PE20031017A1 - Composicion farmaceutica de oxicodona de liberacion sostenida - Google Patents
Composicion farmaceutica de oxicodona de liberacion sostenidaInfo
- Publication number
- PE20031017A1 PE20031017A1 PE2003000425A PE2003000425A PE20031017A1 PE 20031017 A1 PE20031017 A1 PE 20031017A1 PE 2003000425 A PE2003000425 A PE 2003000425A PE 2003000425 A PE2003000425 A PE 2003000425A PE 20031017 A1 PE20031017 A1 PE 20031017A1
- Authority
- PE
- Peru
- Prior art keywords
- release
- nucleus
- dosage form
- compound
- cmax
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
FORMA DE DOSIFICACION QUE COMPRENDE: a)UN NUCLEO QUE CONTIENE: i)UN AGENTE OSMOTICO; Y, ii)OXICODONA Y UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LA MISMA; b)UNA MEMBRANA SEMIPERMEABLE QUE ENVUELVE AL NUCLEO; Y, c)UN ORIFICIO DE SALIDA POR (b) QUE SE COMUNICA CON EL NUCLEO DE MANERA QUE PERMITE LA LIBERACION DEL COMPUESTO AL ENTORNO; DONDE LA FORMA DE DOSIFICACION ORAL LIBERA EL COMPUESTO DURANTE UN PERIODO PROLONGADO A UNA VELOCIDAD UNIFORME DE LIBERACION DE MODO QUE LA VELOCIDAD DE LIBERACION HORARIA PROMEDIO DEL NUCLEO VARIA DE MANERA POSITIVA O NEGATIVA EN NO MAS DE 30% CON RESPECTO A LA VELOCIDAD DE LIBERACION HORARIA PROMEDIO PRECEDENTE O POSTERIOR DURANTE UN PROMEDIO Tuniforme DE AL MENOS 4 h, QUE EMPIEZA CUANDO LA LIBERACION ACUMULATIVA DEL COMPUESTO DEL NUCLEO LLEGA A 25% Y TERMINA CUANDO LA LIBERACION ACUMULATIVA DEL COMPUESTO DEL NUCLEO LLEGA A 75%. LA ADMINISTRACION DE LA FORMA DE DOSIFICACION DESCRITA UNA VEZ AL DIA PROPORCIONA AL PACIENTE UN PERFIL DE CONCENTRACION EN PLASMA MEDIO, EN ESTADO ESTABLE, DURANTE UN PERIODO DE 24 h, QUE TIENE SU VALOR MAXIMO Cmax A MAS DE 6 HORAS DESPUES DE LA ADMINISTRACION Y SATISFACE LA RELACION (Cmax-Cmin)/Cmin <= 2, SIENDO Cmax MEDIDO EN ng/ml
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37647002P | 2002-04-29 | 2002-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20031017A1 true PE20031017A1 (es) | 2003-11-29 |
Family
ID=29401352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000425A PE20031017A1 (es) | 2002-04-29 | 2003-04-29 | Composicion farmaceutica de oxicodona de liberacion sostenida |
Country Status (24)
Country | Link |
---|---|
US (1) | US20040010000A1 (es) |
EP (1) | EP1499291B1 (es) |
JP (1) | JP2005525405A (es) |
CN (1) | CN1665482A (es) |
AR (1) | AR039491A1 (es) |
AT (1) | ATE419830T1 (es) |
AU (1) | AU2003234216A1 (es) |
BR (1) | BR0309620A (es) |
CA (1) | CA2483655A1 (es) |
DE (1) | DE60325715D1 (es) |
EC (1) | ECSP045451A (es) |
ES (1) | ES2320435T3 (es) |
HK (1) | HK1072558A1 (es) |
IL (1) | IL164911A0 (es) |
MX (1) | MXPA04010769A (es) |
NO (1) | NO20045117L (es) |
NZ (1) | NZ536252A (es) |
PE (1) | PE20031017A1 (es) |
PL (1) | PL373031A1 (es) |
RU (1) | RU2004134594A (es) |
TW (1) | TW200404010A (es) |
UY (1) | UY27789A1 (es) |
WO (1) | WO2003092648A1 (es) |
ZA (1) | ZA200409549B (es) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
US20110104214A1 (en) * | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
EP1429739A1 (en) | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer release system |
WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
US20050106249A1 (en) * | 2002-04-29 | 2005-05-19 | Stephen Hwang | Once-a-day, oral, controlled-release, oxycodone dosage forms |
