PE20010913A1 - Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2-sustituidas - Google Patents

Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2-sustituidas

Info

Publication number
PE20010913A1
PE20010913A1 PE2000001266A PE0012662000A PE20010913A1 PE 20010913 A1 PE20010913 A1 PE 20010913A1 PE 2000001266 A PE2000001266 A PE 2000001266A PE 0012662000 A PE0012662000 A PE 0012662000A PE 20010913 A1 PE20010913 A1 PE 20010913A1
Authority
PE
Peru
Prior art keywords
ethyl
trifluoromethyl
acid
quinoline
dihydro
Prior art date
Application number
PE2000001266A
Other languages
English (en)
Spanish (es)
Inventor
David Burns Damon
Robert Wayne Dugger
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20010913A1 publication Critical patent/PE20010913A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PE2000001266A 1999-11-30 2000-11-28 Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2-sustituidas PE20010913A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
PE20010913A1 true PE20010913A1 (es) 2001-09-10

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001266A PE20010913A1 (es) 1999-11-30 2000-11-28 Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2-sustituidas

Country Status (44)

Country Link
US (1) US6313142B1 (en:Method)
EP (1) EP1125929B1 (en:Method)
JP (1) JP3579345B2 (en:Method)
KR (1) KR100408177B1 (en:Method)
CN (1) CN1173953C (en:Method)
AP (1) AP2000002011A0 (en:Method)
AR (1) AR029775A1 (en:Method)
AT (1) ATE315028T1 (en:Method)
AU (1) AU784694B2 (en:Method)
BG (1) BG105009A (en:Method)
BR (1) BR0005636A (en:Method)
CA (1) CA2327029C (en:Method)
CO (1) CO5261552A1 (en:Method)
CY (1) CY1104989T1 (en:Method)
CZ (1) CZ20004407A3 (en:Method)
DE (1) DE60025317T2 (en:Method)
DK (1) DK1125929T3 (en:Method)
DZ (1) DZ3079A1 (en:Method)
EA (1) EA003668B1 (en:Method)
EE (1) EE200000659A (en:Method)
ES (1) ES2254109T3 (en:Method)
GE (1) GEP20022798B (en:Method)
GT (1) GT200000190A (en:Method)
HN (1) HN2000000203A (en:Method)
HR (1) HRP20000804A2 (en:Method)
HU (1) HUP0004747A3 (en:Method)
ID (1) ID28489A (en:Method)
IL (1) IL139849A (en:Method)
IS (1) IS5715A (en:Method)
MA (1) MA25223A1 (en:Method)
NO (1) NO20006039L (en:Method)
NZ (1) NZ508509A (en:Method)
OA (1) OA11494A (en:Method)
PA (1) PA8503801A1 (en:Method)
PE (1) PE20010913A1 (en:Method)
PL (1) PL344208A1 (en:Method)
SG (1) SG102603A1 (en:Method)
SK (1) SK17792000A3 (en:Method)
TN (1) TNSN00230A1 (en:Method)
TW (1) TW591016B (en:Method)
UA (1) UA65615C2 (en:Method)
UY (1) UY26451A1 (en:Method)
YU (1) YU71500A (en:Method)
ZA (1) ZA200006947B (en:Method)

