PE20020456A1 - Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedades - Google Patents
Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedadesInfo
- Publication number
- PE20020456A1 PE20020456A1 PE2001000833A PE2001000833A PE20020456A1 PE 20020456 A1 PE20020456 A1 PE 20020456A1 PE 2001000833 A PE2001000833 A PE 2001000833A PE 2001000833 A PE2001000833 A PE 2001000833A PE 20020456 A1 PE20020456 A1 PE 20020456A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- heterocycloalkyl
- treatment
- quinuclidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DE QUINUCLIDINA DE FORMULA I DONDE R1 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ALQUILO HALOGENADO C1-C6, ARILO; R2 ES H, ALQUILO C1-C6, ALQUILO HALOGENADO, CICLOALQUILO, BENCILO, ARILO SUSTITUIDO CON F, Cl, Br, I, R7, R9, OR10; R10 ES H, ALQUILO, CICLOALQUILO, HETEROCICLOALQUILO; X ES O, S; W ES UN GRUPO a, b; V, Y SON =N, =CR5; U ES O, S, NR3; Z ES =N, =CH; V E Y SON AMBOS =CR5; Z ES =CH; UN =CR5 ES =CH; U ES O, Y ES =CR5, Z ES =CR5, V NO ES =N-; R5 ES H, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, HETEROCICLOALQUILO, OR8, OR14, R9; R7 ES UN GRUPO HETEROAROMATICO MONOCICLICO, ANILLO FUSIONADO DE 9 MIEMBROS DE FORMULA c; E ES O, S, NR3; R9 ES UN GRUPO HETEROAROMATICO DE 6 MIEMBROS; R11 ES H, ALQUILO, CICLOALQUILO, HETEROCICLOALQUILO; R14 ES H, ALQUILO, ALQUILO HALOGENADO, CICLOALQUILO. SON COMPUESTOS PREFERIDOS N-[(3R)-1-AZABICICLO[2.2.2]-OCT-3-IL]-5-ACETIL-TIOFEN-2-CARBOXAMIDA, CLORHIDRATO DE N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-5-(3-FLUORO-4-HIDROXIFENIL)-TIOFEN-2-CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS SON AGONISTAS DE LOS RECEPTORES DE ACETILCOLINA a7 NICOTINICO nAChRa7 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE BULIMIA, ANOREXIA NERVIOSA, SINTOMAS DE ABSTINENCIA, SINDROME DE GILLES TOURETTE, GLAUCOMA, SINTOMAS ASOCIADOS AL DOLOR; UTILIZANDOSE DE 0,001mg/Kg A 100mg/Kg
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22665200P | 2000-08-21 | 2000-08-21 | |
US28484101P | 2001-04-19 | 2001-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020456A1 true PE20020456A1 (es) | 2002-05-17 |
Family
ID=26920742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000833A PE20020456A1 (es) | 2000-08-21 | 2001-08-21 | Grupos quinuclidina sustituidos con heteroarilo para el tratamiento de enfermedades |
Country Status (4)
Country | Link |
---|---|
US (1) | US6599916B2 (es) |
AU (1) | AU2001284646A1 (es) |
PE (1) | PE20020456A1 (es) |
WO (1) | WO2002015662A2 (es) |
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-
2001
- 2001-08-17 AU AU2001284646A patent/AU2001284646A1/en not_active Abandoned
- 2001-08-17 WO PCT/US2001/021140 patent/WO2002015662A2/en active Application Filing
- 2001-08-17 US US09/932,299 patent/US6599916B2/en not_active Expired - Fee Related
- 2001-08-21 PE PE2001000833A patent/PE20020456A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20020091135A1 (en) | 2002-07-11 |
AU2001284646A1 (en) | 2002-03-04 |
WO2002015662A2 (en) | 2002-02-28 |
WO2002015662A3 (en) | 2002-06-13 |
US6599916B2 (en) | 2003-07-29 |
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