GT200000083A - Amidas de acidos fenilciclohexanocarboxilicos sustituidos. - Google Patents

Amidas de acidos fenilciclohexanocarboxilicos sustituidos.

Info

Publication number
GT200000083A
GT200000083A GT200000083A GT200000083A GT200000083A GT 200000083 A GT200000083 A GT 200000083A GT 200000083 A GT200000083 A GT 200000083A GT 200000083 A GT200000083 A GT 200000083A GT 200000083 A GT200000083 A GT 200000083A
Authority
GT
Guatemala
Prior art keywords
acid
fenilciclohexanocarboxilic
amidas
equal
different
Prior art date
Application number
GT200000083A
Other languages
English (en)
Inventor
Wolf-Dietrich Freud
Stephen Lensky
Sthephan Nicholas Muller
Holger Paulsen
Jorg Keldenich
Ervin Horvarth
Joachim Schuhmacher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200000083A publication Critical patent/GT200000083A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE AL COMPUESTO DE FORMULA I, EN LA QUE LAS LETRAS "A, D, E Y G" SON IGUALES O DIFERENTES Y REPRESENTAN GRUPOS CH O ATOMOS DE NITROGENO, "L" SON IGUALES O DIFERENTES ENTRE SI Y REPRESENTAN INDEPENDIENTEMENTE ENTRE SI UNO O VARIOS RESTOS SELECCCIONADOS ENTRE EL GRUPO DE HIDROGENO, HALOGENO, HIDROXI, CARBOXILO, CIANO, NITRO, TRIFLUOROMETILO, TRIFLUOROMETOXI, ALQUILO C 1 6, ALCOXI O CARBONILO, "R" = CH2OH O UN RESTO DE LA FORMULA CO NR4R5. TAMBIEN SE REFIERE A SUS SALES FISIOLOGICAMENTE TOLERABLES, SIENDO LAS PREFERIDAS LAS FORMADAS CON HCL, ACIDO SULFURICO, ACIDO FOSFORICO, ACIDO ETANOSULFONICO, ACIDO ACETICO, ACIDO LACTICO, ENTRE OTROS. LA INVENCION ABARCA TAMBIEN A SUS ESTEREOISOMEROS Y A SUS MEZCLAS.
GT200000083A 1999-05-29 2000-05-26 Amidas de acidos fenilciclohexanocarboxilicos sustituidos. GT200000083A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19924818A DE19924818A1 (de) 1999-05-29 1999-05-29 Substituierte Phenylcyclohexancarbonsäureamide

Publications (1)

Publication Number Publication Date
GT200000083A true GT200000083A (es) 2001-11-17

Family

ID=7909712

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200000083A GT200000083A (es) 1999-05-29 2000-05-26 Amidas de acidos fenilciclohexanocarboxilicos sustituidos.

Country Status (36)

Country Link
US (2) US6716849B1 (es)
EP (1) EP1185516B1 (es)
JP (1) JP2003500475A (es)
KR (1) KR20020003397A (es)
CN (1) CN1200932C (es)
AR (1) AR024100A1 (es)
AT (1) ATE238997T1 (es)
AU (1) AU765752B2 (es)
BG (1) BG106107A (es)
BR (1) BR0011061A (es)
CA (1) CA2375186A1 (es)
CZ (1) CZ20014288A3 (es)
DE (2) DE19924818A1 (es)
DK (1) DK1185516T3 (es)
EE (1) EE200100634A (es)
ES (1) ES2197870T3 (es)
GT (1) GT200000083A (es)
HK (1) HK1048810A1 (es)
HN (1) HN2000000072A (es)
HR (1) HRP20010955A2 (es)
HU (1) HUP0201350A3 (es)
IL (1) IL146392A0 (es)
MA (1) MA25414A1 (es)
MX (1) MXPA01012241A (es)
MY (1) MY122576A (es)
NO (1) NO20015810L (es)
PE (1) PE20010167A1 (es)
PL (1) PL352101A1 (es)
PT (1) PT1185516E (es)
RU (1) RU2246490C9 (es)
SI (1) SI1185516T1 (es)
SK (1) SK17052001A3 (es)
SV (1) SV2004000087A (es)
UA (1) UA73126C2 (es)
WO (1) WO2000073275A1 (es)
ZA (1) ZA200109263B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1834090B (zh) * 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途
KR101677915B1 (ko) * 2008-06-16 2016-11-21 베링거 인겔하임 인터내셔날 게엠베하 다비가트란 에텍실레이트의 중간체 생성물의 제조 방법
JP6359008B2 (ja) 2012-06-11 2018-07-18 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ−アルファ調節ベンゾイミダゾール
MX2021006121A (es) * 2018-11-25 2021-10-13 Tnt Medical Corp Profarmaco de gemcitabina oralmente activo.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685918B1 (fr) 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE4221009A1 (de) 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Cyclohexanderivate
CA2101311A1 (en) * 1992-07-31 1994-02-01 Neelakantan Balasubramanian Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
DE4304455A1 (de) 1993-02-15 1994-08-18 Bayer Ag Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4401893A1 (de) 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
HRP960015B1 (en) 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19503160A1 (de) 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden

