PE20031017A1 - Composicion farmaceutica de oxicodona de liberacion sostenida - Google Patents

Composicion farmaceutica de oxicodona de liberacion sostenida

Info

Publication number
PE20031017A1
PE20031017A1 PE2003000425A PE2003000425A PE20031017A1 PE 20031017 A1 PE20031017 A1 PE 20031017A1 PE 2003000425 A PE2003000425 A PE 2003000425A PE 2003000425 A PE2003000425 A PE 2003000425A PE 20031017 A1 PE20031017 A1 PE 20031017A1
Authority
PE
Peru
Prior art keywords
release
nucleus
dosage form
compound
cmax
Prior art date
Application number
PE2003000425A
Other languages
English (en)
Inventor
Clark P Allphin
Atul D Ayer
Tracy A Fink
Deborah J Johnson
Padmaja Shivanand
Nishit B Modi
Linda M Hearney
Michael A Desjardin
Sonya Seroff
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29401352&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20031017(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Publication of PE20031017A1 publication Critical patent/PE20031017A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

FORMA DE DOSIFICACION QUE COMPRENDE: a)UN NUCLEO QUE CONTIENE: i)UN AGENTE OSMOTICO; Y, ii)OXICODONA Y UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LA MISMA; b)UNA MEMBRANA SEMIPERMEABLE QUE ENVUELVE AL NUCLEO; Y, c)UN ORIFICIO DE SALIDA POR (b) QUE SE COMUNICA CON EL NUCLEO DE MANERA QUE PERMITE LA LIBERACION DEL COMPUESTO AL ENTORNO; DONDE LA FORMA DE DOSIFICACION ORAL LIBERA EL COMPUESTO DURANTE UN PERIODO PROLONGADO A UNA VELOCIDAD UNIFORME DE LIBERACION DE MODO QUE LA VELOCIDAD DE LIBERACION HORARIA PROMEDIO DEL NUCLEO VARIA DE MANERA POSITIVA O NEGATIVA EN NO MAS DE 30% CON RESPECTO A LA VELOCIDAD DE LIBERACION HORARIA PROMEDIO PRECEDENTE O POSTERIOR DURANTE UN PROMEDIO Tuniforme DE AL MENOS 4 h, QUE EMPIEZA CUANDO LA LIBERACION ACUMULATIVA DEL COMPUESTO DEL NUCLEO LLEGA A 25% Y TERMINA CUANDO LA LIBERACION ACUMULATIVA DEL COMPUESTO DEL NUCLEO LLEGA A 75%. LA ADMINISTRACION DE LA FORMA DE DOSIFICACION DESCRITA UNA VEZ AL DIA PROPORCIONA AL PACIENTE UN PERFIL DE CONCENTRACION EN PLASMA MEDIO, EN ESTADO ESTABLE, DURANTE UN PERIODO DE 24 h, QUE TIENE SU VALOR MAXIMO Cmax A MAS DE 6 HORAS DESPUES DE LA ADMINISTRACION Y SATISFACE LA RELACION (Cmax-Cmin)/Cmin <= 2, SIENDO Cmax MEDIDO EN ng/ml
PE2003000425A 2002-04-29 2003-04-29 Composicion farmaceutica de oxicodona de liberacion sostenida PE20031017A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37647002P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
PE20031017A1 true PE20031017A1 (es) 2003-11-29

Family

ID=29401352

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000425A PE20031017A1 (es) 2002-04-29 2003-04-29 Composicion farmaceutica de oxicodona de liberacion sostenida

Country Status (24)

Country Link
US (1) US20040010000A1 (es)
EP (1) EP1499291B1 (es)
JP (1) JP2005525405A (es)
CN (1) CN1665482A (es)
AR (1) AR039491A1 (es)
AT (1) ATE419830T1 (es)
AU (1) AU2003234216A1 (es)
BR (1) BR0309620A (es)
CA (1) CA2483655A1 (es)
DE (1) DE60325715D1 (es)
EC (1) ECSP045451A (es)
ES (1) ES2320435T3 (es)
HK (1) HK1072558A1 (es)
IL (1) IL164911A0 (es)
MX (1) MXPA04010769A (es)
NO (1) NO20045117L (es)
NZ (1) NZ536252A (es)
PE (1) PE20031017A1 (es)
PL (1) PL373031A1 (es)
RU (1) RU2004134594A (es)
TW (1) TW200404010A (es)
UY (1) UY27789A1 (es)
WO (1) WO2003092648A1 (es)
ZA (1) ZA200409549B (es)

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Also Published As

Publication number Publication date
NZ536252A (en) 2007-06-29
HK1072558A1 (en) 2005-09-02
NO20045117L (no) 2005-01-14
RU2004134594A (ru) 2005-06-27
WO2003092648A1 (en) 2003-11-13
BR0309620A (pt) 2005-03-15
MXPA04010769A (es) 2005-07-05
EP1499291A1 (en) 2005-01-26
PL373031A1 (en) 2005-08-08
IL164911A0 (en) 2005-12-18
JP2005525405A (ja) 2005-08-25
CN1665482A (zh) 2005-09-07
TW200404010A (en) 2004-03-16
ATE419830T1 (de) 2009-01-15
ES2320435T3 (es) 2009-05-22
CA2483655A1 (en) 2003-11-13
ECSP045451A (es) 2005-01-28
DE60325715D1 (de) 2009-02-26
UY27789A1 (es) 2003-08-29
AU2003234216A1 (en) 2003-11-17
ZA200409549B (en) 2006-07-26
EP1499291B1 (en) 2009-01-07
US20040010000A1 (en) 2004-01-15
AR039491A1 (es) 2005-02-23

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