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RU2004121898A (ru) * 2001-12-19 2006-01-20 Атеродженикс, Инк. (Us) Производные халкона и их применение для лечения заболеваний
US7202247B2 (en) 2001-12-19 2007-04-10 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
AU2003230916A1 (en) * 2002-04-11 2003-10-27 Roar Holding Llc Ex vivo method for determination of cetp activity and efficacy of heart disease treatment
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
EP1556047A4 (en) * 2002-10-04 2009-09-30 Millennium Pharm Inc ANTAGONISTS AGAINST THE PGD2 RECEPTOR FOR THE TREATMENT OF INFLAMMATORY DISEASES
US7223870B2 (en) * 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
ES2310676T3 (es) 2002-12-20 2009-01-16 Pfizer Products Inc. Formas de dosificacion que comprenden un inhibidor de cetp y un inhibidor de hmg-coa reductasa.
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
EP1601655A2 (en) * 2003-03-04 2005-12-07 Takasago International Corporation Method for producing optically active amines
CA2519458A1 (en) * 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of s-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]-2-methylpropanethioate
EP1603553B9 (en) * 2003-03-17 2012-06-20 Japan Tobacco Inc. Pharmaceutical compositions of cetp inhibitors
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
ATE442358T1 (de) * 2003-10-08 2009-09-15 Lilly Co Eli Verbindungen und verfahren zur behandlung von dyslipidemie
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
KR20070041452A (ko) * 2004-06-24 2007-04-18 일라이 릴리 앤드 캄파니 이상지혈증 치료를 위한 화합물 및 방법
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
WO2006069162A1 (en) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
CN101146776A (zh) * 2005-02-24 2008-03-19 米伦纽姆医药公司 治疗炎性疾病的pgd2受体拮抗剂
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
EP2134169A2 (en) 2007-03-09 2009-12-23 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
JP2025524532A (ja) 2022-07-05 2025-07-30 ニューアムステルダム ファーマ ベー．フェー． オビセトラピブの塩およびその製造方法およびその中間体

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US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
BG105009A (en) 2001-11-30
IL139849A (en) 2006-10-31
EA200001129A3 (ru) 2001-10-22
MA25223A1 (fr) 2001-07-02
US6313142B1 (en) 2001-11-06
JP3579345B2 (ja) 2004-10-20
CN1302800A (zh) 2001-07-11
HU0004747D0 (en:Method) 2001-02-28
HN2000000203A (es) 2001-06-13
UA65615C2 (uk) 2004-04-15
ID28489A (id) 2001-05-31
UY26451A1 (es) 2001-06-29
CA2327029A1 (en) 2001-05-30
SK17792000A3 (sk) 2002-10-08
AP2000002011A0 (en) 2000-12-31
GT200000190A (es) 2002-04-27
IS5715A (is) 2001-05-31
NZ508509A (en) 2001-06-29
SG102603A1 (en) 2004-03-26
CY1104989T1 (el) 2010-03-03
CA2327029C (en) 2005-08-09
HRP20000804A2 (en) 2001-06-30
AU784694B2 (en) 2006-06-01
DZ3079A1 (fr) 2004-10-24
EA200001129A2 (ru) 2001-06-25
ZA200006947B (en) 2002-05-27
HUP0004747A2 (hu) 2001-10-28
CZ20004407A3 (cs) 2002-06-12
AU7178900A (en) 2001-05-31
CO5261552A1 (es) 2003-03-31
EP1125929A1 (en) 2001-08-22
AR029775A1 (es) 2003-07-16
YU71500A (sh) 2003-02-28
KR20010052012A (ko) 2001-06-25
KR100408177B1 (ko) 2003-12-01
TNSN00230A1 (fr) 2005-11-10
GEP20022798B (en) 2002-09-25
EA003668B1 (ru) 2003-08-28
CN1173953C (zh) 2004-11-03
BR0005636A (pt) 2001-07-17
HK1038007A1 (en) 2002-03-01
IL139849A0 (en) 2002-02-10
EP1125929B1 (en) 2006-01-04
OA11494A (en) 2004-05-07
DK1125929T3 (da) 2006-04-03
JP2001163859A (ja) 2001-06-19
EE200000659A (et) 2001-08-15
HUP0004747A3 (en) 2002-12-28
TW591016B (en) 2004-06-11
NO20006039L (no) 2001-05-31
PL344208A1 (en) 2001-06-04
DE60025317T2 (de) 2006-08-03
NO20006039D0 (no) 2000-11-29
PA8503801A1 (es) 2002-07-30
ATE315028T1 (de) 2006-02-15
ES2254109T3 (es) 2006-06-16
DE60025317D1 (de) 2006-03-30

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed