2009-02-04
PT2049557E (pt) 2011-05-05
CN101501053A (zh) 2009-08-05
NO20085337L (no) 2009-04-24
UY30506A1 (es) 2008-01-31
DK2049557T3 (da) 2011-06-14
JP5102294B2 (ja) 2012-12-19
AU2007277662A1 (en) 2008-01-31
US7851617B2 (en) 2010-12-14
EA016819B1 (ru) 2012-07-30
CO6150170A2 (es) 2010-04-20
EP2049557A1 (en) 2009-04-22
PL2049557T3 (pl) 2011-07-29
MY145106A (en) 2011-12-30
BRPI0715369A2 (pt) 2013-06-18
ATE501159T1 (de) 2011-03-15
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CR10583A (es) 2009-06-05
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UA92100C2 (uk) 2010-09-27
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