Also Published As

Publication number Publication date
HK1048810A1 (zh) 2003-04-17
DE50001982D1 (de) 2003-06-05
CZ20014288A3 (cs) 2002-03-13
BR0011061A (pt) 2002-03-05
AR024100A1 (es) 2002-09-04
KR20020003397A (ko) 2002-01-12
PT1185516E (pt) 2003-09-30
PL352101A1 (en) 2003-07-28
HRP20010955A2 (en) 2003-08-31
UA73126C2 (en) 2005-06-15
EP1185516A1 (de) 2002-03-13
MXPA01012241A (es) 2002-08-12
MA25414A1 (fr) 2002-04-01
AU765752B2 (en) 2003-09-25
RU2246490C9 (ru) 2005-09-20
US20040186106A1 (en) 2004-09-23
SK17052001A3 (sk) 2002-06-04
WO2000073275A1 (de) 2000-12-07
HUP0201350A2 (en) 2002-08-28
MY122576A (en) 2006-04-29
AU4405500A (en) 2000-12-18
ZA200109263B (en) 2003-01-29
IL146392A0 (en) 2002-07-25
DE19924818A1 (de) 2000-11-30
DK1185516T3 (da) 2003-08-11
SV2004000087A (es) 2004-05-07
HN2000000072A (es) 2001-02-02
CN1365356A (zh) 2002-08-21
BG106107A (bg) 2002-05-31
JP2003500475A (ja) 2003-01-07
NO20015810L (no) 2002-01-25
SI1185516T1 (en) 2003-10-31
PE20010167A1 (es) 2001-04-25
ATE238997T1 (de) 2003-05-15
CN1200932C (zh) 2005-05-11
EE200100634A (et) 2003-02-17
EP1185516B1 (de) 2003-05-02
ES2197870T3 (es) 2004-01-16
US6716849B1 (en) 2004-04-06
NO20015810D0 (no) 2001-11-28
CA2375186A1 (en) 2000-12-07
HUP0201350A3 (en) 2003-05-28
RU2246490C2 (ru) 2005-02-20

Similar Documents

Publication Publication Date Title
DE60239072D1 (de) Verfahren zur herstellung von glutaminsäurederivaten
CY1108931T1 (el) Μεθοδος παρασκευης παραγωγων βενζιμιδαζολ-2-υλο-κινολινονης
ATE306925T1 (de) Minoxidil enthaltende zubereitung
AR029696A1 (es) Derivados de ciclopentil-glutaramida como inhibidores de endopeptidasa neutra
IT1307022B1 (it) Processo semplificato per l'ottenimento di poliesteri alifaticibiodegradabili.
ATE554062T1 (de) Verfahren zur herstellung von alkylierten salicylamiden durch ein dicarboxylat- zwischenprodukt
ATE328965T1 (de) Azoverbindungen sowie verfahren zur herstellung derselben
BR0206495A (pt) Tratamento de distúrbios de cns empregando antagonistas de oxidase de d-aminoácido e oxidase de d-aspartato
GT200000083A (es) Amidas de acidos fenilciclohexanocarboxilicos sustituidos.
ATE411277T1 (de) Ein verfahren zur herstellung von n,n'- disubstituierten 5-amino-1,3-benzoldicarboxamiden
DE60113277T2 (de) Verfahren zur herstellung von dicarbonsäurediarylestern
ATE309992T1 (de) Verfahren zur herstellung von bis-benzazolyl verbindungen
DE50110723D1 (de) Isolierte luziferasen sowie deren verwendung
DE60104381D1 (de) Verfahren zur Herstellung von einer Amid Verbindung
DE69937988D1 (de) Verfahren zur herstellung von 3-cephemderivaten
ATE399152T1 (de) Verfahren zur herstellung von optisch aktiven azetidin-2-carbonsäuren
GT200000119A (es) Sulfonamidas sustituidas con naftilo.
DE60021410D1 (de) Verfahren zur herstellung von ketiminen
DE60014103D1 (de) Verfahren zur herstellung von debromohymenialdisin und deren analogen
BR9914739A (pt) éster de ácido fosfórico
DE60227386D1 (de) Zwischenprodukte für die herstellung von neuraminidase-inhibitor-konjugaten
ATE244262T1 (de) Verfahren zur herstellung von peptidzwischenprodukten
ATE267167T1 (de) Verfahren zur herstellung von 7-azabicyclo (4.1.0)-hept-3-ene-3-carbonsäureestern
ES2165022T3 (es) Derivados de acido piridonacarboxilico y sus intermedios de sintesis.
DE69814771D1 (de) Gamma-oxohomophenylalanin derivate und ein verfahren zur herstellung von homophenylalanin derivaten durch reduktion derselben