PE20010167A1 - Amidas de acidos fenilciclohexanocarboxilicos sustituidos con actividad inhibidora de la incorporacion de adenosina - Google Patents
Amidas de acidos fenilciclohexanocarboxilicos sustituidos con actividad inhibidora de la incorporacion de adenosinaInfo
- Publication number
- PE20010167A1 PE20010167A1 PE2000000506A PE0005062000A PE20010167A1 PE 20010167 A1 PE20010167 A1 PE 20010167A1 PE 2000000506 A PE2000000506 A PE 2000000506A PE 0005062000 A PE0005062000 A PE 0005062000A PE 20010167 A1 PE20010167 A1 PE 20010167A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- cycloalkyl
- adenosine
- incorporation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DE AMIDAS DE ACIDOS FENILCICLOHEXANOCARBOXILICOS SUSTITUIDOS DE FORMULA I DONDE A, D, E, G SON CH, N; L1 Y L2 SON H, HALOGENO, OH, CARBOXILO, CIANO, NITRO, ENTRE OTROS; R1 ES CH2-OH, CO-NR4R5; R4 Y R5 SON H, ALQUILO C1-C6; R2 ES CICLOALQUILO C3-C8, ALQUILO C1-C8, HETEROCICLO DE 4-8 MIEMBROS UNIDO A UN IMIDAZOL, HETEROCICLO DE 4-8 MIEMBROS CON NR7, N, O, S, CICLOALQUILO C3-C8, ALQUILO C1-C8, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C6, HIDROXIALQUILO C1-C6, CICLOALQUILO C3-C7; R8 Y R9 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C7, JUNTO CON N FORMAN UN HETEROCICLO DE 4 A 8 MIEMBROS; R3 ES FENILO, NAFTILO, PIRIMIDINILO, PIRIDILO, FURILO, TIENILO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES (S)-N-{{(1R,2R)-2-{4-{[2-(4-METIL-PIPERAZIN-1-IL)-BENCIMIDAZOL-1-IL]METIL}-FENIL}-CICLOHEX-1-IL}CARBONIL}-FENILGLICINAMIDA. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y A COMPUESTOS INTERMEDIOS. LOS COMPUESTOS DE FORMULA I TIENEN ACTIVIDAD INHIBIDORA DE LA INCORPORACION DE ADENOSINA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ISQUEMICAS CEREBRALES, TRAUMA CEREBRAL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19924818A DE19924818A1 (de) | 1999-05-29 | 1999-05-29 | Substituierte Phenylcyclohexancarbonsäureamide |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010167A1 true PE20010167A1 (es) | 2001-04-25 |
Family
ID=7909712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000506A PE20010167A1 (es) | 1999-05-29 | 2000-05-26 | Amidas de acidos fenilciclohexanocarboxilicos sustituidos con actividad inhibidora de la incorporacion de adenosina |
Country Status (36)
Country | Link |
---|---|
US (2) | US6716849B1 (es) |
EP (1) | EP1185516B1 (es) |
JP (1) | JP2003500475A (es) |
KR (1) | KR20020003397A (es) |
CN (1) | CN1200932C (es) |
AR (1) | AR024100A1 (es) |
AT (1) | ATE238997T1 (es) |
AU (1) | AU765752B2 (es) |
BG (1) | BG106107A (es) |
BR (1) | BR0011061A (es) |
CA (1) | CA2375186A1 (es) |
CZ (1) | CZ20014288A3 (es) |
DE (2) | DE19924818A1 (es) |
DK (1) | DK1185516T3 (es) |
EE (1) | EE200100634A (es) |
ES (1) | ES2197870T3 (es) |
GT (1) | GT200000083A (es) |
HK (1) | HK1048810A1 (es) |
HN (1) | HN2000000072A (es) |
HR (1) | HRP20010955A2 (es) |
HU (1) | HUP0201350A3 (es) |
IL (1) | IL146392A0 (es) |
MA (1) | MA25414A1 (es) |
MX (1) | MXPA01012241A (es) |
MY (1) | MY122576A (es) |
NO (1) | NO20015810L (es) |
PE (1) | PE20010167A1 (es) |
PL (1) | PL352101A1 (es) |
PT (1) | PT1185516E (es) |
RU (1) | RU2246490C9 (es) |
SI (1) | SI1185516T1 (es) |
SK (1) | SK17052001A3 (es) |
SV (1) | SV2004000087A (es) |
UA (1) | UA73126C2 (es) |
WO (1) | WO2000073275A1 (es) |
ZA (1) | ZA200109263B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1834090B (zh) * | 2005-03-18 | 2011-06-29 | 中国科学院上海药物研究所 | 苯并咪唑类化合物、其制备方法以及用途 |
AR072143A1 (es) * | 2008-06-16 | 2010-08-11 | Boehringer Ingelheim Int | Procedimiento para la preparacion de un producto intermedio para la sintesis de etexilato de dabigatran |
EP2858983B1 (en) | 2012-06-11 | 2018-04-18 | UCB Biopharma SPRL | Tnf-alpha modulating benzimidazoles |
