ECSP066681A - Formas sólidas de anticuerpos anti-egfr - Google Patents
Formas sólidas de anticuerpos anti-egfrInfo
- Publication number
- ECSP066681A ECSP066681A EC2006006681A ECSP066681A ECSP066681A EC SP066681 A ECSP066681 A EC SP066681A EC 2006006681 A EC2006006681 A EC 2006006681A EC SP066681 A ECSP066681 A EC SP066681A EC SP066681 A ECSP066681 A EC SP066681A
- Authority
- EC
- Ecuador
- Prior art keywords
- solid forms
- antibodies
- mab
- aqueous medium
- egfr antibodies
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Metallurgy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La invención se refiere a formas sólidas de anticuerpos contra el receptor EGF, en particular a precipitados y cristales de anticuerpos monoclonales contra el receptor EGF, con preferencia particular de Mab C225 (cetuximab) y Mab h425 (EMD 72000), que dan como resultado proteínas de anticuerpo biológicamente activas por disolución o la suspensión en medio acuoso, que se pueden obtener por precipitación del anticuerpo y/o una de sus variantes y/o fragmentos disueltos o suspendidos en medio acuoso por medio de un reactivo de precipitación. La invención también se refiere a preparaciones farmacéuticas que comprenden al menos una forma sólida de los anticuerpos antes mencionados en forma de precipitado no cristalino, precipitado cristalino o en forma soluble o suspendida, y opcionalmente excipientes y/o coadyuvantes y/u otros ingredientes activos farmacéuticos, y a un procedimiento para preparar formas sólidas de anticuerpos anti-EGFR de acuerdo con la invención.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10355904A DE10355904A1 (de) | 2003-11-29 | 2003-11-29 | Feste Formen von anti-EGFR-Antikörpern |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066681A true ECSP066681A (es) | 2006-10-25 |
Family
ID=34625406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006681A ECSP066681A (es) | 2003-11-29 | 2006-06-28 | Formas sólidas de anticuerpos anti-egfr |
Country Status (21)
Country | Link |
---|---|
US (1) | US7960516B2 (es) |
EP (2) | EP1974723A3 (es) |
KR (2) | KR20060111539A (es) |
CN (1) | CN1886118A (es) |
AR (1) | AR046677A1 (es) |
AU (1) | AU2004292742B9 (es) |
BR (1) | BRPI0416968A (es) |
CA (1) | CA2547446C (es) |
CO (1) | CO5690537A2 (es) |
DE (1) | DE10355904A1 (es) |
EC (1) | ECSP066681A (es) |
IL (1) | IL175935A (es) |
MX (1) | MXPA06005968A (es) |
MY (1) | MY148228A (es) |
NZ (1) | NZ548210A (es) |
PE (1) | PE20050667A1 (es) |
RU (1) | RU2397755C2 (es) |
TW (1) | TWI350291B (es) |
UA (1) | UA84893C2 (es) |
WO (1) | WO2005051355A1 (es) |
ZA (1) | ZA200605348B (es) |
Families Citing this family (48)
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US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
CA2373815A1 (en) * | 1999-05-14 | 2000-11-23 | Imclone Systems Incorporated | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
CA2418083A1 (en) * | 2000-08-09 | 2002-02-14 | Imclone Systems Incorporated | Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists |
US20080008704A1 (en) * | 2001-03-16 | 2008-01-10 | Mark Rubin | Methods of treating colorectal cancer with anti-epidermal growth factor antibodies |
US20080026068A1 (en) * | 2001-08-16 | 2008-01-31 | Baxter Healthcare S.A. | Pulmonary delivery of spherical insulin microparticles |
JP2006506317A (ja) | 2002-01-11 | 2006-02-23 | バイオマリン ファーマシューティカル インコーポレイテッド | 治療用リソソーム酵素の送達のための酵素送達系としてのp97の使用 |
EP1622941A2 (en) * | 2003-03-20 | 2006-02-08 | ImClone Systems Incorporated | Method of producing an antibody to epidermal growth factor receptor |
DK1735348T3 (da) * | 2004-03-19 | 2012-07-16 | Imclone Llc | Humant anti-epidermalt vækstfaktorreceptorantistof |
JP2007537288A (ja) * | 2004-05-12 | 2007-12-20 | バクスター インターナショナル インコーポレイテッド | オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用 |
MXPA06012990A (es) | 2004-05-12 | 2007-02-12 | Baxter Int | Microesferas de acidos nucleicos, produccion y suministro de las mismas. |
US8728525B2 (en) * | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
JP5634009B2 (ja) * | 2004-05-12 | 2014-12-03 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | タンパク質を含み、そして高濃度のタンパク質で注射性能を示すミクロスフェア |
