PE20070753A1 - Derivados de oxazolidona como moduladores de progesterona - Google Patents
Derivados de oxazolidona como moduladores de progesteronaInfo
- Publication number
- PE20070753A1 PE20070753A1 PE2007001100A PE2007001100A PE20070753A1 PE 20070753 A1 PE20070753 A1 PE 20070753A1 PE 2007001100 A PE2007001100 A PE 2007001100A PE 2007001100 A PE2007001100 A PE 2007001100A PE 20070753 A1 PE20070753 A1 PE 20070753A1
- Authority
- PE
- Peru
- Prior art keywords
- oxazolidin
- thiazol
- progesterone
- modulators
- oxazolidone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE OXAZOLIDONA DE FORMULA (I), DONDE R1, R2 ,R5 Y R6 SON H, ALQUILO C1-C10, -(CH2)n-ARILO, ENTRE OTROS; V ES OXIGENO O S; X Y Z SON N O CR14; Y ES OXIGENO O S; Q ES ARILO, HETEROARILO, ENTRE OTROS; n ES UN ENTERO DE 0 A 3. SON COMPUESTOS PREFERIDOS: 3-[4-(4-CLOROFENIL)-1,3-TIAZOL-2-IL]-1,3-OXAZOLIDIN-2-ONA, 3-[4-(4-BROMOFENIL)-1,3-TIAZOL-2-IL]-1,3-OXAZOLIDIN-2-ONA, 4-[2-(2-OXO-1,3-OXAZOLIDIN-3-IL)-1,3-TIAZOL-4-IL]BENZONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE PROGESTERONA Y SON UTILES EN EL TRATAMIENTO DE FIBROIDES, ENDOMETRIOSIS, SANGRADO DISFUNCIONAL, ANTICONCEPCION, ENTRE OTRAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83789806P | 2006-08-15 | 2006-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070753A1 true PE20070753A1 (es) | 2008-08-14 |
Family
ID=39082681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001100A PE20070753A1 (es) | 2006-08-15 | 2007-08-15 | Derivados de oxazolidona como moduladores de progesterona |
Country Status (22)
Country | Link |
---|---|
US (1) | US7618990B2 (es) |
EP (1) | EP2054410A2 (es) |
JP (1) | JP2010500409A (es) |
KR (1) | KR20090039774A (es) |
CN (1) | CN101501031B (es) |
AR (1) | AR062327A1 (es) |
AU (1) | AU2007284599B2 (es) |
BR (1) | BRPI0716622A2 (es) |
CA (1) | CA2659208A1 (es) |
CR (1) | CR10617A (es) |
GT (1) | GT200900032A (es) |
IL (1) | IL196886A0 (es) |
MX (1) | MX2009001698A (es) |
NO (1) | NO20090457L (es) |
NZ (1) | NZ574753A (es) |
PE (1) | PE20070753A1 (es) |
RU (1) | RU2009105113A (es) |
SA (1) | SA07280440B1 (es) |
SV (1) | SV2009003168A (es) |
TW (1) | TW200815428A (es) |
WO (1) | WO2008021331A2 (es) |
ZA (1) | ZA200901055B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20081803A1 (es) * | 2007-03-09 | 2008-12-11 | Wyeth Corp | Sintesis y caracterizacion de la forma ii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo |
PE20090167A1 (es) * | 2007-03-09 | 2009-02-11 | Wyeth Corp | Sintesis y caracterizacion de la forma iii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo |
CN101525310B (zh) * | 2009-04-21 | 2019-04-16 | 大连九信精细化工有限公司 | 1-苯甲酰基-3-(2-羟基-1,1-二甲基乙基)硫脲的合成方法 |
WO2012047617A1 (en) * | 2010-09-28 | 2012-04-12 | Radius Health, Inc. | Selective androgen receptor modulators |
BR112013010372A2 (pt) * | 2010-12-14 | 2016-07-05 | Merck Sharp & Dohme | composto, e, método para preparar um composto |
SG11201610975RA (en) * | 2014-07-03 | 2017-01-27 | Celgene Quanticel Res Inc | Inhibitors of lysine specific demethylase-1 |
Family Cites Families (51)
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DE1670338A1 (de) | 1966-03-14 | 1972-08-10 | Heyden Chem Fab | Verfahren zur Herstellung von antimikrobiell wirksamen Nitrofuranderivaten |
US3493565A (en) | 1966-03-14 | 1970-02-03 | Squibb & Sons Inc | 3-amino-5-(nitrofuryl)-1,2,4-oxadiazole derivatives |
NL6809997A (es) * | 1967-08-04 | 1969-02-06 | ||
GB1224995A (en) | 1968-09-20 | 1971-03-10 | Delalande Sa | New 5-propargyloxymethyl-2-substituted oxazolidinones and their process of preparation |
US4293558A (en) * | 1975-10-28 | 1981-10-06 | Eli Lilly And Company | Antiviral thiazolinyl benzimidazoles and derivatives |
CA1076582A (en) * | 1975-10-28 | 1980-04-29 | Charles J. Paget | Antiviral thiazolinyl or thiazinyl ketobenzimidazoles |
