HK1048810A1 - 具有腺苷攝取抑制作用的取代的苯基環已烷甲酰胺 - Google Patents
具有腺苷攝取抑制作用的取代的苯基環已烷甲酰胺Info
- Publication number
- HK1048810A1 HK1048810A1 HK03100922.0A HK03100922A HK1048810A1 HK 1048810 A1 HK1048810 A1 HK 1048810A1 HK 03100922 A HK03100922 A HK 03100922A HK 1048810 A1 HK1048810 A1 HK 1048810A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- carboxylic acid
- acid amides
- inhibiting effect
- adenosine uptake
- uptake inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19924818A DE19924818A1 (de) | 1999-05-29 | 1999-05-29 | Substituierte Phenylcyclohexancarbonsäureamide |
PCT/EP2000/004417 WO2000073275A1 (de) | 1999-05-29 | 2000-05-16 | Substituierte phenylcyclohexancarbonsäureamide mit adenosinaufnahme-hemmender wirkung |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1048810A1 true HK1048810A1 (zh) | 2003-04-17 |
Family
ID=7909712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK03100922.0A HK1048810A1 (zh) | 1999-05-29 | 2003-02-07 | 具有腺苷攝取抑制作用的取代的苯基環已烷甲酰胺 |
Country Status (36)
Country | Link |
---|---|
US (2) | US6716849B1 (zh) |
EP (1) | EP1185516B1 (zh) |
JP (1) | JP2003500475A (zh) |
KR (1) | KR20020003397A (zh) |
CN (1) | CN1200932C (zh) |
AR (1) | AR024100A1 (zh) |
AT (1) | ATE238997T1 (zh) |
AU (1) | AU765752B2 (zh) |
BG (1) | BG106107A (zh) |
BR (1) | BR0011061A (zh) |
CA (1) | CA2375186A1 (zh) |
CZ (1) | CZ20014288A3 (zh) |
DE (2) | DE19924818A1 (zh) |
DK (1) | DK1185516T3 (zh) |
EE (1) | EE200100634A (zh) |
ES (1) | ES2197870T3 (zh) |
GT (1) | GT200000083A (zh) |
HK (1) | HK1048810A1 (zh) |
HN (1) | HN2000000072A (zh) |
HR (1) | HRP20010955A2 (zh) |
HU (1) | HUP0201350A3 (zh) |
IL (1) | IL146392A0 (zh) |
MA (1) | MA25414A1 (zh) |
MX (1) | MXPA01012241A (zh) |
MY (1) | MY122576A (zh) |
NO (1) | NO20015810L (zh) |
PE (1) | PE20010167A1 (zh) |
PL (1) | PL352101A1 (zh) |
PT (1) | PT1185516E (zh) |
RU (1) | RU2246490C9 (zh) |
SI (1) | SI1185516T1 (zh) |
SK (1) | SK17052001A3 (zh) |
SV (1) | SV2004000087A (zh) |
UA (1) | UA73126C2 (zh) |
WO (1) | WO2000073275A1 (zh) |
ZA (1) | ZA200109263B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1834090B (zh) * | 2005-03-18 | 2011-06-29 | 中国科学院上海药物研究所 | 苯并咪唑类化合物、其制备方法以及用途 |
DK2297132T3 (da) * | 2008-06-16 | 2015-05-26 | Boehringer Ingelheim Int | Fremgangsmåde til fremstilling af et mellemprodukt af dabigatran-etexilat |
TR201807207T4 (tr) | 2012-06-11 | 2018-06-21 | Ucb Biopharma Sprl | Tnf-alfa modüle edici benzimidazol bileşikleri. |
AU2019384826A1 (en) * | 2018-11-25 | 2021-07-15 | Tnt Medical Corporation | Orally active prodrug of gemcitabine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2685918B1 (fr) | 1992-01-08 | 1995-06-23 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
DE4221009A1 (de) | 1992-06-26 | 1994-01-05 | Bayer Ag | Imidazolyl-substituierte Cyclohexanderivate |
ES2125285T3 (es) | 1992-07-31 | 1999-03-01 | Bristol Myers Squibb Co | Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles. |
DE4304455A1 (de) | 1993-02-15 | 1994-08-18 | Bayer Ag | Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate |
