PE20070180A1 - Compuestos de bencilpiperazina como agonistas del receptor gpr38 - Google Patents

Compuestos de bencilpiperazina como agonistas del receptor gpr38

Info

Publication number
PE20070180A1
PE20070180A1 PE2006000888A PE2006000888A PE20070180A1 PE 20070180 A1 PE20070180 A1 PE 20070180A1 PE 2006000888 A PE2006000888 A PE 2006000888A PE 2006000888 A PE2006000888 A PE 2006000888A PE 20070180 A1 PE20070180 A1 PE 20070180A1
Authority
PE
Peru
Prior art keywords
phenyl
methyl
piperidinamine
piperazinyl
fluorophenyl
Prior art date
Application number
PE2006000888A
Other languages
English (en)
Inventor
Christopher Norbert Johnson
David Timothy Macpherson
Steven James Stanway
Geoffrey Stemp
Mervyn Thompson
Susan Marie Westaway
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0515381A external-priority patent/GB0515381D0/en
Priority claimed from GB0611469A external-priority patent/GB0611469D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070180A1 publication Critical patent/PE20070180A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

SE REFIERE A COMPUESTOS DE BENCILPIPERAZINA DE FORMULA (I), EN DONDE A ES FENILO O HETEROARILO DE 6 MIEMBROS OPCIONALMENTE SUSTITUIDO CON, ALQUILO O ALCOXI(C1-C4); R1 Y R2 SON INDEPENDIENTEMENTE H O ALQUILO(C1-C4); R3 ES FENILO O HETEROARILO DE 5 A 6 MIEMBROS OPCIONALMENTE SUSTITUIDO; X ES (CR4R5)n; n ES 1 O 2; Y ES NH, O O CH2; R4 Y R5 SON INDEPENDIENTEMENTE H Y ALQUILO(C1-C4); LOS CARBONOS C* DE LA PIPERAZINA TIENEN LA CONFIGURACION 3R,5S. SON PREFERIDOS: 1-[(4-{[(3R,5S)-3,5-DIMETIL-1-PIPERAZINIL]METIL}FENIL)ACETIL]-N-(4-FLUOROFENIL)-4-PIPERIDINAMINA, N-(3-FLUOROFENIL)-1-[(4-{[(3S)-3-METIL-PIPERAZINIL]METIL}FENIL)ACEIL]-4-PIPERIDINAMINA, N-(4-FLUOROFENIL)-1-[(4-{[(3S)-3-METIL-1-PIPERAZINIL]METIL}-FENIL)ACETIL]-4-PIPERIDINAMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON AGONISTAS PARCIAL O TOTAL DEL RECEPTOR GPR38 (RECEPTOR ACOPLADO A PROTEINA G), Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS GASTROINTESTINALES ASOCIADOS CON HOPOMOTILIDAD, TAL COMO TRANSTORNOS FUNCIONALES DEL INTESTINO, DISPEPSIA FUNCIONAL O SINDROME DE INTESTINO IRRITABLE
PE2006000888A 2005-07-26 2006-07-24 Compuestos de bencilpiperazina como agonistas del receptor gpr38 PE20070180A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0515381A GB0515381D0 (en) 2005-07-26 2005-07-26 Compounds
GB0611469A GB0611469D0 (en) 2006-06-09 2006-06-09 Compounds

Publications (1)

Publication Number Publication Date
PE20070180A1 true PE20070180A1 (es) 2007-04-25

Family

ID=37560776

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000888A PE20070180A1 (es) 2005-07-26 2006-07-24 Compuestos de bencilpiperazina como agonistas del receptor gpr38

Country Status (29)

