PE20011268A1 - Composiciones farmaceuticas que comprenden una dispersion de solidos amorfos de [(1s)-bencil-(2r)-hidroxi-3-((3r,4s)-dihidroxi-pirrolidin-1-il)-3-oxipropil]amida del acido 5-cloro-1h-indol-2-carboxilico en un polimero que aumenta la concentracion com - Google Patents
Composiciones farmaceuticas que comprenden una dispersion de solidos amorfos de [(1s)-bencil-(2r)-hidroxi-3-((3r,4s)-dihidroxi-pirrolidin-1-il)-3-oxipropil]amida del acido 5-cloro-1h-indol-2-carboxilico en un polimero que aumenta la concentracion comInfo
- Publication number
- PE20011268A1 PE20011268A1 PE2001000250A PE2001000250A PE20011268A1 PE 20011268 A1 PE20011268 A1 PE 20011268A1 PE 2001000250 A PE2001000250 A PE 2001000250A PE 2001000250 A PE2001000250 A PE 2001000250A PE 20011268 A1 PE20011268 A1 PE 20011268A1
- Authority
- PE
- Peru
- Prior art keywords
- polymer
- oxypropyl
- indol
- pyrrolidin
- dihydroxy
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UNA DISPERSION DE SOLIDO AMORFO DE 10% A 60% EN PESO DE [(1S)-BENCIL-(2R)-HIDROXI-3-((3R,4S)-DIHIDROXI-PIRROLIDIN-1-IL)-3-OXIPROPIL]AMIDA DEL ACIDO 5-CLORO-1H-INDOL-2-CARBOXILICO EN UN POLIMERO QUE AUMENTA LA CONCENTRACION DONDE DICHO POLIMERO ES UN POLIMERO IONIZABLE SELECCIONADO DE POLIMORES CELULOCICOS IONIZABLES, NO ISONIZABLES, TAL COMO HIDROXIPROPIL METILCELULOSA, HIDROXIPROPILCELULOSA, METILCELULOSA ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION DE LA COMPOSICION Y FORMAS DE DOSIFICACION DE LIBERACION INMEDIATA, RETRASADA, CONTROLADA O SOSTENIDAS LAS CUALES COMPRENDEN DICHAS DISPERSIONES SOLIDAS Y EXCIPIENTES. LAS COMPOSICION ACTUAN COMO INHIBIDOR DE LA GLUCOGENO FOSFORILASA Y ES UTIL PARA EL TRATAMIENTO DE DIABETES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19012500P | 2000-03-16 | 2000-03-16 |
Publications (1)
Publication Number | Publication Date |
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PE20011268A1 true PE20011268A1 (es) | 2001-12-12 |
Family
ID=22700102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000250A PE20011268A1 (es) | 2000-03-16 | 2001-03-15 | Composiciones farmaceuticas que comprenden una dispersion de solidos amorfos de [(1s)-bencil-(2r)-hidroxi-3-((3r,4s)-dihidroxi-pirrolidin-1-il)-3-oxipropil]amida del acido 5-cloro-1h-indol-2-carboxilico en un polimero que aumenta la concentracion com |
Country Status (16)
Country | Link |
---|---|
US (2) | US20010053791A1 (es) |
EP (1) | EP1263433A2 (es) |
JP (2) | JP2003526666A (es) |
AR (2) | AR028253A1 (es) |
AU (1) | AU2001240978A1 (es) |
CA (1) | CA2403233A1 (es) |
CO (1) | CO5271644A1 (es) |
GT (1) | GT200100039A (es) |
MX (1) | MXPA02009098A (es) |
PA (1) | PA8513701A1 (es) |
PE (1) | PE20011268A1 (es) |
SV (1) | SV2002000342A (es) |
TN (1) | TNSN01041A1 (es) |
TW (1) | TW200304377A (es) |
UY (1) | UY26615A1 (es) |
WO (1) | WO2001068092A2 (es) |
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DE19637082A1 (de) * | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Schnellzerfallende Pellets |
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JP2000072676A (ja) | 1998-09-01 | 2000-03-07 | Taiho Yakuhin Kogyo Kk | 吸収を改善した医薬組成物 |
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-
2001
- 2001-03-14 GT GT200100039A patent/GT200100039A/es unknown
- 2001-03-14 US US09/808,559 patent/US20010053791A1/en not_active Abandoned
- 2001-03-14 UY UY26615A patent/UY26615A1/es not_active Application Discontinuation
- 2001-03-14 AR ARP010101186A patent/AR028253A1/es unknown
- 2001-03-15 PE PE2001000250A patent/PE20011268A1/es not_active Application Discontinuation
- 2001-03-15 SV SV2001000342A patent/SV2002000342A/es unknown
- 2001-03-15 TN TNTNSN01041A patent/TNSN01041A1/fr unknown
- 2001-03-16 AU AU2001240978A patent/AU2001240978A1/en not_active Abandoned
- 2001-03-16 JP JP2001566656A patent/JP2003526666A/ja active Pending
- 2001-03-16 WO PCT/IB2001/000389 patent/WO2001068092A2/en not_active Application Discontinuation
- 2001-03-16 PA PA20018513701A patent/PA8513701A1/es unknown
- 2001-03-16 EP EP01912061A patent/EP1263433A2/en not_active Withdrawn
- 2001-03-16 MX MXPA02009098A patent/MXPA02009098A/es unknown
- 2001-03-16 TW TW092109925A patent/TW200304377A/zh unknown
- 2001-03-16 CO CO01021774A patent/CO5271644A1/es not_active Application Discontinuation
- 2001-03-16 CA CA002403233A patent/CA2403233A1/en not_active Abandoned
-
2003
- 2003-03-21 US US10/393,549 patent/US7235260B2/en not_active Expired - Lifetime
- 2003-06-19 AR ARP030102181A patent/AR040281A2/es unknown
-
2007
- 2007-02-27 JP JP2007047459A patent/JP2007182449A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2001068092A2 (en) | 2001-09-20 |
JP2007182449A (ja) | 2007-07-19 |
AU2001240978A1 (en) | 2001-09-24 |
WO2001068092A3 (en) | 2002-03-21 |
AR028253A1 (es) | 2003-04-30 |
TW200304377A (en) | 2003-10-01 |
TNSN01041A1 (fr) | 2005-11-10 |
US20010053791A1 (en) | 2001-12-20 |
PA8513701A1 (es) | 2002-10-24 |
US20030185891A1 (en) | 2003-10-02 |
JP2003526666A (ja) | 2003-09-09 |
EP1263433A2 (en) | 2002-12-11 |
UY26615A1 (es) | 2001-10-25 |
GT200100039A (es) | 2001-12-31 |
MXPA02009098A (es) | 2003-03-12 |
CO5271644A1 (es) | 2003-04-30 |
CA2403233A1 (en) | 2001-09-20 |
AR040281A2 (es) | 2005-03-23 |
US7235260B2 (en) | 2007-06-26 |
SV2002000342A (es) | 2002-07-16 |
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