PE20041057A1 - Derivados de azabiciclos sustituidos de piridiloximetilo y bencisoxazol - Google Patents

Derivados de azabiciclos sustituidos de piridiloximetilo y bencisoxazol

Info

Publication number
PE20041057A1
PE20041057A1 PE2004000256A PE2004000256A PE20041057A1 PE 20041057 A1 PE20041057 A1 PE 20041057A1 PE 2004000256 A PE2004000256 A PE 2004000256A PE 2004000256 A PE2004000256 A PE 2004000256A PE 20041057 A1 PE20041057 A1 PE 20041057A1
Authority
PE
Peru
Prior art keywords
iloximethyl
ilmethyl
alcoxy
pyrid
isoxazol
Prior art date
Application number
PE2004000256A
Other languages
English (en)
Inventor
Gene Michael Bright
Michael Aaron Brodney
Bishop Wlodecki
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20041057A1 publication Critical patent/PE20041057A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

SE REFIERE A DERIVADOS AZABICICLICOS DE PIRIDILOXIMETILO Y BENCISOXASOL DE FORMULA I DONDE m ES 0-1; Z ES C(O)-R7, -CH2-R8, ENTRE OTROS; DONDE R7 ES H, ALCOXI C1-C3; R8 ES H, OH, ALCOXI C1-C3; Y ES METILENO DONDE n ES 0-2; R1 Y R2 SON H, HALO, ALQUILO C1-C6; ALCOXI C1-C6; R3 Y R4 SON H, ALQUILO C1-C6; CICLOALQUILO C3-C7, GRUPO HETEROCICLICO DE 5 A 6 MIEMBROS, ENTRE OTROS; R3 Y R4 JUNTO AL N AL QUE ESTAN UNIDOS FORMAN UN ANILLO MONOCICLICO OPCIONALMENTE INSATURADO DE 3 A 7 MIEMBROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (7R,9aS)-TRANS-2-BENZO[d]ISOXAZOL-3-IL-7-(6-MORFOLIN-4-1-ILMETIL-PIRIDIN-2-ILOXIMETIL)-OCTAHIDRO-PIRIDO-[1,2-a]PIRAZINA, (7R,9aS)-TRANS-2-BENZO[d]ISOXAZOL-3-IL-7-(5-PIPERIDIN-1-ILMETIL-PIRIDIN-2-ILOXIMETIL)-OCTAHIDRO-PIRIDO-[1,2-a]PIRAZINA, (7R,9aS)-TRANS-2-(5-FLUORO-BENZO[d]ISOXAZOL-3-IL)-7-(5-PIRROLIDIN-1-ILMETIL-PIRIDIN-2-ILOXIMETIL)-OCTAHIDRO-PIRIDO-[1,2-a]PIRAZINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS INHIBEN LOS RECEPTORES 5-HT1B, 5-HT2A Y D2 Y SON UTILES PARA TRATAR UNO O MAS TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL COMO ESQUIZOFRENIA Y DEPRESION
PE2004000256A 2003-03-12 2004-03-09 Derivados de azabiciclos sustituidos de piridiloximetilo y bencisoxazol PE20041057A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45392503P 2003-03-12 2003-03-12

Publications (1)

Publication Number Publication Date
PE20041057A1 true PE20041057A1 (es) 2005-01-22

Family

ID=32990837

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000256A PE20041057A1 (es) 2003-03-12 2004-03-09 Derivados de azabiciclos sustituidos de piridiloximetilo y bencisoxazol

Country Status (31)

Country Link
US (1) US7345038B2 (es)
EP (1) EP1608648B1 (es)
JP (2) JP3910627B2 (es)
KR (2) KR20070074667A (es)
CN (1) CN100389115C (es)
AP (1) AP2005003390A0 (es)
AR (1) AR043537A1 (es)
AU (2) AU2004220327B2 (es)
BR (1) BRPI0408248A (es)
CA (1) CA2518740C (es)
EA (1) EA009527B1 (es)
EC (1) ECSP056011A (es)
GT (1) GT200400041A (es)
HK (1) HK1085725A1 (es)
HR (1) HRP20050798A2 (es)
IL (1) IL170290A (es)
MA (1) MA27747A1 (es)
MX (1) MXPA05009660A (es)
NL (1) NL1025710C2 (es)
NO (1) NO20054095L (es)
OA (1) OA13038A (es)
PA (1) PA8597501A1 (es)
PE (1) PE20041057A1 (es)
PL (1) PL378749A1 (es)
RS (1) RS20050692A (es)
TN (1) TNSN05224A1 (es)
TW (1) TW200502234A (es)
UA (1) UA78437C2 (es)
UY (1) UY28225A1 (es)
WO (1) WO2004081007A1 (es)
ZA (1) ZA200506373B (es)