US4008243A (en) * | 1975-11-19 | 1977-02-15 | Eli Lilly And Company | Antiviral thiazolinyl or thiazinyl benzimidazole esters |
US4268679A (en) * | 1980-02-19 | 1981-05-19 | Ppg Industries, Inc. | 3-[5- or 3-Substituted-5- or 3-isoxazolyl]-1-allyl or alkyl-4-substituted-5-substituted or unsubstituted-2-imidazolidinones |
US4426527A (en) * | 1982-02-12 | 1984-01-17 | Ppg Industries, Inc. | 3-[5- Or 3-substituted-1,2,4-oxadiazol-3- or -5-yl]-1-substituted-4-substituted-5-substituted or unsubstituted-2-imidazolidinones |
DE3227329A1 (de) | 1982-07-22 | 1984-01-26 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von 2-n,n-disubstituierten aminothiazolen |
US4756744A (en) * | 1985-06-24 | 1988-07-12 | Ppg Industries, Inc. | Herbicidally active 4-aminoalkylamino-3-isoxazolyl-2-imidazolidinone derivatives |
DE3723797A1 (de) | 1987-07-18 | 1989-01-26 | Merck Patent Gmbh | Oxazolidinone |
AU9030691A (en) | 1990-11-06 | 1992-05-26 | Smithkline Beecham Corporation | Imidazolidinone compounds |
ES2144403T3 (es) | 1990-11-30 | 2000-06-16 | Otsuka Pharma Co Ltd | Derivados de tiazol como inhibidores de oxigeno activo. |
DE4335876A1 (de) * | 1993-10-17 | 1995-04-20 | Schering Ag | Kombination von Progesteronantagonisten und Antiöstrogenen mit partialer agonistischer Wirkung für die Hormonsubstitutions-Therapie für peri- und postmenopausale Frauen |
JPH07149745A (ja) | 1993-11-30 | 1995-06-13 | Hisamitsu Pharmaceut Co Inc | 新規な2−アミノチアゾール誘導体 |
WO1995015955A1 (de) | 1993-12-06 | 1995-06-15 | Basf Aktiengesellschaft | 2,4-diaminothiazole und ihre herstellung |
DE4425613A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-gliedrige Heteroaryl-oxazolidinone |
DE19540027A1 (de) | 1995-10-27 | 1997-04-30 | Gruenenthal Gmbh | Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe |
US5714607A (en) * | 1995-12-01 | 1998-02-03 | American Cyanamid Company | Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide |
DE19601264A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
DE19649095A1 (de) | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue Heteroaryl-Oxazolidinone |
DE19604223A1 (de) | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
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EP0928789B1 (en) | 1996-07-31 | 2004-09-29 | Nikken Chemicals Company, Limited | 6-phenyltetrahydro-1,3-oxazin-2-one derivatives and medicinal compositions containing the same |
US5819742A (en) * | 1996-11-06 | 1998-10-13 | Family Health International | Vaginal device for preventing conception or the transmission of sexually transmitted diseases, or both |
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DE10034623A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Heterocyclisch substituierte Pyridine als Cytokin-Inhibitoren |
DE10034628A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Pyridinhaltige Oxazolidinone als Cytokin-Inhibitoren |
DE10034622A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Substituierte Imidazol-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
US20020115669A1 (en) * | 2000-08-31 | 2002-08-22 | Wiedeman Paul E. | Oxazolidinone chemotherapeutic agents |
FR2823209B1 (fr) | 2001-04-04 | 2003-12-12 | Fournier Lab Sa | Nouvelles thiohydantoines et leur utilisation en therapeutique |
GB0118407D0 (en) | 2001-07-27 | 2001-09-19 | Cipla Ltd | Oxazolidinone derivatives as antibacterial agents |
KR100437972B1 (ko) * | 2001-10-27 | 2004-07-02 | 한국과학기술연구원 | 피롤리디논 유도체, 이의 제조 방법 및 이를 포함하는제약 조성물 |
US7119111B2 (en) | 2002-05-29 | 2006-10-10 | Amgen, Inc. | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use |
KR20050071471A (ko) | 2002-08-08 | 2005-07-07 | 스미스클라인 비참 코포레이션 | 티오펜 화합물 |
TWI324596B (en) * | 2002-08-26 | 2010-05-11 | Nat Health Research Institutes | Imidazolamino compounds |
US7109223B2 (en) | 2002-08-28 | 2006-09-19 | Merck & Co. Inc. | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EP4 receptor agonists in the treatment of glaucoma |