EP2647712A3 (en) | 2006-08-04 | 2013-11-20 | Baxter International Inc | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
WO2008057240A2 (en) * | 2006-10-27 | 2008-05-15 | Abbott Biotechnology Ltd. | Crystalline anti-htnfalpha antibodies |
WO2008131129A2 (en) * | 2007-04-17 | 2008-10-30 | Baxter International Inc. | Nucleic acid microparticles for pulmonary delivery |
RU2010107994A (ru) * | 2007-08-08 | 2011-09-20 | Эбботт Лэборетриз (Us) | Композиции и способы кристаллизации антител |
EP2212412A4 (en) * | 2007-10-15 | 2011-03-09 | Biogen Idec Inc | METHODS OF MANUFACTURING A BIOLOGICAL PRODUCT USING AN INTERMEDIATE STABLE STORAGE PRODUCT |
US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US8323685B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US10143652B2 (en) * | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
CN102153648B (zh) * | 2011-01-27 | 2012-07-04 | 中国人民解放军军事医学科学院生物工程研究所 | 一种抗egfr人源化抗体l4-h3及其编码基因与应用 |
US9150846B2 (en) | 2011-07-05 | 2015-10-06 | Bioasis Technologies, Inc. | P97-antibody conjugates and methods of use |
PT2739649T (pt) | 2011-08-05 | 2018-01-03 | Bioasis Technologies Inc | Fragmentos de p97 com atividade de transferência |
AU2013296557B2 (en) | 2012-07-31 | 2019-04-18 | Bioasis Technologies Inc. | Dephosphorylated lysosomal storage disease proteins and methods of use thereof |
CN110478481A (zh) | 2013-03-13 | 2019-11-22 | 比奥阿赛斯技术有限公司 | p97片段及其应用 |
WO2015031673A2 (en) | 2013-08-28 | 2015-03-05 | Bioasis Technologies Inc. | Cns-targeted conjugates having modified fc regions and methods of use thereof |
JP6603227B2 (ja) | 2014-02-03 | 2019-11-06 | バイオアシス テクノロジーズ インコーポレイテッド | P97融合タンパク質 |
WO2015126729A1 (en) | 2014-02-19 | 2015-08-27 | Bioasis Technologies, Inc. | P97-ids fusion proteins |
CA2943890A1 (en) | 2014-05-01 | 2015-11-05 | Bioasis Technologies, Inc. | P97-polynucleotide conjugates |
US10111955B2 (en) * | 2014-12-04 | 2018-10-30 | Delta-Fly Pharma, Inc. | PEG derivative |
RU2708461C2 (ru) * | 2015-02-15 | 2019-12-09 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Конъюгат лиганда с цитотоксическим лекарственным средством, способ его получения и применение |
US10792370B2 (en) * | 2015-02-17 | 2020-10-06 | Shanghai Miracogen Inc | Antibody-drug conjugate |
AR103726A1 (es) | 2015-02-27 | 2017-05-31 | Merck Sharp & Dohme | Cristales de anticuerpos monoclonales anti-pd-1 humanos |
TW201709932A (zh) * | 2015-06-12 | 2017-03-16 | 西雅圖遺傳學公司 | Cd123抗體及其共軛物 |
IL303690A (en) * | 2015-06-30 | 2023-08-01 | Seagen Inc | Anti–NTB–A antibodies and related preparations and methods |
CN105810072A (zh) * | 2016-03-25 | 2016-07-27 | 淮海工学院 | 一种蛋白质结晶的教学试剂盒及其方法 |
CN109415441B (zh) | 2016-05-24 | 2023-04-07 | 英斯梅德股份有限公司 | 抗体及其制备方法 |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
RU2019138507A (ru) | 2017-05-02 | 2021-06-02 | Мерк Шарп И Доум Корп. | Составы антител против lag3 и совместные составы антител против lag3 и антител против pd-1 |
WO2019195959A1 (en) | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
US20230009076A1 (en) * | 2019-06-28 | 2023-01-12 | Serina Therapeutics, Inc. | Polyoxazoline-drug conjugates with novel pharmacokinetic properties |
EP3954393A1 (en) | 2020-08-13 | 2022-02-16 | Bioasis Technologies Inc. | Combination therapies for delivery across the blood brain barrier |
CA3200812A1 (en) * | 2020-12-04 | 2022-06-09 | Qingsong GUO | Antibody-drug conjugate, and intermediate thereof, preparation method thereof, and application thereof |
CN115073437B (zh) * | 2021-03-11 | 2023-07-18 | 北京师范大学 | 基于二氰基吡喃的大环多胺[12]aneN3化合物及其制备方法与用途 |
CN114652826B (zh) * | 2022-01-24 | 2022-10-14 | 景泽生物医药(合肥)有限公司 | 抗egfr抗体的用途 |
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Publication number | Priority date | Publication date | Assignee | Title |
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
EP0463151B1 (en) | 1990-01-12 | 1996-06-12 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
US5558864A (en) * | 1991-03-06 | 1996-09-24 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies |
WO1993000807A1 (en) | 1991-07-03 | 1993-01-21 | Cryolife, Inc. | Method for stabilization of biomaterials |