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US6994726B2 (en) * 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
CN1898240B (zh) * 2003-10-15 2011-08-03 Osi制药公司 咪唑并吡嗪类酪氨酸激酶抑制剂
BRPI0507250A (pt) * 2004-01-29 2007-06-26 Pfizer Prod Inc combinações para tratar desordens do snc
BRPI0509576A (pt) 2004-04-02 2007-05-29 Osi Pharm Inc composto, método de tratamento de um paciente tendo uma condição que é mediada pela atividade de proteìna quinase, e, composição farmacêutica
TW200613306A (en) 2004-07-20 2006-05-01 Osi Pharm Inc Imidazotriazines as protein kinase inhibitors
MX2007002842A (es) * 2004-09-10 2007-04-30 Pfizer Prod Inc Metodos de tratamiento de trastornos cognitivos que usan derivados azabiciclicos de piridiloximetilo y benzoisoxazol.
US8575164B2 (en) * 2005-12-19 2013-11-05 OSI Pharmaceuticals, LLC Combination cancer therapy
WO2009091939A1 (en) * 2008-01-18 2009-07-23 Osi Pharmaceuticals, Inc. Imidazopyrazinol derivatives for the treatment of cancers
JP2011520970A (ja) * 2008-05-19 2011-07-21 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 置換されたイミダゾピラジン類およびイミダゾトリアジン類
CA2752826A1 (en) 2009-04-20 2010-10-28 OSI Pharmaceuticals, LLC Preparation of c-pyrazine-methylamines
JP2012526138A (ja) * 2009-05-07 2012-10-25 オーエスアイ・ファーマシューティカルズ，エルエルシー 副腎皮質癌を治療するためのｏｓｉ−９０６の使用
JP2013540145A (ja) * 2010-10-21 2013-10-31 ウニベルシテート デス ザールランデス コルチゾール依存性疾患の治療用の選択的ｃｙｐ１１ｂ１阻害剤
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
US9980945B2 (en) 2015-01-13 2018-05-29 Vanderbilt University Benzoisoxazole-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer
WO2023083445A1 (en) 2021-11-10 2023-05-19 Symrise Ag Compositions comprising trpm8 agonistic cooling agents

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Also Published As

Publication number Publication date
RS20050692A (en) 2007-11-15
MXPA05009660A (es) 2005-10-20
ZA200506373B (en) 2006-10-25
JP2006519830A (ja) 2006-08-31
NO20054095D0 (no) 2005-09-02
EP1608648B1 (en) 2012-07-18
HK1085725A1 (en) 2006-09-01
PA8597501A1 (es) 2005-05-24
TW200502234A (en) 2005-01-16
JP3910627B2 (ja) 2007-04-25
UA78437C2 (en) 2007-03-15
US7345038B2 (en) 2008-03-18
EP1608648A1 (en) 2005-12-28
CN100389115C (zh) 2008-05-21
CA2518740C (en) 2011-01-11
AU2004220327A1 (en) 2004-09-23
GT200400041A (es) 2005-03-23
AU2004220327B2 (en) 2010-06-24
EA009527B1 (ru) 2008-02-28
WO2004081007A1 (en) 2004-09-23
PL378749A1 (pl) 2006-05-15
AR043537A1 (es) 2005-08-03
CN1759116A (zh) 2006-04-12
KR20070074667A (ko) 2007-07-12
NO20054095L (no) 2005-09-26
US20050026922A1 (en) 2005-02-03
EA200501148A1 (ru) 2006-04-28
UY28225A1 (es) 2004-11-08
HRP20050798A2 (en) 2006-02-28
AP2005003390A0 (en) 2005-09-30
TNSN05224A1 (fr) 2007-06-11
ECSP056011A (es) 2006-01-27
OA13038A (en) 2006-11-10
AU2010203303A1 (en) 2010-08-12
CA2518740A1 (en) 2004-09-23
BRPI0408248A (pt) 2006-03-01
MA27747A1 (fr) 2006-02-01
NL1025710C2 (nl) 2005-10-10
KR20050113221A (ko) 2005-12-01
IL170290A (en) 2011-02-28
JP2007051155A (ja) 2007-03-01
NL1025710A1 (nl) 2004-09-14
KR100767854B1 (ko) 2007-10-17

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