SI1185516T1 - Substituted phenylcyclohexane carboxylic acid amides that have an adenosine uptake inhibiting effect - Google Patents

Substituted phenylcyclohexane carboxylic acid amides that have an adenosine uptake inhibiting effect

Info

Publication number
SI1185516T1
SI1185516T1 SI200030147T SI200030147T SI1185516T1 SI 1185516 T1 SI1185516 T1 SI 1185516T1 SI 200030147 T SI200030147 T SI 200030147T SI 200030147 T SI200030147 T SI 200030147T SI 1185516 T1 SI1185516 T1 SI 1185516T1
Authority
SI
Slovenia
Prior art keywords
carboxylic acid
acid amides
inhibiting effect
adenosine uptake
uptake inhibiting
Prior art date
Application number
SI200030147T
Other languages
English (en)
Slovenian (sl)
Inventor
Wolf-Dietrich Freund
Stephen Lensky
Stephan Nicholas M�LLER
Holger Paulsen
Jrg Keldenich
Ervin Horvath
Joachim Schuhmacher
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of SI1185516T1 publication Critical patent/SI1185516T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200030147T 1999-05-29 2000-05-16 Substituted phenylcyclohexane carboxylic acid amides that have an adenosine uptake inhibiting effect SI1185516T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19924818A DE19924818A1 (de) 1999-05-29 1999-05-29 Substituierte Phenylcyclohexancarbonsäureamide
EP00925288A EP1185516B1 (de) 1999-05-29 2000-05-16 Substituierte phenylcyclohexancarbonsäureamide mit adenosinaufnahme-hemmender wirkung
PCT/EP2000/004417 WO2000073275A1 (de) 1999-05-29 2000-05-16 Substituierte phenylcyclohexancarbonsäureamide mit adenosinaufnahme-hemmender wirkung

Publications (1)

Publication Number Publication Date
SI1185516T1 true SI1185516T1 (en) 2003-10-31

Family

ID=7909712

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030147T SI1185516T1 (en) 1999-05-29 2000-05-16 Substituted phenylcyclohexane carboxylic acid amides that have an adenosine uptake inhibiting effect

Country Status (36)

Country Link
US (2) US6716849B1 (xx)
EP (1) EP1185516B1 (xx)
JP (1) JP2003500475A (xx)
KR (1) KR20020003397A (xx)
CN (1) CN1200932C (xx)
AR (1) AR024100A1 (xx)
AT (1) ATE238997T1 (xx)
AU (1) AU765752B2 (xx)
BG (1) BG106107A (xx)
BR (1) BR0011061A (xx)
CA (1) CA2375186A1 (xx)
CZ (1) CZ20014288A3 (xx)
DE (2) DE19924818A1 (xx)
DK (1) DK1185516T3 (xx)
EE (1) EE200100634A (xx)
ES (1) ES2197870T3 (xx)
GT (1) GT200000083A (xx)
HK (1) HK1048810A1 (xx)
HN (1) HN2000000072A (xx)
HR (1) HRP20010955A2 (xx)
HU (1) HUP0201350A3 (xx)
IL (1) IL146392A0 (xx)
MA (1) MA25414A1 (xx)
MX (1) MXPA01012241A (xx)
MY (1) MY122576A (xx)
NO (1) NO20015810L (xx)
PE (1) PE20010167A1 (xx)
PL (1) PL352101A1 (xx)
PT (1) PT1185516E (xx)
RU (1) RU2246490C9 (xx)
SI (1) SI1185516T1 (xx)
SK (1) SK17052001A3 (xx)
SV (1) SV2004000087A (xx)
UA (1) UA73126C2 (xx)
WO (1) WO2000073275A1 (xx)
ZA (1) ZA200109263B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1834090B (zh) * 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途
PL2297132T3 (pl) * 2008-06-16 2015-07-31 Boehringer Ingelheim Int Sposób wytwarzania produktu pośredniego dla eteksylanu dabigatranu
CA2874303C (en) 2012-06-11 2020-10-13 Ucb Biopharma Sprl Tnf -alpha modulating benz imidazoles
SG11202105512PA (en) * 2018-11-25 2021-06-29 Tnt Medical Corp Orally active prodrug of gemcitabine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685918B1 (fr) 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE4221009A1 (de) 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Cyclohexanderivate
ATE174913T1 (de) 1992-07-31 1999-01-15 Bristol Myers Squibb Co Diphenyl oxazole-, thiazole- und imidazole- derivate als inhibitoren der wiederaufnahme des adenosins
DE4304455A1 (de) 1993-02-15 1994-08-18 Bayer Ag Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4401893A1 (de) 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
HRP960015B1 (en) 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19503160A1 (de) 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden

Also Published As

Publication number Publication date
PL352101A1 (en) 2003-07-28
EE200100634A (et) 2003-02-17
RU2246490C2 (ru) 2005-02-20
US6716849B1 (en) 2004-04-06
EP1185516A1 (de) 2002-03-13
RU2246490C9 (ru) 2005-09-20
DE19924818A1 (de) 2000-11-30
AR024100A1 (es) 2002-09-04
CN1365356A (zh) 2002-08-21
ES2197870T3 (es) 2004-01-16
ZA200109263B (en) 2003-01-29
UA73126C2 (en) 2005-06-15
BR0011061A (pt) 2002-03-05
JP2003500475A (ja) 2003-01-07
IL146392A0 (en) 2002-07-25
MA25414A1 (fr) 2002-04-01
CZ20014288A3 (cs) 2002-03-13
BG106107A (bg) 2002-05-31
NO20015810L (no) 2002-01-25
EP1185516B1 (de) 2003-05-02
MY122576A (en) 2006-04-29
HK1048810A1 (zh) 2003-04-17
DK1185516T3 (da) 2003-08-11
HUP0201350A2 (en) 2002-08-28
ATE238997T1 (de) 2003-05-15
HRP20010955A2 (en) 2003-08-31
PT1185516E (pt) 2003-09-30
SK17052001A3 (sk) 2002-06-04
WO2000073275A1 (de) 2000-12-07
SV2004000087A (es) 2004-05-07
MXPA01012241A (es) 2002-08-12
AU765752B2 (en) 2003-09-25
GT200000083A (es) 2001-11-17
DE50001982D1 (de) 2003-06-05
HUP0201350A3 (en) 2003-05-28
PE20010167A1 (es) 2001-04-25
KR20020003397A (ko) 2002-01-12
HN2000000072A (es) 2001-02-02
AU4405500A (en) 2000-12-18
US20040186106A1 (en) 2004-09-23
CA2375186A1 (en) 2000-12-07
CN1200932C (zh) 2005-05-11
NO20015810D0 (no) 2001-11-28

Similar Documents

Publication Publication Date Title
GB2351077B (en) Improved acid corrosion inhibitor
GB9923804D0 (en) Electronic commerce system
GB2357664B (en) Electronic commerce system
EP1318726A4 (en) CLEANING AGENTS FOR MARINADES
PL367196A1 (en) Carboxylic acid derivative and salt thereof
HUP0101467A3 (en) Halogenated amidino amino acid derivatives useful as nitric monoxide synthase inhibitors
HK1054038A1 (en) Substituted n-benzyl-indol-3-yl gloyoxylic acid derivatives having an antitumural effect
HK1047274A1 (zh) 氨基苯甲酸衍生物
GB2350982B (en) Electronic commerce system
IL146392A0 (en) Substituted phenylcyclohexane carboxylic acid amides that have an adenosine uptake inhibiting effect
ZA200108894B (en) Substituted phenylcyclohexane carboxylic acid amides and their use as adenosine uptake inhibitors.
IL154633A0 (en) Substituted phenylcyclohexane carboxylic acid amides and the use thereof
GB2371133B (en) E commerce system
HK1054602A1 (en) Electronic commerce system
GB2348095B (en) Bite indicator
HK1039609A1 (zh) 甲氧基亞氨基苯基乙酰胺
GB2352524B (en) Trailer noseweight indicator
HUP0103891A3 (en) Cycloalkane carboxylic acid amides, fungicidal compositions containing thereof and their use
PL357012A1 (en) Novel alpha-sulfin- and alpha-sulfonamino acid amides
SI1178958T1 (en) N-cyanomethyl amides as protease inhibitors
GB9912903D0 (en) Fold-away tow bar
GB2348096B (en) Bite indicator
GB9907205D0 (en) Tow hitch
ZA200000799B (en) Hydroxymandelic acid amides of phenolic amines.
GB0026419D0 (en) Carboxylic acid complexes