WO1994002602A1 (en) | 1992-07-24 | 1994-02-03 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
ES2144440T3 (es) | 1992-08-18 | 2000-06-16 | Centro Inmunologia Molecular | Anticuerpos monoclonales que reconocen el receptor del factor de crecimiento epidermico, celulas y metodos para su produccion y compuestos que los contienen. |
EP1978033A3 (en) | 1995-04-27 | 2008-12-24 | Amgen Fremont Inc. | Human antibodies derived from immunized xenomice |
US7060808B1 (en) | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
WO1996040210A1 (en) * | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
IL156618A0 (en) * | 2000-12-28 | 2004-01-04 | Altus Biologics Inc | Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same |
EP1389090A2 (en) * | 2001-04-26 | 2004-02-18 | Board of Regents, The University of Texas System | Diagnostic imaging compositions, their methods of synthesis and use |
DE10133394A1 (de) | 2001-07-13 | 2003-01-30 | Merck Patent Gmbh | Flüssige Formulierung enthaltend Cetuximab |
DE10163459A1 (de) * | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
WO2006009694A2 (en) * | 2004-06-14 | 2006-01-26 | Imclone Sysetms Incorporated | Crystal of egfr extracellular domain and cetuximab fab fragment and uses thereof |
-
2003
- 2003-11-29 DE DE10355904A patent/DE10355904A1/de not_active Withdrawn
-
2004
- 2004-11-12 KR KR1020067010456A patent/KR20060111539A/ko active Search and Examination
- 2004-11-12 MX MXPA06005968A patent/MXPA06005968A/es active IP Right Grant
- 2004-11-12 US US10/580,563 patent/US7960516B2/en not_active Expired - Fee Related
- 2004-11-12 BR BRPI0416968-9A patent/BRPI0416968A/pt not_active IP Right Cessation
- 2004-11-12 EP EP08011237A patent/EP1974723A3/de not_active Withdrawn
- 2004-11-12 CN CNA2004800345872A patent/CN1886118A/zh active Pending
- 2004-11-12 EP EP04797849A patent/EP1686961A1/de not_active Ceased
- 2004-11-12 NZ NZ548210A patent/NZ548210A/en not_active IP Right Cessation
- 2004-11-12 CA CA2547446A patent/CA2547446C/en not_active Expired - Fee Related
- 2004-11-12 KR KR1020127017106A patent/KR20120093406A/ko not_active Application Discontinuation
- 2004-11-12 WO PCT/EP2004/012837 patent/WO2005051355A1/de active Application Filing
- 2004-11-12 AU AU2004292742A patent/AU2004292742B9/en not_active Ceased
- 2004-11-12 RU RU2006123005/15A patent/RU2397755C2/ru not_active IP Right Cessation
- 2004-11-24 MY MYPI20044872A patent/MY148228A/en unknown
- 2004-11-26 PE PE2004001170A patent/PE20050667A1/es not_active Application Discontinuation
- 2004-11-26 TW TW093136625A patent/TWI350291B/zh not_active IP Right Cessation
- 2004-11-26 AR ARP040104385A patent/AR046677A1/es not_active Application Discontinuation
- 2004-12-11 UA UAA200607231A patent/UA84893C2/ru unknown
-
2006
- 2006-05-25 CO CO06050507A patent/CO5690537A2/es unknown
- 2006-05-25 IL IL175935A patent/IL175935A/en not_active IP Right Cessation
- 2006-06-28 ZA ZA200605348A patent/ZA200605348B/xx unknown
- 2006-06-28 EC EC2006006681A patent/ECSP066681A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2547446C (en) | 2013-05-14 |
UA84893C2 (en) | 2008-12-10 |
AR046677A1 (es) | 2005-12-14 |
AU2004292742B2 (en) | 2011-08-25 |
KR20120093406A (ko) | 2012-08-22 |
CN1886118A (zh) | 2006-12-27 |
RU2006123005A (ru) | 2008-01-20 |
EP1974723A2 (de) | 2008-10-01 |
PE20050667A1 (es) | 2005-09-27 |
IL175935A (en) | 2013-10-31 |
EP1686961A1 (de) | 2006-08-09 |
MY148228A (en) | 2013-03-29 |
KR20060111539A (ko) | 2006-10-27 |
EP1974723A3 (de) | 2010-06-09 |
DE10355904A1 (de) | 2005-06-30 |
AU2004292742B9 (en) | 2011-11-24 |
ZA200605348B (en) | 2007-04-25 |
BRPI0416968A (pt) | 2007-02-21 |
CO5690537A2 (es) | 2006-10-31 |
MXPA06005968A (es) | 2006-07-06 |
WO2005051355A1 (de) | 2005-06-09 |
US7960516B2 (en) | 2011-06-14 |
TWI350291B (en) | 2011-10-11 |
TW200530268A (en) | 2005-09-16 |
AU2004292742A1 (en) | 2005-06-09 |
US20070122411A1 (en) | 2007-05-31 |
CA2547446A1 (en) | 2005-06-09 |
RU2397755C2 (ru) | 2010-08-27 |
NZ548210A (en) | 2010-10-29 |
IL175935A0 (en) | 2006-10-05 |
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