DE4401893A1 (de) | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
DE19503160A1 (de) | 1995-02-01 | 1996-08-08 | Bayer Ag | Verwendung von Phenylcyclohexylcarbonsäureamiden |
HRP960015B1 (en) | 1995-02-01 | 2000-12-31 | Bayer Ag | Substituted indole derivatives |
-
1999
- 1999-05-29 DE DE19924818A patent/DE19924818A1/de not_active Withdrawn
-
2000
- 2000-05-10 HN HN2000000072A patent/HN2000000072A/es unknown
- 2000-05-16 EE EEP200100634A patent/EE200100634A/xx unknown
- 2000-05-16 JP JP2000621341A patent/JP2003500475A/ja active Pending
- 2000-05-16 WO PCT/EP2000/004417 patent/WO2000073275A1/de not_active Application Discontinuation
- 2000-05-16 IL IL14639200A patent/IL146392A0/xx unknown
- 2000-05-16 ES ES00925288T patent/ES2197870T3/es not_active Expired - Lifetime
- 2000-05-16 CA CA002375186A patent/CA2375186A1/en not_active Abandoned
- 2000-05-16 CZ CZ20014288A patent/CZ20014288A3/cs unknown
- 2000-05-16 KR KR1020017015263A patent/KR20020003397A/ko active IP Right Grant
- 2000-05-16 SI SI200030147T patent/SI1185516T1/xx unknown
- 2000-05-16 SK SK1705-2001A patent/SK17052001A3/sk unknown
- 2000-05-16 MX MXPA01012241A patent/MXPA01012241A/es active IP Right Grant
- 2000-05-16 US US09/980,243 patent/US6716849B1/en not_active Expired - Fee Related
- 2000-05-16 PT PT00925288T patent/PT1185516E/pt unknown
- 2000-05-16 CN CNB008110492A patent/CN1200932C/zh not_active Expired - Fee Related
- 2000-05-16 RU RU2001135715/04A patent/RU2246490C9/ru not_active IP Right Cessation
- 2000-05-16 AU AU44055/00A patent/AU765752B2/en not_active Ceased
- 2000-05-16 DK DK00925288T patent/DK1185516T3/da active
- 2000-05-16 UA UA2001129201A patent/UA73126C2/uk unknown
- 2000-05-16 HU HU0201350A patent/HUP0201350A3/hu unknown
- 2000-05-16 EP EP00925288A patent/EP1185516B1/de not_active Expired - Lifetime
- 2000-05-16 DE DE50001982T patent/DE50001982D1/de not_active Expired - Fee Related
- 2000-05-16 BR BR0011061-2A patent/BR0011061A/pt not_active IP Right Cessation
- 2000-05-16 AT AT00925288T patent/ATE238997T1/de not_active IP Right Cessation
- 2000-05-16 PL PL00352101A patent/PL352101A1/xx not_active Application Discontinuation
- 2000-05-24 AR ARP000102549A patent/AR024100A1/es not_active Application Discontinuation
- 2000-05-26 PE PE2000000506A patent/PE20010167A1/es not_active Application Discontinuation
- 2000-05-26 GT GT200000083A patent/GT200000083A/es unknown
- 2000-05-26 MY MYPI20002352A patent/MY122576A/en unknown
- 2000-05-26 SV SV2000000087A patent/SV2004000087A/es unknown
-
2001
- 2001-11-09 ZA ZA200109263A patent/ZA200109263B/xx unknown
- 2001-11-13 BG BG106107A patent/BG106107A/bg unknown
- 2001-11-26 MA MA26427A patent/MA25414A1/fr unknown
- 2001-11-28 NO NO20015810A patent/NO20015810L/no not_active Application Discontinuation
- 2001-12-24 HR HR20010955A patent/HRP20010955A2/hr not_active Application Discontinuation
-
2003
- 2003-02-07 HK HK03100922.0A patent/HK1048810A1/zh unknown
-
2004
- 2004-03-18 US US10/805,548 patent/US20040186106A1/en not_active Abandoned
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