MXPA04012021A (es) * | 2002-05-31 | 2005-08-16 | Johnson & Johnson | Formas de dosis y composiciones para la administracion osmotica de dosis variables de oxicodona. |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
ATE495732T1 (de) | 2003-03-26 | 2011-02-15 | Egalet As | Morphin-system mit kontrollierter freisetzung |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102004020220A1 (de) * | 2004-04-22 | 2005-11-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE102004032051A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
DE102005005446A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
CN1933837A (zh) * | 2003-10-29 | 2007-03-21 | 阿尔扎公司 | 一天一次经口受控释放氧可酮剂型 |
TWI483944B (zh) * | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
LT1765292T (lt) | 2004-06-12 | 2018-01-10 | Collegium Pharmaceutical, Inc. | Nuo piktnaudžiavimo apsaugotos vaistų formos |
DE102004032103A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
PL116330U1 (en) * | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
EP1954514B1 (en) * | 2005-11-23 | 2013-07-17 | Valmet Automotive Oy | Convertible top having overcenter linkage |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
DE102007011485A1 (de) * | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
AU2008258596B2 (en) | 2007-06-04 | 2013-02-14 | Egalet Ltd | Controlled release pharmaceutical compositions for prolonged effect |
US20090030072A1 (en) * | 2007-07-03 | 2009-01-29 | Sucampo Ag | Pharmaceutical combination of opioid and prostaglandin compound |
JP5774853B2 (ja) | 2008-01-25 | 2015-09-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 医薬投薬形 |
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CA2723438C (en) | 2008-05-09 | 2016-10-11 | Gruenenthal Gmbh | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
AU2010211220B2 (en) | 2009-02-06 | 2013-08-01 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
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NZ603579A (en) | 2009-06-24 | 2014-02-28 | Egalet Ltd | Controlled release formulations |
MX2012000369A (es) | 2009-07-22 | 2012-02-01 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion para opioides sensibles a la oxidacion. |
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US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
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ES2487244T3 (es) | 2010-09-02 | 2014-08-20 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación que comprende un polímero aniónico |
AU2011346757B2 (en) | 2010-12-22 | 2015-08-20 | Purdue Pharma L.P. | Encased tamper resistant controlled release dosage forms |
JP5638151B2 (ja) | 2010-12-23 | 2014-12-10 | パーデュー、ファーマ、リミテッド、パートナーシップ | 不正加工抵抗性の(tamperresistant)固形経口剤形 |
HUE031251T2 (en) | 2011-06-30 | 2017-07-28 | Develco Pharma Schweiz Ag | Controlled release oral dosage form containing oxycodone |
US20130028972A1 (en) | 2011-07-29 | 2013-01-31 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
PT2736495T (pt) | 2011-07-29 | 2017-11-30 | Gruenenthal Gmbh | Comprimido resistente à adulteração proporcionando libertação imediata de fármaco |
BR112014019988A8 (pt) | 2012-02-28 | 2017-07-11 | Gruenenthal Gmbh | Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico |
JP6282261B2 (ja) | 2012-04-18 | 2018-02-21 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 不正使用防止および過量放出防止医薬剤形 |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
KR20150059167A (ko) | 2012-07-06 | 2015-05-29 | 에갈렛 리미티드 | 제어된 방출을 위한 남용 제지 약학적 조성물 |
US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
BR112015029616A2 (pt) | 2013-05-29 | 2017-07-25 | Gruenenthal Gmbh | forma de dosagem resistente à adulteração com perfil de liberação bimodal |
CA2907950A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper-resistant dosage form containing one or more particles |
KR20160031526A (ko) | 2013-07-12 | 2016-03-22 | 그뤼넨탈 게엠베하 | 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형 |
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TW202329972A (zh) | 2016-08-10 | 2023-08-01 | 瑞士商赫孚孟拉羅股份公司 | 包含Akt蛋白質激酶抑制劑之醫藥組合物 |
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-
2003
- 2003-04-25 US US10/423,454 patent/US20040010000A1/en not_active Abandoned
- 2003-04-25 RU RU2004134594/15A patent/RU2004134594A/ru not_active Application Discontinuation
- 2003-04-25 BR BR0309620-3A patent/BR0309620A/pt not_active IP Right Cessation
- 2003-04-25 DE DE60325715T patent/DE60325715D1/de not_active Expired - Lifetime
- 2003-04-25 JP JP2004500833A patent/JP2005525405A/ja not_active Withdrawn
- 2003-04-25 AU AU2003234216A patent/AU2003234216A1/en not_active Abandoned
- 2003-04-25 EP EP03728526A patent/EP1499291B1/en not_active Expired - Lifetime
- 2003-04-25 AT AT03728526T patent/ATE419830T1/de not_active IP Right Cessation
- 2003-04-25 NZ NZ536252A patent/NZ536252A/en unknown
- 2003-04-25 ES ES03728526T patent/ES2320435T3/es not_active Expired - Lifetime
- 2003-04-25 CN CN038154773A patent/CN1665482A/zh active Pending
- 2003-04-25 PL PL03373031A patent/PL373031A1/xx not_active Application Discontinuation
- 2003-04-25 MX MXPA04010769A patent/MXPA04010769A/es unknown
- 2003-04-25 WO PCT/US2003/012781 patent/WO2003092648A1/en active Application Filing
- 2003-04-25 CA CA002483655A patent/CA2483655A1/en not_active Abandoned
- 2003-04-28 TW TW092109908A patent/TW200404010A/zh unknown
- 2003-04-29 PE PE2003000425A patent/PE20031017A1/es not_active Application Discontinuation
- 2003-04-29 UY UY27789A patent/UY27789A1/es not_active Application Discontinuation
- 2003-04-29 AR ARP030101492A patent/AR039491A1/es not_active Application Discontinuation
-
2004
- 2004-10-28 IL IL16491104A patent/IL164911A0/xx unknown
- 2004-11-24 EC EC2004005451A patent/ECSP045451A/es unknown
- 2004-11-24 NO NO20045117A patent/NO20045117L/no not_active Application Discontinuation
- 2004-11-25 ZA ZA200409549A patent/ZA200409549B/en unknown
-
2005
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Also Published As
Publication number | Publication date |
---|---|
NZ536252A (en) | 2007-06-29 |
HK1072558A1 (en) | 2005-09-02 |
NO20045117L (no) | 2005-01-14 |
RU2004134594A (ru) | 2005-06-27 |
WO2003092648A1 (en) | 2003-11-13 |
BR0309620A (pt) | 2005-03-15 |
MXPA04010769A (es) | 2005-07-05 |
EP1499291A1 (en) | 2005-01-26 |
PL373031A1 (en) | 2005-08-08 |
IL164911A0 (en) | 2005-12-18 |
JP2005525405A (ja) | 2005-08-25 |
CN1665482A (zh) | 2005-09-07 |
TW200404010A (en) | 2004-03-16 |
ATE419830T1 (de) | 2009-01-15 |
ES2320435T3 (es) | 2009-05-22 |
CA2483655A1 (en) | 2003-11-13 |
ECSP045451A (es) | 2005-01-28 |
DE60325715D1 (de) | 2009-02-26 |
UY27789A1 (es) | 2003-08-29 |
AU2003234216A1 (en) | 2003-11-17 |
ZA200409549B (en) | 2006-07-26 |
EP1499291B1 (en) | 2009-01-07 |
US20040010000A1 (en) | 2004-01-15 |
AR039491A1 (es) | 2005-02-23 |
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