WO2020107013A1 (en) * | 2018-11-25 | 2020-05-28 | Bluevalley Pharmaceutical Llc | Orally active prodrug of gemcitabine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2685918B1 (fr) | 1992-01-08 | 1995-06-23 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
DE4221009A1 (de) | 1992-06-26 | 1994-01-05 | Bayer Ag | Imidazolyl-substituierte Cyclohexanderivate |
ES2125285T3 (es) * | 1992-07-31 | 1999-03-01 | Bristol Myers Squibb Co | Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles. |
DE4304455A1 (de) | 1993-02-15 | 1994-08-18 | Bayer Ag | Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate |
DE4401893A1 (de) | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
HRP960015B1 (en) | 1995-02-01 | 2000-12-31 | Bayer Ag | Substituted indole derivatives |
DE19503160A1 (de) | 1995-02-01 | 1996-08-08 | Bayer Ag | Verwendung von Phenylcyclohexylcarbonsäureamiden |
-
1999
- 1999-05-29 DE DE19924818A patent/DE19924818A1/de not_active Withdrawn
-
2000
- 2000-05-10 HN HN2000000072A patent/HN2000000072A/es unknown
- 2000-05-16 DK DK00925288T patent/DK1185516T3/da active
- 2000-05-16 UA UA2001129201A patent/UA73126C2/uk unknown
- 2000-05-16 SK SK1705-2001A patent/SK17052001A3/sk unknown
- 2000-05-16 BR BR0011061-2A patent/BR0011061A/pt not_active IP Right Cessation
- 2000-05-16 AU AU44055/00A patent/AU765752B2/en not_active Ceased
- 2000-05-16 MX MXPA01012241A patent/MXPA01012241A/es active IP Right Grant
- 2000-05-16 IL IL14639200A patent/IL146392A0/xx unknown
- 2000-05-16 DE DE50001982T patent/DE50001982D1/de not_active Expired - Fee Related
- 2000-05-16 AT AT00925288T patent/ATE238997T1/de not_active IP Right Cessation
- 2000-05-16 ES ES00925288T patent/ES2197870T3/es not_active Expired - Lifetime
- 2000-05-16 CZ CZ20014288A patent/CZ20014288A3/cs unknown
- 2000-05-16 SI SI200030147T patent/SI1185516T1/xx unknown
- 2000-05-16 HU HU0201350A patent/HUP0201350A3/hu unknown
- 2000-05-16 CA CA002375186A patent/CA2375186A1/en not_active Abandoned
- 2000-05-16 RU RU2001135715/04A patent/RU2246490C9/ru not_active IP Right Cessation
- 2000-05-16 KR KR1020017015263A patent/KR20020003397A/ko active IP Right Grant
- 2000-05-16 EE EEP200100634A patent/EE200100634A/xx unknown
- 2000-05-16 CN CNB008110492A patent/CN1200932C/zh not_active Expired - Fee Related
- 2000-05-16 WO PCT/EP2000/004417 patent/WO2000073275A1/de not_active Application Discontinuation
- 2000-05-16 PT PT00925288T patent/PT1185516E/pt unknown
- 2000-05-16 US US09/980,243 patent/US6716849B1/en not_active Expired - Fee Related
- 2000-05-16 PL PL00352101A patent/PL352101A1/xx not_active Application Discontinuation
- 2000-05-16 EP EP00925288A patent/EP1185516B1/de not_active Expired - Lifetime
- 2000-05-16 JP JP2000621341A patent/JP2003500475A/ja active Pending
- 2000-05-24 AR ARP000102549A patent/AR024100A1/es not_active Application Discontinuation
- 2000-05-26 MY MYPI20002352A patent/MY122576A/en unknown
- 2000-05-26 SV SV2000000087A patent/SV2004000087A/es unknown
- 2000-05-26 GT GT200000083A patent/GT200000083A/es unknown
- 2000-05-26 PE PE2000000506A patent/PE20010167A1/es not_active Application Discontinuation
-
2001
- 2001-11-09 ZA ZA200109263A patent/ZA200109263B/xx unknown
- 2001-11-13 BG BG106107A patent/BG106107A/bg unknown
- 2001-11-26 MA MA26427A patent/MA25414A1/fr unknown
- 2001-11-28 NO NO20015810A patent/NO20015810L/no not_active Application Discontinuation
- 2001-12-24 HR HR20010955A patent/HRP20010955A2/hr not_active Application Discontinuation
-
2003
- 2003-02-07 HK HK03100922.0A patent/HK1048810A1/zh unknown
-
2004
- 2004-03-18 US US10/805,548 patent/US20040186106A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |