PE20050822A1 - Derivados de florfenicol con mejor solubilidad en agua - Google Patents
Derivados de florfenicol con mejor solubilidad en aguaInfo
- Publication number
- PE20050822A1 PE20050822A1 PE2005000020A PE2005000020A PE20050822A1 PE 20050822 A1 PE20050822 A1 PE 20050822A1 PE 2005000020 A PE2005000020 A PE 2005000020A PE 2005000020 A PE2005000020 A PE 2005000020A PE 20050822 A1 PE20050822 A1 PE 20050822A1
- Authority
- PE
- Peru
- Prior art keywords
- florphenicol
- derivatives
- water
- better solubility
- prodrog
- Prior art date
Links
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical class CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 title abstract 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/094—Esters of phosphoric acids with arylalkanols
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53222703P | 2003-12-23 | 2003-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050822A1 true PE20050822A1 (es) | 2005-10-01 |
Family
ID=34738768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000020A PE20050822A1 (es) | 2003-12-23 | 2005-01-03 | Derivados de florfenicol con mejor solubilidad en agua |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7153842B2 (OSRAM) |
| EP (1) | EP1696934B1 (OSRAM) |
| JP (2) | JP4719160B2 (OSRAM) |
| KR (1) | KR20060111605A (OSRAM) |
| CN (1) | CN100579532C (OSRAM) |
| AR (1) | AR046970A1 (OSRAM) |
| BR (1) | BRPI0418133A2 (OSRAM) |
| CA (1) | CA2550660C (OSRAM) |
| EC (1) | ECSP066670A (OSRAM) |
| IL (2) | IL176342A (OSRAM) |
| MX (1) | MXPA06007215A (OSRAM) |
| NO (1) | NO20063244L (OSRAM) |
| NZ (1) | NZ547592A (OSRAM) |
| PE (1) | PE20050822A1 (OSRAM) |
| RU (1) | RU2006126519A (OSRAM) |
| TW (1) | TWI262181B (OSRAM) |
| WO (1) | WO2005063257A1 (OSRAM) |
| ZA (1) | ZA200605165B (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY146351A (en) | 2003-05-29 | 2012-08-15 | Schering Plough Ltd | Compositions for treating infection in cattle and swine |
| US7439268B2 (en) | 2003-07-18 | 2008-10-21 | Idexx Laboratories | Compositions containing prodrugs of florfenicol and methods of use |
| MXPA06007215A (es) * | 2003-12-23 | 2006-08-18 | Schering Plough Ltd | Profarmaco florfenicol con mejor solubilidad en agua. |
| US7361689B2 (en) * | 2003-12-31 | 2008-04-22 | Schering-Plough Animal Health Corporation | Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof |
| NZ553777A (en) | 2004-09-23 | 2010-11-26 | Schering Plough Ltd | Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives |
| US7705038B2 (en) | 2004-11-19 | 2010-04-27 | Intervet, Inc. | Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives |
| JP2008545788A (ja) * | 2005-06-09 | 2008-12-18 | シェーリング−プラウ・リミテッド | Ｎ−［（フェニルオキシ）フェニル］−１，１，１−トリフルオロメタンスルホンアミドおよびｎ−［（フェニルスルファニル）フェニル）］−１，１，１−トリフルオロメタンスルホンアミド誘導体による動物中の寄生生物の制御 |
| US8119667B2 (en) * | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
| EP2091909A1 (en) * | 2006-12-13 | 2009-08-26 | Schering-Plough Ltd. | Water-soluble prodrugs of florfenicol and its analogs |
| EP2102154A1 (en) * | 2006-12-13 | 2009-09-23 | Schering-Plough Ltd. | Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof |
