PE20050667A1 - Formas de anticuerpos anti-egfr - Google Patents

Formas de anticuerpos anti-egfr

Info

Publication number
PE20050667A1
PE20050667A1 PE2004001170A PE2004001170A PE20050667A1 PE 20050667 A1 PE20050667 A1 PE 20050667A1 PE 2004001170 A PE2004001170 A PE 2004001170A PE 2004001170 A PE2004001170 A PE 2004001170A PE 20050667 A1 PE20050667 A1 PE 20050667A1
Authority
PE
Peru
Prior art keywords
forms
referred
crystalline precipitate
egfr antibodies
antibodies
Prior art date
Application number
PE2004001170A
Other languages
English (en)
Inventor
Susanne Matheus
Hanns-Christian Mahler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34625406&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20050667(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PE20050667A1 publication Critical patent/PE20050667A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

REFERIDA A FORMAS SOLIDAS DE UN ANTICUERPO CONTRA EL RECEPTOR EGF (ANTI-EGFR) TALES COMO SULFATO DE AMONIO, ACETATO DE SODIO, CITRATO DE SODIO, PEG, ENTRE OTROS, COMO PRECIPITADOS O CRISTALES DE ANTICUERPOS MONOCLONALES CON Mab DE C225 Y Mab h425 (EMD 72000) Y UNA CONCENTRACION DE ANTICUERPOS ENTRE 10-200 mg/ml. TAMBIEN REFERIDA A PREPARACIONES FARMACEUTICAS QUE COMPRENDEN AL MENOS UNA FORMA SOLIDA ANTES MENCIONADA COMO PRECIPITADO NO CRISTALINO, PRECIPITADO CRISTALINO, SOLUBLE O SUSPENDIDO. DICHAS PREPARACIONES SON UTILES EN EL TRATAMIENTO DE TUMORES UROGENITALES, DEL SISTEMA LINFATICO, LARINGEOS, CEREBRALES, ENTRE OTROS
PE2004001170A 2003-11-29 2004-11-26 Formas de anticuerpos anti-egfr PE20050667A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10355904A DE10355904A1 (de) 2003-11-29 2003-11-29 Feste Formen von anti-EGFR-Antikörpern

Publications (1)

Publication Number Publication Date
PE20050667A1 true PE20050667A1 (es) 2005-09-27

Family

ID=34625406

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004001170A PE20050667A1 (es) 2003-11-29 2004-11-26 Formas de anticuerpos anti-egfr

Country Status (21)

Country Link
US (1) US7960516B2 (es)
EP (2) EP1686961A1 (es)
KR (2) KR20060111539A (es)
CN (1) CN1886118A (es)
AR (1) AR046677A1 (es)
AU (1) AU2004292742B9 (es)
BR (1) BRPI0416968A (es)
CA (1) CA2547446C (es)
CO (1) CO5690537A2 (es)
DE (1) DE10355904A1 (es)
EC (1) ECSP066681A (es)
IL (1) IL175935A (es)
MX (1) MXPA06005968A (es)
MY (1) MY148228A (es)
NZ (1) NZ548210A (es)
PE (1) PE20050667A1 (es)
RU (1) RU2397755C2 (es)
TW (1) TWI350291B (es)
UA (1) UA84893C2 (es)
WO (1) WO2005051355A1 (es)
ZA (1) ZA200605348B (es)

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US8367427B2 (en) 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
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US8323615B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US10143652B2 (en) * 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
CN102153648B (zh) * 2011-01-27 2012-07-04 中国人民解放军军事医学科学院生物工程研究所 一种抗egfr人源化抗体l4-h3及其编码基因与应用
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PT2739649T (pt) 2011-08-05 2018-01-03 Bioasis Technologies Inc Fragmentos de p97 com atividade de transferência
CA2880162C (en) 2012-07-31 2023-04-04 Bioasis Technologies, Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
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Also Published As

Publication number Publication date
AR046677A1 (es) 2005-12-14
IL175935A0 (en) 2006-10-05
TWI350291B (en) 2011-10-11
AU2004292742B2 (en) 2011-08-25
EP1974723A3 (de) 2010-06-09
WO2005051355A1 (de) 2005-06-09
RU2397755C2 (ru) 2010-08-27
DE10355904A1 (de) 2005-06-30
US7960516B2 (en) 2011-06-14
ECSP066681A (es) 2006-10-25
UA84893C2 (en) 2008-12-10
MXPA06005968A (es) 2006-07-06
NZ548210A (en) 2010-10-29
IL175935A (en) 2013-10-31
CO5690537A2 (es) 2006-10-31
KR20060111539A (ko) 2006-10-27
ZA200605348B (en) 2007-04-25
EP1686961A1 (de) 2006-08-09
AU2004292742A1 (en) 2005-06-09
BRPI0416968A (pt) 2007-02-21
RU2006123005A (ru) 2008-01-20
US20070122411A1 (en) 2007-05-31
EP1974723A2 (de) 2008-10-01
MY148228A (en) 2013-03-29
CA2547446C (en) 2013-05-14
CN1886118A (zh) 2006-12-27
KR20120093406A (ko) 2012-08-22
CA2547446A1 (en) 2005-06-09
AU2004292742B9 (en) 2011-11-24
TW200530268A (en) 2005-09-16

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