Country Link
US (2) US8536182B2 (es)
EP (2) EP2441763A1 (es)
JP (1) JP4938777B2 (es)
KR (1) KR101281435B1 (es)
AR (1) AR054508A1 (es)
AU (1) AU2006274212B2 (es)
BR (1) BRPI0613987A2 (es)
CA (1) CA2616513C (es)
CR (1) CR9722A (es)
CY (1) CY1113257T1 (es)
DK (1) DK1907374T3 (es)
EA (1) EA014061B1 (es)
EG (1) EG26235A (es)
ES (1) ES2390812T3 (es)
HK (1) HK1116477A1 (es)
HR (1) HRP20120833T1 (es)
IL (1) IL188854A (es)
JO (1) JO2747B1 (es)
MA (1) MA29723B1 (es)
MX (1) MX2008001211A (es)
MY (1) MY150098A (es)
NO (1) NO340489B1 (es)
NZ (1) NZ565062A (es)
PE (1) PE20070180A1 (es)
PL (1) PL1907374T3 (es)
PT (1) PT1907374E (es)
SI (1) SI1907374T1 (es)
TW (1) TWI376375B (es)
WO (1) WO2007012479A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
EP2441763A1 (en) * 2005-07-26 2012-04-18 Glaxo Group Limited Benzylpiperazine derivatives useful for the treatment of gastrointestinal disorders
GB0524814D0 (en) * 2005-12-05 2006-01-11 Glaxo Group Ltd Compounds
US8183374B2 (en) 2006-01-27 2012-05-22 M's Science Corporation Piperidine and piperazine derivatives
MX2009000110A (es) * 2006-06-28 2009-01-23 Glaxo Group Ltd Derivados de piperazinilo utiles en el tratamiento de enfermedades mediadas por el receptor grp38.
GB0723317D0 (en) * 2007-11-28 2008-01-09 Glaxo Group Ltd Compounds
MX2011008857A (es) 2009-02-27 2011-09-30 Raqualia Pharma Inc Derivados de oxiindol con actividad agonistica del receptor de motilina.
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
CN113292485B (zh) * 2021-06-08 2023-10-27 河南大学 苄基哌嗪脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
TW355711B (en) 1992-11-04 1999-04-11 Chugai Pharmaceutical Co Ltd Erythromycin derivatives
JP3449766B2 (ja) 1993-11-19 2003-09-22 中外製薬株式会社 モチリンアンタゴニスト
US5593994A (en) * 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors
JP3901239B2 (ja) 1996-03-13 2007-04-04 大正製薬株式会社 アリールアルカン誘導体
US5965578A (en) * 1996-04-03 1999-10-12 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5734012A (en) 1996-05-16 1998-03-31 Ohmeda Pharmaceutical Products Division Inc. Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity
DE19644195A1 (de) * 1996-10-24 1998-04-30 Solvay Pharm Gmbh 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6100239A (en) * 1996-11-26 2000-08-08 Chugai Seiyaku Kabushiki Kaisha 13-membered ring macrolide compound, medicine containing the same, and process for producing the same
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
JP3583928B2 (ja) * 1997-08-15 2004-11-04 中外製薬株式会社 フェネチルアミン誘導体
US5972939A (en) * 1997-10-28 1999-10-26 Ortho-Mcneil Pharmaceutical, Inc. Cyclopentene derivatives useful as antagonists of the motilin receptor
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
DE19805822B4 (de) 1998-02-13 2009-02-05 Solvay Pharmaceuticals Gmbh 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
GB9804734D0 (en) * 1998-03-05 1998-04-29 Pfizer Ltd Compounds
ATE354582T1 (de) * 1998-06-12 2007-03-15 Merck & Co Inc Klonierung und identifizierung des motilin- rezeptors
JP2000191700A (ja) * 1998-12-28 2000-07-11 Kyowa Hakko Kogyo Co Ltd 持続型消化管運動ペプチド
US20020010184A1 (en) * 2000-02-18 2002-01-24 Dinsmore Christopher J. Inhibitors of prenyl-protein transferase
US20020052380A1 (en) * 2000-02-18 2002-05-02 Dinsmore Christopher J. Inhibitors of prenyl-protein transferase
WO2001068621A1 (en) 2000-03-13 2001-09-20 Ortho-Mcneil Pharmaceutical, Inc. Novel cyclohexene derivatives useful as antagonists of the motilin receptor
WO2001068620A1 (en) * 2000-03-13 2001-09-20 Ortho-Mcneil Pharmaceutical, Inc. Novel cyclopentene derivatives useful as antagonists of the motilin receptor
AU2001247357A1 (en) * 2000-03-13 2001-09-24 Ortho-Mcneil Pharmaceutical, Inc. Novel cyclobutene derivatives useful as antagonists of the motilin receptor
US6511980B2 (en) * 2000-05-05 2003-01-28 Ortho Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
ATE308537T1 (de) * 2001-05-10 2005-11-15 Solvay Pharm Gmbh Neue 1-amidomethylcarbonyl-piperidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US6977264B2 (en) * 2001-07-25 2005-12-20 Amgen Inc. Substituted piperidines and methods of use
PA8575901A1 (es) 2002-07-18 2004-07-20 Pfizer Prod Inc Derivados de piperidina novedosos
US7223788B2 (en) * 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
US7452862B2 (en) * 2003-07-31 2008-11-18 Tranzyme Pharma, Inc. Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US7262195B2 (en) 2003-09-17 2007-08-28 Bristol-Myers Squibb Company Compounds useful as motilin agonists and method
US7338954B2 (en) 2003-09-17 2008-03-04 Bristol-Myers Squibb Company Compounds useful as motilin agonists and method
JPWO2005063720A1 (ja) 2003-12-25 2007-07-19 日本新薬株式会社 アミド誘導体及び医薬
WO2005077345A1 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Compounds for the treatment of gastro-esophageal reflux disease
WO2005077368A2 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
WO2005077373A2 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
JP2007538004A (ja) * 2004-03-18 2007-12-27 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド シヌクレイノパチーを治療する方法
US20050272722A1 (en) * 2004-03-18 2005-12-08 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
WO2005089502A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
EP1732549A4 (en) * 2004-03-18 2009-11-11 Brigham & Womens Hospital METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES
US20070293539A1 (en) * 2004-03-18 2007-12-20 Lansbury Peter T Methods for the treatment of synucleinopathies
PE20060315A1 (es) 2004-05-24 2006-05-15 Irm Llc Compuestos de tiazol como moduladores de ppar
SE0401345D0 (sv) 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds: Pyridine as scaffold
GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
EP1902022A1 (en) * 2005-07-12 2008-03-26 Glaxo Group Limited Piperazine heteroaryl derivates as gpr38 agonists
EP2441763A1 (en) * 2005-07-26 2012-04-18 Glaxo Group Limited Benzylpiperazine derivatives useful for the treatment of gastrointestinal disorders
GB0524814D0 (en) 2005-12-05 2006-01-11 Glaxo Group Ltd Compounds
MX2009000110A (es) 2006-06-28 2009-01-23 Glaxo Group Ltd Derivados de piperazinilo utiles en el tratamiento de enfermedades mediadas por el receptor grp38.
GB0723317D0 (en) 2007-11-28 2008-01-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
WO2007012479A2 (en) 2007-02-01
KR20080037663A (ko) 2008-04-30
EA014061B1 (ru) 2010-08-30
HK1116477A1 (en) 2008-12-24
KR101281435B1 (ko) 2013-07-02
JP2009502842A (ja) 2009-01-29
IL188854A (en) 2013-08-29
MX2008001211A (es) 2008-03-24
EP1907374A2 (en) 2008-04-09
CY1113257T1 (el) 2016-04-13
US20130317041A1 (en) 2013-11-28
EP2441763A1 (en) 2012-04-18
EA200800421A1 (ru) 2008-06-30
CA2616513C (en) 2013-02-19
EG26235A (en) 2013-05-07
AU2006274212A1 (en) 2007-02-01
TWI376375B (en) 2012-11-11
MY150098A (en) 2013-11-29
US20090054456A1 (en) 2009-02-26
US8536182B2 (en) 2013-09-17
PT1907374E (pt) 2012-11-05
DK1907374T3 (da) 2012-10-15
TW200745081A (en) 2007-12-16
NO20081014L (no) 2008-04-10
HRP20120833T1 (hr) 2012-11-30
WO2007012479A3 (en) 2007-04-26
JO2747B1 (en) 2014-03-15
IL188854A0 (en) 2008-04-13
NZ565062A (en) 2011-02-25
PL1907374T3 (pl) 2012-12-31
SI1907374T1 (sl) 2012-11-30
CA2616513A1 (en) 2007-02-01
ES2390812T3 (es) 2012-11-16
JP4938777B2 (ja) 2012-05-23
CR9722A (es) 2008-04-10
AU2006274212B2 (en) 2011-06-09
BRPI0613987A2 (pt) 2011-03-01
MA29723B1 (fr) 2008-09-01
EP1907374B1 (en) 2012-08-22
AR054508A1 (es) 2007-06-27
NO340489B1 (no) 2017-05-02

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