| WO2008076261A2 (en) * | 2006-12-13 | 2008-06-26 | Schering-Plough Ltd. | Water-soluble phenicol prodrugs in a lipophilic vehicle system |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| MX2009013748A (es) | 2007-06-27 | 2010-01-26 | Du Pont | Metodo de control de plagas en animales. |
| PE20091171A1 (es) * | 2007-12-14 | 2009-08-03 | Schering Plough Ltd | Proceso para recuperar florfenicol y analogos de florfenicol |
| JP2011529895A (ja) * | 2008-07-30 | 2011-12-15 | インターベツト・インターナシヨナル・ベー・ベー | フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法 |
| IN2012DN00838A (OSRAM) | 2009-08-05 | 2015-06-26 | Du Pont | |
| UA110924C2 (uk) | 2009-08-05 | 2016-03-10 | Е. І. Дю Пон Де Немур Енд Компані | Мезоіонні пестициди |
| AU2010279574A1 (en) | 2009-08-05 | 2012-02-09 | E. I. Du Pont De Nemours And Company | Mesoionic pesticides |
| WO2012087630A1 (en) | 2010-12-20 | 2012-06-28 | E.I. Du Pont De Nemours And Company | Pyridine and pyrimidine compounds for controlling invertebrate |
| WO2012150520A1 (en) | 2011-05-02 | 2012-11-08 | Pfizer Inc. | Novel cephalosporins useful as antibacterial agents |
| BR112013032813A2 (pt) | 2011-06-20 | 2016-08-16 | Du Pont | composto de fórmula, composição e método para o tratamento, controle, prevenção ou proteção dos animais contra a infecção por helmintos |
| KR20140094026A (ko) | 2011-11-28 | 2014-07-29 | 이 아이 듀폰 디 네모아 앤드 캄파니 | N-(4-퀴놀리닐메틸) 설폰아미드 유도체 및 구충제로서의 이의 용도 |
| WO2013158422A1 (en) | 2012-04-17 | 2013-10-24 | E. I. Du Pont De Nemours And Company | Heterocyclic compounds for controlling invertebrate pests |
| WO2014099837A1 (en) | 2012-12-18 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Sulfonamide anthelmintics |
| CN103242363B (zh) * | 2013-04-18 | 2015-10-28 | 湖北龙翔药业有限公司 | 氟苯尼考磷酸二酯及盐及其制备方法 |
| CN103923118A (zh) * | 2014-04-08 | 2014-07-16 | 张家港威胜生物医药有限公司 | 一种水溶性氟苯尼考衍生物的合成方法 |
| CN105111234B (zh) * | 2015-09-23 | 2017-05-17 | 河北远征禾木药业有限公司 | 一种氟苯尼考磷酸酯的合成方法 |
| CN110078729A (zh) * | 2019-06-11 | 2019-08-02 | 石家庄学院 | 一种水溶性氟苯尼考前药及其制备方法 |
| CN115286544A (zh) * | 2022-10-08 | 2022-11-04 | 世华合创生物技术开发(山东)有限公司 | 一种氟苯尼考衍生物、制备方法及其在抗细菌感染的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2776992A (en) | 1956-03-14 | 1957-01-08 | Du Pont | Trifluoromethylsulfonylphenyldichloracetamidopropandiol |
| US4235892A (en) * | 1979-02-05 | 1980-11-25 | Schering Corporation, Patent Dept. | 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor |
| FR2562543B1 (fr) * | 1984-04-10 | 1987-09-25 | Elf Aquitaine | Nouveaux phosphonites cycliques, leur preparation et applications |
| US5352832A (en) | 1992-12-18 | 1994-10-04 | Schering Corporation | Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates |
| US6864240B1 (en) | 1999-06-15 | 2005-03-08 | Elan Pharmaceuticals, Inc. | Dipeptide inhibitors of β-secretase |
| US6670344B2 (en) | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| CA2418102A1 (en) | 2001-06-15 | 2002-12-27 | George R. Pettit | Combretastatin a-3 prodrug |
| TW200406372A (en) | 2002-03-08 | 2004-05-01 | Schering Plough Ltd | Novel florfenicol-type antibiotics |