US20040167192A1 (en) * | 2003-01-16 | 2004-08-26 | David Solow-Cordero | Methods of treating conditions associated with an Edg-7 receptor |
US7169797B2 (en) * | 2003-02-14 | 2007-01-30 | Abbott Laboratories | Protein-tyrosine phosphatase inhibitors and uses thereof |
CA2523125A1 (en) | 2003-03-25 | 2004-10-14 | Vertex Pharmaceuticals Incorporated | Thiazoles useful as inhibitors of protein kinases |
JP2006522164A (ja) | 2003-04-03 | 2006-09-28 | メルク エンド カムパニー インコーポレーテッド | 代謝調節型グルタミン酸受容体−5のジアリール置換ピラゾール修飾因子 |
BRPI0412382A (pt) | 2003-07-08 | 2006-09-19 | Astrazeneca Ab | composto , método para a verificação de novos compostos medicinais que se ligam a e modulam a atividade, por agonismo , agonismo parcial, ou antagonismo, do receptor de acetilcolina nicotìnico alfa7, método de tratamento ou profilaxia de uma doença ou condição humana, método para tratamento de jetlag, induzindo interrupção de fumar, vìcio em nicotina, abstinência, dor, e para colite ulcerativa, composição farmacêutica, e, método de tratamento ou prevenção de uma condição ou distúrbio que surge da disfunção de neurotransmissão do receptor de acetilcolina nicotìnico em um mamìfero, e, uso de um composto |
-
2007
- 2007-07-31 TW TW096127981A patent/TW200815428A/zh unknown
- 2007-08-10 AR ARP070103552A patent/AR062327A1/es not_active Application Discontinuation
- 2007-08-13 CA CA002659208A patent/CA2659208A1/en not_active Abandoned
- 2007-08-13 BR BRPI0716622-2A patent/BRPI0716622A2/pt not_active IP Right Cessation
- 2007-08-13 KR KR1020097002974A patent/KR20090039774A/ko not_active Application Discontinuation
- 2007-08-13 NZ NZ574753A patent/NZ574753A/en not_active IP Right Cessation
- 2007-08-13 EP EP07836789A patent/EP2054410A2/en not_active Withdrawn
- 2007-08-13 CN CN2007800302230A patent/CN101501031B/zh not_active Expired - Fee Related
- 2007-08-13 WO PCT/US2007/017931 patent/WO2008021331A2/en active Application Filing
- 2007-08-13 AU AU2007284599A patent/AU2007284599B2/en not_active Ceased
- 2007-08-13 MX MX2009001698A patent/MX2009001698A/es active IP Right Grant
- 2007-08-13 JP JP2009524654A patent/JP2010500409A/ja active Pending
- 2007-08-13 RU RU2009105113/04A patent/RU2009105113A/ru not_active Application Discontinuation
- 2007-08-13 US US11/891,748 patent/US7618990B2/en not_active Expired - Fee Related
- 2007-08-14 SA SA07280440A patent/SA07280440B1/ar unknown
- 2007-08-15 PE PE2007001100A patent/PE20070753A1/es not_active Application Discontinuation
-
2009
- 2009-01-29 NO NO20090457A patent/NO20090457L/no not_active Application Discontinuation
- 2009-02-03 IL IL196886A patent/IL196886A0/en unknown
- 2009-02-12 SV SV2009003168A patent/SV2009003168A/es unknown
- 2009-02-12 GT GT200900032A patent/GT200900032A/es unknown
- 2009-02-13 ZA ZA200901055A patent/ZA200901055B/xx unknown
- 2009-02-13 CR CR10617A patent/CR10617A/es unknown
Also Published As
Publication number | Publication date |
---|---|
RU2009105113A (ru) | 2010-09-27 |
WO2008021331A2 (en) | 2008-02-21 |
AU2007284599B2 (en) | 2011-07-21 |
AR062327A1 (es) | 2008-10-29 |
US20080045556A1 (en) | 2008-02-21 |
AU2007284599A1 (en) | 2008-02-21 |
IL196886A0 (en) | 2009-11-18 |
US7618990B2 (en) | 2009-11-17 |
CN101501031B (zh) | 2012-02-01 |
GT200900032A (es) | 2011-03-29 |
MX2009001698A (es) | 2009-02-25 |
JP2010500409A (ja) | 2010-01-07 |
EP2054410A2 (en) | 2009-05-06 |
NZ574753A (en) | 2011-04-29 |
TW200815428A (en) | 2008-04-01 |
CA2659208A1 (en) | 2008-02-21 |
WO2008021331A3 (en) | 2008-05-22 |
KR20090039774A (ko) | 2009-04-22 |
SA07280440B1 (ar) | 2010-10-20 |
NO20090457L (no) | 2009-04-27 |
CR10617A (es) | 2009-03-12 |
CN101501031A (zh) | 2009-08-05 |
ZA200901055B (en) | 2009-12-30 |
SV2009003168A (es) | 2010-01-14 |
BRPI0716622A2 (pt) | 2013-10-08 |
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