| US7439268B2 (en) * | 2003-07-18 | 2008-10-21 | Idexx Laboratories | Compositions containing prodrugs of florfenicol and methods of use |
| MXPA06007215A (es) | 2003-12-23 | 2006-08-18 | Schering Plough Ltd | Profarmaco florfenicol con mejor solubilidad en agua. |
| US7361689B2 (en) | 2003-12-31 | 2008-04-22 | Schering-Plough Animal Health Corporation | Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof |
-
2004
- 2004-12-20 MX MXPA06007215A patent/MXPA06007215A/es active IP Right Grant
- 2004-12-20 NZ NZ547592A patent/NZ547592A/xx not_active IP Right Cessation
- 2004-12-20 RU RU2006126519/04A patent/RU2006126519A/ru not_active Application Discontinuation
- 2004-12-20 AR ARP040104805A patent/AR046970A1/es not_active Application Discontinuation
- 2004-12-20 US US11/016,794 patent/US7153842B2/en not_active Expired - Lifetime
- 2004-12-20 KR KR1020067012460A patent/KR20060111605A/ko not_active Withdrawn
- 2004-12-20 EP EP04814736.7A patent/EP1696934B1/en not_active Expired - Lifetime
- 2004-12-20 WO PCT/US2004/042591 patent/WO2005063257A1/en not_active Ceased
- 2004-12-20 BR BRPI0418133-6A patent/BRPI0418133A2/pt not_active IP Right Cessation
- 2004-12-20 TW TW093139689A patent/TWI262181B/zh not_active IP Right Cessation
- 2004-12-20 CN CN200480038867A patent/CN100579532C/zh not_active Expired - Lifetime
- 2004-12-20 JP JP2006547183A patent/JP4719160B2/ja not_active Expired - Fee Related
- 2004-12-20 CA CA2550660A patent/CA2550660C/en not_active Expired - Fee Related
-
2005
- 2005-01-03 PE PE2005000020A patent/PE20050822A1/es not_active Application Discontinuation
-
2006
- 2006-06-15 IL IL176342A patent/IL176342A/en not_active IP Right Cessation
- 2006-06-22 ZA ZA200605165A patent/ZA200605165B/xx unknown
- 2006-06-22 EC EC2006006670A patent/ECSP066670A/es unknown
- 2006-07-12 NO NO20063244A patent/NO20063244L/no not_active Application Discontinuation
- 2006-08-29 US US11/511,810 patent/US7572777B2/en not_active Expired - Lifetime
-
2009
- 2009-07-23 IL IL200041A patent/IL200041A0/en unknown
-
2011
- 2011-02-23 JP JP2011037689A patent/JP2011148804A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007516286A (ja) | 2007-06-21 |
| RU2006126519A (ru) | 2008-01-27 |
| CA2550660C (en) | 2011-03-15 |
| CN100579532C (zh) | 2010-01-13 |
| NO20063244L (no) | 2006-09-20 |
| US20070021387A1 (en) | 2007-01-25 |
| CN1897954A (zh) | 2007-01-17 |
| EP1696934A1 (en) | 2006-09-06 |
| JP2011148804A (ja) | 2011-08-04 |
| AU2004308913A1 (en) | 2005-07-14 |
| NZ547592A (en) | 2009-07-31 |
| ZA200605165B (en) | 2007-12-27 |
| ECSP066670A (es) | 2006-10-25 |
| IL176342A0 (en) | 2006-10-05 |
| EP1696934B1 (en) | 2013-05-29 |
| TWI262181B (en) | 2006-09-21 |
| IL176342A (en) | 2011-08-31 |
| US7572777B2 (en) | 2009-08-11 |
| US20050182031A1 (en) | 2005-08-18 |
| TW200533640A (en) | 2005-10-16 |
| BRPI0418133A2 (pt) | 2009-03-24 |
| MXPA06007215A (es) | 2006-08-18 |
| WO2005063257A1 (en) | 2005-07-14 |
| AR046970A1 (es) | 2006-01-04 |
| JP4719160B2 (ja) | 2011-07-06 |
| US7153842B2 (en) | 2006-12-26 |
| KR20060111605A (ko) | 2006-10-27 |
| CA2550660A1 (en) | 2005-07-14 |
| IL200041A0 (en) | 2010-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |